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Articles 1 - 10 of 10
Full-Text Articles in Medicine and Health Sciences
Placental Expression Of Angiopoietin-1, Angiopoietin-2 And Tie-2 During Placental Development In An Ovine Model Of Placental Insufficiency-Fetal Growth Restriction., Amy S Erickson Hagen, Ryan J Orbus, Randall B Wilkening, Timothy Regnault, Russell V Anthony
Placental Expression Of Angiopoietin-1, Angiopoietin-2 And Tie-2 During Placental Development In An Ovine Model Of Placental Insufficiency-Fetal Growth Restriction., Amy S Erickson Hagen, Ryan J Orbus, Randall B Wilkening, Timothy Regnault, Russell V Anthony
Paediatrics Publications
Fetal growth restriction (FGR) is associated with increased perinatal morbidity and mortality, and often results from functional placental insufficiency. Placentation requires extensive vasculogenesis and subsequent angiogenesis, in both maternal and fetal tissues. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are angiogenic growth factors expressed in the placenta, and compete for binding to a common receptor, Tunica interna endothelial cell kinase-2 (Tie-2). Our objective was to examine Ang-1, Ang-2 and Tie-2 expression in ovine placental tissue obtained from normal and FGR pregnancies throughout gestation. Fetal cotyledon and maternal caruncle tissue concentrations of Ang-1, Ang-2 and Tie-2 mRNA were assessed by real-time reverse transcriptase-polymerase …
Basal Body Temperature Assessment: Is It Useful To Couples Seeking Pregnancy?, Mary Lee Barron, Richard Fehring
Basal Body Temperature Assessment: Is It Useful To Couples Seeking Pregnancy?, Mary Lee Barron, Richard Fehring
College of Nursing Faculty Research and Publications
Advanced practice nurses in primary care settings are often asked to give appropriate advice to couples seeking pregnancy. This article examines the issue of basal body temperature (BBT), a time-honored way to establish the presence of ovulatory cycles, and asks if BBT is an outdated recommendation. The article also reviews the benefits and limitations of recommending BBT to couples seeking pregnancy in light of recent fecundity research.
P38 Mitogen-Activated Protein Kinase (Mapk) First Regulates Filamentous Actin At The 8-16-Cell Stage During Preimplantation Development., Andrew J M Paliga, David R Natale, Andrew J Watson
P38 Mitogen-Activated Protein Kinase (Mapk) First Regulates Filamentous Actin At The 8-16-Cell Stage During Preimplantation Development., Andrew J M Paliga, David R Natale, Andrew J Watson
Obstetrics & Gynaecology Publications
BACKGROUND INFORMATION: The MAPK (mitogen-activated protein kinase) superfamily of proteins consists of four separate signalling cascades: the c-Jun N-terminal kinase or stress-activated protein kinases (JNK/SAPK); the ERKs (extracellular-signal-regulated kinases); the ERK5 or big MAPK1; and the p38 MAPK group of protein kinases, all of which are highly conserved. To date, our studies have focused on defining the role of the p38 MAPK pathway during preimplantation development. p38 MAPK regulates actin filament formation through the downstream kinases MAPKAPK2/3 (MAPK-activated protein kinase 2/3) or MAPKAPK5 [PRAK (p38 regulated/activated kinase)] and subsequently through HSP25/27 (heat-shock protein 25/27). We recently reported that 2-cell-stage murine …
A Critical Role For The Programmed Death Ligand 1 In Fetomaternal Tolerance, Indira Guleria, Arezou Khosroshahi, Mohammed Javeed Ansari, Antje Habicht, Miyuki Azuma, Hideo Yagita, Randolph J. Noelle
A Critical Role For The Programmed Death Ligand 1 In Fetomaternal Tolerance, Indira Guleria, Arezou Khosroshahi, Mohammed Javeed Ansari, Antje Habicht, Miyuki Azuma, Hideo Yagita, Randolph J. Noelle
Dartmouth Scholarship
Fetal survival during gestation implies that tolerance mechanisms suppress the maternal immune response to paternally inherited alloantigens. Here we show that the inhibitory T cell costimulatory molecule, programmed death ligand 1 (PDL1), has an important role in conferring fetomaternal tolerance in an allogeneic pregnancy model. Blockade of PDL1 signaling during murine pregnancy resulted in increased rejection rates of allogeneic concepti but not syngeneic concepti. Fetal rejection was T cell
Investigating The Causes Of Low Birth Weight In Contrasting Ovine Paradigms., J M Wallace, Timothy Regnault, S W Limesand, W W Hay, R V Anthony
Investigating The Causes Of Low Birth Weight In Contrasting Ovine Paradigms., J M Wallace, Timothy Regnault, S W Limesand, W W Hay, R V Anthony
Paediatrics Publications
Intrauterine growth restriction (IUGR) still accounts for a large incidence of infant mortality and morbidity worldwide. Many of the circulatory and transport properties of the sheep placenta are similar to those of the human placenta and as such, the pregnant sheep offers an excellent model in which to study the development of IUGR. Two natural models of ovine IUGR are those of hyperthermic exposure during pregnancy, and adolescent overfeeding, also during pregnancy. Both models yield significantly reduced placental weights and an asymmetrically growth-restricted fetus, and display altered maternal hormone concentrations, indicative of an impaired trophoblast capacity. Additionally, impaired placental angiogenesis …
Hemorrhagic Corpus Luteum Mimicking Heterotopic Pregnancy, Saba Sohail
Hemorrhagic Corpus Luteum Mimicking Heterotopic Pregnancy, Saba Sohail
Department of Radiology
Hemorrhagic corpus luteum (CL) is clinically known to simulate a number of medical, surgical and gynecologic conditions that cause acute abdomen. One such case is hereby presented that mimicked ectopic pregnancy clinically and heterotopic pregnancy on ultrasound. Laparoscopy was decisive.
The Effects Of Energy Restricted Diet On The Activities Of Plasma Cu-Zn Sod, Gsh-Px, Cat And Tbars Concentrations In Late Pregnant Ewes, Kemal Öztabak, Sabi̇ha Ci̇velek, Aysel Özpinar, Gülden Burçak, Feraye Esen
The Effects Of Energy Restricted Diet On The Activities Of Plasma Cu-Zn Sod, Gsh-Px, Cat And Tbars Concentrations In Late Pregnant Ewes, Kemal Öztabak, Sabi̇ha Ci̇velek, Aysel Özpinar, Gülden Burçak, Feraye Esen
Turkish Journal of Veterinary & Animal Sciences
The aim of the study was to determine the effects of low energy diets on the enzymatic antioxidant activities of ewes in late pregnancy. Thirty Chios ewes were used. Twenty pregnant ewes were divided into 2 groups of 10 ewes each (groups II and III), with 10 non-pregnant ewes being separated into a third group (group I). The ewes in groups I, II and III were fed rations containing 9.14 MJ ME/kg of dry matter (DM)-10.23% crude protein (CP), 10.20 MJ ME/kg of DM-15.04% CP, and 8.82 MJ ME/kg of DM-14.47% CP, respectively. Plasma copper-zinc superoxide dismutase (Cu-Zn SOD), glutathione …
Predictors Of Early Onset Of Sexual Intercourse In Male And Female Residents Of The United States, Brianna Michele Magnusson
Predictors Of Early Onset Of Sexual Intercourse In Male And Female Residents Of The United States, Brianna Michele Magnusson
Theses and Dissertations
Abstract Purpose: The United States has the highest rate of teen pregnancy of any industrialized nation. Adolescents who have their first sexual intercourse at a young age are at increased risk for teen pregnancies and acquiring a sexually transmitted disease. This study examines predictors of early onset sexual intercourse in male and female residents of the United States. Methods: A nationally representative sample of N=7,643 females and N=4.928 males ages 15-44 was procured from the 2002 National Survey of Family Growth (NSFG), Cycle 6. Age at first sexual intercourse was used to define early onset of sexual debut(<18 years). Socio-demographic and behavioral characteristics of the respondents, demographic and selected reproductive characteristics of the respondent's parents were examined using multiple logistic regression modeling. Results: Non-fispanic black, being raised without both parents, having a mother less than 18 years old at the age of first birth and age difference between partners were significant predictors of early onset of sexual intercourse for both males and females. Maternal education less than high school was a significant protective factor for female respondents [OR=0.72 (95%CI=0.58- 0.90)] and paternal education completed high school only [OR=1.4 (95% CI=l. 1-1.7)] was a significant risk factor for male respondents. Conclusions: Racelethnicity, age difference between partners, not being raised by both parents, having a mother who had her first birth before the age of 18 and parental education are important predictor variables. Further study should be conducted to investigate the protective effect of lack of maternal education for female respondents. Intervention programs for teen pregnancy and sexually transmitted infection prevention should target these at risk groups.
Effects Of Vitamin A And /Beta-Carotene Injection On Levels Of Vitamin E And On Glutathione Peroxidase Activity In Pregnant Tuj Sheep, Nadi̇de Nabi̇l Kami̇loğlu, Ebru Beytut, Kutlay Gürbulak, Meti̇n Öğün
Effects Of Vitamin A And /Beta-Carotene Injection On Levels Of Vitamin E And On Glutathione Peroxidase Activity In Pregnant Tuj Sheep, Nadi̇de Nabi̇l Kami̇loğlu, Ebru Beytut, Kutlay Gürbulak, Meti̇n Öğün
Turkish Journal of Veterinary & Animal Sciences
The objective of research was to study the effect of vitamin A and /beta-carotene injections, before breeding and during pregnancy, on the levels of vitamin E in plasma and on the activity of erythrocyte glutathione peroxidase (GSH-Px) in sheep. Thirty-two healthy female and four healthy male Tuj sheep, 4-5 years old and weighing approximately 57 kg each, were used. The female animals were divided into 4 groups with 8 sheep in each. The oestrus cycles of the ewes were synchronised by the application of sponges containing medroxyprogesterone acetate (MPA) and by the intramuscular administration of 500 IU of PMSG. Twenty-four …
Predictors Of Induced Abortion Among Female Youth Center Users In Port-Au-Prince, Haiti, Rachel Barker
Predictors Of Induced Abortion Among Female Youth Center Users In Port-Au-Prince, Haiti, Rachel Barker
Theses and Dissertations
Objective: Induced abortions occur in every country in the world. However sixty percent of the world's women live in countries where abortion is illegal. 19 million pregnancies end in unsafe and/or illegal abortions. Annually, 68,000 women die from unsafe abortions. Legal or not, unsafe abortion is one of the great neglected problems of health care in developing countries like Haiti and is a serious concern to women during their reproductive lives. Methods: The data for this study was collected from youth centers (ages 15-24) and used to estimate percentage distributions of abortion ratios by selected characteristics of women, particularly age …