Medicine and Health Sciences Commons^™

The Effects Of Mediterranean Diet On The Epileptic Population With Depression, Celina Navarro

Cohort XII

Background: People with epilepsy often develop depression during the course of their disease progression. This condition is multifactorial, often related to the unpredictability of their disease, the lack of control on their symptoms, and the medications they use to treat their seizures. Mental health services continue to be insufficient for our growing border region, and patients with epilepsy, often will lack the proper mental health management due to mental health provider shortage. Multiple medications can be used to successfully treat depression in the general population, however people with epilepsy often will struggle as anti-seizure drugs can interact with antidepressants. Also, …

Initiating Early Review Of Paxlovid Criteria With Suspected Covid + Patients To Reduce Disqualification Of Anti-Viral Therapy, Emily Robinson

Cohort XII

Introduction: Nearly 742 million cases of COVID have been detected since the beginning of the COVID-19 pandemic and over 6 million people have lost their lives due to COVID or a COVID related illness. While Arizona’s COVID-19 emergency declaration ended on March 30, 2022, there are still nearly 100,000 new cases each week as of September 2023. Nirmatrelvir-ritonavir (Paxlovid) is an outpatient antiviral medication recommended for adults with mild-to-moderate COVID-19 who have elevated risk of severe illness.

Aim/Methods: Regardless of vaccination status, taking Paxlovid within 5 days of diagnosis reduces the hospitalization rate by 51%. The majority of COVID positive …

What A Pain In The Back!!!, Sylvia De La Rosa

Cohort XII

Background: After reviewing my 10-day Practice Assessment Log (PAL) and documenting a clinical needs assessment of my practice, I documented, reviewed, and reflected upon my findings. In my current practice we address low back pain with Gabapentin 300mg TID and Methocarbamol 500mg BID. The present outcome is that most patients do not experience much in relief.

Aims/Methods: My Practice Improvement Project (PIP), validated via research, points to adding Celebrex 100mg BID, an anti-inflammatory, to patient’s regimen. I carried out this project for 30 days with a 2-week follow-up. The Translational Framework Knowledge-to-Action model was used to help me prepare the …

Following National Guidelines And Treatment To Eradicate Streptococcus Pharyngitis In Pediatrics, Rosa I. Montenegro

Cohort XII

Introduction: Sore throat (acute pharyngitis) is considered a prevalent disease worldwide among children and adults that requires healthcare. It is important to know that the etiology of sore throat in 70%-95% of cases is viral. Streptococcus pyogenes (group A streptococcus) is detected in approximately 15%-30% of all cases with sore throat, 5%-15% in adults, while 20%-30% in children. For the diagnosis of GAS infection, a throat swab is the gold standard procedure. Most guidelines are based on the seriousness of GAS infection to support the decision on the use of antibiotic treatment. All guidelines on sore throat give recommendations on …

Improving Bipolar Diagnosis With The Rapid Mood Screener, Leslie Richard

Cohort XII

Background: Bipolar disorder is a chronic, debilitating mental illness that affects individuals globally. It is characterized by significant challenges in diagnosis, often leading to delays in receiving appropriate treatment. This condition can mirror the symptoms of unipolar depression, leading to frequent misdiagnoses and hindering timely intervention that could improve functional outcomes and quality of life.

Aims/Methods: This project aims to enhance the accuracy of bipolar disorder diagnoses in clinical settings, specifically bipolar disorder type 1 (BPT1), at the earliest possible stage of the illness. By doing so, it seeks to improve symptom management, reduce the duration of episodes, and enhance …

Reaching Gold: Diagnosing And Individualizing Care Using Gold Abe Guidelines, Martha Flores

Cohort XII

Background: Chronic obstructive pulmonary disease (COPD) remains the fifth leading cause of disease-related deaths worldwide, resulting in an annual cost of $3.5 billion in the United States due to COPD exacerbations. COPD treatment necessitates a multifaceted approach that includes collecting complex, subjective, and objective patient information. A ten-day patient assessment log was completed in an outpatient pulmonary clinic to evaluate any shortcomings in the current practice, revealing that the current evaluation of breathlessness involved gathering subjective reporting with binary yes/no responses, leading to variability in diagnosis and treatment.

Methods/Aims: The binary evaluation fell short of the recommendations of the Global …

Hypertension And Treatment Modalities: What Does The Current Evidence Say?, Luis R. Tellez

Cohort XII

Background/Problem Statement: The significantly elevated rates of cardiovascular (CV) disease observed among individuals with mental health conditions might stem from suboptimal handling of cardiovascular risk factors. In this project, I sought to address one aspect of cardiovascular risk: hypertension in patients 18-74 years of age, marked with a blood pressure >140/90 mmHg in a psychiatric inpatient setting. A tenday review of patient care revealed that hypertension management provided to patients under our service was inadequate and might be improved by adopting and implementing more consistent and systematic protocols for medication administration.

Aims/Methods: At the onset of my project, I undertook …

On Solid Ground: A Quality Improvement For Fall Prevention, Jessica Vergara

Cohort XII

Background/Problem Statement: Falls among older adults are a significant concern, affecting up to 30% of individuals aged 65 and older annually. Multiple risk factors contribute to falls, including age, comorbidities, medications, and environmental hazards. Despite the common belief that falls are inevitable with aging, this project emphasizes the preventability of falls through multidisciplinary management and proactive engagement in fall prevention programs.

Aims/Methods: The initiative focuses on implementing the Matter of Balance (MoB) program within an institutional setting. MoB has shown favorable effects on fall-related concerns. The study employs a comprehensive outreach strategy targeting older adults at risk of falling, those …

Incorporating Aac Training In Nursing Education Programs To Enhance Understanding Of Caring For Patients With Complex Communication Needs, Tessa Bradley

Honors College Theses

As healthcare professionals, nurses must be able to effectively communicate with their patients to ensure their health, safety, and comfort. However, this can be particularly challenging when it comes to patients with complex communication needs (CCN), where communication breakdowns can lead to sentinel events. Alternative and augmentative communication (AAC) can help those with CCN improve communication across various settings, including in healthcare. Unfortunately, there is a severe lack of training for nurses when it comes to communicating with patients with CCN and the use of AAC. Webb et al. (2024) investigated the effectiveness of a combined synchronous and asynchronous training …

Functional Movement Screen: Exploring Interrater Reliability Between Students, Katie Biegel, Maari Dolan, Sidni Kast, Abi Kuznia, Blake Sjostrom

Physical Therapy Scholarly Projects

Purpose/Hypothesis: The purpose of this study was to assess the interrater reliability between five second-year physical therapy students on the scoring of the Functional Movement Screen (FMS) on 45 participants via pre-recorded videos. To our knowledge, few studies have been completed regarding interrater reliability on the FMS with the new criteria on the ankle mobility clearing test and updated criteria on the rotary stability test.

Materials/Methods: The students and an FMS expert reviewed grading criteria for each test and clearing test. Each student rater was allowed to watch each video once to score the motion to the best of …

Outpatient Physical Therapy Treatment For A Patient With A Transtibial Amputation: A Case Report, Cade D. Salentine

Physical Therapy Scholarly Projects

Introduction: Transtibial amputations (TTA) impose significant functional difficulty on those who undergo the procedure. Physical therapy is one of the resources that can be used to maximize a patient's outcomes following surgery. Physical therapists play a vital role in the improvement of strength, functional mobility, and independence following a TTA. This report covers the outpatient physical therapy evaluation and treatment of a patient status post-TTA. The purpose of this case was to identify different treatments, considerations, and outcome measures, that can be used when treating a patient with a TTA.

Case Description: The patient is a 66-year-old male who …

Isolation Of Aged Mouse Primary Microglia As A Model System For Alzheimer’S Disease Research, Michael Landis

Biology Honors Papers

Microglia and their role as the immune cells of the central nervous system are an emerging area of interest within Alzheimer’s research, particularly as they have shown in a benevolent and malevolent cellular context. Models of Alzheimer’s disease are very light in studying microglia, so in this study a model of microglia isolated from aged mice is established in order to study the phagocytic activity and protein expression of microglia in response to Amyloid Beta. The cells were isolated from aged mice and cultured before being used to confirm cellular identity, as well as to measure phagocytic activity. This study …

Investigating The Relationships Between Study Abroad, Language Immersion, And Intercultural Sensitivity, Isabella Bea Battistoni

Communication Science and Disorders Honors Theses

An increasing number of students are choosing to study abroad. Once only an experience for those learning a language (University of Delaware, 2024), international education has become much more accessible for students of all disciplines. When choosing a program, students face a decision in choosing the level of language immersion and learning the trip will offer. This study examined the impact of different levels of language immersion on a student's intercultural sensitivity following a short-term study abroad trip. Intercultural sensitivity, defined as, “an individual's ability to develop emotion towards understanding and appreciating cultural differences that promotes appropriate and effective behavior …

A Problem-Based Approach To Racial And Ethnic Inequities In The German Health System, Thomas C. Lane

German Studies Undergraduate Senior Theses

This work is the first comprehensive book-length survey of racial and ethnic inequities in Germany’s health system. It takes a novel approach to understanding health inequities by focusing on the overarching structures which shape them in the German context, using examples from various areas of the health system to clarify their nuances. The Introduction grounds the need for understanding and combating health inequities in Germany’s unique postwar constitutional commitment to human dignity. Next, Chapter 1 outlines the current methods by which inequities are measured in Germany and why they are problematic. Chapter 2 covers current inequities in the provision of …

The Perceptions Of Psychologists And Speech-Language Pathologists On Intervention Methods For Selective Mutism, Abby Olmstead

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Introduction: This is a study done to evaluate the perceptions of speech-language pathologists, psychologists/licensed professional counselors and their thoughts on selective mutism intervention. These thoughts will be gathered and analyzed to be compared to speech-language pathologists perceptions to see if there are differences. The goal is to be able to see the overall most-shared opinion to better be able to understand the intervention involving selective mutism. Selective Mutism (SM) is a rare disorder as only 1% of the population is diagnosed with it. The purpose is to provide more education on the disorder and help various kinds of professionals better …

Physical Therapy Interventions And Outcomes For A Patient With Multiple Co-Morbidities: A Case Study, Morgan M. Johnson

Physical Therapy Scholarly Projects

Introduction. Multimorbidity is present in a significant percentage of hospital admissions with 84.1% involving one or more co-morbidities leading to longer, more expensive stays and higher inpatient mortality rates. The purpose of this case study is to evaluate physical therapy’s effects, interventions and outcomes for a patient with common co-morbidities to determine physical therapy outcomes.

Case Description. The patient was a 75-year-old female who presented to physical therapy with an admitting diagnoses of congestive heart failure and acute kidney injury. Her additional relevant medical diagnoses were hypertension, diabetes mellitus type 2, obesity, depression, 2-month status post ORIF of right ankle …

A Comparison Of Senior Athlete Data To Normative Values: A Research Study, Brooke M. Flicek, Kailen G. Halvorson, Ashley J. Schuster, Kacee J. White

Physical Therapy Scholarly Projects

It is common to develop certain conditions with aging that can include but not limited to: osteoarthritis, cardiovascular disease, osteoporosis, falls, and general geriatric syndromes (delirium, dementia, depression, pressure ulcers, urinary incontinence, sarcopenia, chronic pain). Physical activity can help prevent many conditions. This is where the Senior Athlete Fitness Exam (SAFE) becomes relevant. It is specifically designed by physical therapist Becca Jordre, in order to evaluate cardiovascular, muscular, flexibility, and balance fitness within the older adult population. At the Senior Games, the SAFE is used as a screening tool designed to identify health and risk factors for the senior athlete. …

A Valid And Reliable Method For Measuring Navicular Drop, Kayla Ellison, Bree Lindley, Ashley Conneran

Physical Therapy Scholarly Projects

Purpose/Hypothesis: Understanding navicular motion during gait is crucial for research and clinical applications. This study aimed to assess a method of measuring navicular drop during dynamic walking trials. Our technique used a two-stage assessment of navicular drop; these stages consisted of an initial static examination of the navicular position in subtalar neutral, combined with a dynamic evaluation of navicular drop during walking gait. These stages were conducted twice, with a week between data collections. This study aimed to determine the reliability of this two-stage method. We hypothesize that a two-stage process, using two independent Vicon systems, will be able …

The Effect Of Physical Therapy Intervention On Fatigue, Balance, Depression And Quality Of Life In Clients Following Medical Treatment For Cancer: A Pilot Study, Elle G. Bryant, Morghan J. Bugge, Riley A. Grube, Megan M. Lacrosse, Hunter M. Lake, Katie J. Leary

Physical Therapy Scholarly Projects

Approximately 18.1 million people living in the United States have survived cancer. The treatment for cancer can be accompanied by many long-lasting residual side effects including fatigue, decreased quality of life, balance deficits, and depression. A current problem that healthcare providers face is understanding these side effects and how to effectively treat the people who experience them.

The purpose of this pilot study is to investigate how cancer treatments affect the human body, specifically with fatigue, balance, quality of life, and depression, and how physical therapy interventions can be used to combat these factors. To assess the effects of physical …

Identifying The Roles Of Mir-17 In Ciliogenesis And Cell Cycle, Ashwaq Alanazi

Pharmaceutical Sciences (PhD) Dissertations

Emerging evidence suggests a significant contribution of primary cilia to cell division and proliferation mechanisms. MicroRNAs, especially miR-17, contribute to cell cycle regulation and proliferation. Recent investigations have highlighted the dysregulated expression of miR-17 in various malignancies, underlining its potential role in cancer. However, the correlation between primary cilia and miR-17 has yet to be fully elucidated. The present study examines the presence of miR-17 in primary cilia. The miR-17 expression is studied in selected ciliary protein knockdown cells. Using in-situ hybridization (ISH), we identified the subcellular localization of miR-17 in both cilia and cell bodies. We confirmed the importance …

Psychiatric Clinicians' Perspectives On Pharmacogenetic Testing In An Inpatient Setting And A Proposal Of A Guideline For Patients With Extended Hospitalization, Michelle Dickerson, Jessica Lewis

Doctoral Projects

The purpose of this doctoral project is to enhance the understanding and application of pharmacogenetic testing among inpatient psychiatric clinicians. In addition, it proposes a guideline for PGx use in patients who have been hospitalized for a duration exceeding 90 days. In modern mental health care, psychotropic medications are extensively prescribed in the treatment of numerous mental health conditions. However, the use of psychotropic medications raises concerns among patients regarding their effectiveness and possible adverse reactions, leading to a lack of adherence to therapy. Over the past two decades, researchers have been exploring the effects that genetic variants have on …

Investigating The Efficacy Of Yoga Vs Traditional Physical Therapy In Chronic Low Back Pain: A Systematic Review, Courtney Andrade, Casey David, Grace Hicks-Green, Riley Young

DPT Capstones

Introduction: Chronic low back pain (CLBP) is a complex diagnosis causing an increase in disability and decreased quality of life. This condition is defined as having low back pain for more than three months, in which an individual experiences a decline in function due to enduring pain. Several factors contribute to CLBP including core muscle weakness and decreased motor control to allow for lumbar stability. Though CLBP can be treated in multiple ways; this systematic review (SR) investigates the treatment effects of yoga combined with physical therapy (PT) vs. PT alone to measure the disability using the Oswestry Disability Index …

Prevalence Of And Influences For Incorporating Clinically-Relevant Spanish Into Doctor Of Physical Therapy Programs, Daniela Quinones, Deyanira Verdeja Sosa, Megan Giron

DPT Capstones

Introduction. The United States has 63.7 million Hispanic/Latino individuals, and approximately 40% of Spanish speakers have limited English proficiency (LEP). Patient-provider language discordance is a major contributor towards health disparities. Hence, many health professions educators offer clinically-relevant Spanish. The primary study purposes were to: 1) identify the prevalence of Doctor of Physical Therapy (DPT) programs in the United States that incorporate clinically-relevant Spanish language learning in their curriculum; and 2) describe how DPT programs incorporate Spanish language learning in their curriculum.

Review of Literature. Researchers in a 2014 report identified 12 DPT programs offering Spanish; however, the current prevalence is …

Effects Of Using External Biofeedback In Improving Ankle Kinematics In Those With Chronic Ankle Instability Compared To Conventional Therapy Without External Biofeedback: A Systematic Review, Lachlan Cubbin, Kelli Kirkpatrick

DPT Capstones

I. Introduction: Lateral ankle sprains are amongst the most common injuries to occur in athletes and the general population alike. While most can recover without complications, there exists a considerable risk of recurrent injury which can result in ongoing difficulties related to pain, function, and overall quality of life. This high recurrence rate is due to excessive lateral deviations in the location of pressure-related variables in the foot. Ongoing instability of the foot, known as chronic ankle instability (CAI), results due to these abnormal gait and ankle kinematics which causes significantly greater inversion of the foot during initial contact of …

From Cells To Clinics- The Role Of College Biology Education In Shaping Future Physician Assistants, Monica Manley

Honors Theses

This thesis provides a personal reflection on translating concepts and techniques learned in multiple biology courses (i.e. microbiology, neuroscience, comparative physiology, and genetics) in to clinical practice as an intern in the emergency room of a hospital. Each selected concept contains a description followed by an example of how this knowledge relates to a specified duty of a physician assistant with in an emergency medical setting.

The Role Of Myocardin And Its Effector Proteins In Tgf-Β Induced Cytoskeletal Remodeling Of Ipf Fibroblasts, Khadijat Abolore Olawuyi

Biotechnology Theses

Idiopathic pulmonary fibrosis (IPF) is characterized by thickening and stiffness around the air sacs. Approved treatments like nintedanib and pirfenidone slow disease progression in IPF and often have tolerability issues. More research is needed to fully grasp the mechanisms behind abnormal cytoskeletal changes in lung cells, notably fibroblasts and epithelial cells, and their role in fibrosis progression. Previous studies suggest that myocardin expression and function, traditionally limited to smooth/cardiac development in physiology, become active in pathophysiological conditions like pleural fibrosis. Myocardin's role in liver and kidney fibrosis is known, but its involvement in IPF is unclear. To get more insights, …

Exploring Asynchronous Pronunciation Training Through Context-Aware Pronunciation Applications, Claire L. Schweikert

Theses/Capstones/Creative Projects

This paper provides a survey of various research articles on context-aware asynchronous pronunciation training applications. First, a set of seven articles is reviewed and summarized. Next, they are synthesized over the three main topics of 1) automated speech recognition, 2) non-native speaker considerations in language learning, and 3) future directions for research and development within computer-assisted pronunciation training (CAPT). Research in the areas of acoustic and pronunciation modeling (both implicit and explicit), pedagogical considerations for CAPT application design, Goodness of Pronunciation algorithm scoring, accent recognition and neutralization, and more are discussed.

Artificial Intelligence Applications For Optimizing Population And Clinical Drug Decision-Making Processes, Khulud Bukhari

Pharmaceutical Sciences (PhD) Dissertations

Introduction: In our study, we evaluated the application of ChatGPT4, an artificial intelligence chatbot, in the pharmacy field, specifically the capability of ChatGPT4 to extract and analyze FDA drug information, conduct a cost-effectiveness analysis of two antibiotics, and identify and classify adverse drugs events (ADE). We compare the results of ChatGPT4 with those from manual searches and specialized software programs. Methods: The first study used ChatGPT4 to extract and assess the quality of regulatory information for antibiotics indicated for complicated urinary tract infections (cUTI) approved by the FDA in 2014-2023. The second study involved comparing the cost-effectiveness analysis of cefiderocol …

Dementia Of The Alzheimer’S Type In Adults With Down Syndrome: Knowledge Among Graduate Students In Physical Therapy, Occupational Therapy, And Speech-Language Pathology., Abigail Regan Donaway

Electronic Theses and Dissertations

This non-experimental study utilized a convenience sample (N = 322) to investigate graduate students in physical therapy (PT), occupational therapy (OT), and speech-language pathology’ s (SLP) knowledge of the connection between Down syndrome and dementia of the Alzheimer's type (DAT). Ninety-two-point-five percent of participants were female, and 79.80% were white. All participants completed a survey comprised of items relating to information about general knowledge (i.e. facts) of the association between DS and DAT, the signs/symptoms that occur in each stage of dementia of the Alzheimer’s type for people with Down syndrome, and familiarity regarding the diagnosis and care. Descriptive and …

Tongue-Tie: Impact On Oropharyngeal Function During Swallow., Kolbie A. Vincent

Electronic Theses and Dissertations

Swallowing is an intricate process involving over 50 muscle pairs and numerous nerves, with dysphagia resulting from deficits in various stages (Hennessy & Goldenberg, 2016). Lingual restriction may adversely impact swallowing function, affecting bolus preparation, size, and overall efficiency. Tongue-tie can pose challenges to speech, chewing, and swallowing (Becker & Mendez, 2022; Chaubal et al, 2011; García-Pola, M. J., et al., 2002). This pilot study seeks to determine how tongue-tie affects swallowing function in an adult male, and whether surgical revision of a submucosal lingual tether leads to measurable changes in oropharyngeal swallow function. Results showed inconsistent changes in diameter …