Medicine and Health Sciences Commons^™

The Association Of Individual Characteristics, Treatment Type, Treatment Satisfaction, Symptoms Of Pain And Fatigue With Health-Related Quality Of Life Among Adults With Gaucher Disease Type 1, Shauna L. Mangum

Nursing ETDs

People with rare disease have lower health-related quality of life (HRQoL) than the general population. Gaucher disease type 1 (GD1) is a rare, autosomal recessive, lysosomal storage disorder that affects multiple bodily systems. HRQoL improved with enzyme replacement and/or substrate reduction therapies, however, little is known about specific variables associated with HRQoL in GD1. This study explored associations between individual characteristics (gender, race, ethnicity, age, and genotype), treatment variables (treatment type, length of time on treatment, and treatment satisfaction) and symptoms of fatigue and pain with HRQoL among 97 adults with GD1. No significant associations were found among individual characteristics …

Failure To Rescue Black And Brown Maternity Patients, Dorothy Marie Glisson

Walden Dissertations and Doctoral Studies

Reducing maternal mortality rates is one of the leading health indicators in the nation. Pregnant and postpartum Black mothers make up a disproportionate number of maternal deaths. Many result from failure to rescue (FTR), defined as the inability to prevent a death from a disease, illness, or complication. Over 700 women die daily from preventable causes related to pregnancy. Black patients are attributable to almost 40% of maternity mortality rates and represent over 50% of pregnancy-related deaths due to complications. Black women are more likely to die during pregnancy or after pregnancy, with heart disease causing almost half of pregnancy-related …

The Mediating Effect Of Self-Efficacy And Symptom Distress In The Relationship Between Symptom Occurrence And Quality Of Life Among Cancer Patients, Kailei Yan

USF Tampa Graduate Theses and Dissertations

Cancer symptoms significantly impact the quality of life (QOL) among cancer patients. Self-efficacy plays a key role in managing symptoms and improving QOL. Also, as a suffering from symptom occurrence, symptom distress predicts QOL. However, it is not clear whether self-efficacy and/or symptom distress mediate the effects of symptoms on QOL. This dissertation seeks to explore if and how self-efficacy and symptom distress mediate the relationship between symptom occurrence and QOL among 534 cancer patients. The specific aims were to: 1) test the factor structure and the longitudinal invariance of the Cancer Behavioral Inventory in our sample of cancer patients …

Targeting Tumor Microenvironmental Factors In Bladder Cancer To Enhance Responses With Immunotherapy, Sarah Bazargan

USF Tampa Graduate Theses and Dissertations

Bladder cancer is the tenth most common cancer in the world and has one of the highest recurrence rates. Despite the local delivery options and mutational status of bladder tumors, responses with immunotherapies have been limited with low durability. The bladder tumor microenvironment is enriched with highly immunosuppressive populations and harsh conditions that restrict anti-tumor immunity and subsequently attenuate immunotherapy response. We predict that targeting two of these immunosuppressive components, namely acidity and myeloid derived suppressor cells (MDSCs), will bolster T cell responses and enhance outcomes with immunotherapy. In Chapter 2, we characterized the effects of acidity on T cell …

Understanding The Demographic And Health Factors Associated With The Incidence Of Stroke In Jamaica, Zandy Elliott

Walden Dissertations and Doctoral Studies

Stroke, the leading cause of death and disability worldwide, is a significant public health issue in Jamaica, affecting individuals, families, and the healthcare system. This study identified demographic and health factors associated with stroke, enabling medical professionals to better understand high-risk factors and implement preventative care strategies in Jamaica—filling a significant gap in public health knowledge. The quantitative cross-sectional study examined Jamaican demographics, health, and stroke rates. Secondary data from the Office of the Consultant Neurologist (OCN) from 2000-2023 was integrated into the Social Ecological Model (SEM). The study included 291 stroke patients aged 18 and older, excluding those under …

Dosimetric Comparison Of 3d Conformal And Vmat With Dibh For Right Breast Cancer, Lundie Cervantes

Masters Projects

This study explores the use of the Deep Inspiration Breath Hold (DIBH) technique in radiotherapy for right-sided breast cancer, comparing the dosimetric outcomes of 3D conformal radiation therapy (3DCRT) and volumetric modulated arc therapy (VMAT). Using a retrospective design, ten patients with prior left breast DIBH scans were analyzed to assess right breast radiation dose distributions to critical organs at risk (OARs), including the heart, lungs, liver, and contralateral breast. Each patient’s treatment plan was developed for both VMAT and 3DCRT using Varian Eclipse software.

The results show that 3DCRT significantly lowered mean heart dose (0.56 Gy vs. 1.26 Gy, …

On The Role Of Prediction In Streaming Hierarchical Learning, Ramy Mounir

USF Tampa Graduate Theses and Dissertations

In today's world, AI systems need to make sense of large amounts of data as it unfolds in real-time, whether it's a video from surveillance and monitoring cameras, streams of egocentric footage, or sequences in other domains such as text or audio. The ability to break these continuous data streams into meaningful events, discover nested structures, and predict what might happen next at different levels of abstraction is crucial for applications ranging from passive surveillance systems to sensory-motor autonomous learning. However, most existing models rely heavily on large, annotated datasets with fixed data distributions and offline epoch-based training, which makes …

Interventions Aimed To Reduce Hospital Admissions In Patients With Cardiovascular Disease Related To Substance Use Disorder, Hannah Lambert, Kayla Landaverde

Master's Projects

Heart failure (HF) and substance use disorder (SUD) are both growing epidemics in the United States. When combined, patients with concurrent substance abuse and heart failure may present with various cardiac complaints such as chest pain, hypertension, and shortness of breath. There are little to few studies specifically evaluating interventions for decompensated heart failure to counteract the rising rates of cardiovascular issues associated with SUD. This review aims to investigate the effects of interventions targeted to prevent hospital readmission in patients with congestive heart failure associated with substance use disorder. An integrative review methodology was applied to gain an inclusive …

Does The Use Of Hydrotherapy And Behavioral Therapy In Addition To Pharmaceutical Medicine Reduce Chronic Back Pain In Adults?, Srujal Amin, Payton Golden

Master's Projects

Background: Chronic back pain (CBP) is a debilitating condition affecting millions worldwide, significantly impairing physical function, reducing quality of life, and imposing substantial healthcare costs. CBP is traditionally managed with pharmacological treatments, including opioids, acetaminophen, and nonsteroidal anti-inflammatory drugs (NSAIDs) which are often supplemented by prescribed physical activity to alleviate pain and improve quality of life. Recently, alternative therapies such as hydrotherapy and behavioral interventions have become more popular as safe and effective approaches to improving pain management in CBP patients. This integrative review aims to provide valuable insights into pain management, supporting healthcare professionals in developing more effective holistic …

A Scoping Review: Multimodal Pain Management To Reduce Perioperative Opioid Use In Total Knee Arthroplasty, Renee Merrill, Curt C. Stilp, Shane Merrill, Michelle Rhea, Jason Brumitt

Doctor of Medical Science (DMSc)

Background: The opioid epidemic ranks among the most significant public health crises of our time, with prolonged opioid use often resulting from overprescription following surgeries such as total knee arthroplasty.

Methods: PubMed and Medline (EBSCO) were searched from inception until July 2024 for studies comparing multimodal pain management interventions aimed at reducing opioid use after total knee arthroplasty (TKA) to a control group. Twenty-eight articles were identified that met the inclusion criteria.

Results: Opioid-sparing multimodal pain management approaches, including acetaminophen, non-steroidal anti-inflammatory drugs, cyclooxygenase-2 inhibitors, gabapentinoids, peripheral nerve blocks, cryoneurolysis and local infiltration analgesia, can effectively manage pain after a …

Improving Sep-1 Compliance Among Clinicians And Registered Nurses In The Emergency Department, Luke Roesler

Doctor of Nursing Practice Papers

Background: Sepsis is attributable to more than one in three in-hospital deaths in the United States and 20% of deaths globally each year. In 2015, the Centers for Medicare and Medicaid Services (CMS) adopted an early goal-directed 3 and 6-hour bundle intervention measure titled “SEP-1” based on recommendations from the International Surviving Sepsis Campaign (SSC) consensus panel to improve patient outcomes in cases of severe sepsis and septic shock. Sepsis is most often identified in the emergency department (ED) setting due to 87% of cases beginning in the community (Sepsis Alliance, 2022). National compliance with SEP-1 is 50% despite a …

Neurokinin 3 Receptor Antagonists Compared To Paroxetine For Reducing Vasomotor Symptoms In Postmenopausal Women: A Systematic Review., Jessie Vandor, Heather Justice, Erika Mccarthy, Kara Roman, Jason Brumitt

Doctor of Medical Science (DMSc)

Roughly half of the population will experience menopause. Postmenopausal symptoms can present with physical and mental health manifestations, such as anxiety, depression, dyspareunia, vaginal dryness, brain fog, hot flashes, and night sweats. The latter two symptoms are collectively known as vasomotor symptoms.^1,2 Up to 80% of postmenopausal women will experience vasomotor symptoms and about 10% will experience them as severe.³ Vasomotor symptoms are the leading reason why postmenopausal women seek medical evaluation.⁴ Not only are hot flashes bothersome throughout the day, but they often cause intense night sweats that contribute to insomnia and daytime fatigue.⁴ Vasomotor …

Disparities In Cognitive Decline Along The Texas-Mexico Border: Insights From The 2021 Brfss, Bianca D. Valenzuela

Health and Kinesiology Theses

The aging global population has brought increased attention to cognitive health and early detection of cognitive decline. Subjective Cognitive Decline (SCD), defined as self-reported memory or thinking problems, is an early marker of neurodegenerative diseases. Despite growing research, gaps remain in understanding how geographic disparities influence SCD prevalence and contributing factors. The Texas-Mexico border region, predominantly Hispanic and facing unique socioeconomic and health care challenges, offers a unique context to explore these influences. The purpose of this study was to examine the prevalence of SCD and related functional limitations in Texas-Mexico border counties versus non-border counties, using 2021 Behavioral Risk …

Characterization Of Aromatic Stationary Phases For Uses In High Performance Liquid Chromatography, Anastasia Davis

Honors Theses

High Performance Liquid Chromatography (HPLC) is an analytical chemist technique used to separate a sample into its components to characterize and study a specific molecule or compound. Traditionally, High-Performance Liquid Chromatography in different industries, such as the environmental and pharmaceutical fields, uses stationary phases that are already well characterized, such as the C18 stationary phase for separation. However, aromatic stationary phases have recently been produced, which have phenyl groups bonded to the interior surface of the column. Still, they have not been well characterized because of how modern they are. This project characterized several aromatic stationary phases (Biphenyl, pentafluorophenyl, and …

Mental Fatigue And Self-Care In Informal Oncology Caregivers: A Descriptive Mixed Methods Study, Megan Wayne

MUSC Theses and Dissertations

Purpose:

This dissertation study aimed to enhance understanding of informal caregiver wellbeing by exploring the presence of mental fatigue, the relationships among mental fatigue, self-care, and informal oncology caregiver quality of life (QOL), and determining whether differences exist in self-care engagement and QOL between caregivers who report high and low levels mental fatigue.

Problem:

Healthcare is becoming increasingly reliant on informal caregivers for the management and care of individuals with serious illnesses such as cancer. Previous research has shown that informal caregivers routinely experience many negative effects as a result of providing care including decreased mental health and …

Dance Inclusivity For People With Low Vision, Emma Winckler

Honors Theses

The primary concentration of my project was providing education to promote inclusivity in dance for people with low vision. My objectives for this project were to create a literature review relating to my project, create an educational infographic for how to best support those with low vision in a dance class, and share the infographic I created with the WMU dance department and at the Barbra Rider Colloquium.

Dance has been an integral part of my life and in my experience, I’ve never seen dance opportunities provided to people with low vision. After looking more into dance with low vision …

Bridging The Gap Between Occupational Therapy And Therapeutic Horseback Riding: An Interdisciplinary Approach To Further Engagement In Childhood Occupations, Veronica Smith

Honors Theses

My name is Veronica Smith and I have been a CTRI (certified therapeutic riding instructor) since 2022. I began volunteering at a therapeutic riding program center in elementary school and have accumulated 5000+ hours of experiences that instilled this passion in me. With these experiences, I recognized a gap and developed my thesis project with a clear vision.

With a passion for occupational therapy, and a special interest in equines, I focused my undergrad honors thesis project that also served as my baccalaureate project for the occupational therapy assistant program around these values. I created an activity book that can …

Contactless And Scalable Approaches For Human Health And Performance Sensing, Ngoc Doan Thu Tran

Dissertations and Theses Collection (Open Access)

Human health and performance sensing has been extensively studied, from physiology to mental health and movement analytics. However, typical approaches rely on invasive and contact sensors or require professional practitioners, limiting their scalability. For example, the gold standard for measuring heart rate is through an electrocardiogram (ECG), which requires multiple probes attached to the skin and is impractical for individuals with skin issues. Additionally, it typically needs to be performed in a hospital setting under the supervision of a trained cardiac physiologist. Depression detection often relies on the expertise of psychologists or psychiatrists. However, there is a shortage of these …

Genomics Insights Into Anti-Platelets Therapy: Unraveling Of Variants And The Implementation Of Clopidogrel-Guided Therapy In The United Arab Emirates, Lubna Qasem Khasawneh

Dissertations

Anti-platelet therapy is a cornerstone in the management of cardiovascular diseases such as Acute Coronary Syndrome (ACS) and stroke. These medications are essential for reducing the risk of thrombotic events by preventing platelet aggregation. However, variations in cardiovascular pharmacogenes can significantly impact the metabolism, efficacy, and safety of anti-platelet therapies, making personalized medicine increasingly important for optimizing treatment outcomes. Pharmacogenomic testing has emerged as a crucial tool in tailoring anti-platelet therapy, particularly for patients with subtherapeutic responses due to genetic factors. While extensive research has been conducted globally to identify and study the effect of the pharmacogenomic variants that influence …

Impact Of Participation In Cardiac Rehabilitation Post Myocardial-Infarction: An Integrative Review, Zoie Maynard, Mallory Stinson

Master's Projects

As one of the most common causes of hospitalization, the prevalence of myocardial infarction is indisputable Since this condition is so ubiquitous, a treatment protocol is initiated with methods to help patients modify their lifestyle, treat their underlying disease process, educate them to prevent reoccurrence, and improve their healthcare outcomes. This protocol relies heavily on the use of cardiac rehabilitation. Despite the implementation of this treatment protocol, the concern for recurrence and rehospitalization remains. The goal of this integrative review is to determine how participation in cardiac rehabilitation post-myocardial infarction impacts healthcare outcomes including rates of rehospitalization and depression. The …

Mindful Self Care Interventions In Travel Nurses Who Have Worked During And After The Covid-19 Pandemic, Danika Desgazon

Doctor of Nursing Practice Projects

Background

The COVID-19 pandemic placed significant mental strain on frontline healthcare workers, particularly travel nurses deployed to high-risk areas. This group experienced heightened anxiety, fear, and post-traumatic stress, which often limited their engagement in essential self-care practices. Previous research indicates that structured self-care interventions, particularly those incorporating mindfulness, can help mitigate stress and improve mental health. However, the specific impact of such interventions on travel nurses has not been widely studied.

Purpose

This study aimed to evaluate the effectiveness of an 8-week mindful self-care intervention in reducing stress and improving self-care behaviors among travel nurses who worked during and after …

Enhancing Clinical Staff Knowledge And Skills In Ankle-Brachial Index (Abi) Measurements: A Training Intervention Study In A Small Family Medicine Clinic, Christopher Avellanet Manzano

Doctor of Nursing Practice Projects

Background

Peripheral arterial disease (PAD) is a common yet often underdiagnosed condition that can lead to serious complications. This study aimed to evaluate the impact of an Ankle-Brachial Index (ABI) education training program on clinical staff's referral rates, accuracy in performing ABI measurements, knowledge regarding PAD, and confidence levels in a small family medicine clinic in Dallas.

Method

The study utilized a pre- and post-intervention design. Clinical staff participated in a structured ABI training program, after which referral rates to vascular specialists were measured alongside evaluations of accuracy, knowledge, and confidence levels. The paired t-test was employed to analyze the …

Conceptions Of Latinos And Latinas About The Grieving Process And Associate Concepts Of Dying, Death, Bereavement, And Loss: A Covid-19-Post-Pandemic Case Study, Rosario Garcia Ortiz

Dissertations

The purpose of this study was to recognize the grieving process and the related concepts of Latinos who lost a loved one to the COVID-19 pandemic. Death and dying have been studied in the United States, with limited studies focusing on the Latino culture. The COVID-19 pandemic was a devastating experience for the world and continues to be studied for understanding and lessons in the aftermath. This research included four participants from the Latino culture who lost a loved one during the COVID-19 pandemic. An inductive approach and data analysis were used to form theoretical constructs. Three main categories were …

Patient Reported Outcomes Amidst Isolated And Concomitant Chronic Cardiopulmonary Illnesses, Walter B. Wills

USF Tampa Graduate Theses and Dissertations

As the prevalence of many chronic cardiopulmonary illnesses are expected to rise within the United States through 2030, there is a growing emphasis on investigating the patient-reported outcomes relevant to the morbidity and social burden of these diseases. Thus, the overall aim of this dissertation is to examine these outcomes among those that live with chronic obstructive pulmonary disease and cardiovascular diseases (namely, heart failure). Specifically, the works in this dissertation aimed to compare how individuals report their health-related quality of life when living with and without cardiovascular disease across the spectrum of airflow limitation demonstrated within chronic obstructive pulmonary …

Mouse Mammary Tumor Virus (Mmtv) Genomic Rna (Grna) Packaging: Selective Grna Encapsidation Is Facilitated By Long-Range Interactions (Lris) That Facilitate Specific Gag Binding, Suresha G. Prabhu

Dissertations

Mouse mammary tumor virus (MMTV) is a betaretrovirus that induces breast cancer and sporadically, T-cell lymphomas in mice. MMTV serves as a pertinent model for elucidating the mechanism(s) of oncogenesis and the genetics associated with the development of mammary tumors. Being a rodent retrovirus, MMTV is phylogenetically distant from human and other primate retroviruses; thus, positioning it ideally as a potential vector of choice for human gene therapy. This may circumvent safety concerns such as recombination with other related endogenous human retroviruses. In addition, MMTV is distinct from most other retroviruses, but similar to lentiviruses, in that it has the …

Implementing Bedside Shift Report In The Home Health Care Pediatric Setting, Ruth Elena Ramos-Ardila

Electronic Theses and Dissertations

Developing and maintaining good communication is central in nursing because the goal is to achieve the best outcomes for the patient. In the past, written handover reports have been the standard way nurses communicate with each other, especially in the hospital and in home-based practice. Despite this rationale, this approach has considerable weaknesses: its high risk of mistakes and misunderstanding could negatively influence patient outcomes. In light of these concerns, this project examines the role of bedside shift reports in pediatric home care and the patient readmission rate. This project employed a quantitative, cross-sectional research approach involving 32 pediatric home …

Impact Of Diabetes Self-Management Education On Hemoglobin A1c Levels In The Rural Patient Population, Barbara Adomakomensah Sarpong

Electronic Theses and Dissertations

The global prevalence of type 2 diabetes is one of the greatest health threats in society, especially in the rural population. Rural healthcare data analysis has proved a need for type 2 diabetes control education. Despite the existence of helpful diabetes control interventions, rural diabetes patients still struggle to maintain healthy behaviors, with about 60% of the patients recording hemoglobin A1c levels above 9. Many suffer severe conditions (e.g., stroke, kidney failure, and heart attacks) because of poor management of the condition. The project examined the impact of diabetes self-management education on hemoglobin A1c levels in the rural patient population. …

Transgender Education In School Nursing To Decrease Stigma And Promote Self-Efficacy, Brandy Shannon-Loyola

Electronic Theses and Dissertations

This Doctor of Nursing Practice project evaluated whether transgender education provided to school nurses and healthcare technicians decreased stigma and promoted self-efficacy. Concerns that transgender individuals have voiced were that they felt healthcare professionals could not effectively care for transgender patients, which may be due to personal or religious beliefs or lack of knowledge concerning the lesbian, gay, bisexual, transgender, and queer community. Participants included credentialed school nurses and healthcare technicians in secondary education settings. The method consisted of a presurvey, education in the form of a handout, followed by a postsurvey to determine if education was successful. The Wilcoxon …

The Mediational Role Of Religiosity In The Relationship Between Emotional Regulation And Relationship Satisfaction In Uae And Turkey: A Cross-Sectional Study, Beril Berksu

Theses

Marriage and romantic relationships are significant turning points in personal and social development, contributing to overall well-being and health. In romantic relationship studies, relationship satisfaction is one of the most researched aspects and is affected by various variables, which are gender, relationship duration, and other factors. Among these, religiosity and emotional regulation have been proposed as important aspects as well. However, there is still a gap in the literature to understand how these aspects are connected in non-Western countries like Turkey and the UAE regarding cultural differences. The study aims to explore the mediating role of religiosity in the relationship …

A Study Of Management Of Marine Oil Spills In Malaysia, Mohd Arma Noramin Bin A Rashid

World Maritime University Dissertations

No abstract provided.