Medicine and Health Sciences Commons^™

The Role Of Serum Total Cholesterol In Coronary Heart Disease: A Prospective Cohort Analysis From The Framingham Heart Study, Sanish Maharjan

Capstone Experience: Master of Public Health

Objective: To investigate the association between serum total cholesterol and coronary heart disease (CHD), accounting for key risk factors in adults aged 32–70 years.

Methods: We analyzed data from 4,382 participants of the Framingham Heart Study, a prospective cohort study with 24 years of follow-up. Multivariable logistic regression was used to assess the relationship between serum cholesterol and CHD, adjusting for age, sex, smoking status, systolic blood pressure, BMI, diabetes, and heart rate.

Results: Individuals with high (aOR = 1.87; 95% CI = 1.52 - 2.32; p<.0001) and borderline high (aOR = 1.40; 95% CI = 1.13 - 1.75; p = 0.0024) cholesterol levels have significantly higher odds of developing CHD than those with normal cholesterol. Older (aOR=1.03; 95% CI=1.03–1.05), male (aOR=2.16; 95% CI=1.86–2.51), current smokers (aOR=1.20; 95% CI=1.03–1.39), hypertensive (aOR=1.88; 95% CI=1.55–2.26), obese (aOR=3.03; 95% CI=1.24–7.43), and diabetic individuals (aOR=2.41; 95% CI=1.63–3.56), had significantly higher CHD risk.

Conclusions: Elevated serum cholesterol significantly increases CHD risk, emphasizing …

Reducing The Cost Of Implementing The F.I.T. Game Healthy Eating Program In Diverse Schools While Observing Effects On Food Waste, Robert Gifford

All Graduate Theses and Dissertations, Fall 2023 to Present

It is well known that children do not eat enough fruits and vegetables. The FIT Game Healthy Eating Program is an interactive, story-board type narrative that has increased fruit and vegetable consumption in elementary school children. While The FIT Game intervention has shown progress in the past, the schools studied had minimal diversity and the intervention was time intensive and costly.

This research utilized The FIT Game intervention in four Salt Lake City area, Title 1, schools with a large amount of student diversity. The first portion of research was conducted in two phases. The first phase compared an intervention …

Pavlovian Conditioned-Reinforcer Training As A Means Of Reducing Impulsive Choice, Emma Visser

All Graduate Theses and Dissertations, Fall 2023 to Present

Impulsive choice is associated with a host of human maladaptive behaviors warranting investigations aimed at reducing impulsive choice. Pavlovian conditioning was explored in 22 male Wistar rats. The experimental group was exposed to a stimulus that signaled a large delay-reduction to an food, whereas the control group experienced a stimulus that was controlled by a random schedule that did not predict food. Subsequently, a test of conditioned reinforcement was conducted, indicating a difference in conditioning between groups. Finally, a test of impulsive choice failed to find effects of training on impulsive choice.

Metabolic Capabilities Of Latilactobacillus Curvatus And The Potential Use As An Adjunct Culture For Food Safety And Quality Control In Yogurt, R. Chase Wahlstrom

All Graduate Theses and Dissertations, Fall 2023 to Present

In the quest for healthier and more natural food products, using beneficial lactic acid bacteria to preserve food, known as biopreservation, is becoming increasingly important. This research focused on a strain of beneficial bacteria called Latilactobacillus curvatus and its ability to inhibit fungal growth both in lab settings and in a yogurt system. This has the potential to enhance the safety and quality of dairy products.

We studied a specific strain of this bacteria, named WSU-1, found in dairy. Through detailed analysis, we discovered that this strain could produce substances that may help protect food from harmful microbes. In laboratory …

Development Of A Multidimensional Index Of Fall Risk For Older Adults: The Cache County Study, Alexandra G. Hammond

All Graduate Theses and Dissertations, Fall 2023 to Present

One out of four adults over the age of 65 are estimated to fall each year in the U.S. alone, with that number expected to rise to 52 million falls per year by the year 2030. Improving accuracy for identification of older adults at a higher risk of falling is increasingly important and may be integral in informing the distribution of limited resources and assist in preventing falls in older adults. This project examined the relationship between previously identified risk factors and fall risk to create multidimensional fall risk indexes for older adults, specific for each sex.

Factors best associated …

From Pasture To Plate: Striking An Omega Balance Between Grass-Fed And Grain-Fed Beef Ribeyes - Fatty Acid Composition, Minerals, Soil, And Forage Analysis, Travis Earl Statham

All Graduate Theses and Dissertations, Fall 2023 to Present

Most beef cattle in the US are feedlot-finished where intensive feeding of grains is used to increase weight and yield; however, a minority are raised in grass-fed operations that use exclusive pasture, rangeland, and hay for feeding, possibly leading to benefits for the land, soil, ecosystems, forages, and the meat itself. These operations use a variety of methods, and the goal of this was to recognize differences in the soil and forage metrics to help understand the resulting meat fatty acid composition and mineral content. We collected these samples from 78 sets of farmers while testing 25 sets of grain-fed …

Implementing The Methodology To Generate Diagnostic And Therapeutic Antibodies, Andrea Mariana Carlin

Open Access Theses & Dissertations

This research aimed to establish the methodology for developing monoclonal antibodies at The University of Texas at El Paso. Monoclonal antibodies are indispensable across multiple fields, including diagnostics, therapeutics, and biotechnology, yet there is a shortage of commercially available antibodies targeting specific proteins or possessing specialized characteristics. To address this gap, three models were selected: a peptide derived from the intracellular protein Schlafen 8 and two cell surface protein receptors: mouse vascular endothelial growth factor receptor 2 (VEGFR2) and human melanocortin receptor 4 (MC4R). These proteins present unique challenges in antibody generation, including issues of accessibility, expression, and specificity.

Throughout …

Protective And Risk Exposures Of Cancers Disproportionately Affecting Hispanics In A U.S. - Mexico Border Population: A Clinical Informatics Approach, Amir Hernandez

Open Access Theses & Dissertations

BACKGROUND: Cancer is the second leading cause of death in the U.S. with over 8 million new cases between 2016 and 2020. A variety of protective and risk exposures are associated with multiple cancers and disparities and inequalities exist in the health outcomes of minority populations. Hispanic populations in the U.S. and Texas have some of the highest rates of cancer incidence and mortality when compared to other populations. The use of Population and Public Health Informatics approaches to address these issues have shown promise when employed in healthcare institutions METHODS: A case-control study design examined associations between multiple cancers …

Enhancement Of Zika Virus Infection By West Nile And Dengue Virus Antibody Positive Cord-Blood Samples From Mothers In El Paso-Texas, Jeanette Orbegozo

Open Access Theses & Dissertations

The recent Zika virus (ZIKV) outbreak and its association with microcephaly cases and other neurological syndromes are important public health concerns. A phenomenon known as antibody-dependent enhancement (ADE) involves preexisting flavivirus antibodies to a specific flavivirus that enhances the severity of a second infection with a different flavivirus. Since ZIKV is related to flaviviruses like West Nile virus (WNV) and dengue virus (DENV), prior exposure to these viruses could elicit cross-reactive antibodies that may enhance a subsequent ZIKV infection. Therefore, this study aimed to determine if WNV and DENV antibodies from cord blood enhanced ZIKV infection in vitro. Initially, a …

Examining The Relationship Between Adverse Childhood Experiences, Coping Behaviors, And Metabolic Syndrome In Mexican-American Men, Paulina Torres

Open Access Theses & Dissertations

Background: The prevalence of metabolic syndrome (MetS) has been increasing in the US over recent years. Individuals who have experienced adverse childhood experiences (ACEs) and developed maladaptive coping strategies are at increased risk of developing MetS. Hispanic men might have an increased risk of developing MetS due to higher exposure to ACEs and increased use of maladaptive coping strategies.Purpose: To examine the relationship between ACEs, coping, and MetS among Mexican-American men. Methods: A secondary analysis of cross-sectional study of 100 adult men from El Paso, Texas in 2018-19. ACEs were examined using the 10-item ACE questionnaire. Coping was assessed through …

Myofibroblast Targeted Liposomes For The Treatment Of Skin Fibrosis, Elfa Beaven

Open Access Theses & Dissertations

Continuous overactivation of myofibroblasts leads to excessive deposition of profibrotic proteins, which in turn causes tissue stiffness and, ultimately, organ failure. One of those proteins, Cadherin-11 (CDH11), is reported to be overexpressed in the tissue of fibrotic skin, specifically on myofibroblasts. Similarly, chronic inflammation drives fibrosis progression in autoimmune-related illnesses like systemic sclerosis (SSc). Therefore, it is hypothesized that CDH11 could be a target for cell-specific delivery of antifibrotic therapies to fibrotic skin tissue. Here, a CDH11 peptide conjugated liposome loaded with Tofacitinib, a JAK inhibitor, was developed to understand the potential of targeted therapies to treat skin fibrosis. The …

Novel Therapuetic Approaches For Chagas Disease, Juan Carlos Silva

Open Access Theses & Dissertations

Chagas disease (CD) is caused by the hemoflagellate protozoan Trypanosoma cruzi. This disease is considered one of the 20 neglected tropical diseases (NTD), and it is estimated that 6 to 8 million people worldwide are diagnosed with CD. In the United States, Chagas infection is not reported in all states; however, most reported CD cases are chronic infections. Chagas infection is characterized by two phases: an acute and a chronic phase. Until this present moment, no prophylactic or therapeutic human vaccine is available. However, in a recent study in a murine model, our group showed that the synthetic 20-merpeptide (DAENPGGEVFNDNKKGLSRV) …

Assessing Sedimentation Impact Through Dem, Point Cloud, And Discharge Analysis, Shandell Thomas

Open Access Theses & Dissertations

This study focused on five arroyos flowing into the Rio Grande, in the stretch between Caballo Dam and Las Cruces, New Mexico. Drone imagery was acquired from study areas in each arroyo. Photogrammetry was used to create high-resolution digital elevation models (DEMs), point clouds, drone imagery and potential discharges were acquired for each arroyo. Investigation of seven different methods resulted in the selection of the Terrain Ruggedness Map (TRM) as a predictor of surface roughness, along with high-resolution DEMâ??s to illustrate small and low-relief channel features. The five arroyos with varying sediment sizes and characteristics were studied to understand how …

The Inclusion Of Soybean Co-Products In Ruminant Supplements On Health And Reproductive Efficiency, Kirsten Midkiff

Graduate Theses and Dissertations

Soybeans are a vital commodity for Arkansas and the United States, with co-products such as soybean meal having wide popularity in animal feeds due to high protein content and palatability. Soybean meal primarily is utilized in diets for swine and poultry operations with a small market in the beef cattle industry, likely due to the increased costs that are associated with the product. On the other hand, soybean oil is a product from the production of soybean meal that is not as widely used in the livestock industry as most of the oil produced is used for industrial purposes. Additionally, …

Locating Health Inequities: Understanding The Dynamic Role Of ‘Place’ In The Social Determinants Of Health And Healthcare Accessibility, Abbie Sudduth Page

Graduate Theses and Dissertations

Objective. The social determinants of health (SDH) are various non-medical factors that influence health behaviors and health outcomes, and they are measured in variety of different ways. The purpose of this dissertation is to explore the relationship SDH items that may group to form a new domain and may be associated with outcomes of health care accessibility. This dissertation seeks to explain a novel understanding of social determinants of health and healthcare accessibility through the lens of the socioecological model and place-based SDH items.
Methodology. This retrospective study design utilized data from the baseline survey and year-22 wave of the …

Policies And Price Controls On The Research And Development Of Orphan Drugs In The United States And The European Union, Bena Pearl Filipczak Smith

Master's Theses

There is substantive literature surrounding the impact of price controls on the research and development (R&D) of new pharmaceutical products. The European Union (EU) and United States (US) are often studied in contrast to examine the influence of price controls as the US has fewer pharmaceutical price controls than the EU.

We find moderate evidence that the US spent more on annual domestic pharmaceutical R&D than the EU between 2004 and 2021, on average, before and after adjusting for GDP growth per capita and year. We find strong evidence that the US increased annual domestic R&D spending at a faster …

Exploring The Contribution Of Mobile Money To The Well-Being Of Rural Tanzanian Villagers And Assessing Their Readiness To Adopt A Similar Model To Advance Their Healthcare Access An Exploratory Study, Sr. Magdalena P. Chubwa

Seton Hall University Dissertations and Theses (ETDs)

Background: Healthcare for rural villages in Tanzania has always been rudimentary. Lack of the infrastructure and poverty are among the many obstacles facing this population’s access to healthcare. While, the rise of telehealth has improved access to healthcare in many parts of the world, its use in rural Tanzania has been extremely limited to poor internet access. However, given the availability of non-internet connected mobile phones in rural Tanzania, the potential to use this devise to improve healthcare access exists. Individuals using mobile phones for financial transactions may be motivated to access healthcare via telehealth by using their non-internet connected …

Genetic Testing And Anorexia Nervosa: Knowledge, Attitudes And Awareness, Sarah Ramsay

All Dissertations

This dissertation consists of three parts, each building on the results of the former, evaluating the treatment and research of anorexia nervosa (AN) from a healthcare genetics perspective. These three parts are bookended by an introduction and a conclusion summarizing key findings and providing suggestions for future work. First, in order to assess how Severe and Enduring Anorexia Nervosa (SE-AN) is defined in the literature, and inclusion of those with SE-AN in genetics research, a comprehensive literature review was performed. The review found a lack of consistent identification and inclusion of the SE-AN subtype in AN genetic study participants. Second, …

Bactericidal Mechanism Of Peracetic Acid Against Salmonella Mediated By Reactive Oxygen Species, Mohammed Khalid Wheib Al-Doury

Graduate Theses and Dissertations

Peracetic acid (PAA) is extensively used as a bactericidal agent in poultry processing to reduce foodborne pathogens, including Salmonella enterica serotype Typhimurium (S. Typhimurium). Despite its widespread application, the exact mechanisms underlying its bactericidal effects, particularly the role of reactive oxygen species (ROS), remain incompletely understood. This dissertation examines the role of ROS in PAA-mediated bacterial killing and explores both genetic and metabolic factors that influence bacterial susceptibility to PAA. Findings from these studies have implications for enhancing the efficacy of PAA, thereby improving food safety practices in the industry.

The first study investigates ROS as a central component …

Implementation Of A Transition-Of-Care Model For Adult Ischemic Stroke Survivors, Megan Akacsos

Electronic Theses and Dissertations

The lasting physical and cognitive deficits associated with the complexities of newly acquired

disabilities resulting from an acute ischemic stroke (AIS) may lead to hospital readmissions. The

participating healthcare facility on the U.S. West Coast reported a hospital readmission rate for

AIS survivors of 24.29% within 30 days of discharge. This doctoral nursing project aimed to

determine if implementing the Comprehensive Post-Acute Stroke Services (COMPASS) model

would reduce 30-day readmission rates compared to no standardized transition-of-care model in

adult AIS survivors over 30 days. Implementing the COMPASS model in this patient population

was expected to better educate and support stroke …

Factors Impacting Ehr Implementation: A Case Study In Belize, Jessica Y. Resendiz

Electronic Theses and Dissertations

Electronic health record systems are a tool used throughout healthcare organizations to provide safe and efficient patient care. They are used to record and retrieve patient information related to health history, diagnostics, and treatment plans. Electronic health records have become increasingly integrated into healthcare practice and are demonstrative of safe and quality care. Healthcare organizations that do not have electronic health record systems in place jeopardize safe and efficient patient care. In addition, access and financial means to implement electronic health record systems in developing countries are challenging as resources are often restricted. This project aims to identify factors that …

Public Health Implications Of State-Level Public Health Organizational And System Structures, Cameron Ferguson Hays

Dissertations

Public health thought leaders such as the Institute of Medicine and National Academies of Science, Engineering, and Medicine have long been concerned about the lack of standardization among state-level public health systems (IOM, 1988; NASEM, 2023). However, little research studies these systems, their structures, and whether structural constructs affect population health outcomes.

This study attempted to examine the structural constructs that make up these systems and the impact of those constructs using an exploratory sequential mixed-methods design. Variables from management science were qualitatively extracted from materials describing all 50 state-level public health systems. Those variables were then analyzed using a …

Intelligent Health Monitoring Systems Via Flexible Hybrid Electronics And Machine Learning, Masoud Panahi

Dissertations

Advanced data analytics approaches, such as artificial intelligence (AI), are increasingly being integrated into all aspects of patient care. This integration is paving the way for minimally invasive or non-invasive treatment modalities. By combining recent advancements in fabrication technology and computing ingenuity, wearable devices now enable continuous health monitoring and provide data for AI-driven analysis. These intelligent devices seamlessly integrate with the Internet of Things (IoT), enabling remote or “at-home” patient monitoring.

This dissertation study investigates the integration of recent advancements in flexible hybrid electronics (FHE) and machine learning (ML) to develop intelligent health monitoring systems. The developed FHE-based health …

Inattentional Deafness And Musical Training: Effects Of Perceptual Load On Tonal And Verbal Auditory Suppression, Annelise Coffey

All-Inclusive List of Electronic Theses and Dissertations

Inattentional deafness (ID) is a cognitive phenomenon of which we have relatively little understanding. The current study attempted to address this by considering current cognitive theories of thought and examined how musical training affects incidence rates of inattentional deafness. This study utilized a cognitive task and auditory stimuli previously designed to elicit inattentional deafness and measured musical training by administering the Goldsmith’s Musical Sophistication Index. Participants were instructed to engage in a high-load cognitive task, providing a condition in which inattentional deafness is likely to occur. During the task, a brief pure tone was presented simultaneously with the visual task …

Predictors Of Mystical Experiences In The Electronic Dance Music Scene, Cody Edward Lesniak

All-Inclusive List of Electronic Theses and Dissertations

The present study examined the nature and frequency of reported mystical experiences within the Electronic Dance Music (EDM) scene and the roles psychedelic and psychedelic-like substances, set, and setting play in facilitating these experiences. Participants were recruited using posts on a variety of EDM-related Facebook groups (EDM, EDM Universal, EDM Festivals and Raves, etc.) and Reddit threads (bonaroo, electricdaisycarnival, RavesAndRavers, etc.). Participants completed a self-report survey consisting of questions pertaining to their involvement in the EDM scene, motives for attendance at EDM events, motives for drug use, importance of the values of peace, love, unity, and respect (PLUR), the proportion …

The Lived Experience Of Nurses Caring For People Experiencing Homelessness: A Descriptive Phenomenological Study, Debra Guerrini

Theses & Dissertations

Background:

Marginalized patient populations, such as people experiencing homelessness, receive a lower quality of care linked to stereotyping and biases (Alspach, 2018). Populations receiving substandard healthcare are often subconsciously identified by attributes such as age, race, mental health, housing, and social status (Padilla-Moledo et al., 2016). These stigmatized attributes can be the underpinning of bias. The health status of people experiencing homelessness is generally poorer than housed populations, with evidence demonstrating the difficulties they encounter when attempting access to healthcare (Klop et al., 2018).

Purpose:

The purpose of this phenomenological study was to explore and gain a more in-depth understanding …

The Lived Experience Of Older Adults Using Telemedicine Services, Cathy Anne Cahill

Theses & Dissertations

The coronavirus 2 (SARS-CoV-2) and the subsequent pandemic transformed the healthcare delivery system in the U.S. Telemedicine became an essential mode of healthcare, and its usage increased significantly during the public health emergency. Telemedicine improved access to care, especially for vulnerable patient populations and those with chronic medical conditions. There were many other benefits, including convenience, cost savings, and reduced coronavirus transmission. It also reduced the strain on healthcare facilities and overburdened healthcare providers. A qualitative, Heideggerian phenomenological method of inquiry was conducted to understand the experience of the older adult population utilizing telemedicine services. These methods included a description …

Accumbal Plasticity And Associated Behavioral Adaptations In The Spared Nerve Injury Model Of Chronic Neuropathic Pain, Yu-Hsuan Chang

Arts & Sciences Electronic Theses and Dissertations

Chronic pain is a debilitating neurological disorder that affects hundreds of millions of individuals worldwide. It is associated with cognitive symptoms such as cognitive inflexibility, which is defined as the inability to adaptively update behavior in response to changing environmental conditions. To date, there are no effective treatments for these symptoms, even though they substantially contribute to the decreased quality of life of chronic pain patients and are associated with reduced efficacy of pain management strategies. Therefore, understanding the neural circuit adaptations that drive cognitive symptoms of chronic pain, like cognitive inflexibility, is essential for improving existing treatments for this …

Staff Education On The Rapid Mood Screener In An Outpatient Psychiatric Setting: Enhance Screening Practices, Yetunde Fakinlede

Walden Dissertations and Doctoral Studies

Summary The persistent misdiagnosis of bipolar disorder in this psychiatric practice was thought to be due to the provider's lack of knowledge and confidence in using assessment tools. Rapid Mood Screener (RMS) is a validated brief screening tool that differentiates between bipolar disorder and unipolar depression. In this project, I educated outpatient psychiatric nurse practitioners and staff in using RMS. The project practice-focused question was: Will an educational intervention improve the knowledge and self-efficacy of the outpatient mental health providers and staff regarding using Rapid Mood Screener? I followed the ADDIE framework and incorporated Knowles' adult learning theory for the …

Early Recognition And Management Of Aggressive Behaviors In Delirium, Melissa Dawn Martin

Walden Dissertations and Doctoral Studies

Patients experiencing delirium are challenging for nurses, especially when aggressive behavior is also present. Nurses from all specialties have the potential to encounter patients who have or develop delirium during their hospitalization, particularly in the intensive care unit. Nurses may lack the experience needed to recognize impending aggression which often presents as subtle cognitive changes or do not know the proper way to manage these types of patients. This makes standardized guidelines crucial for the safety of both the nurse and the patient. This project addresses that practice gap through developing an evidence-based clinical practice guideline (CPG) that will help …