Medicine and Health Sciences Commons^™

Justification For The Continuance Of A Pediatric Physician's Office Laboratory, Veronica C. Santilli

Seton Hall University Dissertations and Theses (ETDs)

The continued viability of the Physician's Office Laboratory (POL) has been questioned because of barriers imposed by managed care organizations, oversight by regulatory agencies and competition for professionally trained laboratory staff. Pediatricians view the POL as an important adjunct to quality healthcare services for children and do not consider the POL as a "profit center", whose priority is generation of revenues for the The practice. parents of pediatric patients consider an on-site laboratory a convenience and valuable service. Through an analysis of patients' satisfaction, physicians' perceptions of enhancement to quality care, managed care reimbursement data and costs associated with maintenance …

Retirees And Pharmaceutical Costs: Is There Really A Crisis?, Justine Maiello

Seton Hall University Dissertations and Theses (ETDs)

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Parents' Homophobia And Childrearing Gender Role Beliefs: Correlates In A Local Populations, Angela Ackerman Brogle

Honors Capstones

Capstone submitted as a graduation requirement for the BSU Honors Program.

The Effects Of A 10-Week Exercise Program On Physiological Variables And Quality Of Life In Type 2 Diabetes, David Robb Holton

Human Movement Studies & Special Education Theses & Dissertations

The purpose of this study was to determine the interaction between psychological and physiological parameters before and after a 10-week, aerobic training study of sedentary diabetic individuals and sedentary controls. Tests measuring physiological parameters (interstitial NO, blood flow, lactate threshold, VO₂ peak and glycosylated hemoglobin) and a quality of life survey were completed before and after training. Nine previously sedentary diabetic (DE, diabetic exerciser) and 10 control sedentary subjects (CE, control exerciser) engaged in 10 weeks of supervised aerobic exercise. A non-training diabetic group (DS, diabetic sedentary, n=12) and a non-training control group (CS, control sedentary, n=I0) were also …

Perceived Paternal Style And Its Relationship To The Child's Explanatory Style And Depression, Janice E. Halecki

Psychology Theses & Dissertations

Seligman' (1974) theory of learned helplessness and the reformulated hopelessness depression model (Abramson, Metalsky, & Alloy, 1989) suggest that a learned sense of lack of control can lead to a pessimistic explanatory style and subsequently depression. The current study used a retrospective cross-sectional design to investigate whether issues of parental control and affection in the early family environment are associated with the individual's explanatory style and history of depression in adulthood.

The participants,158 undergraduate students, completed self-report measures to assess their level of depressive symptoms, perception of their parents' behavior, and negative stressful events.

Perception of a high level of …

Comparisons Of Perceived Exertion Of Elliptical Training Versus Treadmill Exercise, Marcisha Brazley

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Education at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Arts by Marcisha Brazley on June 28, 2002.

Modular Machine Learning Methods For Computer-Aided Diagnosis Of Breast Cancer, Mia Kathleen Markey '94

Doctoral Dissertations

The purpose of this study was to improve breast cancer diagnosis by reducing the number of benign biopsies performed. To this end, we investigated modular and ensemble systems of machine learning methods for computer-aided diagnosis (CAD) of breast cancer. A modular system partitions the input space into smaller domains, each of which is handled by a local model. An ensemble system uses multiple models for the same cases and combines the models' predictions.

Five supervised machine learning techniques (LDA, SVM, BP-ANN, CBR, CART) were trained to predict the biopsy outcome from mammographic findings (BIRADS™) and patient age based on a …

Protein-Protein Interactions And Muscle Cell Signaling Via Syntrophin, Shilpa A. Oak

Theses and Dissertations (ETD)

Absence of dystrophin results in Duchenne muscular dystrophy (DMD), a lethal neuromuscular d isorder that afflicts 1 in 3500 live male births. In the sarcolemma, dystrophin is associated with a complex of proteins and glycoproteins, known as the dystrophin glycoprotein complex. The DGC constituents are dystrophin, a-dys troglycan, b-dystroglycan, syntrophin, a-sarcoglycan, b-sarcoglycan, g-sarcoglycan, d-sarcoglycan, and sarcospan. Not al l of these are single protein species. The syntrophins consists of a group of three homologous proteins composed of acidic (a) and basic (b) components. Syntrophins are known to self-associate to form oligomers.

In this dissertation, syntrophin's oligomerization and its interactions with …

The Impact Of Systematically Varying The Duration Of Breath Samples During Infrared-Based Alcohol Breath Testing, Chris C. Clatterbuck

Dissertations

The present study set out to investigate the reliability and performance of the BAC DataMaster®, an infrared-based alcohol breath testing instrument. The focus of this study was to determine: (a) the impact of varying breath sample duration during testing, (b) if Blood Alcohol Concentration (BAC) levels produced by the DataMaster® (BAC_DM) are significantly different from BAC levels produced by analysis of whole blood (BAC_WB), and (c) if the relationship between BAC_DM estimates and BAC_WB is influenced by the amount of alcohol an examinee has ingested. Each of 27 participants was randomly assigned to one …

Pain Experienced By Patients During Periodontal Recall Treatment, Thu-Diem Chung

Loma Linda University Electronic Theses, Dissertations & Projects

The aims of this study were to determine; 1) the degree of pain experienced by patients during probing and debridement; 2) if the treating hygienists could estimate the degree of pain experienced by the patients; and 3) if the patients' pain responses could be predicted by factors such as the patients' age, gender, number of residual periodontal lesions, and the patients' answers to a questionnaire on dental anxiety.

Prior to the maintenance procedures, 2 groups of 20 adult patients to be treated by 2 hygienists completed an anxiety questionnaire. Subsequently, measurements of probing depths were performed, followed by pain ratings …

Inducible Gene Expression In Cell Cultures And In Microencapsulated Cells, Yong Yu

Loma Linda University Electronic Theses, Dissertations & Projects

The mifepristone-regulated transcriptional activation system provides a means to exogenously control gene expression in transformed mammalian cells in a temporal and spatial fashion. Such a promoter activation system consists of three components: The first of these is a steroidal inducer drug, mifepristone. This drug binds to the second component, a chimeric transcription factor complex, consisting of the mutant human progesterone receptor fused to the yeast GAL4 DNA-binding domain and the Herpes simplex virus protein VP 16 activation domain. The third component is a synthetic promoter, consisting of a series of GAL4 recognition sequences upstream of the adenovirus major late E1B …

The Role Of Psychologists In Primary Care: An Integrative Curriculum, Gary Charles Hawley

Loma Linda University Electronic Theses, Dissertations & Projects

Psychologists have been service providers in the health care sector for many years. They are consistently recognized as valued members of health care teams but are not frequently included as primary care providers. Integrated primary care services that include psychologists are a positive step toward achieving a comprehensive model of patient care. The biopsychosocial model is suggested to supplant the current biomedical model for health and wellness conceptualization. Psychologists are trained in the dynamic interplay between biological, psychological, and social domains. However, education at the graduate level for psychologists working specifically in primary care has not been well conceptualized, developed …

Effect Of Electrode Size, Shape, And Placement On Electrical Current And Subject Comfort During Electrical Stimulation, Bonnie J. Forrester

Loma Linda University Electronic Theses, Dissertations & Projects

Six healthy subjects were studied to determine the optimal size, shape and placement of stimulating electrodes during the application of electrical stimulation (ES) to the biceps, quadriceps, and tibialis anterior muscles. Subjects were recruited to allow for diversity in age, sex, and skin pigmentation. Subjects sat in a custom designed multi-positional chair, which allowed precise positioning of each extremity. After determining the maximal voluntary contraction (MVC) of the muscle and careful determination of the motor point, ES, with a biphasic square wave of 300 ms duration and a frequency of 30 Hz, was used to bring the muscle to 10% …

Microleakage Of Various Restorative Materials Used For Preventive Resin Restorations, Jenny Chung Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: This research was designed to compare the microleakage of various restorative materials used for preventive resin restorations and two methods of cavity preparation. The purpose of this study was: (1) to compare microleakage of four different restorative materials using two different type of preparation methods (bur and air particle abrasion) and (2) whether the use of a pit and fissure sealant over the restoration decreases microleakage.

Methods: One hundred and twenty eight, permanent human molars were randomly divided into four groups and restored with four restorative materials. Each group had been randomly divided into two subgroups. The teeth in …

The Effects Of A Hypocaloric Diet Enriched In Oleic Acid Using Almonds Versus Complex Carbohydrates On Metabolic And Anthropometric Parameters During Weight Reduction, Michelle Ann Wien

Loma Linda University Electronic Theses, Dissertations & Projects

The purposes of this study were to determine the effect of almonds rich in oleic acid as an alternative to complex carbohydrates on metabolic and anthropometric parameters during weight reduction and to evaluate self-reported satiety and satisfaction. A convenience sample of 57 adults was recruited from the Diabetes and Cardiovascular Risk Reduction Program at City of Hope National Medical Center. Subjects were randomized to an almond-enriched hypocaloric diet or to a complex carbohydrate-enriched hypocaloric diet for twenty-four weeks. Mixed model analysis showed that the use of almonds more favorably influenced weight loss (p< 0.0001), body mass index (p = 0.0001), waist circumference (p = 0.0255) and fat mass (p = 0.0205) compared to complex carbohydrates. Additionally, blood ketone levels were statistically significantly higher in the almond group (p = 0.0230) than in the complex carbohydrate group. No significant difference was found in the total cholesterol:HDL ratio between the groups, however both groups had statistically improved ratios over time with resulting decreases in cardiovascular risk. The glucose (p = 0.0006), insulin (p< 0.0001), insulin:glucose ratio (p = 0.0008), HgbAlc (p

The Relationship Between The Osteonal Cement Line And Bone Strength, Avery Kazuhiro Egerer

Loma Linda University Electronic Theses, Dissertations & Projects

Bone includes many structural and chemical components which provide both flexibility and strength. One such structure is the cement line, a 1-5 μm-thin structure located primarily in compact bone. Past research has correlated the pathological condition of “shin splints” with the micro-damage of bone, which often follows cement lines. It has been suggested that cement lines have rather paradoxical properties. Upon fatigue fracture of bone, microcracks often travel along cement lines and become trapped. This trapping and subsequent dispersion of energy have been hypothesized to prevent a complete fracture from occurring, extending bone life. Cement lines have been implicated in …

Patterns Of Scholarly Productivity In Physical Therapy Faculty, Ardith L. Williams-Meyer

Loma Linda University Electronic Theses, Dissertations & Projects

Due to the proliferation of entry-level doctorate physical therapy programs (DPT), there are two important qualifications for current physical therapy educators: 1) they should hold academic doctorate degrees and 2) they need to conduct scholarly activity, such as research, to increase the scientific base for physical therapy practice. In order to determine current faculty preparation for the increasing number of DPT programs, this descriptive study compared the current percentage of doctorally prepared faculty teaching in entry-level doctorate and masters degree programs, and determined their contributions through original research, publications as first or contributing authors or presentations, during the last five …

A Case Study Of An Ergonomic Evaluation For A Shop Floor Facility, Ivan Siguencia

Theses

The aim of this paper is to discuss and recommend solutions for the ergonomic hazards present in a shop floor type of manufacturing facility. This type of study is important since the ergonomic issues that concern the shop floor worker are different than those faced by the assembly line worker. The shop floor employee for the most part enjoys work satisfaction, task variety, and is able to control his own work pace. From an ergonomic standpoint, this is the preferred work environment.

The focus of this paper is a case study. This study is a one-day ergonomic assessment of a …

30s Ribosomal Subunit Assembly Is A Target For Inhibition By Aminoglycoside Antibiotics In Escherichia Coli., Roopal Manoj Mehta

Electronic Theses and Dissertations

Antibacterial agents specific for the 50S ribosomal subunit not only inhibit translation but also prevent assembly of that subunit. I examined the 30S ribosomal subunit in growing Escherichia coli cells to see if antibiotics specific for that subunit also had a second inhibitory effect. I used the aminoglycoside antibiotics paromomycin and neomycin, which bind specifically to the 30S ribosomal subunit. Both antibiotics inhibited the growth rate, viable cell number, and protein synthesis. I used a ³H-uridine pulse and chase assay to examine the kinetics of ribosome subunit assembly in the presence and absence of each antibiotic. Analysis revealed a …

Feature Retention And Phonological Knowledge Across Children With Suspected Developmental Apraxia Of Speech, Phonological Impairment, And Typically Developing Speech., Tracy A. Ford

Electronic Theses and Dissertations

The purpose of this research effort was to examine whether the feature retention patterns and phonological knowledge of children with suspected apraxia of speech (AOSc) in comparison to those of children with phonological impairment (PI). A second purpose was to determine if a relationship exists between phonological knowledge and feature retention.

The study consisted of three groups of children: PI, AOSc, and typically developing (TD), ages four to seven. A 245-item speech sample was collected from each group. Feature retention percentages and phonological knowledge, represented by percent correct underlying representations (PCUR) were calculated for each child.

All groups retained place …

Early Academic Performance In Children With Cleft Lip And/Or Palate., Krista Leanna Lowe

Electronic Theses and Dissertations

Studies of preschool children have shown early speech and language deficits in children with cleft lip and/or palate (CLP). For some children, the deficits during kindergarten diminish as they begin school while some children continue to show delays. The purpose of this study was to determine if a relationship exists between speech and language skills and early reading skills of phonological awareness, letter identification, and rapid naming in children with and without CLP. The subjects, four kindergarten children with and four without CLP, were administered a battery of speech, language, early reading skills, and nonverbal cognition measures. Two-way analysis of …

Do Cellular Phones Cause Headaches?, Jasmine Gay

McCabe Thesis Collection

Many people have recently complained about experiencing headaches in association with the use of their cellular telephones. There is much controversy over this subject because it has not yet been proven that the microwaves emitted by cellular telephones cause headaches. The research questions include the following: What are the effects, if any, of the use of cellular telephones on human health? Do they cause headaches? Are they responsible for the increase in size of some brain tumors?

There have been many experiments performed by various scientists in the field of bioelectromagnetics and by the World Health Organization (WHO); however, these …

Affective Development Of Battered Women Subsequent To Leaving Abusive Partner, Cheryl Harrah

Graduate Theses

The present study consisted of semi-structured interviews of formerly battered women who have been out of the relationship for at least one year. The interviews focused on the women’s narratives concerning their experience leaving the relationship and were coded for affect using an Emotional Adjective Checklist. A total of 10 women were recruited from the campus of The University of Texas of the Permian Basin. While each story was unique, a pattern did emerge whereby the women expressed feelings of fear and relief, followed by depression, numbness, and resolve to survive. Long term emotional consequences of the abuse that persisted …

Mutagenesis Induced By The Tumor Microenvironment: Implications Of Increased Dna Damage And Diminished Dna Repair, Jianling Yuan

Yale Medicine Thesis Digital Library

Tumors are characterized by microenvironmental heterogeneity, with regions of hypoxia, low pH, and nutrient deprivation. It has been proposed that such conditions may be an important factor contributing to cancer genetic instability. Using a chromosomally based lambda phage shuttle vector as a mutation reporter, we show that growth of cells in hypoxia and/or at low pH results in elevated mutation frequencies in two different reporter genes. To elucidate the mechanism of the tumor microenvironment-induced genetic instability, we first measured the production of DNA damage upon hypoxia and re-oxygenation in culture. We found that under such conditions, the intracellular level of …

Focal Temperature Change Facilitates The Peak-To-Peak Soleus Hoffmann Reflex And Muscle Response, Bentley Andrew Krause

All-Inclusive List of Electronic Theses and Dissertations

Objective: Cryotherapy is a widely used rehabilitative modality in sports medicine. Cooling joint tissues has been observed to facilitate active exercise following injury. Mechanisms effecting motoneuron recruitment during and following cryotherapy are presumed to be both local and central in nature. Focal cooling facilitates motoncuron pool recruitment and may alter the excitability of motoncurons. The purpose of this investigation was to determine if changes in focal temperature alter the characteristics of the maximum peak-to-peak Hoffmann reflex (Hmax) and muscle response (Mmax). Design and setting: A 4x5 factorial design with repeated measures on time was used in this study. Hmax and …

A Sampling Of Athletes Attitudes Toward Alcohol And Drug Use In College And Professional Athletes, Gregory A. Andis

Graduate Theses

Athletes of today are looking for every advantage over the competition, often subjecting themselves to harmful drugs. The purpose of this study was to determine the attitudes of athletes concerning drug use. Subjects for the study were 71 athletes acquired from the local college, university and professional hockey team. A Modified Tricker/Cook Drug Attitude Survey was used to compare each athlete’s response to the other respondents by looking at each of the following categories, sport, country, ethnicity, age, gender, level of education and level of activity. The survey was administered and results were calculated. Results showed that athletes sport, country, …

The Application Of Kinesio Tape Does Not Alter Knee Extensor Torque Production Following Muscle Fatigue, Takeru Hatachi

All-Inclusive List of Electronic Theses and Dissertations

Objective: Muscle fatigue is defined as the inability to maintain force output. It seems plausible that some sports injuries can be prevented if muscular fatigue can be reduced. Research evaluating Kinesio tape is still limited. And further study is needed in this area for clearing the effects of the elastic tape to apply effectively, and safely to the clinical setting. The purpose of this study was to investigate the effects of Kinesio tape on knee extensor force output before and after muscle fatigue. Design and Setting: A 2 x 3 factorial design was used to compare force output before and …

Home-Care Nurses' Knowledge And Perceived Preparedness To Counsel Patients On Advance Directives, Mary Moran Barr

Masters Theses

This study examined home-care nurses’ knowledge and perceived preparedness to counsel patients on advance directives (ADs). Joyce Fitzpatrick’s “life perspective rhythm” model provided the framework for the thesis. Sixty-two registered nurses actively practicing in home-care in West Michigan were surveyed over a 4-week period. Each nurse completed a 16-question survey, which included an 11-question true-false test of knowledge of ADs. Survey results indicated that nurses who feel prepared to counsel patients are more knowledgeable than those who do not feel prepared to counsel (t=2.89, df=57, p=<0.05). Overall knowledge was high (87.4%) but only 40 nurses (64%) felt prepared to counsel patients on ADs. The study implies that factors other than knowledge may have an impact on preparedness to counsel. Possibilities for further study include more research on education of healthcare providers about ADs, patient education, and the need for mutual discussions on end-of-life care issues in relationship to completing ADs.

The Splicing Of U12-Type Introns Is A Rate-Limiting Step In Gene Expression, Abhijit A. Patel

Yale Medicine Thesis Digital Library

Metazoan genes have recently been found to contain a novel class of introns that display non-canonical consensus sequences and are excised by a distinct splicing machinery. These introns occur very rarely, and have been called U12-type introns because recognition of their branch point sequences requires the U12 snRNP, which performs an analogous function to the U2 snRNP in splicing major-class introns. The persistence of two spliceosomes throughout virtually all of metazoan evolution suggests that the two spliceosomes play distinct and probably indispensable cellular roles. One enticing possibility is that the U12-type spliceosome functions in post-transcriptional regulation, serving as the rate-determining …

Post-Processing Of Low Dose Mammography Images, Jesung Kim

Theses and Dissertations

In mammography, X-ray radiation is used in sufficient doses to be captured on film for cancer diagnosis. A problem lies in the inherent nature of X-rays to cause cancer. The resolution of the images obtained on film is directly related to the radiation dosage. Thus, a trade-off between image quality and radiation exposure is necessary to ensure proper diagnosis without causing cancer. A possible solution is to decrease the dosage of radiation and improve the image quality of mammograms using post- processing methods applied to digitized film images. Image processing techniques that may improve the resolution of images captured at …