Medicine and Health Sciences Commons^™

The Phenomenon Of Amoralism: An Investigation Of The Cognitive And Emotive Roots, Andrei G. Zavaliy

Dissertations, Theses, and Capstone Projects

An amoralist is defined as a person who rejects the claims of moral reasons to special authority, and systematically acts without regard to the generally accepted moral standards. A psychopath can be seen as a paradigm case of an extreme amoralist, although the less severe cases of selective amoralists are considered. The research into the typical behavioral pattern, motivational structure, and the value system of psychopaths can shed light on at least three aspects related to the analysis of the moral agency. First, it can help elucidating the emotive and cognitive conditions necessary for moral performance. Secondly, it can provide …

Development Of Lexical Tone Production In Disyllabic Words By 2- To 6-Year-Old Mandarin-Speaking Children, Puisan Wong

Dissertations, Theses, and Capstone Projects

This study investigated children's development in the production of Mandarin lexical tones in familiar disyllabic words and tested the hypothesis that disyllabic tone contours with more complex fundamental frequency contours are more difficult for children to produce. Participants were forty-four 2- to 6-year-old monolingual Mandarin-speaking children and 12 mothers. Their disyllabic tone productions were elicited by picture naming and low-pass filtered to eliminate lexical information while retaining the fundamental frequency contours. Three Mandarin-speaking judges listened to the filtered stimuli, and categorized the children's and adult's disyllabic tones. Acoustic analysis was performed on selected accurate child and adult productions and on …

Antibiotics That Inhibit 30s Or 50s Ribosomal Subunit Formation: Hygromycin B, Quinupristin-Dalfopristin And Xrp 2868., Susan Mabe Mcgaha

Electronic Theses and Dissertations

Several antibiotics that prevent translation by binding to ribosomal subunits have been shown to also inhibit ribosomal subunit assembly (Champney and Tober 2003). The aminoglycoside hygromycin B was examined in Escherichia coli cells for inhibitory effects on translation and ribosomal subunit assembly. The streptogramin antibiotics quinupristin-dalfopristin and XRP 2868 (NXL 103) were examined for similar effects on these 2 cellular functions in antibiotic-resistant strains of Haemophilus influenzae, Staphylococcus aureus, and Streptococcus pneumoniae.

Pulse chase experiments were performed which verified slower rates of ribosomal subunit formation in drug treated cells. Hygromycin B exhibited a concentration dependent inhibitory effect …

Light Image Therapy In The Health Care Environment., Anna Rae Dutro

Electronic Theses and Dissertations

Use of positive distraction in the built healthcare environment to assist in alleviating stress in a patient was investigated. A backlit light image was mounted in the ceiling of an examination room to create a positive distraction for patients in the ETSU Pediatric Clinic in Johnson City, TN. Survey instruments were used to collect sample data from patients and physicians in a randomized, balanced controlled study designed to determine if patients experienced less stress in the room with the backlit image as compared to other rooms (treatments). Although a statistical difference was not determined between the room with the backlit …

A Study Of Clinical Outcomes Using Serum Albumin And Percentage Of Weight Loss Following Nutritional Intervention In Post-Operative Bariatric Patients., Jennifer Michelle Angus

Electronic Theses and Dissertations

The purpose of this study was to determine if post-operative serum albumin and percentage of weight loss improved in patients who received formalized pre-operative nutrition counseling. Nutrition intervention was measured quantitatively. A retrospective review of records was conducted on 77 RYGB patients (68 female subjects and 9 male subjects), ages 21-64, during January 2001 through January 2006.

The results indicated that patients who received pre-operative nutrition intervention had better clinical outcomes of serum albumin than those with no nutrition intervention from a registered dietitian. However, outcomes regarding percentage of weight loss varied. Both pre-operatively and at the 3 month post-operative …

Localization Of A Microsporidia Adam (A Disintegrin And Metalloprotease Domain) Protein And Identification Of Potential Binding Partners., Carrie E. Jolly

Electronic Theses and Dissertations

Microsporidia are spore-forming, obligate intracellular pathogens typically associated with opportunistic infections in immunocompromised individuals. Treatment options for microsporidia infections in humans are limited and additional research is necessary to create better therapeutic agents. For many pathogenic organisms, adhesion to the host cell surface is a prerequisite for tissue colonization and invasion. Our previous research has demonstrated a direct relationship between adherence of microsporidia spores to the surface of host cells and infectivity in vitro. In an effort to better understand adherence, we have turned our attention to determining what proteins may be involved in this process. Examination of the …

Bridging The Gap With Old Order Amish: A Cultural Brokering Model Based On Culture Care Theory, Sharon M. Mcgill

Theses and Graduate Projects

The Old Order Amish people have chosen to live a humble lifestyle consistent with their cultural beliefs and values. This lifestyle guides the Amish people in utilizing home based care (generic care) for their everyday health need.s and professional care (Western medical- care) to meet their needs during a health crisis. In fact many Old Order Amish seek professional care as the last resort. The purpose of this protect is to develop a model of advanced transcultural nursing practice that bridges the gaps between the Old Order Amish generic care practices and Western professional health care practices - This model …

A Comparison Of An Individually Tailored And A Standardized Asthma Self-Management Education Program, Judy Ann Shackelford

Dissertations

Asthma is one of the most prevalent chronic diseases in the United States (Centers for Disease Control [CDC], 2003). According to the CDC (2003), prevalence of asthma continues to rise in epidemic proportions and is very costly. While asthma cannot be prevented or cured, it can be controlled to improve quality of life. Self-management is key to controlling asthma (CDC, 2003; National Heart, Lung, and Blood Institute [NHLBI], 2002). State of the science for asthma self-management establishes that health care costs decrease for self-management intervention groups (Lindberg et al, 2002; Thoonen et al, 2003). Education is essential to support asthma …

Missouri Ozark Women's Experiences Of Living With Postpartum Depression Symptoms, Nathalie B. Williams

Dissertations

Depression is a serious complication of the postpartum period that affects not only women but their children and families as well. Rural women are of particular concern because of the significant barriers to health care that they experience as a result of isolation, poverty, traditional beliefs, and a lack of accessible and adequate health related services. A review of the literature to identify evidence based nursing interventions that focused on primary and secondary prevention of postpartum depression revealed few interventions and there were no studies identified that targeted or even included women living in rural areas of the United States. …

Perceptions Of Dyspnea, Physical Activity, And Functional Status In Obese Women, Donna Althea Jewell

Dissertations

PURPOSE: King's Theory of Goal Attainment guided this study exploring the physical sensation of dyspnea that obese women feel and how it affects their functioning. BACKGROUND AND SIGNIFICANCE: Obesity prevalence has doubled since 1980. Current research is investigating how to reduce prevalence and examining obesity's impact on the respiratory system. Little research was found that investigated the impact obesity has on routine activities because of dyspena and function and whether physical activity has a mitigating effect. METHODS: A comparative descriptive research design was used. A survey of dyspnea felt during routine activities was created; IRB approval to survey community-dwelling women …

Leadership Competencies In Today's Complex Healthcare Environment, Judy Moseley

Theses and Graduate Projects

The increasingly diverse, multicultural population in the United States is offering significant challenges to nurses to provide culturally competent care. If the provision of the best possible care for all patients is the goal, nurse leaders must have the expertise and skill to lead staff through the complex problems of organizations. Nurses must possess the ability to generate solutions consistent with the organization's mission and with sensitivity to the needs of a diverse patient population. Through the interconnected processes of teaching and practice, an innovative Master of Arts in Nursing program that emphasizes transcultural nursing practice experience for leaders was …

Characterization Of The Anti-Angiogenic Properties Of Kdr-Ig4-7 And Its Variants As Potential Anti-Cancer Therapeutics, Jang Pyo Park

All Dissertations

Beginning with the development of an embryo and throughout one's adult life angiogenesis plays an essential role for organ growth and repair. The balancing of pro-angiogenic factors to anti-angiogenic factors is what regulates the process of angiogenesis. When this balance is disrupted in one direction or the other, numerous disorders can occur including ocular and inflammatory diseases and, in particular, tumor growth and metastasis. Therefore, inhibition of angiogenesis has become an effective therapy for arresting the growth of tumors.
A key regulator of angiogenesis involves vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2 (KDR). The binding of VEGF to …

Evaluation Of Human Prolactin, Its Antagonist, And Antagonist-Based Fusion Proteins As Chemopreventative And Therapeutic Agents, Seth Tomblyn

All Dissertations

Cancer is a collection of diseases with many different manifestations and is the second leading cause of death in the United States. Breast cancer accounts for nearly one third of cancer diagnosis in women. Prolactin (PRL) functions as a lactogen and as a mammary gland differentiation factor. PRL acts in an autocrine/paracrine manner within the mammary gland and in breast tumors which implies PRL may be involved in breast cancer progression. This is corroborated by the PRLR over-expression in breast cancer cells lines and the majority of patient biopsies. These reasons make PRL and PRLR attractive targets for breast cancer …

Tetraspanin Kai1/Cd82 Inhibits Cell Migration-Related Cellular Events Via Reorganizing Actin Network, Wei Liu

Theses and Dissertations (ETD)

To determine how tetraspanin KAI1/CD82, a tumor metastasis suppressor, inhibits cell migration, we assessed which motility-related cellular events are altered by KAI1/CD82 and how KAI1/CD82 regulates these events. We found that KAI1/CD82-overexpressing cancer cells exhibit various morphologies but typically display elongated cellular extensions and a lack of lamellipodia. Live imaging demonstrated that the formation of lamellipodia and retraction of extensions were deficient upon KAI1/CD82 overexpression.

The deficiency in developing motility-related cellular events was accompanied by defects in actin cortical network and stress fiber formations. Notably, actin polymerization was attenuated by KAI1/CD82. Although Rac1 activity was diminished upon KAI1/CD82 expression, Rac1 …

Enzyme Architecture And Flexibility Affect Dna Topoisomerase I Function, Mariè Van Der Merwe

Theses and Dissertations (ETD)

DNA topoisomerase I (Top1) is a highly conserved enzyme composed of four domains: a positively charged N-terminus; a DNA binding/core domain that circumscribes duplex DNA; a non-conserved linker domain; and a C-terminal/catalytic domain. Top1 catalyzes changes in DNA topology by transient cleavage of a single DNA strand and the concomitant formation of a phosphotyrosyl linkage between the enzyme and the 3’ DNA end. This covalent Top1-DNA complex is the binding site for camptothecin (CPT), which selectively inhibits religation of the cleaved DNA strand. CPT binding stabilizes the covalent complex, while the collision of replication forks with CPT-Top1-DNA adducts produces DNA …

Uncovering P53 Mutations And Abnormal Gene Expression In Pediatric Adrenocortical Cancer, Alina Nico West

Theses and Dissertations (ETD)

Pediatric adrenocortical cancer is extremely rare and often fatal (approximately 0.3-0.4 cases per million worldwide; 50% 5-year survival). The incidence of pediatric adrenocortical cancer in southern Brazil is 10-15 times higher than the worldwide incidence. Due to the rarity of adrenocortical cancer, especially in children, underlying gene dysregulation and mechanisms of tumorigenesis of the adrenal gland are very poorly described in the literature. However, it is well-known that the tumor suppressor p53, which is mutated in over 50% of all human cancers, is commonly mutated in pediatric adrenocortical cancer. In addition, evidence strongly suggests that if a child has adrenocortical …

African American Grandmother Caregivers: Relationships Among Information Need, Perceived Burden, Perceived Health, And Service Need And Use, Gloria F. Carr

Nursing Dissertations - Archive

African American (AA) grandmothers who parent their grandchildren may experience burden related to these responsibilities. Little is known about perceived caregiver burden and its influence on AA grandmother health and service needs. The purpose of this descriptive, correlational research study was to investigate relationships among personal characteristics, information need, perceived burden, perceived health, service need, and service use in AA grandmothers who are the primary caregivers for one or more of their biological grandchildren. Recruited through churches and community centers, 93 AA grandmothers, ages 36 to 78, participated in this study. These grandmothers were primary caregivers for 211 grandchildren. The …

Treatment Of Co-Morbid Methamphetamine Substance Abuse And Borderline Personality Disorder Features Using Modified Dialectical Behavior Therapy, Jessica R. Schultz Fischer

Dissertations

The study investigated the effectiveness of a time-limited, skills-based treatment in a population of female substance abusers. This project implemented a pilot clinical trial to evaluate the effectiveness of a 12-session modified Dialectical Behavior Therapy (DBT) protocol among a small sample of women, with co-morbid borderline personality disorder features, receiving concurrent outpatient treatment for methamphetamine abuse. A non-concurrent multiple baseline design was used. In addition to on-going assessment conducted during baseline and weekly over the course of treatment, a comprehensive assessment battery was administered pre-, and post-treatment as well as at 1 and 3 months following treatment. Findings suggest that …

Creating A Culture Of Safety: The Influence Of Medical Simulation On The Attitudes Of Surgical Team Members, Diane J. Jones

Dissertations

The objective of this study was to determine change in individual and aggregate attitudes of the members of two subspecialty surgery teams (cardiac and vascular) in six domains (teamwork climate, safety climate, job satisfaction, stress recognition, perception of management, and working conditions) following medical team simulation and debriefing exercises. The study was a pre-post partially randomized controlled, quasi-experimental study that took place in a 545-bed hospital with a high-volume cardiovascular surgery program. Participants included interdisciplinary team members caring for cardiac and vascular surgery patients.

Main outcome measures included change in responses to safety attitudes questionnaires (SAQs) administered before, 1 week …

The Relationship Among Spirituality, Self-Efficacy, And Quality Of Life In Adults With Sickle Cell Disease, Maxine A. Adegbola

Nursing Dissertations - Archive

For the individual with sickle cell disease (SCD), the lifespan is increasing but adults report decreased quality of life (QOL), low self-efficacy, and ineffective coping skills. The care of adult patients with SCD requires a complex multidisciplinary team approach with focus not only on physiological, psychological, and social needs, but also on spiritual needs. Quality of life, spirituality, and self-efficacy have been sparsely and separately studied in individuals with SCD. These three constructs have never been combined in one study in the adult SCD population. Objective: The purpose of this study was to explore and describe the relationships among spirituality, …

An Assessment Of Athletic Health Care Provided To High School Athletes In Indiana, Lori Jane Vancza

All-Inclusive List of Electronic Theses and Dissertations

Objective: The purpose of this study is to assess various aspects of athletic health care being provided to athletes in high risk sports in Indiana and the personnel providing this care relative to school enrollment size in comparison to the recent recommendations published by the National Athletic Trainers' Association (NATA) regarding appropriate medical care for secondary school-aged athletes. Design and Settings: Based on a literature review, a 34 item web based survey for athletic directors (ADs) and a 33 item web based survey for identified head coaches were developed and distributed to 406 Indiana High School ADs. The survey instruments …

A Mixed Methods Analysis Of The Concept Of Female Sexual Health, Laura C. Ford

Dissertations

The theoretical concept of health includes the ability to function physiologically, perceive a state of wellness, participate in social relationships, and be disease-free. Currently, the medical field approaches sexuality from a disease prevention and treatment perspective. Female sexual health must be understood holistically (i.e., emotionally, sociologically, and physiologically) for healthcare providers to help their patients optimize their sexual health; however, little research has been conducted from a holistic perspective. This study's purpose was to begin an exploration of the meaning of female sexual health.

This study utilized focus groups and a survey to explore the concept female sexual health as …

An Investigation Of Relationship Characteristics, Exercise And Physical Activity, Couple And Life Satisfaction, Mark W. St. Martin

Dissertations

Exercise has been shown to be positively related to many different variables including sexual satisfaction, mental health, and physical health. These variables, in turn, have been linked to increased life satisfaction and couple satisfaction. The primary purpose of this study was to examine the relationships between exercise and couple satisfaction as well as exercise and life satisfaction. A secondary purpose was to replicate previous findings on the relationships between communication, love, sexual satisfaction, self-esteem, and physical health and couple satisfaction.

A total of 229 undergraduate and graduate students from a large Midwestern university in the United States participated in this …

A Study Of Disaster Preparedness Of Rural Hospitals In The United States, Barbara Cliff

Dissertations

This dissertation examines disaster preparedness in the U.S. and explores the relationships between risk perception, funding from the Health Resources and Services Administration (HRSA), and preparedness. Secondary data analysis was conducted using the National Study of Rural Hospitals from Johns Hopkins University. The study, based on a random sample of rural hospitals, consisted of a mail questionnaire and a follow-up phone interview with the hospital's Chief Executive Officer (n = 134).

A model of disaster preparedness was utilized to examine seven elements of preparedness. Risk perception was examined by seven risk threats, and HRSA funding was examined as a …

Perceived Organizational Support And Ethical Work Climates As Predictors Of Turnover Intention Of Licensed Nurses In Skilled Nursing Facilities, Anna A. Filipova

Dissertations

The purpose of this study was twofold: (1) to replicate Victor and Cullen's (1987; 1988) studies to confirm whether ethical climates (ECs) arise in skilled nursing facilities (SNFs), and whether organizations and groups within organizations have identifiable ECs; and (2) to test a model that examines the effects of ECs and perceived organizational support (POS) on licensed nurses' turnover intention (TOI) through job satisfaction (JS) and organizational commitment (OC).

A cross-sectional survey design was implemented. Three hundred and fifty nine freestanding SNFs were selected in a midwestern state. While a total of 110 facilities (31%) agreed to participate, responses were …

Perceptions And Intervention Practices Of Speech-Language Pathologists Serving Students With Emotional/Behavioral Disorders, Laura A. Getty

Dissertations

A relationship between emotional/behavioral disorders (E/BD) and language deficits has been validated by researchers in special education (Cantwell & Baker, 1991; Beichman, Cantwell, Forness, Kavale, & Kaufmann, 1998; Cohen, Barwick, Horodezky, Vallance, & Im, 1998) as well as researchers in speech-language pathology (Hyter, 2003; Hyter, Rogers-Adkinson, Self, Simmons, Jantz, 2001; Ruhl, Hughes, & Camarata, 1992; Gallagher, 1999; Fujiki, Brinton, Morgan, & Hart, 1999). The exact prevalence rate between E/BD and language deficits was not definitive as it varies between 35% and 97% depending on the study reviewed (Benner, Nelson, & Epstein, 2002). While it has been documented that a relationship …

Efficacy Of Cognitive Therapy And Pharmacotherapy In Depression: A Meta-Analysis, Daniel B. Michel

Loma Linda University Electronic Theses, Dissertations & Projects

A meta-analysis comparing the long-term effectiveness of cognitive behavioral therapy (CBT) and pharmacotherapy in preventing relapse following treatment discontinuation was performed using published studies of depressed participants. Twenty-three articles met inclusionary criteria and were included in the analyses. Weighted effect sizes and moderators, treatment type, were calculated using statistical analysis software. Initially, fixed effects models were applied to the data, but due to significant between-group heterogeneity that could not be fully explained by treatment type, mixed effect models were used to account for the residual heterogeneity. Results indicated that overall, depressed individuals treated to remission with CBT evidence decreased relapse …

Immediate Implant Placement In Extraction Sites With Periapical Lesions: A Retrospective Study, Yuan-Lung Hung

Loma Linda University Electronic Theses, Dissertations & Projects

Immediate implant placement into fresh extraction sites has become a relatively routine clinical procedure with a favorable prognosis. However, immediate placement into extraction sockets with lesions has not been extensively documented in humans. Therefore, the purpose of this study was to retrospectively determine the survival rate of implants placed into extraction sockets with visible periapical lesions.

Patient charts of 544 immediately placed implants from Loma Linda University School of Dentistry, Center for Prosthodontics and Implant Dentistry were examined. Eighty-six of the 544 implants had been placed immediately into extraction sockets with periapical lesions and they were included in this study. …

Is Electrical Stimulation A Predictive Tool For Autonomic Dysfunction In Males With Diabetes?, Susan Dorothy Rand

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to examine whether electrical stimulation can be used as a predictive tool to assess autonomic dysfunction in males with diabetes. The study was designed to better understand the extent of autonomic nervous system (ANS) dysfunction in the diabetic population.

Controls and patients with diabetes were recruited from the community at large and the Loma Linda University Diabetes Treatment Center and were managed by a physician. Twelve (12) people with diabetes and thirteen (13) control subjects participated. Mean age (years) for people with diabetes was 52.4 +/- 6.1 and 47.2 +/-11.1 for controls (p =0.05). …

Distraction Of Heterotopic Bone Formed With Bmp-2 In A Rat Model: The Technique, Stacie Dawn Fenderson

Loma Linda University Electronic Theses, Dissertations & Projects

Multiple studies have shown that ectopic bone forms when bone morphogenic proteins (for example BMP-2 and BMP-7) and a collagen matrix are surgically placed in a rat model either orthotopically or heterotopically. Bone begins to form by the 14 day, and is at it maximum calcified state by the 21st day. The purpose of this study is to observe and quantify the effect of distraction osteogenesis on the ectopic bone. First, a preliminary procedure was performed by surgically placing a titanium cage into the back of a rat just caudal to the thoracic vertebrae. The anterior corners were sutured to …