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Articles 60331 - 60360 of 71130
Full-Text Articles in Medicine and Health Sciences
Psychosocial Functioning In Childhood Cancer Survivors, Measured By Parent, Teacher And Child Surveys, Tamara Porter Miller
Psychosocial Functioning In Childhood Cancer Survivors, Measured By Parent, Teacher And Child Surveys, Tamara Porter Miller
Yale Medicine Thesis Digital Library
The purpose of the current study is to understand emotional and neurocognitive functioning in childhood cancer survivors. In this single-evaluation cross sectional study, 41 childhood cancer survivors (53.2% of those eligible) in the Health Education Research Outcomes in Survivors (HEROS) Clinic at Yale-New Haven Hospital between the ages of six and eighteen and their parents and teachers completed the Behavior Assessment System for Children, Second Edition (BASC-II), Behavior Rating Inventory of Executive Functioning (BRIEF) and Pediatric Quality of Life Inventory (PedsQL). Patients, parents and teachers scores were compared to those of normative populations for emotional, neurocognitive and quality of life …
The Regulation Of Mitochondrial Uncoupling Proteins In The Heart, Karl Robert Laskowski
The Regulation Of Mitochondrial Uncoupling Proteins In The Heart, Karl Robert Laskowski
Yale Medicine Thesis Digital Library
The mitochondrial uncoupling proteins (UCPs) are a recently discovered group of proteins that are present in the inner mitochondrial membrane and mediate a variety of important functions. Involved in transmembrane proton transport, UCPs regulate cellular metabolism as well as prevent reactive oxygen species formation (ROS) and detoxify exogenous ROS. In the heart, these proteins may protect tissue during times of ischemic or metabolic stress. Also activated during metabolic stress is AMP-activated protein kinase (AMPK), which has been shown to provide cardioprotection during ischemia/reperfusion. We hypothesized that AMPK activation plays a role in upregulating the expression of uncoupling proteins UCP2 and …
Prevalence & Rationale Of Creatine Use In Diii Ncaa Athletes, Raquisha Lynnette Bailey
Prevalence & Rationale Of Creatine Use In Diii Ncaa Athletes, Raquisha Lynnette Bailey
ETD Archive
Athletes often seek out ergogenic aids to improve sport performance. Creatine is one of the most popular supplements consumed among young athletes. At the Division III level of collegiate sports, certain perceptions or influences have led to or have sustained creatine use in this athletic population and needs to be examined. The purpose of this study was to determine the prevalence of creatine supplementation among Division III collegiate athletes and to summarize educational resources, attitudes, and rationale for its use across gender and sport. In the Spring of 2007, 61 Division III varsity athletes football (39/61), basketball (10/61), baseball (4/61), …
The Effect Of Surya Namaskara Yoga Practice On Resting Heart Rate And Blood Pressure, Flexibility, Upper Body Muscle Endurance, And Perceived Well-Being In Healthy Adults, Kristine Marie Fondran
The Effect Of Surya Namaskara Yoga Practice On Resting Heart Rate And Blood Pressure, Flexibility, Upper Body Muscle Endurance, And Perceived Well-Being In Healthy Adults, Kristine Marie Fondran
ETD Archive
Surya Namaskara (SN) is a yoga practice(routine) that consists of a series of 12 physical postures made up of a variety of forward and backward bends. The series of movements stretch the spinal column and massage, tone and stimulate vital organs through alternately flexing the body forwards and backwards. Purpose: The purpose of the study was to determine the effects of a twice daily SN yoga practice on resting heart rate (HR) and blood pressure (BP), flexibility, upper body muscle endurance, and perceived well-being in low to moderately active adult males and females. Methods: Participants (24 females, 6 males mean …
Validation Of The Sensewear Hr Armband For Measuring Heart Rate And Energy Expenditure, Manuella Barbosa Crawley
Validation Of The Sensewear Hr Armband For Measuring Heart Rate And Energy Expenditure, Manuella Barbosa Crawley
ETD Archive
The purpose of this study was to determine the validity of the SenseWear HR Armband in measuring heart rate and energy expenditure. The SenseWear HR Armband was compared to an electrocardiogram (ECG), the Actiheart Mini Mitter and the Polar Heart Rate Monitor. Energy expenditure estimations were compared to indirect calorimetry (Cosmed's K4 b2) measurement and the Actiheart Mini Mitter's estimations. Thirty healthy adults (18-59 years old) participated in the study. The protocol consisted of 5-minute stages, starting with two resting stages (sitting and standing), followed by four walking stages (1.5, 2.0, 2.5 and 3.0 mph) and ending with a standing …
Reinventing Nursing For Future Generations, Connie A. Luedtke
Reinventing Nursing For Future Generations, Connie A. Luedtke
Theses and Graduate Projects
By 2020 the USA will experience a tremendous nursing shortage. Unfortunately the public does not know what nurses do nor the rewards associated with the profession of nursing. Nursing has had difficulty competing with other professions offering more pay, better schedules and promises of exciting careers. The purpose of this graduate integrative project is to describe a children's book written with the intention of educating and recruiting future generations for the profession of nursing. Background information will be provided to illustrate the need for such a book, including general information on the current nursing shortage, the disparity of men and …
The Positive Energy Patrol: One Nursing Division's Approach To Address The Issue Of Morale In The Workplace, Mary Ann Ryan
The Positive Energy Patrol: One Nursing Division's Approach To Address The Issue Of Morale In The Workplace, Mary Ann Ryan
Theses and Graduate Projects
The purpose of this project is to develop an article for submission to a professional journal describing a staff led initiative to address employee morale in the hospital setting. It is well documented in professional nursing literature that the morale of a work environment has a direct effect upon the care provided to the patients and families served. Empowerment of staff, mutual respect, and transpersonal care as described by nursing theorist Jean Watson provide a healthy framework for a workplace where people want to engage and contribute. A morale initiative as trialed at one institution will be shared for consideration …
Nursing Education To Minimize Anxiety For Patient And Family During Transfer From Intense Care To General Care, Renee L. Wilson
Nursing Education To Minimize Anxiety For Patient And Family During Transfer From Intense Care To General Care, Renee L. Wilson
Theses and Graduate Projects
The purpose of this project is to design an education module for nurses on the phenomenon of transfer anxiety so they are able to recognize patient and family behaviors manifested as a result of anxiety at the time of transfer from intensive to general care. Anxiety at the time of transfer can negatively impact patients' therapeutic response to health care as well as minimize the effectiveness of family members as needed support. The multifactorial causes of transfer anxiety are well documented in professional literature but not well known by nurses. Information from published literature that supports transfer anxiety as a …
Validation Of A Bioelectrical Impedance Analysis Equation Predicting Body Composition Using Conductor Length Instead Of Height, Jessica Dawn Nye
Validation Of A Bioelectrical Impedance Analysis Equation Predicting Body Composition Using Conductor Length Instead Of Height, Jessica Dawn Nye
Undergraduate Honors Theses
Bioelectrical impedance analysis (BIA) is widely used in predicting body composition. Impedance of an electrical current that passes through the body is related to the composition of the body and the length of the conductor, conventionally estimated using height. The purpose of this study was to compare a BIA equation prediction fat-free mass (FFM) that utilized actual conductor length (Parsons) with a conventional BIA equation (NHANES), using hydrodensitometry as the reference method. Thirty-nine male and 53 female subjects were studied. For both sexes, FFM predicted by both Parsons and NHANES equations were equally and highly correlated with FFM measured using …
The Metabolic Effects Of Epigallo Catechin Gallate On Females At Rest And Low Exertion, Bret Mcconaughy Rust
The Metabolic Effects Of Epigallo Catechin Gallate On Females At Rest And Low Exertion, Bret Mcconaughy Rust
Undergraduate Honors Theses
Green tea extract (GTE) containing catechin polyphenols is marketed widely as a dietary supplement intended to enhance weight loss. Epigallo Catechin Gallate (EGCG) is a polyphenol found in green tea that some studies have found to increase Energy Expenditure (EE) and to decrease Respiratory Quotient (RQ) in human subjects. The purpose of this study was to determine the effect of two weeks of chronic supplementation of 540 mg of EGCG on anthropometric measurements, body composition, blood pressure, EE and RQ in adult women at rest and at low levels of exertion. Results trended toward reducing resting RQ (p=.098) but showed …
The Uses Of Rickets: Race, Technology, And The Politics Of Preventive Medicine In The Early Twentieth Century, M. Allison Arwady
The Uses Of Rickets: Race, Technology, And The Politics Of Preventive Medicine In The Early Twentieth Century, M. Allison Arwady
Yale Medicine Thesis Digital Library
Rickets, the bone disease classically caused by Vitamin D deficiency, was one of the most common diseases of children 100 years ago. It has been recognized as a disease of urban living and linked to issues of race and culture for generations. This paper uses unpublished patient records from 1904 to 1909 and archival and published materials from multiple community-based trials, including the New Haven Rickets Study (1923-1926), to explore how the definition, diagnosis, and treatment of rickets shifted in the first decades of the twentieth century in the United States. Before 1910, as evidenced by patient records, neither the …
Hospital Administrators' Perceptions Regarding Their Role In Quality Improvement, Benjamin F. Brown
Hospital Administrators' Perceptions Regarding Their Role In Quality Improvement, Benjamin F. Brown
MUSC Theses and Dissertations
As the formal leaders of their organizations, hospital administrators play a major role in ensuring that their hospitals meet the challenge of continually improving the care that is provided within their organizations. While the literature identifies some of the things that these leaders should be doing to lead their organizations toward providing exemplary care, the literature is lacking with regard to the specifics of how those who are successful are actually able to do so. This study sought to fill this gap in the literature through a qualitative examination of hospital administrators' perceptions of their roles in Q I. The …
Anticipating Mothering In The Mexican Origin Woman, Susan M. Baxley
Anticipating Mothering In The Mexican Origin Woman, Susan M. Baxley
Nursing Dissertations - Archive
Not all women experience pregnancy and motherhood in the same way. There needs to be a greater understanding of how Mexican origin women experience pregnancy and anticipate mothering since Hispanics comprise the largest and fastest growing minority group in the United States. The purpose of this qualitative, descriptive inquiry was to explore the meaning of attachment, commitment, and preparation during pregnancy as an anticipatory phase of mothering for the Mexican origin woman giving birth in the United States. Culture, the partner, family and friends were also explored as to how they influenced the process of anticipating mothering. Semi-structured interviews provided …
Tissue Engineering The Motoneuron To Muscle Segment Of The Stretch Reflex Arc Circuit Utilizing Micro-Fabrication, Interface Design And Defined Medium Formulation, Mainak Das
Electronic Theses and Dissertations
The stretch reflex circuit is one of the most primitive circuits of mammalian system and serves mainly to control the length of the muscle. It consists of four elements: the stretch sensor (muscle spindle/ intrafusal fiber lie parallel between extrafusal, contractile musculature), extrafusal muscle fiber, sensory neuron and motoneuron. The basic principle of the stretch reflex arc circuit is as follows: whenever there is a sudden stretch in a muscle, it needs to compensate back to its original length so as to prevent any kind of injury. It performs this compensation process using a simple negative feed back circuit called …
Racial Disparities Of Post Stroke Physical Therapy In South Carolina, Aaron E. Embry
Racial Disparities Of Post Stroke Physical Therapy In South Carolina, Aaron E. Embry
MUSC Theses and Dissertations
Background and Purpose: Stroke is a devastating event that drastically changes the lives of many people worldwide. Stroke statistics vary across the United States with the highest rates in the southeast. Physical therapy is often required to return to normal function. Appropriateness for physical therapy is based on individual impairments, thus access to and amount of physical therapy should not differ between races. Methods: Using a South Carolina UB-92 data subset for 2002, univariate analysis is performed against physical therapy and race for ischemic stroke victims. Logistic regression is used to test for differences in access to physical therapy. Multiple …
Novel Implications Of The Kallikrein-Kinin System In Diabetic Vasculopathy: A Proposed Role Of Prekallikrein In The Causation And Development Of Vascular Pathology In Diabetics, Rany Abdallah
MUSC Theses and Dissertations
Despite the clear association between diabetes and atherosclerotic vascular disease, the factors and mechanisms underlying the association between the two diseases are not well understood. Our preliminary studies, based on data obtained from the national Diabetes Control and Complication Trial/Epidemiology of Diabetes and Complications (DCCT/EDIC) cohort of type 1 diabetes subjects, suggest that diabetic atherosclerosis is linked to defects in the Kallikrein-Kinin System (KKS). Our research also found that apoliporotein E (ApoE) knockout mice, which have marked increase in total plasma cholesterol levels and a higher number of atherosclerotic lesions compared to wild type mice, have markedly higher plasma prekallikrein …
Characterization Of Calpain 10 Activity, Expression, And Inhibition, Christopher Joseph Giguere
Characterization Of Calpain 10 Activity, Expression, And Inhibition, Christopher Joseph Giguere
MUSC Theses and Dissertations
Calpains are a family of Ca^2+-activated, non-lysosomal, cysteine proteases that have been implicated in a variety of physiological and pathological processes. Currently, the family consists of 14 members, of which eight are typical (calpains 1, 2, 3, 8, 9, 11, 12, and 14) and six are atypical (calpains 5, 6, 7, 10, 13, 15), based on the presence or absence of the Ca^2+-binding domain (domain IV), respectively. The atypical calpain have recently gained attention due to studies that have linked human diseases to mutations in specific calpain genes (Type 2 diabetes linked to calpain 10 and Limb Girdle Muscular Dystrophy …
An Assessment Of Noninvasive Measurements Of Arterial Compliance, Andrea D. Boan
An Assessment Of Noninvasive Measurements Of Arterial Compliance, Andrea D. Boan
MUSC Theses and Dissertations
Arterial stiffness is considered both a risk factor and indicator of cardiovascular disease. The purpose of this study was to examine the associations of cardiovascular risk indicators of arterial compliance among 226 black and white individuals enrolled in an outpatient clinical setting. Data were collected by survey and examination with a computerized arterial pulse waveform analyzer. Arterial stiffness was estimated by indirect estimates of small artery and large artery compliance, as well as pulse pressure. After adjustments for age, race, and gender, logistic regression identified hypertension, end organ damage, and overweight as the strongest predictors for the three arterial stiffness …
Fli-1 In B Cell Proliferation And Systemic Lupus Erythematosus, Sarah Gail Bradshaw
Fli-1 In B Cell Proliferation And Systemic Lupus Erythematosus, Sarah Gail Bradshaw
MUSC Theses and Dissertations
PBMC from patients with SLE and splenic lymphocytes from murine models of SLE demonstrate increased expression of the ETS transcription factor Fli-1. Transgenic overexpression of Fli-1 in normal mice leads to SLE-like disease. These findings suggest investigation of the role of Fli-1 in SLE may elucidate etiology of the disease and potential therapies. The MRL/lpr mouse is a model of SLE exhibiting increased lymphocytic expression of Fli-1. Reduction of Fli-1 expression by heterozygousity at the Fli-1 locus (Fli1+/-) results in decreased auto- and alloantibodies, proteinuria, and renal pathology; and drastically decreased mortality. Disruption of the C-terminal transactivation domain (Fli1ΔCTA/ΔCTA) reduces …
Cultural Diversity: Pain Beliefs And Treatment Among Mexican-Americans, African-Americans, Chinese-Americans And Japanese-Americans, Anthony J. Alvarado
Cultural Diversity: Pain Beliefs And Treatment Among Mexican-Americans, African-Americans, Chinese-Americans And Japanese-Americans, Anthony J. Alvarado
Senior Honors Theses and Projects
The purpose of this project was to examine culture and the impact it has on the pain experience. Pain, albeit acute or chronic, is an important subject to understand because it can have detrimental effects on the body if not properly managed. Culture has been found to be a factor that influences one’s pain experience and thus the need for healthcare professionals to acknowledge this is imperative. The cultures examined in this paper include: Mexican- Americans, African-Americans, Chinese-Americans and Japanese-Americans. Within these four cultural groups their beliefs about the origin of pain, physical responses to pain, health and illness beliefs …
Tu Corazon Y Mi Pasion, Marygrace Hernandez-Leveille
Tu Corazon Y Mi Pasion, Marygrace Hernandez-Leveille
Nursing Dissertations - Archive
Background: Coronary heart disease (CHD) continues to be a major public health problem and is the leading cause of death in the United States (US).The estimated cost of cardiovascular disease (CVD) and stroke in the US for 2007 was 431.8 billion dollars. CVD, including CHD and stroke, claims the lives of approximately 500,000 women a year, making it the number one killer of women in the United States and exceeds the number of deaths in men and the next 7 causes of death in women combined.Review of Literature: Few studies have been completed evaluating atherosclerosis, non-invasive cardiovascular testing, ethnic minorities …
Outcomes Of Patients Transferred To The University Of Michigan Health System On A Short-Term Ventricular Assist Device For Cardiogenic Shock, Christina L. Leventhal
Outcomes Of Patients Transferred To The University Of Michigan Health System On A Short-Term Ventricular Assist Device For Cardiogenic Shock, Christina L. Leventhal
Master's Theses and Doctoral Dissertations
Short-term ventricular assist devices (VADs) are mechanical pumps that are used to temporarily support a patient who is in cardiogenic shock. These VADs are effective in sustaining a patient’s life until he or she can been transferred to a tertiary cardiac center such as the University of Michigan Health System. The researcher examined patients’ clinical status at the time of transfer and used univariate analysis to determine which factors are likely to predict a successful outcome. Multivariate analysis showed that younger age and better kidney function were prognostic variables in the patients’ 30-day and long-term survival. These factors improve the …
The Role Of Centaurin Alpha-1 In The Regulation Of Neuron Al Differentiation, Carlene Drucilla Moore
The Role Of Centaurin Alpha-1 In The Regulation Of Neuron Al Differentiation, Carlene Drucilla Moore
All ETDs from UAB
In the nervous system, PI 3-kinase has been implicated in neuronal differentiation. My studies have focused on a candidate neuronal PI 3-kinase target centaurin alpha-1, which binds PtdIns(3,4,5)P3, and is an Arf6 GAP. Centaurin alpha-1 is localized in dendrites, dendritic spines and synapses, and is required for neuronal differentiation and spine morphogenesis. In dissociated neuronal cultures, expression of centaurin alpha-1 enhances dendritic branching, and increases dendritic filopodia, lamellipodia and spine-like protrusions. Expression of centaurin alpha-1 GAP inactive mutant or knocking down centaurin alpha-1 levels using siRNA leads to inhibition of dendritic outgrowth and branching. Manipulations of centaurin alpha-1 also disrupt …
Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols
Relationships Among Anger, Patterns Of Anger Expression And Blood Pressure, Glucose, And Cortisol In Overweight School-Aged Children, Kimberly Nichols
All ETDs from UAB
Overweight and obesity in school-aged children have become a major health issue. With overweight and obesity, children have increased risk of developing elevated blood pressure readings, glucose levels, and cortisol. Trait anger and patterns of anger expression have been shown to contribute to the elevations of blood pressure, glucose and cortisol in normoweight children and overweight adolescents. However, little research has been done with overweight school-aged children. The purpose of this study was to examine the relationships among trait anger and each of the patterns of anger expression (anger-suppression, anger-out, and anger-reflection/control) and blood pressure, glucose, and cortisol in overweight …
Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson
Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson
All ETDs from UAB
Thrombospondin-1 (TSP-1) is a 420 kilodalton homotrimeric protein; it is one of the first identified anti-angiogenic proteins found to be expressed in some normal tissues. Peptides derived from the type-1 repeat (TSR) domains of full length TSP-1 have been shown to have anti-angiogenic activity, and thus anti-tumor activity in some non-glioma tumor models. I hypothesized that peptides derived from the TSRs of TSP-1, such as ABT-510, could inhibit angiogenesis and thus malignant glioma tumor growth in vivo. I found that ABT-510 inhibited angiogenesis of the human brain microvascular endothelial cell (MvEC) in an in vitro tubulomorphogenesis assay. To determine the …
Human Papillomavirus: Segregation And Replication, Luan D. Dao
Human Papillomavirus: Segregation And Replication, Luan D. Dao
All ETDs from UAB
Human papillomavirus are small DNA tumor viruses. The viral genome is a small circular double stranded DNA that replicates autonomously as an extrachromosomal plasmid. Occasionally infections by the high risk HPV viruses can lead to DNA integration and progression to cancer. How the HPV DNA is maintained and becomes established in the dividing host cells is not well understood. Additionally, as a double-stranded DNA virus it is likely that double-stranded DNA breaks in the viral genome, either from replication or random damage, will trigger a DNA repair response from the host cell. Such responses have been alternatively reported to be …
Perception Of Motion-In-Depth: Induced Motion Effects On Monocular And Binocular Cues, John Eric Gampher
Perception Of Motion-In-Depth: Induced Motion Effects On Monocular And Binocular Cues, John Eric Gampher
All ETDs from UAB
Three cues are available to the visual system to determine motion: image displacement across the retina (retinal slip), eye movements, and configuration changes within a scene (Becklen and Wallach, 1985). Any one may lead to the false perception of motion. Induced motion is the illusory movement of one object (or objects) as a result of other movement in the visual field. A wide variety of displays have been used to study induced motion, leading to apparently different classes of induced motion. Current theories of induced motion can be categorized based on local motion, global motion, eye movement suppression, and cognitive …
Mechanism Of The Cross Talk Between Growth Hormone Receptor And Epidermal Growth Factor Receptor, Xin Li
Mechanism Of The Cross Talk Between Growth Hormone Receptor And Epidermal Growth Factor Receptor, Xin Li
All ETDs from UAB
EGF receptor (EGFR) is a receptor tyrosine kinase, mediating cell growth from ectodermal and mesodermal origin. The overexpression and aberrant function of EGFR are involved in a wide range of human carcinomas. Growth hormone receptor (GHR) coexists with EGFR in various cell types and implicated in malignant tumor behavior. Previously in our lab, we found that via ERK activation GH can threonine phosphorylate EGFR and reduce EGF-induced EGFR downregulation. GH also synergizes with EGF in activating ERK. In this project, using reconstitution, we studied the mutation of the ERK phosphorylation consensus residue on EGFR, 669T. CHO-GHR cells, which lack EGFR …
Urine Protein Electrophoresis: Comparison Of Agarose Gel And Capillary Zone Electrophoretic Techniques., Anne-Marie Curtin
Urine Protein Electrophoresis: Comparison Of Agarose Gel And Capillary Zone Electrophoretic Techniques., Anne-Marie Curtin
Theses
Proteinuria is the excess excretion of protein in the urine and is found in a variety of conditions including renal diseases and neoplastic conditions such as multiple myeloma (MM). The investigation of proteinuria type through the use of electrophoresis is a useful and widely used non-invasive diagnostic tool. The aim of this study was to compare various agarose gel and capillary zone electrophoresis techniques in order to establish a method choice for the separation of protein in routine laboratories. Comparisons were made based on urine monoclonal peak quantification and protein fractions detected. An examination of a capillary zone electrophoresis (CZE) …
Evaluation Of A Simple Intervention To Increase Self- Efficacy For Independent Exercise In Cardiac Rehabilitation Participants, Sherry A. Barkley
Evaluation Of A Simple Intervention To Increase Self- Efficacy For Independent Exercise In Cardiac Rehabilitation Participants, Sherry A. Barkley
Electronic Theses and Dissertations
Purpose: While benefits of exercise after a cardiac event are well documented, participation in and adherence to cardiac rehabilitation (CR) programs is often low. The purpose of this study was to test the effectiveness of a self- efficacy coaching intervention (SCI): a simple theory-based behavioral intervention to increase self-efficacy for independent exercise as well as independent exercise behavior in CR patients. It was hypothesized that persons receiving the SCI treatment (T) would have higher levels of self-efficacy for exercise and greater participation in independent exercise than participants in an attention control (C) group.
Methods: People referred to a hospitalbased CR …