Medicine and Health Sciences Commons^™

In Vitro Comparison Of 360° Unirotational Disposable Prophylaxis Angles Versus 90° Reciprocating Disposable Prophylaxis Angles On Spatter During Rubber Cup Polishing, Kelly Marie Schulz

Dental Hygiene Theses & Dissertations

The purpose of this in vitro study was to compare the traditional 360° unirotational disposable prophylaxis angle (DPA) to a 90° reciprocating DPA in terms of spatter production. The 2x3x3 factorial design involved: 2 types of DP As x 3 types of prophylaxis pastes (fine, medium and coarse) x 3 dental handpiece revolutions per minute (rpm) settings (1500, 2000, and 3000). The eStylus'™ operated the DP As under controlled speeds. Using a mounted dental manikin, 90° reciprocating DP As and 360° unirotational DP As were evaluated for spatter production with the use of prophylaxis pastes of various grits in 270 …

An Approach To Identifying The Biomechanical Differences Between Intercostal Cartilage In Subjects With Pectus Excavatum And Normals In Vivo: Reconstruction And Ct Registration, Zhenzhen Yan

Electrical & Computer Engineering Theses & Dissertations

Pectus excavatum (PE) is a congenital chest wall deformity affecting the ribs and sternum and exhibiting a concave appearance in the anterior chest wall. In this thesis, we describe a study to investigate in vivo differences in the pectus excavatum rib cage and outline steps using normals and pectus patients data in developing models and methods to be used in carrying out the study. We propose methods to develop reconstructed models in order to enable proper registration between data collection points (DCPs) on the 3D CT rib cage model and CT skin surface model and registration between CT surrogate models …

College Students Concern Toward Public Intoxication, Ashley N. Mason

Sociology & Criminal Justice Theses & Dissertations

A survey of college students was administered in order to better understand why students choose to either walk after consuming alcoholic beverages or drive after consuming alcoholic beverages. Students were asked to answer demographic questions along with opinion questions as well. The main variables used in this study were perceived severity of offense, perceived certainty of offense (i.e. level of concern about getting stopped), moral condemnation and punishment avoidance.

Univariate, bivariate and multivariate analyses were examined to see what characteristics have an impact on students behavior regarding public intoxication. Although significant with one or both dependent variables, perceived severity, perceived …

An Assessment Of An Education Intervention On Youth Sports Coaches Knowledge Of Concussions, Heidi Elizabeth Brigham

Human Movement Studies & Special Education Theses & Dissertations

Research has shown that sport related concussions are occurring at high rates across the United States. Research has also shown that there are many misconceptions among youth sports coaches regarding concussions. Therefore the purpose of this study was to determine the effects of an educational intervention on the knowledge of concussion recognition, management and prevention for youth sports coaches. A secondary purpose was to compare various relationships between demographic characteristics and the concussion knowledge assessment scores. A twenty-one question multiple choice assessment and 16 option symptom recognition checklist was utilized to assess concussion knowledge prior to and following an educational …

Developing A Software For Pharmaceutical Promotional Meeting Planning, Michele S. Brouse

UNLV Theses, Dissertations, Professional Papers, and Capstones

“How wrong I was!” This admission from John H. Young (Young, 2006, p. 340) relates to his first exposure to pharmaceutical marketing more than 20 years ago. Young states he had been “sent to represent the medical group at a planning meeting of the launch of a new non-steroidal.” He felt competent he could hold his own at the meeting. At the planning meeting, however, as competition, inventories, market segments, inventories, formulation issues, opinion leader development, and public relations campaigns highlighted discussions, Young learned he would out of his depth. He needed to, Young determined, learn about marketing and production …

Application Of The Asset Mapping Model To Church Based Hiv/Aids Prevention And Control In Aba, Abia State, Nigeria, Godwin Nwadibia Aja

Loma Linda University Electronic Theses, Dissertations & Projects

This study examined whether HIV/AIDS activities were more frequent among churches with needs and assets for HIV/AIDS prevention and control in Aba, Nigeria and whether this connection was mediated by collective efficacy. A cross-sectional design was used to obtain data in two phases. First, a three-step forum focus group discussion (FFGD) method was used to obtain data from 32 representatives of five denominations. Second, a quantitative survey questionnaire was constructed based on the result of the FFGD and the collective efficacy model. This questionnaire was administered to 830 members aged 18 years and above from 83 churches that had operated …

A Delphi Study Assessing Long-Term Access To Electronic Medical Records (Emr), Byron D. Nicholson

Theses and Dissertations

This research effort addressed the issue of long-term access to electronic medical records as technological generations become obsolete, thereby preventing the access to patient health information. Using the Delphi methodology, experts with experience in electronic medical records and applicable systems provided insight based on their years of hands-on experience managing and/or using records and these systems. The end result of this research was a collection of ideas that medical institutions and medical informaticians must consider to ensure that patients and hospitals do not lose long-term access to electronic medical records as electronic medical records and technology continually evolves. Results of …

Nucleoplasmic And Cytoplasmic Degradation Of Telomerase: Implications Toward Telomerase-Based Cancer Therapy, Binh Nguyen

Theses and Dissertations

Telomerase is a ribonucleoprotein that is reactivated in cancer cells to allow for continuous cellular division and indefinite growth. With telomerase being expressed in more than 85% of all cancer, it is imperative that we understand how to selectively inactivate and degrade this unique DNA polymerase. In doing so, we can specifically target tumor cells to erode their telomeres so that they will undergo apoptosis or senescence. Through this research, we have learned that telomerase can be degraded in the nucleoplasm by Hsp90 chaperone inhibition and in the cytoplasm by the dominant negative mutant, D712A V713I. These findings should guide …

Three Models Of Anthrax Toxin Effects On The Map-Kinase Pathway And Macrophage Survival, Daniel J. Schneider

Theses and Dissertations

Lethal factor (LF), a component of anthrax toxin, is the primary virulence factor that allows Bacillus anthracis to evade the immune response by blocking the activation of mitogen-activated protein kinase (MAPK) enzymes. This research modifies three published MAPK models to reflect this signal inhibition and to estimate a first-order reaction rate by fitting the models to published viability data for two macrophage cell lines cultured with the LF-producing Bacillus anthracis-Vollum1B strain. One model appears to be ill-suited for this purpose because not all relevant MAPK components could be integrated into the inhibition equations. Despite different underlying parameters and values, the …

Micro-Etched Platforms For Thermal Inactivation Of Bacillus Anthracis And Bacillus Thuringiensis Spores, Leslie S. Hawkins

Theses and Dissertations

This research developed and applied microlithography techniques to etch microscope slide platforms in order to measure thermal inactivation of Bacillus thuringiensis and Bacillus anthracis spores, two closely related Bacillus species. B.t. is widely used as a surrogate for B.a. in response studies and in some field studies. This work addressed the previously identified problem of measuring both spore growth and spore thermal kill threshold using the traditional method of spreading a diluted spore solution on a plate. The micro-etched platforms forced spore separation thereby preventing neighbor growth from obscuring germination and initial vegetative growth measurements using a microscope. The technique …

Struggling With Disconnection: The Lived Experience Of Being Homeless And In Need Of Healthcare, Nonceba Mbangata

Theses and Graduate Projects

The intent of this field project was to study the disconnection that is experienced by homeless persons within the healthcare system. Homelessness is a growing concern that affects all age groups throughout the United States. It is not a secret that the increase in homelessness is stressing the health care system and limiting choices of becoming a healthy individual. The state of the health care system today and the nomadic habits of homeless persons make it impossible for those struggling with homelessness to stay connected to health care services. This project will illuminate the lived experiences of homeless persons as …

Accuracy Of Automated Analysis Of Language Samples From Persons With Deafness Or Hearing Impairment, Anne M. Hasting

Theses and Dissertations

Developmental Sentence Scoring (DSS) and the Language Assessment, Remediation, and Screening Procedure (LARSP) are among the more common analyses for syntax and morphology, and automated versions of these analyses have been shown to be effective. This study measured the accuracy of automated DSS and LARSP on the written English output of six prelingually deaf young adults, ranging in age from 18 to 32 years. The samples were analyzed using the DSS and LARSP programs on Computerized Profiling; manual analysis was then performed on the samples. Point-by-point accuracy for DSS and for each level of LARSP was reported. Characteristics of the …

The Effects Of Deep Brain Stimulation On The Speech Of Patients With Parkinson's Disease, Erin Suzanne Bjarnason

Theses and Dissertations

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has received more attention in recent years as a treatment option for regulating the symptoms of Parkinson's disease. Previous studies of DBS documented consistent improvements in motor function but more variability in speech outcomes. In the present study, six participants diagnosed with idiopathic Parkinson's disease who reported worsened speech with stimulation were recorded performing speech acoustic tasks with the stimulators on, and again with the stimulators off. Improvements were noted for most participants in measurements of formant slopes, long term average spectrum (LTAS) of a sustained vowel, and spirantization with stimulation …

The Effect Of Regional Dialect On The Validity And Reliability Of Word Recognition Scores, Jamie Ann Garlick

Theses and Dissertations

The purpose of this study was to examine the effect of talker and listener dialect on the validity and reliability of word recognition scores from two sets of Mandarin speech audiometry materials. Four lists of bisyllabic words in Mainland Mandarin and Taiwan Mandarin dialects were administered to 16 participants of each dialect with normal hearing across two test sessions. The performance on materials presented in the native dialect was compared to performance on non-native dialect assessment to determine validity and reliability of test materials. Statistical analysis indicated significant differences between word recognition scores across test sessions, talker and listener dialect, …

Event Related Potentials Of Syntactic Language Processing In Two Children With Specific Language Impairment: A Case Study, Melissa Ann Willes

Theses and Dissertations

This study examined the electrophysiological activity of two children with Specific Language Impairment (SLI) and two aged-matched peers while listening to syntactically correct sentences versus syntactically incorrect sentences. The study specifically analyzed the N400 and P600 components. The N400 component is a negative wave occurring approximately 400 ms post-stimulus and is elicited by semantically incorrect stimuli. The P600 component is a positivity that occurs approximately 600 ms post-stimulus and reflects processing of syntactically incorrect stimuli. The participants in the study included a 7-year-old child and a 9-year-old child with SLI and two age-matched peers with typically developing language. Each participant …

The Effect Of Non-Native Dialect On Speech Recognition Threshold For Native Mandarin Speakers, Nathan Edward Richardson

Theses and Dissertations

Speech recognition thresholds are used for several clinical purposes, so it is important that they be accurate reflections of hearing ability. Variations in the acoustic signal may artificially decrease threshold scores, and such variations can result from being tested in a second dialect. Thirty-two native Mandarin-speaking subjects (sixteen from mainland China and sixteen from Taiwan) participated in speech recognition threshold testing in both dialects to see whether using non-native dialect test materials resulted in a significantly lower score. In addition, tests were scored by two interpreters, one from each dialect, to see whether the scorer's dialect resulted in a significantly …

In Vitro Toxicity Of Aluminum Nanoparticles In Human Keratinocytes, Stephanie Mccormack-Brown

Theses and Dissertations

Nanotechnology promises to be the defining technology of the 21st century. At an annual investment of $1B, it provides significant contributions to manufacturing, medicine, energy conservation, and the environment. Nanoparticles are structures with at least one dimension in the 1 to 100 nanometer (nm) range. DoD and US Air Force interest in aluminum nanoparticles (AL NPs) stems from its ability to enhance combustion jet fuel, thus increasing fuel efficiency. The addition of AL NPs to JP-8 may pose a unique dermal hazard to aircraft maintenance workers. There is no published data on AL NP toxicity effects on human skin. This …

The Development Of Intentionality, Vocabulary, And Grammar In A Child With Autism, Heidi Huckabee

Honors Capstones

No abstract provided.

Precision Of Temporary Anchorage Device Placement With 2d Vs. 3d Diagnostic Tools And Surgical Guides, Howard Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Current methods of temporary anchorage device (TAD) planning and placement are performed by radiographic analysis in a two-dimensional plane that lends itself to inaccuracy secondary to variations in the angle from which the radiograph is taken, as well as the magnification of the radiographic image, resulting in an increased likelihood of placement errors. The purpose of this study was to compare a three-dimensional (3D) TAD planning and placement technique to a traditional two-dimensional (2D) technique. In the 2D group, periapical radiographs and pre-fabricated wire guides were used for planning and placement of TADs on five plastic models. For the 3D …

Radiation-Induced Glutamate Transport Alterations In Neuron-Astrocyte Coupling, Martha Celia Sanchez

Loma Linda University Electronic Theses, Dissertations & Projects

Exposure of the central nervous system (CNS) to ionizing radiation is known to result in behavioral, cognitive, and motor deficits - effects similar to those seen in many neurodegenerative disorders. Neurons and astrocytes, two principal cell types in the brain, coexist as an interdependent metabolic unit via the neurotransmitter glutamate. Disruption of this metabolic coupling would have widespread effects within the CNS, therefore it is hypothesized that ionizing radiation impairs glutamate transport and metabolism, and increases oxidative stress, ultimately impairing neuron-astrocyte coupling. We propose to investigate the mechanism and determine the impetus for radiation-induced neurotoxicity by measuring the temporal sequence …

Influence Of Mandibular Fixed Retainers On Diagnostic Quality Of Cranial Mri, Norman E. Carter

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to evaluate the diagnostic quality of MR images taken on subjects with different types of orthodontic lingual retainers in place. The study provides guidelines and recommendations for use of lingual retainer materials in those patients who are or may potentially undergo routine magnetic resonance imaging. Ten subjects had impressions taken and models made for retainer tray fabrication. Removable trays with each lingual retainer material incorporated in them were fabricated from the models. Subjects underwent scans with each of the five test trays in place. T1 sagittal (T1), T2 axial (T2), gradient echo (GRE), and …

Memory For Emotional Images : Recognition And Temporal Contexts, George E. Devore

Loma Linda University Electronic Theses, Dissertations & Projects

Negative emotional stimuli are usually better remembered than neutral emotional stimuli. Previous examination of binding theory found no differences in recall for homogeneous lists of taboo and neutral words. The current study expands on binding theory using negative and neutral visual stimuli in homogeneous lists. A rapid serial visual presentation paradigm and recognition and temporal memory item-discrimination tasks were used. Binding theory predicts no differences between negative and neutral images for recognition and temporal memory. Results were consistent with the assumptions of binding theory and no significant differences were found. This result suggests that binding theory generalizes for visual stimuli …

Infant Feeding Decisions Among Pregnant Black Wic Participants And The Role Of Peer Support, Astrid D. Mickens

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to identify the important factors that impact infant feeding decisions among Black women, and to determine whether peer support influences the relationship among theoretical constructs of the social learning theory. A convenience sample of 110 Black pregnant women, ages 18-45, attending Women, Infant and Children (WIC) clinics throughout Riverside and San Bernardino Counties were recruited to participate in the study through the Nutrition Services Department. Eligible participants included pregnant Black WIC clients in any stage of pregnancy.

The survey questions contained information about perceived support, cognitive knowledge, abilities and beliefs regarding breastfeeding. The goal …

Ultra-Fine Particle Formation Using Principle Of Rapid Expansion Of Supercritical Solutions`, Miraj Minesh Sheth

Theses

There are indications in the chemical and pharmaceutical industries that the reduction in size of a crystalline particle can lead to better performance of the drug compound, particularly for water insoluble drugs, in the final dosage form. Many particle formation techniques have been investigated in recent years by researchers to obtain desired particulate sizes and size distributions. Supercritical fluid technologies have been successfully investigated for particle formation due to its unique gas/liquid properties in the supereritical state. In this report, results of particle formation using the principles of Rapid Expansion of Supercritical Solutions (RESS) have been documented.

In the RESS …

Long Driving Hours And Health Of Truck Drivers, Stephen J. Benstowe

Theses

In recent time, the health of truck drivers has become a concern for regulatory agencies and safety professionals all over the world. Fatal and non-fatal injury rates for truck drivers are among the highest of all occupations. Truck driving is an important and tedious job. Driving for long hours, drivers are confined to a small space, sit with static lower and upper extremities posture, mentally focus and absorb vibrations.

This thesis provides an in-depth review of the literature related to the problems of long distance truck drivers and commercial motor vehicle operators. The Literature suggests that continuous exposure of truck …

A Comparison Of Perinatal Care Providers' Use Of The National Institute Of Child Health And Human Development Standardized Terminology In Documentation Of Intrapartal Fetal Heart Rate Patterns, Faye M. Sigman

Dissertations

The purpose of this study was to determine if perinatal team members; nurses (RN) and primary care providers (PCP), were using the NICHD standardized terminology to document Fetal Heart Rate patterns during labor. Agreement in documentation of FHR and agreement in concept between the RN and PCP was also studied. A descriptive, comparative research design was used. Cohen?s Kappa statistics measured agreement in documentation of FHR patterns and Chi square measured agreement in concept, p< 0.05 for each. A retrospective medical records chart review was performed on 400 charts, meeting inclusion criteria, from three community hospitals. There were three data collection points and four criteria reviewed. This study found the use of NICHD terminology to document FHR alarmingly low (RN=51%; PCP=13%). It was used most often for decelerations (81%) RN, (22%) PCP, and least often for variability (19%) RN, (3%) PCP. Incomplete documentation was extremely high for the PCP (69%) and 81 charts (20%) had no FHR documentation. Agreement in documentation varied between the RN and PCP. They agreed most often on accelerations (81.4%) and least often on baseline rate (41.5%). When looking at all there points in time the RN and PCP agreed in documentation 59% but agreed in concept 78%. There were four areas where the RN and PCP agreed in their use of NICHD terminology: Accelerations on admission n=151, Kappa=0.091, p=0.007; variability during labor n=68, Kappa=0.27, p=0.015; variability prior to delivery n=33 Kappa=0.33, p=0.010, and decelerations during labor n=103, Kappa=0.16, p=0.018. Data from this study supports expanding this research, to identifying barriers to documentation. It also appears that education in use of NICHD terminology is needed.

Knowledge And Utilization Of The Perioperative Nursing Data Set By Perioperative Staff Nurses In Southeastern Michigan, Jill Ortmann

Master's Theses and Doctoral Dissertations

The purpose of this descriptive/correlational study was to describe what perioperative nurses practicing in southeastern Michigan know about the Perioperative Nursing Data Set (PNDS), how they are utilizing the PNDS, and their opinion of the PNDS, and also to examine the relationship between these variables and demographic data. Four research questions were addressed by the use of a questionnaire.

The results of this study were drawn from the return of 151 questionnaires out of a possible 319 questionnaires submitted to practicing perioperative registered nurses (RNs) in southeastern Michigan (47 percent return rate). These results showed that overall, perioperative RNs did …

Role Of Transient Receptor Potential Canonical-6 (Trpc6) Channel In Metastasis Of Glioblastoma Multiforme, Rajarajeshwari Venkataraman

Electronic Theses and Dissertations

Glioblastoma multiforme (GBM) is one of the extremely fatal brain tumors. The main reason that makes it so lethal is its capability to invade and spread to other parts of CNS producing secondary tumors. Among other factors hypoxia, reduced oxygen availability, is linked to higher metastatic potential of cancers. Hypoxia causes numerous changes in genome and proteome of the cell. These changes help a normal cell to adapt to nutritional deficiency, but the same changes can increase the malignancy and metastasis in tumor cells. Extensive research by a number of curious scientists reveal that various pathways involving numerous proteins cross-talk …

Evaluation Of The Efficacy Of Chloroplast-Derived Antigensagainst Malaria, Melissa Schreiber

Electronic Theses and Dissertations

Malaria is the most prevalent vector-borne parasitic disease worldwide and a major cause of death from infections. There is a great need to develop a low cost vaccine for malaria to control transmission of infection and impact of disease, due to the emergence of anti-malarial resistance. Two leading blood stage malarial vaccine candidates are the apical membrane antigen-1 (AMA-1) and the merozoite surface protein-1 (MSP-1). The aim of this project is to express malarial antigens in tobacco plants via plastid transformation and deliver them by subcutaneous or oral gavage of minimally processed transplastomic tissue to evaluate their efficacy to elicit …

Understanding The Nature And Impact Of Alcoholism : Implications For Ministry In Kenya, Margaret Kemunto Obaga

Master of Theology Theses

No abstract provided.