Medicine and Health Sciences Commons^™

A Guide To Falls In A Skilled Nursing Facility, Sarah Ghione

Doctoral Projects

Approximately one in four older adults experiences a fall each year in the United States (Centers for Disease Control and Prevention [CDC], 2024b; Kakara et al., 2023). Among those residing in nursing homes for either short-term rehabilitation or long-term care, the risk of falls is doubled (Acker & Janssen, 2017; Shao et al., 2023). The purpose of this doctoral capstone project was to develop an educational resource aimed at enhancing staff education and fall prevention efforts within a single nursing home, supporting the facility’s goal of reducing fall rates. Methods included a needs assessment, observational experiences, resource development, and the …

Effects Of Liraglutide On The Gut Bacterial Community, Jami Anne Bull

Graduate Theses/Dissertations

Overweight and obesity are major health concerns associated with metabolic disorders and gut dysbiosis. Treatment options such as GLP-1 receptor agonists, like liraglutide, promote weight loss and improve insulin sensitivity; however, their impact on the gut bacterial community remains unclear. This study investigated the effects of liraglutide on the gut bacterial community of diet-induced obese (DIO) mice using Illumina DNA sequencing of the bacterial 16S rRNA gene. My study used twelve-week-old male C57BL/6J DIO mice. They were placed on a high-fat diet and treated with liraglutide (0.2 mg/kg) via daily subcutaneous injection for 14 Days. High-fat and low-fat diets control …

Preventing Chemical And Biological Attacks: Enhanced Threats Requiring Enhanced Solutions, Alex Elliot Ottoni-Belval

Graduate Theses/Dissertations

Chemical weapons (CW) and biological weapons (BW) are becoming more dangerous for experts to employ and more accessible to amateurs. Despite CW and BW attacks throughout history that killed and maimed millions of people, the international community has failed to establish meaningful consequences to prevent them. Agreements such as the Chemical Weapons Convention and the Biological Weapons Convention vow to eliminate and reduce the effects of CWs and BWs but lack respected response precedents and capabilities. The limited and inconsistent enforcement has inadvertently allowed CWs and BWs to become plausible weapons, especially to gain asymmetric advantages, while modern developments exasperate …

Alpha-Synuclein Interaction With Gedunin, Tony Matundura Nyabayo

Graduate Theses/Dissertations

Parkinson’s disease (PD) and other Proteinopathies develop when α-synuclein misfolds and aggregates into toxic amyloids. While existing treatments for PD are primarily focused on managing its symptoms, a viable solution for slowing down the progress of Parkinson’s disease involves targeting the toxic α-synuclein amyloids. Gedunin, a natural inhibitor of heat shock protein 90, has been extensively used to treat malaria. Also, recent research investigations have shed light on its potential beyond malaria therapy, indicating that Gedunin may offer a possible solution for treating a variety of neurodegenerative diseases. Using plate-based assays, we examined how Gedunin influences α-synuclein fibrillation and its …

An Investigation Of The Physiological And Behavioral Correlates Of Mental Imagery, Matthew Daniel Carroll

Graduate Theses/Dissertations

Many conventional theories hold mental imagery to be fundamental to self-regulation. Recently, a current of research into mental imagery has developed, with the terms anaurelia and aphantasia being coined for the inability to experience, respectively, auditory and visual thought content, yet little is known about the impact that such individual differences have on persons’ lives. The present experiment was performed in order to test the hypotheses that self-regulation and mental imagery positively correlate and that mental imagery mediates the correlation of resting heart-rate variability and self-regulation. Self-regulation was measured via a self-report questionnaire (the Short Self-Regulation Questionnaire), as was mental …

Characterizing A Rad23 Dependent Ultraviolet Radiation Resistance In Tetrahymena Thermophila, Emma June Liimatta

Graduate Theses/Dissertations

In 2020, 10 million deaths were attributed to cancer, with multidrug resistance being responsible for over 90% of deaths in cancer patients receiving treatment. This study utilized the model organism Tetrahymena thermophila to study how cells become resistant to Ultraviolet Radiation (UV) radiation, a process similar to multidrug resistance, specifically focusing on the nucleotide excision repair and ubiquitin shuttle protein Rad23. The National Cancer Institute documented 30-60% of cancers tested had a mutation in RAD23. Knockdown of RAD23 in Tetrahymena thermophila demonstrated a UV resistance phenotype with decreased nucleotide excision repair and differential expression of proteins active within caspase-independent …

A Retrieval Augmented Approach To Improving Accuracy Of Biomedical Term Normalization By Large Language Models, Thanh Son Do

Graduate Theses/Dissertations

Ontology normalization is crucial in biomedical text processing, as it enables the mapping of medical expressions to standardized ontology terms and their corresponding identifiers. This thesis explores the feasibility of using large language models (LLMs) for ontology normalization, with a specific focus on the Human Phenotype Ontology and Gene Ontology. Prior research studies indicated that LLMs employing zero-shot learning tend to exhibit low accuracy and are prone to frequent hallucinations. We propose a retrieval augmented generation (RAG) approach to address these limitations and enhance normalization accuracy. We generated synthetic test sets of ontology-derived synonyms to evaluate normalization performance and developed …

Effects Of Active Learning In An Undergraduate Physiology Class Using Hands-On And Simulation Labs, Ainsley C. Frayer

Graduate Theses/Dissertations

Increasing student engagement has shown positive effects on students and can be achieved by incorporating active learning strategies in the lab. Currently, the undergraduate human physiology lab at Missouri State University utilizes simulations to practice physiological concepts. The proposed project aims to evaluate if incorporating hands-on labs would improve student learning and/or their engagement. The hypothesis is engagement will be increased in hands-on labs, but grades will not differ significantly, based on previous literature. Three simulations were replaced with hands-on lab software to evaluate engagement and learning. Student engagement was assessed using a voluntary, anonymous survey. Exam average scores were …

The Role Of Host Factor Sptbn1 In Hiv-1 Capsid Uncoating In Human Microglial Cells, Callie Marie Fry

Graduate Theses/Dissertations

HIV-1 is the virus that causes acquired immunodeficiency syndrome (AIDS), and currently, there is no cure once an individual is infected. The development of new drugs targeting HIV-1 replication steps is essential for keeping viral loads low or undetectable to prevent further transmission. An attractive replication step for new drug targets is viral capsid uncoating, where the virus loses the protein structure encapsulating the genome. The exact mechanism of capsid uncoating is unknown; however, several host-factors may be involved including protein SPTBN1. Recent studies have shown a significant decrease in viral infectivity when SPTBN1 is knocked down, yet its role …

Menstrual Cycle Phase Effects On Exercise Thermoregulation And Performance In The Heat, Kailei J. Eustis

All Master's Theses

Hormone fluctuations across the menstrual cycle (MC) may influence physiological responses. This study examined whether thermoregulatory measures differ across MC phases, and if these changes impact running performance in the heat. Ten eumenorrheic adults completed two treadmill runs in simulated conditions (wet bulb globe temperature 31.7 ± 1.4°C) during early follicular (EF) and midluteal (ML) phases. First 45min was a constant self-selected light pace followed by a 15min performance test for distance. Core temperature (Tc), mean skin temperature (Ts), heart rate (HR), perceived exertion (RPE), thermal perception (THERM), and comfort perception (COMF) were assessed every 5min. Sweat perception (SP), sweat …

Multifaceted Life Skills Training And Job-Orientation Supports For Individuals In Vocational Rehabilitation Programming, Laura R. Mccray

Graduate Theses, Dissertations, and Problem Reports (ETD)

There is growing support for those with an intellectual or developmental disability (IDD) in the transition process and within the workplace, however, there are areas that need to be addressed to facilitate further inclusion and success in this domain. There are structured institutions within the community that extend support for those transitioning out of high school, focusing on aligning with life training and professional skills while promoting societal integration by delivering services directly and avoiding isolation within traditional service environments (Accardo & Whitman, 2011). Growing research highlights the necessity of providing resources that support individuals with intellectual and developmental disabilities …

The Quick Dash Reformed: Increasing The Holisticity And Occupational Nature Of Upper Extremity Therapeutic Evaluation, Lauren E. Garcia

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: The QuickDASH is one of the most common upper extremity (UE) focused patient-reported outcome measures (PROMs) utilized within current practice. Despite its high utilization rate, there are still many concerns surrounding the QuickDASH, including its applicability to certain populations, difficulty with cross-cultural adaptation, and limited psychosocial evaluation. Purpose: The purpose of this study was to develop and implement a reformed version of the QuickDASH, the OT-DASH, that included modernized and occupation-focused language to achieve increased client applicability and yield more accurate comparisons between client perceptions of dysfunction and their true clinical presentations. Theoretical framework: The Person-Environment-Occupation-Performance model was utilized …

Exploring Associations Between Personality Type & Fruit And Vegetable Consumption, Allison Woldt, Tanya Mora, Liang Ji, Julie Jones, Jeje Noval

Loma Linda University Research Reports

Fruit and vegetable intake is vital for preserving health and avoiding chronic illnesses, yet only approximately 1 in 10 adults in the U. S. adhere to daily consumption guidelines, based on CDC data. While earlier research has examined external factors such as socioeconomic status, cultural influences, and religion as significant determinants of dietary habits, new studies highlight a crucial internal element: personality. Our research delves into this emerging area by examining the connection between personality types, derived from the Myers-Briggs Type Indicator (MBTI), and fruit and vegetable (FV) consumption. In contrast to the extensively studied Big Five personality framework, the …

A Comparison Of Acute Blood Glucose Response To 2% Lactaid Milk Vs. 2% Regular Milk In A Non-Diabetic Population, Alison Kim, Brianna Vanyo, Liang Ji, Lesley Ann Foster-Nicholas, Cindy Kosch

Loma Linda University Research Reports

Rising rates of diabetes and prediabetes have increased interest in how common foods affect blood glucose. This randomized, triple-blinded controlled trial compared the acute glycemic response to 2% regular milk versus 2% Lactaid milk in non-diabetic adults. Fifty participants consumed 500 mL of either milk type after fasting, and blood glucose was measured at baseline, then at 15, 30, 45, and 60 minutes post-consumption. Linear mixed model analysis showed no significant interaction by age or gender. However, borderline significant differences were observed at 15 minutes (p = 0.0524) and 30 minutes (p = 0.0740), with slightly faster and higher glucose …

Social Determinants Of Mental Health Outcomes, Ariana Fein

Honors Theses

Mental health disorders, particularly anxiety and depression, are a growing global concern with profound consequences on individuals' well-being and societal functioning. The burden of these disorders is not only psychological but also economic, affecting quality of life. Mental health outcomes are heavily influenced by a range of social determinants, such as financial status, education, and access to healthcare. While extensive research has focused on WEIRD (Western, Educated, Industrialized, Rich, Democratic) countries, there remains a significant gap in understanding how these determinants affect mental health in low-resource settings or non-WEIRD countries. This study aimed to address this gap by exploring the …

Quality Improvement Project: Improving Nursing Faculty Perception Of Student Advising, Gayla Micek

Doctor of Nursing Practice Projects

This DNP Project aimed to influence a process change within the nursing faculty advising process for pre-licensure nursing students at the project site. The clinical site mandates faculty to meet with their assigned advisees twice per academic semester for advising. However, no guidelines have been provided by the educational institution on items to cover during these advising meetings. A mixed method approach, pre- and post-survey design with quantitative and qualitative data collection was utilized for this project. The major findings from this DNP project support evidence from the literature review that include the need for a structured faculty advising process, …

Transcriptional Regulation Of Mouse Line-1 Subfamilies, Karabi Saha

Electronic Theses and Dissertations

No abstract provided.

Caspases Protect Against Hyperglycemia Induced Necroptosis-Like Cell Death In Brain Endothelial Cells, Aleena S. Mathew

Theses and Dissertations

Acute diabetes characterized by high spikes in blood glucose levels in association with severe hyperglycemia can lead to an increased risk of ischemic stroke in the brain. To better understand high blood glucose levels, hyperglycemia, in the brain we explored its effects on endothelial cells. Endothelial cells line the inner walls of blood vessels and are directly impacted in hyperglycemia. Brain endothelial cells are a major component of the blood brain barrier (BBB) which tightly regulates the brain’s microenvironment. The type of cell death such as apoptosis, caspase dependent, or necroptosis, caspase independent, can exacerbate diabetes associated complications. There is …

Social Rejection, Isolation, And Substance Use Disorders: A Neurobiological Defense Of Social Network Intervention In Single-Site Housing First, Victoria Eichel

Scripps Senior Theses

Abstract

Introduction: Rising rates of homelessness in the United States demand not only increased housing efforts but also comprehensive strategies addressing the underlying causes of chronic homelessness. Among the most prevalent factors is substance use disorder (SUD), which both contributes to and results from housing instability. Conventional abstinence-based treatment models often fail to address the root causes of substance use, particularly the chronic social isolation and rejection experienced by the unhoused. This thesis argues for the adoption of a neuroscience-informed model of recovery rooted in community reintegration and low-barrier housing with on-site support services.

The Neuroscience of Substance Use Disorders …

Combining Internal Family Systems Therapy And Dance Movement Therapy To Treat Survivors Of Sexual Assault, Tierney O'Keefe

Scripps Senior Theses

The mammalian nervous system is primed to connect with loved ones, flee from danger, and shut down when overwhelmed. The nervous system frequently enters a state of chronic dysregulation after a traumatic event, such as a sexual assault. In order to properly heal from such trauma, treatment must address both the body and the mind. Internal family systems therapy and dance movement therapy provide two frameworks to address nervous system dysregulation and restore balance to the system as a whole. This study combines both therapies into a hybrid therapy treatment as an attempt to address the somatic nature of stored …

Gain-Of-Function Tp53 Mutations Induce Non-Canonical Nf-Κb Transcriptional Targets To Promote Tumor Development, Kelsey A. Yutan

Scripps Senior Theses

Background: Gain-of-function TP53 mutations have previously been shown to induce chromosomal instability (CIN) in cancer cells, triggering the cGAS-STING innate immune response and subsequently activating the non-canonical NF-κB (NC-NF-κB) signaling pathway. This signaling cascade promotes cancer cell metastasis and an immunosuppressive tumor microenvironment (TME), significantly impacting tumor development and progression. However, the precise downstream mechanisms by which the mutp53-CIN-cGAS-STING-NC-NF-κB signaling pathway facilitates tumor development and progression remain poorly understood. Here, our objective was to identify direct downstream targets of mutp53-CIN-cGAS-STING-induced NC-NF-κB signaling that potentially impact the TME to promote the development and progression of oral squamous cell carcinoma.

Methods …

Parental Monitoring, Latine Emerging Adult Marijuana And Alcohol Initiation, And The Relationship It Has With Marianismo And Machismo, Paola F. Ojeda

Scripps Senior Theses

The study aimed to expand the research on Latine adolescent alcohol and marijuana initiation in regard to their parent’s monitoring habits. The study investigated if parental monitoring affects the initiation of alcohol and marijuana for their adolescents. It also investigated if traditional gender roles in Latine households such as marianismo and machismo moderated the relationship. This study examined parental monitoring through asking participants about their parents monitoring habits and parents control habits during their adolescence. It also investigated Latine young adults’ substance use initiation. This study was conducted through a Qualtrics survey administered through Prolific with multiple subsections that pertain …

Contact Pathway Factors As Potential Modifiers Of Bleeding Related To Factor Xi Deficiency, Ivy R. Han, Leah Rosenfeldt, Courtney Young, Bal Krishan Phd, Rachel Cantrell Phd, Cassie Sprague, Mousa Kharnaf, William Abplanalp, Joseph Palumbo Md

Williams Honors College, Honors Research Projects

Factor XI (FXI) deficiency, also known as Hemophilia C, is characterized by mild to moderate bleeding symptoms. However, the factors that modify bleeding severity in FXI deficiency are not fully understood. In this study, we investigated whether components of the contact activation pathway can act as modifiers of bleeding in the context of FXI deficiency. Using a tail vein transection (TVT) model in rats, we assessed bleeding in four experimental groups: wild-type Sprague-Dawley rats, Prekallikrein knockout (PKK^-/-) rats, rats treated with a FXI-inhibiting antibody, and PKK-/- rats treated with the FXI antibody.

Under anesthesia, each rat underwent a …

An In-Depth Review Of Euthanasia-Related Practices, Arguments For/Against Them, And Proposed Solutions For Their Most Glaring Legal/Ethical Problems, Macon Plecha

Williams Honors College, Honors Research Projects

This paper’s goal is to cover the topic of euthanasia-related practices at great length. Terminology, history, and current programs around the world are discussed first, with the last point covering a wide geographical range: Colombia, Japan, Israel, and Africa, to name a few outside of the Western world standard. Arguments for and against euthanasia-related practices are explored. Within these arguments, several pressing legal and ethical issues arise, and the most severe of these are expanded on through the offering of potential solutions: how to handle stand-alone psychiatric cases, how to improve advanced directives and poor reporting rates, and how to …

Exploring Psychological Implications Of The Contemporary Lung Transplant, Isaac C. Machar

Williams Honors College, Honors Research Projects

Since its inception in 1963 at the University of Mississippi Medical Center, more than 50,000 lung transplant procedures have been performed. During its 50-year anniversary, 2023 saw just over 3,000 lung transplants performed in the United Sates. However, as this procedure continues to increase in execution each year, it is critical that the psychological implications of this procedure are explored. In this paper, I hope to develop an understanding of the psychological background of contemporary lung transplantation. Reviewing the lung and double lung transplant, the goal is to apply biopsychology principles to the field. Background information about transplant science is …

Medication In Early Adulthood And Long-Term Outcomes In Individuals With Adhd, Emma Deep

Williams Honors College, Honors Research Projects

The main question asked about attention deficit hyperactivity disorder is: What are the long-term consequences for adults who stay on ADHD medication after childhood? Answering that question includes looking into the medical facts surrounding an ADHD diagnosis, examining the adults and children with ADHD, the subtypes of ADHD, diagnosing ADHD, including the symptoms, and types of medications, along with the side effects. ADHD is one of the most common disorders in children and adults. Understanding ADHD, its diagnosis, and treatment options is crucial for individuals and caregivers navigating this condition. This paper examines the long-term effects of ADHD medication from …

Effects Of Energy Drinks On Crayfish Physiology, Melyna Sweeney

Williams Honors College, Honors Research Projects

Energy drinks have become the drink of choice among many college students due to the rush of energy it provides via the megadose of caffeine (Vercammen et al. 2019). Because of their newfound popularity, there is much research to be done about the effects on human physiology. Energy drinks are known to increase endurance in muscles of rat subjects (Imagawa et al. 2009) and stimulate enhanced “alertness” (Smit & Rogers, 2002). The purpose of this research was to uncover the potential effects that energy drinks have on metabolic rate and/or stress responses in crayfish (Procambarus clarkii), with the …

Astrocyte Specific Enhancers In The Cortex And Striatum Of Mice, Mikaela Kottelich

Williams Honors College, Honors Research Projects

Among glial cells, astrocytes have a prevalent influence on supporting neuronal function and overall brain health. Specifically targeting this cell type for disease treatment is an existing issue. Other cell types tend to express the desired treatment, which is not always wanted and can lead to unintended, negative consequences. Astrocytes contribute largely to maintaining the blood brain barrier, which is disrupted in Parkinson’s disease. Certain genes are thought to be the reason for this disruption, so if they can be specifically targeted in astrocytes with a specific enhancer, the disruption of the disease could be reversed. In our experiment, we …

Impact Of Tetrahydrocannabinol (Thc) On Daphnia Magna Heart Rate, Ashley Cosgrave

Williams Honors College, Honors Research Projects

Marijuana (Cannabis) is currently federally illegal within the United States and classified as a Schedule I drug. This leaves a large research gap on the impacts of Tetrahydrocannabinol (THC) use. Daphnia magna are frequently used as a model organism for the human heart and toxicology screenings due to their myogenic heart, similarities in physiological pathways, and sensitivity to toxins. As such, in order to bridge the research gap and uncover potential use of Daphnia magna as a model organism for humans in regard to impact on heart rate, we hypothesized that if Daphnia magna possess CB1 receptors or an equivalent …

Examining The Adjustment, Acculturation, And Well-Being Of International Arab Students In The United States: Implications For Policy And Practice, Hassan A A Kh A A Arab

Wayne State University Dissertations

This paper explored Arab international students studying in the United States to see whether they face acculturation stress, adjustment, or well-being issues. I found that my sample (N=95) experienced moderately high well-being distress and acculturative stress. However, the sample showed resilience and positive adjustment in all aspects, psychological (M=34.7), social (M=38.5), and academic (M=37.4). Moreover, well-being score from a modified GHQ survey came with high SD, indicating some students were dealing with serious mental issues, while others were doing well (M=42.92, SD=5.52). The majority of my participants were males (74.7%), single (75.8%), and graduate students (50.5%). Chi-square analysis found a …