Medicine and Health Sciences Commons^™

The Mediating Effect Of Injury On The Relationship Between Running Mileage And Depressive Symptoms In Division 2 Cross Country Athletes, Jaxon Leduc

Cal Poly Humboldt theses and projects

Training for a cross-country season requires athletes to accumulate a high volume of training miles at different intensities. Over a period of months and years, consistent high training volumes have been shown to contribute to overuse injuries in cross country athletes. Injuries have been shown to negatively impact athlete’s mental health; this is especially true in student athletes. The purpose of this research is to explore the mediating effect of injuries on the relationship between training volume and mental health in collegiate cross-country runners. Participants in this study were 40 members of NCAA Division 2 Cross Country teams with eligibility …

A Comparative Analysis Of Perineuronal Nets In Trout And Zebrafish Models, Adnan Alyan

Cal Poly Humboldt theses and projects

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround certain types of neurons in the central nervous system. Research from the past few decades has cemented PNNs as an integral player in the closure and onset of critical periods, memory modulation, and neural plasticity. These effects are thought to occur when PNNs form around a neuron and structurally stabilize its synaptic connections. PNNs have been directly linked to behavioral changes, making them of interest to psychologists as well as neuroscientists. Several PNN components, such as Hapln1 and aggrecan such as have been found in zebrafish, a teleost fish (Kang …

Utilizing A Virtual Discharge Nurse To Help Decrease Patient Length Of Stay And Improve Earlier Discharge Times, Carol A. Romano

West Chester University Doctoral Projects

Abstract

This Doctor of Nursing Practice (DNP) project explores the impact of implementing a Virtual Discharge Nurse (VDN) on patient length of stay (LOS) and discharge timing at Paoli Hospital within the Main Line Health system. Hospital discharges are often complex and can negatively impact patient flow and outcomes. This study highlights the urgent need for innovative discharge practices in healthcare and supports the potential benefits of integrating technology into nursing roles to improve patient care and operational efficiency. The project's significance lies in addressing these challenges by utilizing VDN to enhance communication, education, and resource management during discharge. We …

Cultivating Civility, Courtney Ruck

West Chester University Doctoral Projects

Nurse leaders play a vital role in creating, sustaining, and ensuring a culture of civility along with a healthy work environment for both staff and patients. A challenge nurse leaders face today is the prevalence of bullying and incivility that continues to grow within the nursing profession and has detrimental effects on nursing staff, patient satisfaction, and healthcare organizations. Bullying and incivility can have disastrous effects on the mental, emotional, physical, and professional lives of those victimized by such behavior. When a culture of incivility is prevalent, patients suffer as secondary victims; patient safety and patient satisfaction are compromised. Organizations …

The Effect Of Fructose Metabolism On Hepatic De Novo Lipogenesis And Adipose Tissue Insulin Resistance, Taghreed Ibrahim Fadhul

Theses and Dissertations--Nutritional Sciences

There is a worldwide epidemic of obesity and metabolic dysfunction. The root cause of obesity is driven by a positive energy balance, which is a consequence of increased caloric intake and decreased energy expenditure. Energy intake is the more dominant force, as increasing energy expenditure is a time-consuming and labor-intensive process. The caloric surplus can be mainly accounted for by increased consumption of high-fat and high-sugar diets. While the risks associated with fat consumption are well-documented, the impact of sugar intake is less understood.

Fructose is a simple sugar widely consumed in modern diets. Its intake has been associated with …

Synthesis, Characterization, And Biological Activity Of Ni(Ii) And Co(Iii) Thiosemicarbazone Complexes As Potential Anticancer Agents, Jack Martin

Pitzer Senior Theses

The mechanics by which Reactive Oxygen Species work is an area of great interest given ROS’s wide range of biological applications. From cell signaling and mitochondrial regulation to pathogenesis and tumor cell death, varying concentrations of ROS in a system can lead to a whole host of positive and negative effects. In a similar vein, thiosemicarbazones are known to be equally useful for their myriad of antibacterial, antifungal, antiviral, and antitumoral effects. They have been at the core of the pharmaceutical world or the better part of the last century. The purpose of this work is to synthesize, characterize and …

Optimizing Decision-Making In A Cerebral Palsy Model Using Reinforcement Learning, Richard Ampah

Pitzer Senior Theses

This study presents an original interdisciplinary investigation into how reinforcement learning (RL) can model motor and cognitive defects and potentially improve motor and cognitive functions in individuals with cerebral palsy (CP), a non-progressive neurological disorder that impairs movement and adaptability. Integrating computational neuroscience and machine learning, the research applies policy gradient methods and Markov Decision Processes (MDPs) to simulate adaptive learning in agents with and without CP-related constraints.

The central aim is to compare the cumulative rewards of optimal policies, derived from value iteration, and human-like learning policies using the REINFORCE algorithm, both with and without the Bellman baseline. The …

The Anatomy Of A Reconstruction: From Fourier Space To Image Recovery In Computed Tomography, Charlotte P. Maurer

Honors Theses

This thesis develops the mathematical foundations of computed tomography (CT) reconstruction through the lens of harmonic analysis. Beginning with the Schwartz class, we introduce the Fourier transform and its role in expressing the Radon transform and its inversion via a fractional Laplacian. After constructing the Radon transform in general dimension R^d, we specialize to the cases d = 2 and d = 3, demonstrating explicit inversion formulas and the associated instability in lower dimensions. For its computational advantages, we study filtered back-projection using classical low-pass filters (Ram-Lak, Shepp–Logan, Cosine, Gaussian) and formulate a discrete reconstruction algorithm grounded in …

How Does Cocaine Exposure Affect Early Gene Expression Changes In The Prefrontal Cortex (Pfc) And Striatum?, Saathvika Diviti

Honors Theses

Cocaine use disorder (CUD) remains a significant public health concern, yet the molecular mechanisms underlying individual susceptibility are poorly understood. This study investigates early transcriptional responses to acute cocaine exposure in two key brain regions implicated in addiction, the prefrontal cortex (PFC) and striatum, using genetically diverse Diversity Outbred (DO) mice. Paired tissue samples were collected following a standardized sensitization protocol and analyzed via bulk RNA sequencing. Differential expression analysis revealed 37 significantly differentially expressed genes in the striatum. These genes overlapped with gene sets associated with substance use, neurodevelopmental disorders, and immune signaling, implicating shared pathways in central nervous …

Perinatal Policy Disparities And Their Impact On Maternal, Paternal, And Child Health, D'Ashanae Y. Pippens

Theses and Dissertations

This systematic review synthesized evidence on perinatal policy framework to evaluate their public health significance and impact on family outcomes. Following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) methodology, peer-reviewed literature, policy documents, and corporate data from 2015-2025 were reviewed across national, state, and global levels. The analysis revealed seven thematic domains, (1) policy design and duration, (2) wage replacement, (3) insurance continuity, (4) workplace breastfeeding accommodations, (5) parental leave, (6) equity in access, and (7) policy enforcement. Evidence shows that integrated and inclusive policies particularly those in Sweden, Germany, and progressive U.S. states (NY and CA), yield substantial …

Implementing Holograms To Perform Cognitive Health History Screenings, Franchesca I. Gonzalez

Honors Undergraduate Theses

Marginalized populations, defined as a group of individuals who experience systematic disadvantages due to various social identity factors (Oxford Review, n.d.), experience uneven barriers to cognitive and mental health assessments, including socioeconomic, linguistic, and educational inequities, that contribute to misdiagnosis (Petersen et al., 2018, Saeed & Masters, 2021). This study investigates the feasibility of hologram-based patient simulations as an educational intervention for undergraduate nursing and graduate Nurse Practitioner students. Culturally representative, three-dimensional holographic patients were created to replicate complex geriatric encounters and facilitate cognitive health screenings. Established assessment tools, including the Mini-Mental Status Examination, Patient Health Questionnaire 2 and Patient …

A Systematic Literature Review On The Benefits Of Biofeedback Therapy As A Treatment For Diabetes Mellitus Induced Chronic Peripheral Neuropathy, Amy Krueger

Honors Undergraduate Theses

The objective of this systematic literature review is to examine the research on biofeedback therapy and evaluate its effectiveness in treating chronic diabetic peripheral neuropathy. This comprehensive review was conducted using the PRISMA 2020 method of analysis. All studies included at least 10 patients with T1D or T2D and current or past foot ulcers and/or DPN. Each study was also available in their entirety. Studies with fewer than 10 participants, those which examined neuropathy unrelated to diabetes, or those with healthy test populations were excluded. Studies that were only partially available were also not used. The databases used were PubMed, …

Ultra-Plex Immunofluorescence Stainings To Classify Precancerous Lesions For The Stratification Of Their Risk For Progression Toward Esophageal Squamous Cell Carcinoma, Arthi Jaishankar

Honors Undergraduate Theses

Esophageal squamous cell carcinoma (ESCC) is the most common and fatal type of esophageal cancer since it is usually only diagnosed at a later stage. Similar to other cancers, ESCC arises through precursor lesions which are known as dysplasias and occurs when cells have uncontrolled growth and changes to both the tissue structure and gene expression. Clinical intervention at the precancerous stage would greatly improve survival rates, however predicting which lesions will actually become malignant continues to be a challenge. The current traditional method for ESCC diagnosis is hematoxylin and eosin (H&E) histopathology, but it is not sufficient for predicting …

Effect Of Sapropterin Dihydrochloride On Neuropsychiatric Functions For Individuals With Phenylketonuria: A Systematic Review, Ricky Lin

Honors Undergraduate Theses

Phenylketonuria (PKU) is a rare metabolic disorder that occurs in approximately 1 in 10,000 births worldwide. Individuals with PKU cannot properly metabolize phenylalanine (Phe) due to a deficiency in phenylalanine hydroxylase (PAH), leading to elevated Phe levels and associated cognitive and neuropsychiatric impairments. Although early dietary management has reduced the risk of severe intellectual disability, many individuals with PKU continue to experience deficits in attention, executive functions, and mood regulation. Sapropterin dihydrochloride, a synthetic form of the PAH cofactor tetrahydrobiopterin (BH4), offers a pharmacological alternative that enhances residual enzyme activity in responsive individuals. While its efficacy in lowering blood Phe …

Lifetime History Of Concussions In Relation To Blind Perceptual Distance Estimation Ability, Mackenzie K. Miller

Honors Undergraduate Theses

This study examined the relationship between visuospatial estimation and a lifetime history of concussions. Current literature on concussions investigates visuospatial working memory and estimation ability separately, but not conjointly. In order to examine this relationship, a novel neuropsychological task was designed to measure visuospatial estimation ability in working memory, named the Perceptual Estimation Test (PET). This novel task was designed with three variations that would increase in complexity as they progressed, and each variation would include three trials. Participants were scored on their accuracy performance during the PET. Participants aged 18-25 were recruited from students attending the University of Central …

Finding Love On The Spectrum: An Analysis Of Social And Romantic Relationships Of Autistic College Students, Kaylee Spinner

Masters Theses

Autism Spectrum Disorder (ASD) is characterized by difficulties in socialization, communication, and developing relationships with others. While many autistic individuals desire to start relationships with others, many do not have a very strong understanding of the use of nonverbal communication or how to develop these connections organically. As autistic individuals have become more open about wanting these resources to form social and romantic relationships, there has been more of a push in the literature to include social skills training for forming social relationships. However, the research on the desire for or development of romantic relationships for autistic individuals is still …

Mindfulness & Mental Health: Balanced Time Perspective As A Mediator, Eddie Trueblood

Masters Theses

Mindfulness is a practice of intentionally paying attention to the present moment in a nonjudgmental way. Being more mindful can decrease symptoms of anxiety, depression, and stress, among other mental and physical health improvements. (Donald et al., 2016; Hofmann et al., 2010; Kabat-Zinn et al.,1992). This study examined if balanced time perspective (BTP) is one of the mechanisms of action of mindfulness in its relationship with depression, anxiety, and stress. BTP refers to a person’s ability to flexibly adapt their time perspective (attention to the past, present, or future, and positive or negative attitudes toward each) to suit the current …

Small Town Voices And Stories: Rural Older Populations And Health Narratives, Wyatt K. Zumbahlen

Masters Theses

Stories play a vital role in our humanity; they help us understand the world around us. As we age, our experiences, along with those of the people around us, shape our perceptions of health and influence our healthcare choices. For older adults, narratives become an essential resource in making healthcare decisions. In rural communities like Coles County, Illinois, these stories are especially important for older adults who are navigating the limited care and services available in the area. This reliance on narratives impacts their willingness to seek care, highlighting the need to recognize the power of stories in empowering older …

Examining Multiple Stakeholder Perspectives On The Acceptability Of Pain-Mitigation As A Tool To Manage Needle Fear, Sarah C M Morton

Theses and Dissertations

Needle fear affects up to 63% of the global adult population and is associated with significant fear-based medical care avoidance (e.g., blood donation refusal, vaccine hesitancy, insulin injection adherence). Current behavioral treatments have low acceptance in this population, and often fail to address the experience of pain associated with needle procedures. Despite the existence of evidence-based pain-mitigation for needle procedures, these interventions are not commonly used in clinical settings. The current study used qualitative methods to examine patient and provider perceptions of: 1) current methods of needle fear management, and 2) the acceptability of pain-mitigation as an effective tool to …

Improving Telehealth Education And Training: A Needs Assessment Of Healthcare Providers And Trainees, Conor Duffy

Theses and Dissertations

Telehealth utilization has increased dramatically since the start of the COVID-19 pandemic. There are many positive impacts of this shift to telehealth, including increasing access to care and reducing patient burden. However, healthcare providers report several consistent challenges that limit their ability to deliver telehealth, such as effective communication, technological difficulties, and difficulty performing physical examinations. To address these concerns, it is necessary to integrate telehealth education and training into healthcare professional training programs and healthcare systems. While many institutions have implemented telehealth education and training since the start of the pandemic, there is little consistency in the content, duration, …

Addressing The Rural Firearm Suicide Crisis: The Impact Of Culture, Mental Health, And Approaching Change, Sasha Ghofrani, Erik E. Langenau

PCOM Capstone Projects

Background. Firearm suicide rates are a growing public health concern, disproportionately impacting rural U.S. communities. This literature review explores risk factors contributing to this crisis.

Methods. This narrative literature review synthesizes research on the primary risk factors for firearm suicide in rural U.S. communities.

Key Findings. Key findings identify four central challenges: (1) a deeply rooted firearm culture based on identity and heritage in rural communities, which often resists traditional safety messaging; (2) prevalent unsafe firearm storage practices that increase the risk of firearm suicide; (3) high rates of social isolation, which are linked to both unsafe …

Using Educational Intervention To Impact Provider And Nurse Knowledge And Self-Efficacy In Contingency Management At An Sud Clinic, Chinwe Egwudo

Doctor of Nursing Practice Projects

The US opioid epidemic crisis led to 700,000 deaths in 2019 alone. Poor adherence to medications for opioid use disorder (MOUD) strains individuals, families, and the healthcare systems, with rising relapses at the project site highlighting the need for evidence-based intervention. Studies show that contingency management (CM), a behavioral intervention that incentivizes desired behaviors, improves adherence to MOUD. Despite its effectiveness, CM remains underutilized in clinical settings due to healthcare providers’ lack of knowledge and self-efficacy. This project aimed to bridge the knowledge gap by implementing an educational intervention to impact healthcare providers’ knowledge and self-efficacy in applying CM protocols …

The Evolution Of Veterinary Technology Education: Growth, Accreditation, And The Role Of Murray State University’S Veterinary Technology Program, Tara Joiner

Murray State Theses and Dissertations

This dissertation examines the evolution of veterinary technology education, focusing on the growth, accreditation, and role of Murray State University’s (MSU) veterinary technology program. The veterinary profession has experienced significant advancement and expansion in recent years. The American Veterinary Medical Association (AVMA) accredits veterinary technology programs, setting standards and conducting reviews to ensure quality. Murray State University’s veterinary technology program, accredited by the AVMA in 1986, prepares students for the Veterinary Technology National Exam (VTNE) through a comprehensive curriculum and internships (practical experience). Findings from a three-year period (2022–2024) highlight mentor confidence in student readiness at 77.3%, with qualitative feedback …

The Geography Of Care: Rural Versus Urban Caregiver Perspectives On Community Resources For Parkinson’S Disease Management, Rebecca Jones

Murray State Theses and Dissertations

This qualitative study investigated the experiences and perceptions of caregivers for individuals with Parkinson's disease (PD) in rural versus urban settings, with particular emphasis on their access to and utilization of community resources. Through semi-structured interviews with 30 caregivers, the research explored how geographical location impacts caregiving challenges, support systems, and resource accessibility. Using Andersen's Behavioral Model of Health Services Use as a theoretical framework, the study revealed both universal caregiving challenges and location-specific barriers. While all caregivers reported significant emotional burden and healthcare system navigation difficulties, rural caregivers faced distinct challenges related to resource accessibility and specialized care availability. …

The Impact Of Facility Dogs On College Students' Stress Management And Emotional Regulation, Anna Reichert

Senior Honors Theses and Projects

College is a demanding transitional time where students experience new friendships and personal growth. During this time, mental health issues can surface, which impact emotional well-being. Studies have shown that dogs reduce stress, anxiety and depression, encourage exercise, lower blood pressure, and raise oxytocin and dopamine levels (American Heart Association, 2021). Eastern Michigan University introduced their own facility dog, Tinker, a two-year-old golden retriever. Since Fall 2024, she has provided emotional comfort and relief to students and the campus community. Students were surveyed on stress levels and if and how Tinker made an impact. Survey results show Tinker’s effect on …

Elementary-School-Based Speech-Language Pathologists’ Perspectives On Implementing Literacy, Samantha Kadian

Master's Theses and Doctoral Dissertations

This study explores elementary-school-based speech-language pathologists’ (SLPs) perspectives about implementing literacy. Though the American Speech-Language-Hearing Association (ASHA) standards specify literacy is within their scope of practice, many school-based SLPs may not be addressing reading and writing competencies. The literature indicates that several constraints may contribute to this lack of involvement, including a lack of preparation, varied expectations, and ambiguous definitions. The purpose of this study was to gain an understanding of the perspectives of elementary-school-based SLPs. Three SLPs were interviewed in a semi-structured format, and the data from the interviews was examined using qualitative analysis. The findings indicated that SLPs …

Racial Health Disparities Among Pregnant Women Of Color In New York City: Biological And Systemic Impacts, Kaylin Peña

Pitzer Senior Theses

Racial Health Disparities Among Pregnant Women of Color in New York City: Biological and Systemic Impacts

Abstract

This thesis aims to explore how racial health disparities, underrepresentation in gynecology, and socioeconomic barriers contribute to adverse pregnancy outcomes among women of color in New York City. Through an interdisciplinary approach that combines resources from medical anthropology and human biology, this research will examine the biological implications of chronic stress, specifically HPA axis dysregulation, and its role in maternal health outcomes. With the idea of intersectionality, as conceptualized by Kimberlé Crenshaw, the study analyzes the various effects of systemic inequities and social …

Development And Clinical Validation Of The Sensor-E Exoskeleton For Objective Hand Function Assessment In Stroke Rehabilitation, Madison Bates

Theses and Dissertations--Biomedical Engineering

Hand function is often impaired following neurological trauma or in conditions such as stroke, limiting independence and the ability to perform activities of daily living (ADLs). Current clinical assessments rely heavily on subjective rating scales that lack the resolution to detect subtle changes in motor performance, which can limit access to rehabilitation. Recent advances in wearable technologies highlight the potential for hand-worn devices to provide objective, real-time measures of hand function. However, most systems focus solely on kinematics and rarely capture both movement and exerted force. Moreover, integration into rehabilitation frameworks and brain-computer interface (BCI) protocols remains limited. To address …

Supporting The Development Of Emotion Regulation For Engagement In Occupation, Alexis Karen Smith

Occupational Therapy Capstones

Purpose: Many children with mental, behavioral, and neurodevelopmental health conditions internalize and externalize symptoms of anxiety, depression, and anger at higher rates compared to children without these conditions (Tajik-Parvinchi, 2021). Difficulties with emotion regulation may lead to heightened experiences of symptoms from mental, behavioral, and neurodevelopmental health conditions (Tajik-Parvinchi, 2021). Occupational therapy practitioners can support children with emotional dysregulation by using evidence-based best practices. The identified problem is the application of evidence-based emotion regulation evaluation and interventions to support children with difficulty in emotion regulation and their caregivers. The challenge of implementing evidence-based emotion regulation services is limited research and …

Benefits Of Nature-Based Play For Children: An Educational Resource For Parents, Kaitlyn Peterson

Occupational Therapy Capstones

Background: In recent years, children’s use of technology has increased, decreasing the time they spend playing in natural contexts and time spent building the parent-child relationship. The lack of time spent in outdoor contexts has negative influences on the child’s overall health and well-being. The time a child spends with their parent is vitally important for a child’s development, view of the world, and sense of belonging. Parents assist children throughout development by supporting their understanding of themselves and the world, along with supporting the child’s ability to communicate with their parents. Interactions with technology, particularly overuse, can influence a …