Medicine and Health Sciences Commons^™

Automated To Ols For Contour Review In Radiotherapy, Barbara Marquez

Dissertations and Theses (Open Access)

Peer review of organ-at-risk and target volume delineation is essential for patient safety and optimization of treatment outcomes. Peer review makes a substantial impact on patient outcomes, reporting notable rates of plan changes when reviewed and worse survival when patient cases are not reviewed. In around half of revised cases, target volume change is the required cause for modification (related to tumor control); in one in ten cases, it is normal tissue sparing (related to treatment toxicity). Essentially all North American institutions with accredited residency training programs hold peer review to some capacity. However, accessibility to practicing routine peer review …

An Investigation Into The Potential Of Cell Therapies For Acute Myeloid Leukemia (Aml) Treatment, Amanda Eckstrom

Dissertations and Theses (Open Access)

Despite recent advances in acute myeloid leukemia (AML) treatment, curative rates remain poor with high rates of relapse and many patients are unable to tolerate the intensive chemotherapy standard of care regimen. Cell therapies have shown great success against hematologic malignancies but face several challenges including treatment-related toxicities and human-leukocyte antigen (HLA) matching. Natural killer (NK) cells and gamma delta (γδ) T cells offer alternative effector cell options for cell therapies that do not require HLA-matching and have shown low toxicity in previous studies. In this project, we sought to evaluate FT538 induced pluripotent stem cell-derived NK (iPSC-NK) and donor-derived …

Evaluating Triage To Genetic Counseling Using An Online Reproductive Genetics Module, Grace Ra

Dissertations and Theses (Open Access)

The American College of Obstetricians and Gynecologists recommends genetic screening for all pregnant women. As clinical recommendations broaden and demand for prenatal screening increases, obstetric practitioners report time constraints and lack of genetics knowledge as challenges to providing sufficient pretest education. These challenges in offering routine screening are further compounded by the inequities in access to genetic counseling and testing. Thus, alternative education and service delivery models have emerged to meet the demands for prenatal genetics education and help mitigate challenges surrounding access. At UTHealth Houston, an online triage and education module, the Prenatal Genetics Education Program (PGEP), was created …

Denial Of Inpatient Genetic Testing: A Study On Outpatient Yield And Outcomes, Cindy Y. Canales

Dissertations and Theses (Open Access)

This study investigates the difference in diagnostic yield between patients approved for inpatient genetic testing compared to those denied inpatient testing and the effect of an earlier diagnosis on outcomes and medical/clinical care. In the literature, research has explored the impact of a diagnostic delay for patients with genetics conditions, assessed the utility of genetic testing in the inpatient setting, and described the impact to care of an earlier diagnosis. However, gaps remain on research exploring the diagnostic yields of inpatient versus outpatient settings and the potential impact to care an inpatient genetic testing request denial may pose. This is …

The Impact Of Lactoferrin And Iron-Enriched Whey On Iron Absorption, Gastrointestinal Symptoms, And Menstrual Health In Women, Mia Dustin

Undergraduate Honors Capstone Projects

Iron is an essential trace mineral involved in oxygen transport, energy metabolism, and cellular function, yet deficiency remains prevalent among women of reproductive age. In the U.S., approximately 20% of women aged 18-45 years fail to meet daily iron requirements due to lack of iron consumption in the diet, menstrual blood loss, or intense exercise, often leading to anemia, fatigue, and cognitive impairment. While ferrous sulfate is a common form of iron supplementation, it frequently causes gastrointestinal discomfort. Researchers have explored lactoferrin, a glycoprotein with immune and iron-binding properties, as an adjunct to traditional supplementation. This study examines the effects …

Investigating The Role Of The Hypocretin/Orexin System In A Novel Model Of Polysubstance Dependence, Tyler Zarin

Electronic Theses and Dissertations

Substance use disorders (SUD) in the United States are steadily increasing. Potent and dangerous substances such as methamphetamine (MA) and fentanyl (FEN) are often co-used as a polysubstance (POLY), either intentionally or unknowingly as FEN is a common adulterant. SUD is characterized by physiological and psychological dependence involving the negative reinforcement of anhedonia and withdrawal which drive hypermotivated drug-taking behaviors. Current theory suggests that recruitment of hypocretin/orexin (HCRT) neuropeptide in reward and stress associated brain regions contributes to drug dependence. Despite strong evidence for HCRT’s role in mono-drug dependence, a relevant model for POLY dependence has yet to be developed, …

Bridging Theory And Practice: Aquatic Occupational Therapy For Functional Rehabilitation In Parkinson’S Disease, Chelsea L. Tate

Occupational Therapy Doctoral Capstones

The purpose of the Doctoral Capstone Experience and Project is to develop a theoretical framework and supporting program to guide the application of aquatic interventions specific to Parkinson’s disease treatment, while highlighting the therapeutic benefits that can be integrated into occupational therapy practice. The framework and program focus on improving overall physicality, cognitive, and functional performance for individuals with Parkinson’s disease.

Care For The Carer: A Program For Caregivers & Their Loved One, Luke Allen

Occupational Therapy Doctoral Capstones

The purpose of the Doctoral Capstone Project is to reduce the burden experienced by dementia caregivers due to unmet physical, mental, and social needs. To meet this objective, CAREpackages with resources pertinent to dementia caregiving, with accompanying Dementia Difficulty educational videos will be delivered to families from low socio-economic backgrounds in the Northeast Arkansas community.

Bridging The Gap Between Occupational Therapy & Animal-Assisted Therapy (Aat), Aspen Campbell Smith

Occupational Therapy Doctoral Capstones

The Doctoral Capstone Project involves developing advocacy resources to support occupational therapy practitioners in the ethical, safe, and effective integration of animal-assisted therapy (AAT) into clinical practice. The tools aim to increase practitioner awareness, support ethical decision-making, and promote client-centered, evidence-based animal-assisted therapy services.

Roadwell: An Occupational Therapy-Based Telehealth Platform To Improve Wellness Among Over-The-Road Truck Drivers, Phylecia G. Mason

Occupational Therapy Doctoral Capstones

This doctoral capstone project aimed to design and implement RoadWell, a mobile wellness platform usingthe Person–Environment–Occupation–Performance (PEOP) model, to improve occupational performance and well-being. RoadWell addresses the interaction between the person, environment, and occupation by delivering real-time, evidence-informed strategies that meet drivers where they are—in their real work environments, doing real work.

Rooted In Play: Empowering Development Through Nature-Based Occupational Therapy, Nicole Roper

Occupational Therapy Doctoral Capstones

The doctoral capstone project included advocating for the use of outdoor play by identifying and emphasizing the benefits of occupational therapy (OT) involvement within nature-based therapy for pediatric patients and creating nature-based therapy recourses for caregivers and occupational therapists.

Impaired Mental Health In Adolescents: Socioeconomically Challenged Geographic Locations, Brittany E. Kunkel

Occupational Therapy Doctoral Capstones

This capstone project aligns occupational therapy strategies with the environmental, social, and institutional contexts that shape adolescent mental health, enabling holistic and culturally responsive interventions that address not only individual needs but also broader systemic influences.

More Than A Crown: Creating Leaders And Connecting Communities, Grace Addison Ross

Occupational Therapy Doctoral Capstones

More than a Crown is a doctoral capstone experience (DCE) that promotes community integration for girls with intellectual disabilities by enhancing their leadership skills. Participants engage in a six-week leadership program that focuses on developing the following skills: confidence, poise, creativity, self-exploration, conversation, and active listening.

Utilizing Animal-Assisted Therapy To Address Pyschosocial Implications Of The Geriatric Population In A Residential Facility, Blaire Kennon Bassham

Occupational Therapy Doctoral Capstones

Older adults in residential care frequently experience psychosocial challenges such as isolation, depression, and reduced engagement in meaningful activity. Animal-Assisted Therapy (AAT), when integrated into occupational therapy, offers a powerful, evidence-based means to address these concerns by promoting emotional well-being, social connection, and purposeful interaction. This capstone project leveraged AAT as a therapeutic intervention specifically designed to meet psychosocial needs.

#Helpplz: Mental Health Representation In Theatre For Young Audiences, Kate Elizabeth Dirrigl

Theses and Dissertations

#HELPPLZ is a play for young theater audiences that depicts four teenagers with various mental health challenges. It’s target audience is for children ages ten to fifteen and should be performed by actors of similar ages. #HELPPLZ is an immersive theatre experience, as a audience members watch four actors perform from four different lifestyles and point of views, all while broadcast on screens behind the actors. Every seat is a good seat in the house. This play follows a shift in trends of mental health depiction in contemporary theatre. No longer demonized and much more accessible, plays such as Dear …

A Psychometric Evaluation Of The Intentionality Bias Task, David Willard

Graduate Theses and Dissertations (2019 - present)

Intentionality Bias Task (IBT) provides quick and easy assessment of the tendency to overattribute intentionality to the behaviors of others. The IBT has been used repeatedly in research that has attempted to connect intentionality bias to a wide range of disorders and socio-emotional abilities, including schizophrenia spectrum disorder, autism spectrum disorder, and cognitive empathy. To date, however, there has been no systematic examination of the IBT’s psychometric properties. The present study attempts to fill this gap by testing whether the IBT possesses a reliable factor structure. Specifically, the 34 items of the IBT were written to reflect two types of …

Beyond Opioids: The Role Of Polysubstance Exposure In Neonatal Abstinence Syndrome Treatment And Hospitalization, Caelyn Harrison

Undergraduate Honors Theses

This thesis explores the impact of prenatal polysubstance exposure, specifically focusing on the need for pharmacological treatment for Neonatal Abstinence Syndrome (NAS) and the duration of their hospital stay. A retrospective analysis of 462 infants, including 121 exposed to polysubstances during pregnancy, showed significant associations between polysubstance exposure and adverse neonatal outcomes. Infants with prenatal polysubstance exposure were more likely to require pharmacological treatment for NAS (52.8%) compared to non-exposed infants (38.7%), as determined by chi-square analysis (χ²(1, N = 462) = 7.36, p = .007). Additionally, infants exposed to polysubstances experienced longer hospital stays on average (M = 14.88 …

A Sex Comparison On The Effects Of Caveolin Scaffolding Domain On Fibrosis Formation After Chronic Sympathetic Stimulation, Crimsyn Price

Undergraduate Honors Theses

Cardiovascular disease (CVD) is the leading cause of mortality worldwide. There are various trends that influence the rates of cardiovascular disease in each country. Factors that create these trends involve diet, exercise, genetics, socioeconomic status, and geographical location. Additionally, CVD is typically higher in middle-income and lower-income classes. Hospital routes, rates of poverty, insurance policies, and lifestyle culture are all factors that can impact the time of treatment which in turn affect the rate of CVD. However, we explored in this study the shift in CVD women experience after menopause. Women were excluded from clinical trials until 1986, and the …

Addiction In The Prison System: Recidivism And Alternatives, Daniel R. Bowers

Undergraduate Honors Theses

The United States criminal justice system has the highest number of incarcerated individuals in the world, with nearly 2 million people currently being behind bars, and around 7.5 million arrests per year according to the most recent available statistics. A key factor in this is addiction, specifically substance use disorders. Between 58% to 68% of adults arrested are addicted to one or more substances, with 68% of drug involved individuals being rearrested within three years of being released. This recidivism rate is incredibly high, and when combined with current prison and jail overcrowding, has created massive problems for the United …

The Development Of Magmas Inhibition As A Potential Therapeutic Target In Temozolomide Resistant Glioma, Jennifer Duyen Tran

Electronic Theses, Projects, and Dissertations

Glioblastoma (GBM) is a highly aggressive brain tumor that remains a significant challenge in neuro-oncology today. Approximately 90% of GBM patients experience tumor recurrence within one to two years of diagnosis. Therefore, due to its high resistance to conventional therapies, new treatment strategies are urgently needed. The current standard of care for GBM is the chemotherapeutic Temozolomide (TMZ). TMZ is an oral alkylating agent, it functions by delivering a methyl group to purine bases. The development of resistance to TMZ is partially regulated by the DNA repair enzyme O6- methylguanine-DNA methyltransferase (MGMT). Despite the potential shown by MGMT promoter methylation …

Implementing A Sustainable Antimicrobial Resistance Surveillance Across Riverside County, Felipe Aperador

Electronic Theses, Projects, and Dissertations

This project focuses on improving health surveillance in remote communities, addressing antimicrobial resistance (AMR) enhancing connectivity and data collection. Geographic barriers, high shipping costs, and logistical challenges have historically hindered healthcare delivery in underserved areas. By integrating healthcare facilities into a cohesive surveillance systems, would improve specimen collection and data analysis. A systematic review of literature identified key strategies, including governmental support, strengthening laboratory capacity, addressing logistical barriers, and enhancing connectivity. Notable results include insights to integrate new facilities when creating a surveillance network, supported by training and state-funded resources. Actionable steps, such as implementing National Action Plans, establishing National …

Social Media Use In Health Education: National Children's Dental Health Month Social Media Toolkit, Jazmin Pelayo

Electronic Theses, Projects, and Dissertations

National Children's Dental Health Month (NCDHM) was created by the American Dental Association and is celebrated annually by local oral health programs all around the country. The celebration began as a one-day event on February 8, 1949, expanded to a week-long observance in 1955, and was later extended to a month-long celebration in 1981. Today local oral health programs celebrate NCDHM in a variety of ways but the one I will be focusing on is a social media tool kit. A social media tool kit consists of videos or posts that are posted on different platforms such as the www.smilesbc.org …

A Whole Person Care Approach To Ending The Hiv Epidemic In The Inland Empire, Roberto Daniel Gonzalez Coronado

Electronic Theses, Projects, and Dissertations

In the last 40 years, the United States has seen remarkable progress in the field of HIV treatment; however, the virus continues to burden the most vulnerable members of society, such as Men Who Have Sex with Men (MSM) and Intravenous Drug Users (IVDU). Unfortunately, these vulnerable members of society continue to lack stable social conditions to get into proper HIV treatment. These social conditions are referred to as social determinants of health, which are non-medical factors that influence whole-person care. With these members of society continuing to face greater social disparities, their linkage to care and retention to care …

#Toomuchcontent: A Quantitative Analysis On Social Media Time Usage And Its Impact On Young Adult Anxiety And/Or Depression In The United States, Sarah Juarez

Electronic Theses, Projects, and Dissertations

As technology continues to advance and grow, society has seen a surge in popularity of various social media sites. Social media has become increasingly popular among young adults, with some spending over 10 hours each day on social media. Social media can be utilized for community building, fostering relationships, providing safe spaces, inspiration, creative expression, and may even provide users with acceptance, validation, and a sense of belonging. Considering these factors, social media may also affect individuals negatively— specifically mental health-wise, in terms of anxiety and depression. This study aimed to identify whether a correlation exists between time spent on …

Passive Electronic Cigarette Exposure Initiates Squamous Metaplasia In A Developing 3d Human Tracheobronchial Epithelial Tissue In-Vitro Model, Edgar Rolon

Electronic Theses, Projects, and Dissertations

The prevalence of vaping has rapidly increased. ECs are often perceived as less harmful than tobacco cigarettes. A recent meta-analysis showed electronic cigarette (EC) aerosols adversely affected the respiratory system, similar to cigarette smoke, with some effects specific to EC use. Failure to prevent these alterations could lead to life-long comorbidities, and predisposition to respiratory diseases, including COPD and squamous cell carcinoma. While these effects are the result of active vaping, EC aerosols can also settle on indoor surfaces, be absorbed passively through the skin or orally, enter the blood stream, and subsequently expose internal organs, including the airway basal …

Explainable Ai (Xai) For A Machine Learning Heart Disease Prediction Model, Sai Abhishek Sanchula

Electronic Theses, Projects, and Dissertations

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, necessitating the development of accurate and interpretable machine learning (ML) models for early diagnosis and risk assessment (World Health Organization, 2021). While ML algorithms such as logistic regression, decision trees, support vector machines (SVM) (Cortes & Vapnik, 1995), and deep learning models (LeCun et al., 2015) have demonstrated high predictive accuracy, their adoption in clinical practice is hindered by their black-box nature (Rudin, 2019). Explainable AI (XAI) techniques, including SHapley Additive Explanations (SHAP) (Lundberg & Lee, 2017), Local Interpretable Model-agnostic Explanations (LIME) (Ribeiro et al., 2016), and feature importance analysis …

Development Of A Jamaican-Inspired Cookbook And Nutrition Resources For Prevention And Management Of Diabetes, Stacy Ann J. Cameron-Roberts

Electronic Theses, Projects, and Dissertations

Background & Aims: Diabetes disproportionately affects minority populations, including Jamaicans affected by dietary habits, sedentary lifestyles, and socioeconomic factors. Culturally relevant interventions are essential for promoting sustainable health behaviors to prevent diabetes. This project developed a Jamaican-inspired cookbook with nutrition education to improve dietary habits among Jamaicans to avoid diabetes.

Methods: The project titled Authentic Flavors: Healthy Jamaican Dishes for People with Pre-Diabetes, a cookbook and resources featuring 34 modified Jamaican recipes with nutrient-dense, low-glycemic ingredients to prevent rapid spikes in blood glucose. Participants were recruited from Jamaican community; and they completed an online nutrition education with pre- and …

The Impact Of Social Media On Dietary Choices Among Young Adults, Celeste Martin

Electronic Theses, Projects, and Dissertations

Background and aims: For decades, the field of nutrition has been influenced by advertising, fad diets, and celebrity endorsements, often leading to confusion. Social media has introduced a new level of influence, potentially leading to more misinformation about health and nutrition. Platforms like TikTok, Instagram, and Facebook may serve as a primary source of news and information for young adults, drastically changing how nutrition advice is shared. Research suggests that social media can positively and negatively impact people’s views on health and nutrition, such as a poor relationship with food and a negative body image. This study aimed to …

Impact Of Water Quality On The Nutritional And Phytochemical Properties Of Culinary Herbs, Genesis Arroyo

Electronic Theses, Projects, and Dissertations

Water quality significantly affected food safety, especially since contaminated water impacted crop growth and the nutrient composition of foods. Nitrates occur naturally in vegetables. However, when introduced into the food supply through water contamination, excessive levels disrupted the natural physiological processes of vegetables and other agricultural plants. These excessive levels eventually led to nutrient imbalances, decreased phytochemical concentrations, and potential health risks such as the formation of carcinogenic N-nitroso compounds in humans. This study evaluated the effects of nitrates on the nutritional outcomes of food crops, focusing on commonly used culinary herbs. While synthesizing findings from relevant peer-reviewed articles, I …

Improving Nurse Confidence Around Communication With Physician Partners Through The Caritas Processes, Deborah M. Yracheta

Doctoral Projects

Nurses are the eyes and ears at the bedside during a patient’s hospital stay. They are responsible for communicating significant changes in a patient’s health status, mainly to their physician partners. Unfortunately, good communication between nurses and doctors is a shortcoming of the nursing profession. Seven thousand reviewed malpractice lawsuits were directly related to poor provider communication, resulting in $1.7 billion in malpractice cases and 2,000 preventable deaths. These communication errors also lead to prolonged hospital delays in care, underscoring the need for improved communication. These poor outcomes compromise patients’ lives, safety, and well-being and decrease patient satisfaction scores, ultimately …