Medicine and Health Sciences Commons^™

Ubiquitin Ligase Trim32 And Chloride-Sensitive Wnk1 As Regulators Of Potassium Channels In The Brain, Eugene Miler Cilento

Graduate College Dissertations and Theses

The voltage-gated potassium channel Kv1.2 impacts membrane potential and therefore excitability of neurons. Expression of Kv1.2 at the plasma membrane (PM) is critical for channel function, and altering Kv1.2 at the PM is one way to affect membrane excitability. Such is the case in the cerebellum, a portion of the brain with dense Kv1.2 expression, where modulation of Kv1.2 at the PM can impact electrical activity of neurons and ultimately cerebellum-dependent learning. Modulation of Kv1.2 at the PM can occur through endocytic trafficking of the channel; however mechanisms behind this process in the brain remain to be defined.

The goal …

Dementia And Primary-Care Health Measures:Hearing, Gait, And Markers Of Inflammation, Elsa Lindgren

Honors Theses and Capstones

Dementia is a syndrome associated with declining cognitive function that has a variety of types and causes, and is encountered frequently in general medical practice. Researchers are actively exploring possible risk factors for dementia. The St. Louis University Mental Status (SLUMS) exam is a dementia-screening exam used in primary care visits to detect cognitive impairment that may be a sign of dementia. This study compared scores on the SLUMS exam to other measures recorded in a typical primary care visit in 86 patients of age 65 and older to look for correlations between indicators of health, such as physical examination …

Communication Sciences And Disorders (Csd) Graduate Students' Preparedness To Work With Individuals Who Are Bilingual, Elizabeth M. Harbaugh

Honors Theses

This study addresses the overall competence of Communication Sciences and Disorders (CSD) graduate students working with individuals who are bilingual. It examined the different CSD graduate programs in the United States and identified key variables that lead to students' preparedness. The author surveyed 238 individuals, consisting of first and second year graduate students and individuals working in their clinical fellowship from 30 different graduate programs. The data were collected from both Mississippi and the total population and were compared as an example of possible future research pertaining to SLP preparedness needed when working with individuals who are bilingual. The results …

Attention Test Performance And Normal Aging: The Effect On Executive Function, Rachel Carmen

Honors Program Theses

In this pilot study, twenty-nine participants completed the following three executive function tests: the Behavioral Assessment of the Dysexecutive System, the Functional Assessment of Verbal Reasoning and Executive Strategies, and Auditory Process Training. Participants, aged blank to blank, were divided into two age groups: young adults, which was comprised of 16 participants, and older adults, which was comprised of 13 participants. Performance means of the two groups were established and compared. There were no predictive qualities to the younger adults’ scores, and there were only in two FAVRES subtests for the older adults: accuracy and reasoning. Further research is needed …

Relevant Decision Criteria And Their Level Of Importance In Consumers' Choice Of Hospital, Jordan Brelje

Honors Program Theses

As the health care industry becomes increasingly consumer-driven, it is crucial for hospitals to understand the considerations involved in their patients’ choice of health care institution. The purpose of this study was to determine the factors which most heavily influence consumers’ choice of hospital, as well as to make recommendations to health care marketers based upon the conclusions reached. This study also hoped to provide beneficial insights to public policy makers who desire to give consumers more control in the health care decision-making process. Very little research has been performed in recent years as to consumers’ choice of hospital decision …

Diagnosing An International Health Crisis: A Structural Exploration Of Ebola 2014, Maddison Zayn Jansen

Honors Program Theses

The Ebola crisis of 2014, though concentrated most heavily in three small countries in western Africa, awoke the international community to its lack of effective health crisis infrastructure. As the disease rocked the globe, multinational groups scrambled to help those directly affected and protect the overwhelming majority of people not directly affected. Most preventative measures failed, and pre-existing initiatives to stem the flow of the disease only served to open the floodgates more. After careful examination of the literature surrounding medical, cultural, financial, national, and global circumstances enabling Ebola to flourish, as well as applying individual analysis and examination, it …

Analysis Of Protein Expression For Potential Biomarkers In Human Pancreatic Tumor Cell Lines, Jade Ashley Simpson

Honors Program Theses

Pancreatic cancer is an aggressive cancer of the pancreas that has been shown to have extremely low survival rates. It can be quite lethal because of its asymptomatic early stages and inability to detect cancer at the cellular level. Once diagnosed, the cancer will have usually spread or metastasized beyond surgical resection. Thus, research is focused on finding potential biomarkers in tumor cell lines to help in earlier diagnosis of this disease leading to better treatment options. Previous work using bioinformatics data suggest several cellular genes including, CTHCR1, EPPK1, AHNAK2, and IGHG3, can be potential biomarkers for pancreatic cancer. The …

Stories Of Contaminated Waste Dump Sites In Amskapi Pikuni Blackfeet Country, Kimberly L. Paul

Graduate Student Theses, Dissertations, & Professional Papers

Abstract:

Significant health disparities affect much of the American Indian/Alaska Native (AI/AN) and Native Hawaiian (NH) populations of America_.^3,6,10,11,14 Inequalities in health care and delivery of services for these populations are a contributing factor to disparate health conditions.² Lack of equity in areas such as social services¹⁸, education, environmental contaminants^5,7,8,17, historical trauma¹ and acute poverty[a1] [KP2] ^{16, 19} strongly influence health conditions⁴. People residing within the remaining tribal lands of the Northern Plains experience markedly higher incidence of disease than other ethnicities within this nation¹⁰, ultimately …

Coenzyme Q10, Sean M. Blumhardt

Graduate Student Theses, Dissertations, & Professional Papers

Blumhardt, Sean, M.A., May 2015, Exercise Science

Coenzyme Q10

Committee Chair: Dr. Steven Gaskill

Coenzyme Q10 (CoQ10) is a strong antioxidant and a key component of energy production in the electron transport chain. CoQ10 levels decrease with both age and cardiac disease in plasma and myocardium. After plasma CoQ10 concentrations decrease, dietary changes are generally unable to reestablish normal levels. CoQ10 supplementation is an inexpensive and safe therapy is able to reduce or prevent damage to cell membranes and vasculature by buffering reactive oxidative species. CoQ10 supplementation can decrease blood pressure in hypertensive patients as well as increase cardiac function …

Joint Attention Intervention With Assisting Parent­ Mediated Techniques To Increase A Toddler With Autism Spectrum Disorders' Use Of Joint Attention: A Single Case Study, Rebecca Schulz

All Graduate Theses, Dissertations, and Other Capstone Projects

Attention Intervention (JAI) conducted by graduate researcher, parent, and caregiver, would change the use of joint attention (JA) by a three-year-old suspected of having Autism Spectrum Disorder (ASD). The participant was a three-­year-­old child suspected of having ASD. Intervention was conducted twice per week for 30-45 minute duration by the student graduate researcher at a university clinic under the supervisor of Dr. Bonnie Berg, CCC­SLP. The parent and child's caregiver were trained in JAI and implemented the intervention daily in the home environment. The author's research question was, "Will the use of a JAI parent­mediated intervention model increase the JA …

A Combination Of Therapeutic Techniques: Severe Broca's Aphasia, Kimberly Ann Homan

All Graduate Theses, Dissertations, and Other Capstone Projects

The effects of Modified Melodic Intonation Therapy for a fifty-nine year old adult with severe Broca's aphasia were examined. Intervention included inner rehearsal and first sound practice to potentially increase initiation abilities. Pre and post self-assessments were used to evaluate self-awareness. Six target phrases (four three-syllable phrases and two two-syllable phrases) were treated over the course of fifteen weeks with two one-hour sessions per week. Results showed an increase in the participant's ability to produce the target phrase. Inner rehearsal proved to be an initiation strategy that met functional needs of the participant in a timelier manner; on the other …

The Fertility Problem Inventory And Infertility-Related Stress: A Case Study, Staci Leigh Born

All Graduate Theses, Dissertations, and Other Capstone Projects

More than seven million people of childbearing age in the United States experience infertility. For women, the experience of infertility is stressful. The Fertility Problem Inventory (FPI) has been used to quantitatively measure women's experience of infertility-related stress. However, the construct of infertility-related stress is poorly described in existing literature. The purpose of this case study was understand how women experience the FPI as a measure of infertility-related stress. To address this issue, women who are undergoing infertility treatment completed the FPI and participated in unstructured interviews. Archival documents were also retrieved to corroborate findings and satisfy saturation. Results indicate …

Employees' Interests And Preferences Regarding Worksite Exercise Programs, Amber Butcher

All Graduate Theses, Dissertations, and Other Capstone Projects

In order to address the problem of an unhealthy workforce, employers often implement disease prevention and health promotion strategies, referred to as worksite wellness programs. The purpose of this study was to examine employees' interests and preferences regarding worksite exercise programs. To collect data, a 12 item survey was developed and administered to employees from a company based in Rochester, Minnesota. A total of 21 participants completed the survey (66.7% male, 28.6% female). The mean age was 51 years old. The findings of the study indicated an interest in worksite exercise programs and that incentives may motivate employees to participate …

Elderly Patient Adherence To Ocular Pharmaceuticals; Impact Of Educational And Physical Barriers, Lucky Wagner

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this research was to assess and evaluate elderly patient's attitudes and behavior regarding educational and physical barriers and the impact on adherence to ocular pharmaceuticals. A 19 question survey was developed and in order to collect data. The survey was administered in person at the Edina Senior Center and the Burnsville Senior Center and online via Zoomerang survey software regarding elderly patient attitudes on educational and physical barriers and their impact on ocular pharmaceutical adherence. Findings from this study indicate elderly patients treating an ocular condition with ocular pharmaceuticals expressed strong agreement with improving upon both educational …

A Phenomenological Study Of The Experience Of Counseling For Women With Addictions, Jennifer Karin Londgren

All Graduate Theses, Dissertations, and Other Capstone Projects

This qualitative study explores the experience of counseling for women with addiction issues. Six women with varying ethnic and racial backgrounds between the ages of 24-44 years old participated in the study. Each woman was diagnosed with a substance use disorder and had to have participated in at least five counseling sessions to be included in the study. The study utilized a phenomenological methodology, which seeks to understand the core essence of the phenomenon of counseling itself. Each woman was interviewed once for at least 45 minutes and two women were interviewed twice. These interviews were recorded, transcribed verbatim, and …

"A Compromise To Help The Community": Rural Sexual Assault Nurse Examiner Experiences, Rebecca R. Gonnering

All Graduate Theses, Dissertations, and Other Capstone Projects

Victims of sexual assault require specialized medical care when they report to hospital emergency departments including physical examination, evidence collection, and emotional support. Sexual Assault Nurse Examiners (SANEs) are medical professionals trained to complete the examination and evidence collection in a prompt and sensitive manner. In fact, where SANE programs exist, emergency room waiting times are shorter, evidence collection improves, and revictimization from untrained staff is reduced. Unfortunately, SANEs are not widely available, particularly in rural areas. This lack of trained examiners employed at local hospitals creates a gap in access to proper care, often resulting in long waits as …

She Got Her Period: Men's Knowledge And Perspectives On Menstruation, Ishwari Rajak

All Graduate Theses, Dissertations, and Other Capstone Projects

Research show that men and women often do not converse freely about menstruation. Shame, taboos and myths associated with menstruation silence the conversation. Silencing conversations about menstruation have negative consequences on women, including: objectification of women's bodies, stereotyping of women as physically, morally and emotionally inferior to men and to extreme cases women losing their uterus due to unhygienic means of menstrual management. On the one hand, not addressing menstruation openly has devastating consequences on women but on the other hand, most men seem oblivious about the impacts on women. Therefore, it is important to engage in open dialogues about …

Hypothyroidism And The Development Of Hypertension, Kaleb Short

All Graduate Theses, Dissertations, and Other Capstone Projects

Low thyroid hormone (TH) in adulthood is associated with increased risk of cardiovascular disease, including risk of hypertension. The Spontaneously Hypertensive Rat (SHR), exhibits alterations in thyroid function when compared to normotensive controls. Interestingly, inhibiting thyroid gland function before 4 weeks of age prevented hypertension in the SHR, indicating that TH is involved in the etiology of SHR hypertension. However, these studies utilized tail-cuff photoplethysmography (PPG), which is known to have stress-induced artifacts, and did not compare effects in the normotensive parent strain Wistar Kyoto (WKY) rat. Therefore, it is uncertain whether TH is responsible for an elevation in baseline …

Evaluation Of Vaccination Policies Among Utah Pediatric Clinic Employees, Tia Peterson

Theses and Dissertations

Introduction: Pediatric health care settings are high risk environments for spreading communicable and vaccine preventable diseases from health care workers to susceptible patients. Methods: All managers of pediatric clinics operating in the state of Utah were included. Participants were invited to complete a two-page questionnaire regarding their clinic vaccination policies. Results: Half (n = 23, 50%) of Utah pediatric outpatient clinics recommend employee vaccinations, although employee refusal is allowed without consequence. Of all adult vaccines, influenza was most often included as part of the employee vaccination policy. Some clinics required unvaccinated employees to wear masks in the event of illness, …

Behavioral Implications Of A Cognitive Training Program For Individuals With Moderate Cognitive Impariment, Joseph L.D. Kennedy

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this study was to evaluate the effectiveness of a cognitive training program on behavioral outcomes for individuals with moderate cognitive impairment. A total of twenty participants were randomized into either a waitlist control or an experimental group. Collateral individuals familiar with each participant completed a series of measures of behavioral and emotional functioning at both pre- and post-intervention. Results demonstrated little effectiveness for the cognitive training program in stabilizing or improving behavioral functioning. Limitations and future directions are then provided to enhance future research in this area.

The Relationship Between Core Stability Related Measures And Performance In Adolescent All-Star Cheerleaders, Rachel S. Leitz

Electronic Theses and Dissertations

Purpose: To determine if a relationship exists between core stability related measures (CSRM) and total cheer performance (TCP); including tumbling, jumping, and stunting. Secondly, to determine if TCP can be predicted by these CSRM.

Methods: Fifty female competitive cheerleading bases aged 10-18 from various all-star cheer programs in the southeastern region of the United States were included. Participants filled out a current health status questionnaire prior to participation. The CSRM included the timed sit-up test, trunk extensor endurance test, trunk flexion to extension range of motion, dominant limb single leg stance test, and normalized to height dominant limb single leg …

The Physiological Stress Response Caused By Hypoxia And Reperfusion Injury In Striped Bass (Morone Saxatilis) And Nile Tilapia (Oreochromis Niloticus), Amanda C. Reynolds

Electronic Theses and Dissertations

Approximately five million people in the United States are affected by cardiovascular related diseases yearly contributing to 300,000 annual deaths, making CVD the leading cause of mortality worldwide. It has been suggested that apoptosis (programmed cell death) contributes to the pathogenesis of cardiovascular diseases. When blood flow is reduced or cut off from the heart, usually by a thrombus, this results in oxygen deprivation (hypoxia) to the cardiomyocytes (heart cells). In response to this hypoxic stress, cardiomyocytes will undergo apoptosis. Since many species of fish can survive levels of hypoxia that would be fatal to mammals, fish are an ideal …

Analytic Thinking Predicts Vaccine Endorsement: Linking Cognitive Style And Affective Orientation Toward Childhood Vaccination, Daniel A. Anderson

University Honors Theses

Though popular opinion in the US is favorable toward vaccination, a growing hesitancy to vaccinate children threatens rates of uptake and coverage. In response, researchers now study psychological factors thought to influence vaccine-decisions, as having this information might be useful in addressing vaccine hesitancy in the clinic and beyond. The present thesis reviews evidence from this body of work, and shares results of a new study on the influence of analytic and intuitive thinking styles upon endorsement of childhood vaccines. In a national sample (N = 543), analytic thinking predicted endorsement alone and in the presence of covariates in …

Multi-Surface Simplex Spine Segmentation For Spine Surgery Simulation And Planning, Rabia Haq

Computational Modeling & Simulation Engineering Theses & Dissertations

This research proposes to develop a knowledge-based multi-surface simplex deformable model for segmentation of healthy as well as pathological lumbar spine data. It aims to provide a more accurate and robust segmentation scheme for identification of intervertebral disc pathologies to assist with spine surgery planning. A robust technique that combines multi-surface and shape statistics-aware variants of the deformable simplex model is presented. Statistical shape variation within the dataset has been captured by application of principal component analysis and incorporated during the segmentation process to refine results. In the case where shape statistics hinder detection of the pathological region, user-assistance is …

History Of Concussion And Current Functional Movement Screen Scores In A Collegiate Recreational Population, Jordan M. Dorrien

Electronic Theses and Dissertations

Introduction: 1.6-3.8 million concussions occur annually related to sport.¹ Although neurometabolic alterations in the brain last 7-10 days following a concussion, an increased Cortical Silent Period (CSP) has been found to persist after 19 months.^2,3 Further, movement impairments have been noted years after injury.⁴ The Functional Movement Screen (FMS) assesses mobility and stability in the body.⁵ The purpose of this study was to assess if FMS scores correlate to history of a concussion in healthy college club sport participants. Methods: Health history and FMS score were collected on 55 participants (38 male, …

Determining The False Positive Rate Of A Concussion Battery In Healthy Division I Collegiate Athletes, Caitlynn S. Hellwig

Electronic Theses and Dissertations

Context: Athletic participation accounts for 1.6-3.8 million concussions, or mild traumatic brain injuries (mTBI) every year in the United States. Accurate assessment and diagnosis of concussions is critical to protect athletes from further injury. The Fourth International Conference on Concussion in Sport Consensus Statement recommends a multifaceted concussion assessment which includes symptom inventories, postural stability assessment, and neurocognitive testing. The accuracy of each test is vital in correctly diagnosing concussions. The Balance Error Scoring System (BESS), Standardized Assessment of Concussion (SAC), and Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) are among the most commonly used assessment tools by NCAA athletic …

Evaluation Of Linear And Nonlinear Postural Stability Measurements Following Concussion, Kelsey Evans

Electronic Theses and Dissertations

Sport related concussions affect nearly 1.6 to 3.8 million athletes annually in the United States. A large number of these athletes suffer from postural instability following concussion. Postural control assessment has become a recommended tool to determine readiness to return to play. Measurement of postural control through the use of center of pressure (CoP) variables may provide a sensitive evaluation following concussion and throughout recovery. Purpose: To evaluate a unipedal and bipedal quiet stance protocol consisting of linear and nonlinear CoP measurements with varying durations in a concussed population throughout recovery. Methods: Thirteen NCAA Division I Collegiate Football players (age: …

Provider Recommendations For Human Papillomavirus Vaccine (Hpv) Among Adolescent Males In Southwest Georgia Counties And The Associated Hpv Prevalence In This Population, Benjamin K. Poku

Electronic Theses and Dissertations

Objective: The purpose of this research study was to examine the variation in healthcare providers’ behavior in recommending the Human Papillomavirus (HPV) vaccine to young male adolescents (aged 11-12), middle male adolescents (aged 13-17) and late male adolescents (aged 18-26) in rural Southwest Georgia counties. This research also aimed to identify factors associated with providers’ behaviors concerning HPV vaccination recommendation to youth in various age groups.

Methods: Upon IRB approval, secondary data were obtained from Albany Area Primary Care for a paper-based survey that was conducted in 2014 using a representative random sample of family physicians (n=12), pediatricians (n=6), and …

Examination Of Racial/Ethnic Disparities In Ovarian Cancer Stage Of Diagnosis, Surgery Treatment And Survival: Multilevel Analysis Of 2001-2012 Seer Data, Chen Chen

Electronic Theses and Dissertations

Context. Racial/ethnic disparities in cancer outcomes are major public health concerns. Ovarian cancer is the tenth most common cancer and the fifth leading cause of cancer-related deaths among women. Identifying individual- and contextual-level factors contributing to racial/ethnic disparities in ovarian cancer stage of diagnosis, surgery treatment and survival is necessary for reducing and eliminating these disparities.

Objective. The study aims to examine racial/ethnic disparities in ovarian cancer diagnosis, surgery treatment and survival outcomes; to explore individual- and contextual-level factors contributing to these disparities, and to examine the trend of ovarian cancer racial/ethnic disparities from 2001 to 2012.

Methods. The …

Public Health Implications Associated With The Practice Of Utilizing Tires To Singe Meat In Three Major Cities Of Ghana: A Concurrent Mixed Methods Study, Tempest D. Hill

Electronic Theses and Dissertations

Utilization of automobile tires to singe meat (e.g., cows) intended for human consumption presents public health risks due to hazardous chemicals released into the environment and meat. This has become a common practice in some African countries such as Ghana. The objective of this study was to investigate the awareness and perception of the residents in three major cities of Ghana (Cape Coast, Kumasi and Accra) using the Health Belief Model and Social Ecological Model. Survey participants (n=196) and focus group discussion members (n=37) completed the study. Data collected from study participants included meat consumption, awareness of the use of …