Medicine and Health Sciences Commons^™

Literature Review On Osteoarthritis Management, Robert A. Weinberg

MEDI 9331 Scholarly Activities Clinical Years

Knee osteoarthritis (OA) is the most common cause of long-term knee pain in adults over 45, and a leading cause of disability worldwide. About one in two people will develop it in their lifetime. This review brings together current evidence on how knee OA is diagnosed and treated, using the main clinical guidelines and the most important trials of the past ten years. The evidence points to a simple, step-by-step plan. Exercise, weight loss, and patient education are the strongly recommended first steps. Oral and topical non-steroidal anti-inflammatory drugs (NSAIDs) are the first-choice medicines. Steroid injections into the joint help …

Literature Review On The Effectiveness Of Surgical Vs Non-Surgical Management In Elderly Patients With Distal Radius Fractures, Robert A. Weinberg

MEDI 9331 Scholarly Activities Clinical Years

Distal radius fractures are common in patients aged sixty years and older. The best management strategy remains debated, particularly in elderly patients where complications risk, radiological outcomes and functional recovery need to be considered. Several studies have compared surgical interventions including open reduction and internal fixation with conservative management including closed reduction and immobilization. The aim of this literature review is to synthesize current evidence on these outcomes for elderly patients with a distal radius fracture who were treated with surgical treatment or non-surgical treatment.

Increasing Occupational Therapy’S Visibility In College Sports Medicine In Student-Athletes With Season-Ending Injuries, Mickaela H. Buzzy, Bonnie Fischer-Camara

Post Professional Occupational Therapy Doctoral (PPOTD) Student Capstone Projects

Sport is an essential part of a student-athlete’s life. Many student-athletes gain a strong “athletic identity” in their sport. When a student-athlete is faced with an injury, specifically a season-ending injury, they are at risk of facing a significant sense of loss of identity and adverse psychological effects on their mental health. In the collegiate athletic setting, athletic trainers are often the first to notice signs of psychological distress of student-athletes; however, they frequently report limited education, training, and confidence in providing necessary psychosocial interventions. The purpose of this capstone project was to increase occupational therapy’s visibility in the collegiate …

Advancing Occupational Therapy In Sports: Bridging The Gap In Mental Performance, Gianna N. Scarantino

Occupational Therapy Student Scholarship

Occupational Therapy’s (OT’s) role in sports mental performance remains an underrecognized and emerging area of practice, with limited awareness among OTs, a lack of available educational resources, and currently no established pathway into the field. The purpose of this doctoral capstone project was to increase awareness of OT’s role in sports mental performance through the development and evaluation of a comprehensive educational resource. The educational resource included a digital portfolio, recorded PowerPoint lecture, educational Instagram content, and a Linktree that organized all project materials into one accessible location. Four licensed OTs completed a Qualtrics pre-resource knowledge checklist, reviewed the educational …

Connecting Through Art: A Collaborative Art Program For The Deaf Community, Andrey Meg Bacal, Cristina Dumitrescu, Gary Dennis, Regina Brejda, Maija Vizvary, Jacie Schneider

Occupational Therapy Student Scholarship

This doctoral capstone project developed, implemented, and evaluated a Deaf-centered, ASL-accessible community art program at the Jessye Norman School of the Arts in Augusta, Georgia. The project addressed communication and environmental barriers that may limit participation in meaningful leisure and community-based occupations. Two ASL-interpreted art sessions and a community art show were completed, with evaluation using adapted PROMIS-based survey items, implementation observations, and quality improvement feedback. Because only two usable anonymous survey responses were available at each time point, findings were summarized descriptively and interpreted as feasibility and implementation information rather than evidence of effectiveness. The project supported the feasibility …

School-Based Sensory Room Education Program: An Occupational Therapy Approach, Makenzie Stiles, Bonnie Fischer-Camara, Tracie Ostrander, Elizabeth Young, Sophia Theodorou, Jacie Schneider

Occupational Therapy Student Scholarship

Sensory rooms are commonly used within school settings to support students' self-regulation, behavior, and participation in educational activities. However, evidence suggests that special education teachers and teacher aides often receive limited training on the appropriate use of sensory rooms, including identifying students who may benefit and selecting activities based on individual sensory needs. The purpose of this mixed-methods, pre-experimental capstone project was to develop, implement, and evaluate a school-based sensory room education program for special education teachers and teacher aides at Deposit Central School District. Guided by Ayres Sensory Integration® and Adult Learning Theory, the project included a needs assessment, …

Risques De Blessures Professionnelles Et Leurs Déterminants Parmi Les Jeunes En Emploi Au Québec Entre 2015 Et 2021 : Analyses Selon Les Parcours D'Emploi Et D'Études, Jaunathan Bilodeau, Marc-Antoine Busque, Martin Lebeau, Gabriel Beauchamp

Rapports de recherche scientifique

Les blessures professionnelles parmi les jeunes demeurent un enjeu de santé publique majeur. Bien que les jeunes soient considérés comme une des populations à mettre en avant pour la prévention de la santé et la sécurité du travail, les mécanismes et processus impliqués dans leurs blessures au travail demeurent à explorer. Cette étude vise ainsi à mieux comprendre les facteurs contribuant aux risques de blessures professionnelles et de leur récurrence parmi les jeunes âgés de 15 à 24 ans. Plus particulièrement, l’objectif consiste à (1) documenter l’association entre les profils de parcours professionnel ainsi que d’études et le risque de …

Clinical Outcomes With Perioperative Nivolumab By Nodal Status In Patients With Stage Iii Resectable Nsclc: Phase 3 Checkmate 77t Exploratory Analysis, Mariano Provencio, Mark M Awad, Jonathan D Spicer, Annelies Janssens, Fedor Moiseyenko, Yang Gao, Yasutaka Watanabe, Aurelia Alexandru, Florian Guisier, Nikolaj Frost, Fabio Franke, T Jeroen Nicolaas Hiltermann, Jie He, Fumihiro Tanaka, Shun Lu, Cinthya Coronado Erdmann, Padma Sathyanarayana, Phuong Tran, Vipul Devas, Tina Cascone

Faculty, Staff and Student Publications

Individuals with non-small-cell lung cancer (NSCLC) with metastases to the ipsilateral mediastinum or subcarinal lymph nodes (N2 disease) have poor long-term survival. This exploratory analysis from the randomized phase 3 CheckMate 77T study assessed clinical outcomes by nodal status in individuals with stage III NSCLC who received neoadjuvant nivolumab plus chemotherapy followed by surgery and adjuvant nivolumab (nivolumab) versus neoadjuvant chemotherapy followed by surgery and adjuvant placebo (placebo). Here we show that among patients with N2 disease, nivolumab versus placebo improved event-free survival (1-year rate, 70% versus 45%; hazard ratio, 0.46 (95% confidence interval, 0.30–0.70)) and pathological complete response rate …

Judge Me Not: Exploring Black Mothers’ Perceptions Of Maternal Health Care Services And Structural Racism In South Carolina, Julisa Tindall, Teri Browne Ph.D., Msw, Tisha M. Felder Phd, Msw, Bongki Woo Ph.D., Bree Alexander-Richardson

Publications

Black women in the United States face disproportionately high rates of maternal mortality, driven by structural racism, patient-provider mistreatment, and gendered and racial discrimination. However, little research has explored Black mothers’ perceptions of maternal health care services and structural racism in the Southeastern U.S. This study aims to address this gap by examining Black mothers’ maternal health care experiences in South Carolina. Using semi-structured interviews conducted during the summer of 2023 with Black mothers who had given birth within the previous five years, this qualitative study employed grounded theory to analyze recurring themes in their maternal health care experiences. The …

Online Lifelong Optimal Adaptive Control Of Partially Uncertain Strict Feedback Discrete-Time Systems With Application To Quadrotor Uavs, Maxwell Geiger, Sarangapani Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This article considers the infinite time horizon optimal adaptive tracking control of partially uncertain strict feedback discrete-time (DT) systems with application to quadrotor uncrewed aerial vehicles (UAVs). First, the strict feedback DT system is transformed into an equivalent affine nonlinear DT system in terms of the tracking error dynamics. The optimal adaptive tracking control problem is solved using an augmented system approach, where a horizon of future bounded reference trajectory points is used in the augmented state, when compared to using a single point. It is assumed that the internal dynamics of the strict feedback system are unknown, but the …

“It Feels Like A Safe Container”: Experiences Of Finding Solid Ground Groups For Adults With Dissociative Disorders., Laura Hawkins, Sarah Chipps, Kim Foreman, Stephanie Johnson, Aimee Mccann, Rebecca Braughton, Abidemi Mary Ajuwon, Dongjuan Xu

School of Nursing Faculty Publications

Objective: Dissociative disorders (DD) are trauma-related conditions marked by disruptions in memory, identity, and consciousness. Despite high prevalence, DDs are underdiagnosed and undertreated. This study explores the experiences of adults with DD participating in a 31-week Finding Solid Ground (FSG) psychoeducational group. Method: Participants (N=72) were mostly women (81%), who experienced a DD or PTSD dissociative subtype, along with multiple mental health comorbidities. Eight groups (seven virtual, one in-person) completed 31 weekly 90-minute sessions based on the FSG curriculum as adjunctive to individual psychotherapy. Thematic qualitative analysis was used to analyze participants’ hopes, challenges, helpful and unhelpful aspects, and perceived …

Perceived Use Of Web-Based Videoconferencing For Social Connectedness Among Older Adults Living In Long-Term Care: Qualitative Study, Anna Garnett, Halyna Yurkiv, Denise M. Connelly, Richard Booth, Lorie Donelle Phd, Rn, Fcan, Faan

Publications

Background:

The COVID-19 pandemic highlighted how restrictions on in-person interactions within long-term care homes (LTCHs) severely compromised social connectedness among older adults and their families. Post pandemic, despite policy changes supporting greater in-person family engagement, frequent outbreaks continue to disrupt face-to-face interactions, and factors such as geography, life circumstances, and health can constrain family members’ ability to make regular in-person visits. Research suggests that web-based videoconferencing technology (WVT) may be a practical solution to help older adults within LTCHs to maintain social connection in the absence of physical gathering. However, increased understanding of end user experience is lacking, and more …

Developing A Best Practice Guideline For Clinical Practice In A Digital Health Environment: Systematic Reviews Based On The Grading Of Recommendations, Assessment, Development, And Evaluation Approach, Lauren Bailey, Lyndsay Howitt, Nafsin Nizum, Christine Buchanan, Maureen Charlebois, Jennifer Yoon, Rob Beleno, Michelle Beyn, Rebecca Bliss, Elizabeth Borycki, Margarita Cleghorne, Sandra Davidson, Lorie Donelle Phd, Rn, Fcan, Faan, Alexander Hamilton, Tsz Yee Ip, Margery Konan, Daile Moffat, Sanaz Riahi, Tiziana Rivera, Tammy Rooke, Vaishali Sengar, Steve Sottile, Meredith Whitehead, Vanessa Burkoski

Publications

Background:

Digital health refers to the field of knowledge and practice associated with the development and use of digital technologies to improve clinical practice and health outcomes. Knowledge of digital health technology is becoming essential for all nurses and health providers.

Objective:

This study aims to present the results of the systematic reviews that were used to inform the recommendations in a best practice guideline (BPG) following the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach. Reviews focused on digital health education for nurses and health providers, peer champion models, and the use of predictive analytics in digital health …

Benefits And Harms Of Copyright Restrictions And Conditions On Burnout And Other Psychometric Assessment Scales, Robert G. Badgett, Sudha Xirasagar, Hayrettin Okut

Publications

INTRODUCTION: Copyright conditions can hinder the scientific and usage impact of essential assessment tools in healthcare, organizational psychology, and other fields. The stories of the Maslach Burnout Inventory (MBI) and the Mini-Mental Status Examination (MMSE) are well-documented. Despite decades-old recommendations to blend copyright restrictions of intellectual property when used for commercial purposes with permissive but distinct copyright terms for non-commercial and scholarly use, few authors of assessment tools do so.

OBJECTIVE

To assess whether restrictive copyrights limit the long-term scientific impact of copyright holders (often medical schools/faculty), by inhibiting downstream use, research, and improvement of measurement tools by other researchers. …

From Screens To Stress: Public Health Implications Of Cancer Worry In A Digitally Connected World, Shreya Mathur, Ethan Burns, Michael Pokojovy, Tzu-Liang Bill Tseng, Sunil Mathur

Mathematics & Statistics Faculty Publications

Aims:

This study examines how digital information environments, genetic testing experiences, health behaviors, and psychological distress influence cancer-related worry among adults in the United States. It further considers the public health implications of elevated or reduced cancer worry for prevention and risk communication.

Methods:

Data were drawn from a nationally representative survey of 6,252 U.S. adults. Measures included reliance on social media for health decision-making, smoking status, history of genetic testing, and psychological distress. Multivariable analyses assessed associations between these factors and levels of cancer worry.

Results/Findings:

Reliance on social media for health decisions was associated with greater cancer worry, …

Technological Interventions For Reducing Climate Change Impacts On Health: An Overview Of Future Possibilities, Sujatha Alla, Vijay Kumar Chattu, Bawa Singh

Engineering Management & Systems Engineering Faculty Publications

Globally, over five million deaths annually are attributed to extreme weather events exacerbated by climate change, such as heatwaves, hurricanes, wildfires, droughts, and floods, which create health crises and economic losses. The 2015 Paris Declaration emphasized climate technology mechanisms, including research and development, to enhance resilience and reduce greenhouse gas emissions. Biotechnological advancements have mitigated about 20% of economic losses since the 1960s, highlighting technology’s potential to address climate-induced health risks.

Mortality From Or With Covid-19 Infection, Dagan Coppock, Joseph Glowacki, Constantine Daskalakis, John Zurlo, Nikita Jaggernauth, Daniel Taupin

Division of Infectious Diseases and Environmental Medicine Faculty Papers

In this retrospective study, we compared the cause of death among hospitalized patients who died with a diagnosis of COVID-19 across two periods of the pandemic two years apart: an early period (admissions June to October 2020), when the population was immunologically naïve, and a later period (admissions April to October 2022), when an estimated 96% of the population had immunity from prior infection, vaccination, or both. Two investigators independently reviewed the medical records of 100 in-hospital deaths (50 per period) and classified each death as COVID-19 related, uncertain, or not COVID-19 related, using logistic regression to compare the two …

Blood Flow Regulates Metabolism In Hematopoietic Development, Pamela L Wenzel

Faculty, Staff and Student Publications

Blood flow modifies oxygen availability and biomechanical forces within the vasculature of the embryo as the hematopoietic system develops. The aorta-gonad-mesonephros (AGM) envelops the largest artery in the body and is a critical site for the emergence of hematopoietic stem cells (HSCs). Herein, I discuss the role of hypoxia-inducible factors (HIFs) and force as determinants of metabolism and fate determination. To address the effects of blood flow on hematopoietic development, I employ mouse embryo models and biomimetic culture. Real-time cell metabolic analyses show that oxygen consumption rates (OCR) and extracellular acidification rates (ECAR) are altered by flow in cultures of …

Meta-Analysis Of The Health Effects Of Gas Cooking In Homes, P. Jacob Bueno De Mesquita, Núria Casquero-Modrego, Erik Pontes

Arts & Sciences Faculty Publications

Background: Given existing evidence linking indoor gas combustion with potential health effects, we aimed to quantify from epidemiologic field studies the health impacts associated with residential gas cooking and unvented heating.

Methods: We evaluated and synthesized results from peer-reviewed epidemiologic studies that isolated associations between exposure to residential gas cooking and/or unvented heating and an unrestricted range of health outcomes. We focused on studies conducted since 2000 that cited at least one of five, well-regarded studies. We evaluated relevant studies and computed pooled effect estimates, where at least three studies contributed data, using random effect meta-analysis models with inverse-variance weighting. …

Continuum Of Care Zine, Natanya Dewar

Open Educational Resources

No abstract provided.

Revisiting Nasal Polyp Scoring In Clinical Trials: Interpretive Variability And The Need For Standardization, Leigh J. Sowerby, Babak Pourmomenarabi, Antonino Maniaci, Olivia Ginty, Joseph Khristian Han

Department of Otolaryngology (ENT) Faculty Publications

[Introduction] Borish et al. provided an excellent review highlighting methodological variability among the six pivotal Phase III trials [1]. One critical yet overlooked issue is the inconsistent application of the endoscopic nasal polyp score (NPS), a primary outcome measure in all trials.

Oropharyngeal Syphilis Presenting As Tongue Based Ulcer With Lymphadenopathy, Serena F. Pu, Kevin J. Carlson, Jonathan R. Mark, Benjamin J. Rubinstein

Department of Otolaryngology (ENT) Faculty Publications

Within the aerodigestive tract, syphilis presents with varied signs and symptoms, some of which may mimic malignancy or other disease processes. We present the case of a 29-year-old man with otalgia and odynophagia who was found on physical examination and office laryngoscopy to have a 4-cm ulcerative mass of the tongue base and cervical lymphadenopathy. While planning for tissue diagnosis, the patient’s serologies revealed positive treponemal antibody testing and elevated rapid plasma reagin (RPR) titers, confirming syphilitic infection, likely representing secondary syphilis. While awaiting operative biopsy, the patient received intramuscular penicillin with complete resolution of the mass and symptoms, and …

Depemokimab: A Twice Yearly Anti-Il 5 Biologic For Chronic Rhinosinusitis With Nasal Polyps (Crswnp) - A Narrative Review, Marn Joon Park, Joseph K. Han, Kent K. Lam

Department of Otolaryngology (ENT) Faculty Publications

Depemokimab is a monoclonal antibody that targets interleukin-5 with enhanced binding affinity and an extended terminal elimination half‑life of 6-8 weeks. The unique pharmacodynamic features of depemokimab enable sustained suppression of type 2 inflammation with twice‑yearly subcutaneous dosing. This narrative review provides details of depemokimab's molecular profile, pharmacokinetics, and pharmacodynamics and results regarding the clinical efficacy and safety of depemokimab from recently published Phase 3 clinical trials for the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP). In 528 severe adult CRSwNP patients (ANCHOR‑1/‑2 trials), depemokimab achieved Δ total endoscopic nasal polyp score by -0.70 (p <  .001) and Δ nasal obstruction verbal response scale by -0.24 (p = .003) at week 52, compared to placebo. Twice‑yearly 100 mg depemokimab provides durable eosinophil suppression and with a safety profile comparable to placebo in Phase 3 trials for CRSwNP. Future work should refine biomarkers and assess comparative cost‑effectiveness and long‑term adherence, safety, and effectiveness.

Dupilumab In Chronic Rhinosinusitis Without Nasal Polyps: Randomized Phase 2 Trial (Orion), Stella E. Lee, Anju T. Peters, Philippe Gevaert, Joseph K. Han, Claus Bachert, Francisco Moreira Da Silva, Andrés Rosenblüt, Chih-Chi Hu, Jennifer Maloney, Paolo Caferra, Adrianna Michalak, Andrew P. Fontenot, Lacey B. Robinson, Neelam A. Phadke

Department of Otolaryngology (ENT) Faculty Publications

BACKGROUND: Chronic rhinosinusitis (CRS) is often driven by type 2 inflammation and is characterized by nasal obstruction/ discharge, facial pain/pressure, and/or reduced smell, either with or without nasal polyps (CRSwNP or CRSsNP).

OBJECTIVE: To test whether dupilumab improves radiographic features in CRSsNP. Methods: ORION (NCT04678856), a phase 2, randomized, multicenter, double blind, placebo-controlled study, assessed dupilumab efficacy and safety in adults with uncontrolled CRSsNP. Patients were randomized 1:1 to dupilumab or placebo for 24 to 52 weeks. Endpoints included changes from baseline at week 24 in Lund–Mackay computed tomography (LMK-CT) score (dupilumab only [primary] and vs placebo [secondary]), sinus Total …

Enteral Nutrition Guidelines Improve Critically Ill Patients’ Outcomes: A Quasiexperimental Study, Marwa Abdo, Sara Elsayed Hegazy

Nursing

Background: Optimal nutritional support is a fundamental element of treatment for critically ill patients. Adherence to evidence-based enteral nutrition guidelines is essential to promote patient care and prevent potential complications. Objectives: To assess the effectiveness of enteral nutrition guidelines in improving critically ill patients’ outcomes. Method: A quasiexperimental study evaluated 68 critically ill patients divided into 2 groups. The intervention group received their nutrition based on the evidence-based enteral nutrition guidelines, while the control group received their nutrition based on the unit’s routine care. The study was conducted in the surgical intensive care units of Mansoura Emergency Hospital in Egypt. …

Building Ai Literacy To Redesign Graduate Public Health Courses: A Case Study Of Pubh 520, Darren Liu

2026 Scholarly Teaching Conference: Concurrent Session Papers

As artificial intelligence (AI) becomes increasingly embedded in public health practice, graduate education must move beyond ad hoc responses to AI toward intentional, ethically grounded instructional design. This conference paper presents a case study of the redesign of PUBH 520, a graduate-level public health course, to explicitly integrate AI literacy within course outcomes, assessments, and learning activities. Guided by higher-education AI literacy frameworks, the redesign foregrounded faculty AI literacy as a prerequisite for responsible AI integration, emphasizing ethical reasoning, technical understanding, pedagogical alignment, and reflective assessment practices. Findings suggest that the redesigned course improved coherence among learning outcomes, assessment integrity, …

Research In Progress. Why Physiology Feels Hard: Supporting The Transition To Self-Directed Learning In Post-Secondary Physiology, Jaelyn Zoe Rohrbaugh, Mark Paternostro

2026 Scholarly Teaching Conference: Poster Session Papers

Physiology is widely recognized as one of the most challenging courses for STEM students. Contributing factors include the discipline’s inherent complexity, instructional methods, and student preparedness, with both faculty and students identifying the nature of the discipline as the primary challenge. Many undergraduates enter college having experienced predominantly teacher-directed, pedagogical instruction, whereas success in college-level physiology requires self-directed, andragogical learning strategies. We hypothesize that students’ difficulties arise more from a lack of self-directed learning skills than from content complexity alone. To investigate this, we administered an anonymous survey to 340 students spanning freshman to professional levels, achieving a 93% completion …

Colon Cancer In Appalachian Kentucky: Unique Genetic, Microbiome And Obesity Findings In A Cohort Comparison, Zeta Chow, Jinpeng Liu, Daheng He, Chi Wang, Tong Gan, Akila Mansour, Nuha Shaker, Caroline Dravillas, Rebecca Hoyd, Eric B. Durbin, Dana L. Napier, Tianyan Gao, Kurt Schaberg, Lyen Huang, Neli Ulrich, Erin Siegel, Stephen Edge, Linda Cook, Bodour Salhia, Michelle L. Churchman, Jill Kolesar, Daniel Spakowicz, B. Mark Evers, Therese J. Bocklage

Markey Cancer Center Faculty Publications

We investigated colon cancer genomics and microenvironmental features in the Appalachian Kentucky population, a group with the highest incidence of colon cancer in the United States. We assessed two inter-related risk factors for colon cancer (obesity and abnormal gut bacterial microbiome) and their genetic associations within this population. To evaluate potential unique characteristics of the high-incidence cohort, we compared 99 propensity-matched colon cancer tumors from Appalachian Kentucky patients to 95 non-Appalachian patient tumors to evaluate driver mutations, differentially expressed genes (DEGs), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, Catalogue of Somatic Mutations in Cancer (COSMIC) mutational signatures, immune cell …

Hexavalent Chromium Promotes Malignant Transformation Via Enhanced Translation Of Suv39h1, Yiwei Gu, Yanan Cao, Qing Ye, Yujing Zhang, Zhishan Wang, Chengfeng Yang, Side Liu, Qing-Bai She

Markey Cancer Center Faculty Publications

Hexavalent chromium [Cr(VI)] is a widespread environmental carcinogen linked to lung cancer and other malignancies. Although genetic and epigenetic mechanisms of Cr(VI)-induced carcinogenesis have been extensively investigated, the role of translational control has remained largely unexplored. Here, we show that chronic low-dose Cr(VI) exposure in BEAS-2BR human bronchial epithelial cells activates eIF4E-driven cap-dependent translation through mTORC1-mediated phosphorylation and inactivation of the translational repressor 4E-BP1. Pharmacological inhibition of this pathway markedly suppresses Cr(VI)-induced cell transformation, cancer stem cell (CSC)-like properties, and DNA damage. Comparable inhibitory effects are observed following raptor knockdown, which disrupts mTORC1, or expression of a constitutively active non-phosphorylatable …

Rna-Micelles As Self-Assembling Structures For Efficient Co-Delivery Of Synergistic Sirna And Nucleoside Analogues To Treat Crc Lung Metastasis, Kai Jin, Piotr G. Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo

Markey Cancer Center Faculty Publications

SiRNA has been widely studied in cancer gene silencing over the last 25 years. However, few siRNA-based therapeutics have been approved by the FDA. An RNA-micelle platform provides a powerful therapeutic tool through simple one-step, high-yield production that is capable of efficient colorectal cancer lung metastasis treatment, a current lethal condition with a short survival rate post-diagnosis. Here, it is reported that the use of RNA-micelles co-carrying siRNA and nucleoside analogues to completely inhibit lung metastasis of colorectal cancer (CRC). The major advantage of the RNA-micelle is the successful co-delivery of siRNA and chemotherapeutic agent in a single delivery vehicle …