Medicine and Health Sciences Commons^™

Benefits Of Regional Anesthesia Versus Opioids In The Management Of Postoperative Pain Following Excision Of A Peripheral Nerve Sheath Tumor., Duveen Nalamothu, Mauricio Arce Villalobos, Joseph D Tobias

Ambulatory and Primary Care Articles

Postoperative opioid exposure in opioid-naive patients may carry a risk of persistent opioid use. We present the case of a 16-year-old female with no significant family history who was recently diagnosed with neurofibromatosis type 1 and found to have a rapidly enlarging mass in her left upper extremity. She was scheduled for excisional biopsy. To minimize the need for postoperative opioids, analgesia via a continuous peripheral nerve catheter was employed following resection of the malignant peripheral nerve sheath tumor. This case report reviews the clinical applications of multimodal analgesia via a continuous peripheral nerve catheter in pediatric patients, including placement …

Myeloid Mmp14 Couples Extracellular Proteolysis To Inflammatory And Metabolic Remodeling During Obesity, Long J Shao, Fathima Elizondo, Feng Gao, Elizabeth L Lieu, Bharati Reddi, Maryam Elizondo, Iqbal Mahmud, Kristin Eckel-Mahan, Philipp E Scherer, Xin Ge, Huaizhu Wu, Sean Hartig, Kai Sun

The Brown Foundation: Institute of Molecular Medicine

Macrophages orchestrate tissue remodeling, inflammation, and metabolic dysfunction in obesity, but the role of macrophage-intrinsic extracellular proteolysis in immunometabolic regulation remains unclear. Matrix metalloproteinase-14 (MMP14), a membrane-bound protease, is strongly induced during monocyte-to-macrophage differentiation and further elevated in adipose tissue macrophages from high-fat diet (HFD)-fed mice. Pharmacological inhibition or myeloid-specific deletion of Mmp14 impaired macrophage differentiation, proliferation, migration, phagocytosis, and inflammatory activation in response to obesity-associated adipose tissue signals. Mechanistically, MMP14 promoted inflammatory programming by increasing endotrophin generation and enhancing TLR4-NFκB signaling. MMP14 also reprogrammed macrophage lipid metabolism by suppressing lipolysis and promoting lipid accumulation, altering metabolic communication with neighboring …

Technology Platform (Peer Plus) Supporting The Work Of Peer Recovery Coaches And The Communication Needs Of Individuals In Recovery From Substance Use Disorder: Protocol For An R21 Development And Usability Trial., Amanda Coupe, Jessica Pater, Rachel Pfafman, Victor P Cornet, Elisabeth Andrews, Mindy Flanagan, Dana Albright, Abhinay Balasani, Christopher Becker, Brian Parise, Erik Hess, Tammy Toscos

Health Services and Informatics Research

BACKGROUND: Substance use disorder (SUD) represents a significant public health concern in the United States. SUD recovery is complex and individualized, and support provided by peer recovery coaches (PRCs) can improve outcomes. The PRC-client relationship requires bidirectional mediated communication that is often informal but should be trackable, efficient, and aligned with health care privacy and security regulations. Current workflows and available apps do not meet these needs, illustrating the opportunity for client-centered technology tools. We have developed Peer PLUS (People Leveraging Urgent Support; Parkview Health System, Inc), a HIPAA (Health Insurance Portability and Accountability Act)-compliant mobile app and client management …

Dnp Final Report: Improving Rehospitalization Rates And Caregiver Quality Of Life In Outpatient Hospice, Carrie M. Judd

DNP Final Reports

Background: Hospital readmissions among home hospice patients disrupt continuity of care, increase healthcare costs, and may compromise end-of-life preferences.

Purpose: This quality improvement project evaluated the feasibility of implementing a telehealth communication intervention in an outpatient hospice organization. Project aims were to reduce Type I live hospice discharges by at least 2.5% and improve caregiver quality of life (QOL).

Methods: Zoom for Healthcare® video visits and three-way telephone communication supplemented standard nurse practitioner hospice visits during a three-month implementation period. Type I live discharge rates were compared with the organization's baseline quality metrics. Caregiver QOL was measured pre- and post-intervention …

Genetic Associations With Pulmonary Embolism Among Those With A Deep Vein Thrombosis: The International Network Against Venous Thrombosis Consortium, Susana Lozano-Esparza, Gabrielle E Shakt, Jennifer A Brody, Angel Martinez-Perez, Matthew P Conomos, Marine Germain, Katharine R Clapham, Maris Teder-Laving, Astrid Van Hylckama Vlieg, Anni Kauko, Florian Thibord, Ohanna C L Bezerra, Girish N Nadkarni, Gaëlle Munsch, Therese Haugdahl Nøst, Ellen L Goode, Yuekai Ji, Daniel I Chasman, Alexander P Reiner, Constance Turman, Kerri L Wiggins, Colleen M Sitlani, Juan Carlos Souto, Pamela L Lutsey, Tiffany Bellomo, Estonian Biobank, Million Veteran Program, Ruifang Li-Gao, Aleksi Kristian Winstén, Ming-Huei Chen, Ron Do, Lénaick Gourhant, Kristian Hveem, Sebastian M Armasu, Noémie Saut, Nathan Pankratz, Franco Giulianini, Jeffrey Haessler, Mingyang Song, Robert Olaso, Eric Boerwinkle, Daniel Dochtermann, Jose Manuel Soria, Stephen S Rich, David Smadja, Satoshi Koyama, Frits R Rosendaal, Teemu Niiranen, France Gagnon, Ha My T Vy, Neil Zakai, Catherine Lemarie, Anne Heidi Skogholt, Jean-François Deleuze, James S Pankow, Paul M Ridker, Yuxi Liu, Kenneth M Rice, Saiju Pyarajan, Mary Cushman, Jospeh Emmerich, Bruce M Psaty, Pradeep Natarajan, Andrew D Johnson, Marc A Rodger, Pierre Suchon, Francis Couturaud, Pierre-Emmanuel Morange, Weihong Tang, Charles Kooperberg, Christopher Kabrhel, Maria Sabater-Lleal, David-Alexandre Trégouët, Alisa S Wolberg, Scott M Damrauer, Nicholas L Smith

Children’s Nutrition Research Center Staff Publications

Background: Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE), the latter of which often originates from DVT and can be fatal.

Objectives: The aim of this study was to identify causal genetic factors that alter risk of PE among those with a presumed DVT.

Methods: Using a case-only design of VTE, we conducted meta-analyses of genome-wide association studies (GWASs) in the International Network Against Venous Thrombosis Consortium. Among participants diagnosed with VTE, each study identified those who had a clinically reported PE, with or without a clinically reported DVT; those remaining had isolated DVT. Logistic regression …

The Biological Response Of Human Np Cells To Soluble Collagen Vi, Jonathan Dalton, Srikanth N. Divi, Yasmine Eichbaum, Panya Luksanapruksa, Mitchell K. Ng, Rachel Huang, Alan S. Hilibrand, Alex R. Vaccaro, Dessislava Z. Markova, Christopher K. Kepler

Department of Orthopaedic Surgery Faculty Papers

Extracellular matrix (ECM) dysregulation plays a significant role in the development of intervertebral disc disease (IVDD). The ECM around the chondrocytes in the nucleus pulposus (NP) is unique in that it contains ColVI. While linked to chondrocyte proliferation in cartilage, ColVI's specific role in IVD degeneration is less clear. Our aim was to determine the expression of ColVI in NP cells from degenerative IVDs, along with the effects of soluble ColVI on NP cells. Thus, we compared the expression levels of ColVI in human degenerated IVD samples, along with the effect of soluble ColVI on primary human NP cells. A …

Implementation Of A Perioperative Normothermia Bundle To Improve Temperature Maintenance In Adult Colorectal And Hysterectomy Surgical Patients: A Quality Improvement Project, Jessica L. Salisbury

Doctor of Nursing Practice Final Project Abstract

Purpose

This quality improvement project evaluated the effectiveness of an evidence based perioperative normothermia bundle in improving maintenance of normothermia among adult colorectal and hysterectomy surgical patients at a community hospital. The project aimed to reduce perioperative hypothermia through standardized warming interventions while improving compliance with evidence based practice.

Background

Preventable perioperative hypothermia increases postoperative complications, prompting implementation of an evidence based warming bundle to maintain intraoperative temperatures 36 Celsius or greater.

Methodology

Using the Iowa Model, an interdisciplinary team implemented an evidence based perioperative normothermia bundle incorporating multimodal warming, temperature monitoring, and staff education. Compliance and temperature outcomes were …

Walking The Talk For Dementia: Building Social Networks And Collaborations, Walter D. Dawson, Jenn Reed, Fernando Aguzzoli-Peres, Kate Irving, Sherril B. Gelmon

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Dementia is one of the greatest global health challenges requiring multimodal efforts to address its impact on people and societies. Walking the Talk for Dementia (WTD) is a unique global initiative designed to challenge the stigma that surrounds dementia, foster intergenerational dialogue, build a community, and inspire a renewed sense of purpose among participants. A social network analysis (SNA) was conducted to provide greater detail and contextualization of the connections made during WTD and insights into the collaborations that arose from this immersive event which may influence dementia policy, care, and services. Methods A robust, comprehensive, and minimally intrusive …

Evaluating The Effectiveness Of Crr Programs On Decreasing Hospitalizations And Improving Client Stability While In The Crr Program, Grace Yoshioka, Megan Messa Lpc, Nicholas Waxmonsky Lpc

Research Scholars

Yoshioka, G., Messa, M., & Waxmonsky, N. (2026, July). Evaluating the Effectiveness of CRR Programs on Decreasing Hospitalizations and Improving Client Stability while in the CRR Program. Presented at Research Scholar Presentation, Lehigh Valley Health Network, Center for Healthcare Education, Center Valley, PA.

Treatment Patterns And Survival Of Triple Negative Breast Cancer Patients Seen At Lehigh Valley Health Network, Part Of Jefferson Health (Lvhn) From 2017-2022, Swarna Rishika Suresh, Savitri Skandan Md, Melissa Kratz Rn, Msn, Aocn

Research Scholars

No abstract provided.

Connecting To The Community Through The Lehigh Valley Practice And Community-Based Research Network, Rachel Rose, Nicole M. Burgess Bs, Autumn Kieber-Emmons Md, Mph, Ashwini Kamath Mulki Md, Mbbs, Mph, Angela Colistra Lpc, Phd, Ms, Roya Hamadani Mph

Research Scholars

No abstract provided.

To Be Understood: The Impact Of Professional Medical Interpreters On Patient Satisfaction, Kassia Kuczynski, Joumana De Santiago

Research Scholars

No abstract provided.

Reducing Emergency Department Length Of Stay Through Split-Flow Optimization, Jessica Lee, Matthew Souchak Bsn, Rn, Ccrn

Research Scholars

No abstract provided.

Common Factors And Conditions Affecting Cabg Readmissions, Jonathan Nelson, Vaughn Mccain, Kelly Lu, Grace Perez, Bryan D. Nelson Mba, Cphq, Nrp, James K. Wu Md

Research Scholars

No abstract provided.

From Awareness To Ownership: A Framework For Values & Habits Adoption, Mariuxi Coyago, Gerald Mcglinn M.A., Acc

Research Scholars

No abstract provided.

Ai In Residency: A Mixed Method Evaluation Of Ai Tools Used In Family Medicine Residency Programs, Josiah Daniel, Autumn Kieber-Emmons Md, Mph, Erin Smith Do, Roya Hamadani Mph

Research Scholars

No abstract provided.

Learning, Growing, Caring: A Psychological Perspective On High School Students In The Junior Research Scholar Program, Kasey Royse, Lisa Keller Med

Research Scholars

No abstract provided.

Comorbidity Burden, Age, And Outcomes In Va Ecmo: A Retrospective Cohort Analysis, Zachary Onsinyo, Kenny Lu, Sophia Gormas, Bryan D. Nelson Mba, Cphq, Nrp, James K. Wu Md

Research Scholars

No abstract provided.

Management And Outcomes Of Multisystem Traumatic Injury: A Retrospective Multicenter Trial Of Combined Traumatic Brain Injury, Solid Organ Injury, And Blunt Cerebrovascular Injury, Sophie Steckel, Michael Steven Farrell Md, Ms

Research Scholars

No abstract provided.

From Prevention To Intervention: Delirium Order Set Utilization At Pennsylvania's First American College Of Surgeons (Acs) Geriatric Surgery Verified (Gsv) Hospital, Emma Dela Cruz, Rovinder Sandhu Md, Lauren Curcio Msn, Rn, Gero-Bc, Tcrn, Christina Holub Msn, Crnp, Fnp-C, Gs-C

Research Scholars

No abstract provided.

Lvhn Harm Reduction Navigator Evaluation, Sandra Eaddy, William Delgado, Nyann Biery Dhsc, Ms, Abby S. Letcher Md

Research Scholars

No abstract provided.

Evaluating Compliance With Evidence Based Guidelines In Diagnostic Workup And First Course Of Treatment For Adenocarcinoma Of The Rectum Stages I-Iii, Sada Fleischaker, Dennis Sopka Md, Melissa Kratz Rn, Msn, Aocn

Research Scholars

No abstract provided.

Is Colder Always Better? Dhca Vs. Mhca In Aortic Surgeries, Sophia R. Gormas, Sofia A. Veluz, Bryan D. Nelson Mba, Cphq, Nrp, James K. Wu Md

Research Scholars

No abstract provided.

Understanding The Voices Of Franklin Park Youth: The Development Of A Needs Assessment, Alexander Ellison-Drum, Rachel Hager, Cheryl Arndt Phd

Research Scholars

No abstract provided.

Evaluating The Impact Of A Medical-Surgical Cohorting Model On Congestive Heart Failure (Chf) Readmissions At Lvh-Muhlenberg, Sonal Lakhani, Karanda Erdman Bsn, Rn, Heather Faust Msn, Rn, Cmsrn, Michael Goldner Do

Research Scholars

No abstract provided.

Implementation Of A Network-Wide Pediatric Stroke Protocol, Isabella Latini, Liborio Larussa Md, Teresa M. Romano Md, Matthew Palilonis

Research Scholars

No abstract provided.

Do Burn Wounds Treated With Dermal Scaffold Need Surgical Reconstruction?, Daniel Magallanes, Melaina Barbe, Sigrid A. Blome-Eberwein Md

Research Scholars

No abstract provided.

Transcatheter Aortic Valve Replacement (Tavr): Does The Surgical Location Impact Outcomes?, Vaughn Mccain, Sam Veluz, Zachary Onsinyo, Bryan D. Nelson Mba, Cphq, Nrp, James K. Wu Md

Research Scholars

No abstract provided.

The Use Of Artificial Intelligence In Healthcare, Sean Mcclain, Terry Purcell Mba

Research Scholars

No abstract provided.

Ai-Assisted Patient Assignment: Enhancing Workload Balance And Supporting Charge Nurse Decision-Making, Grace Mei, Brandon Bush Msn-Rn

Research Scholars

No abstract provided.