Medicine and Health Sciences Commons^™

News Release: Open House At Keller Hall For Fsu’S New School Of Nursing And Business, Florence State University

Correspondence

The news release offers a brief history of Keller Hall, which was first erected as a men's dormitory in 1947, through its transition to the School of Nursing and School of Business in 1973.

Correspondence & Memorandums: Eliza Coffee Memorial Hospital Expansion And Affiliation With Florence State Univeristy, James Cox

Correspondence

Correspondence from James Cox, Executive Vice President of Medical Architectonic, Inc. to Dean Jimmye Stephen of Florence State University's College of Nursing. The correspondence and related memorandums detail the communication between the architecture company, Florence State University, and Eliza Coffee Memorial Hospital regarding plans for an expansion of the hospital and collaboration with the nursing program at FSU.

West Alabama General Hospital Scholarship Letter, Kathryn Hicks

Correspondence

Scholarship letter issued by the Virginia Planz Memorial Nursing Scholarship Committee of West Alabama General Hospital to University of North Alabama nursing student Barbara Montgomery.

St. Thomas Hospital Scholarship Letter, Peter J. Giammalvo

Correspondence

Letter from the St. Thomas Foundation Scholarship Committee to University of North Alabama nursing student Barabara Jean Montgomery detailing a grant in the amount of $1,200 contingent upon her employment at St. Thomas Hospital for one year following graduation.

Pulling The Plug: Alabama's Natural Death Act, A Free Symposium In Five Perspectives -- Law, Religion, Medicine, Nursing, Humanities, The Committee For The Humanities In Alabama, National Endowment For The Humanities, Health Education & Action League

Documents

The program for Pulling the Plug: Alabama's Natural Death Act, a free symposium in five perspectives -- law, religion, medicine, nursing, humanities held in Huntsville, Alabama on May 20, 1982 mentions critical discussions on Alabama's Natural Death Act, the dignity of terminally ill and suffering patients, medical technology, and the impact of ethical and religious conviction.

Memorandum & Fact Sheet: Una Student Nurses' Association, The Dean And Faculty Of The Una School Of Nursing

Correspondence

Memorandum and fact sheet issued from the dean and faculty of the University of North Alabama school of Nursing to nursing majors concerning the Student Nurses' Association. The document details information about the benefits of joining the organization and various facts.

Student Nurses Association Awardees (1980-1981), Student Nurses' Association (Sna)

Documents

List of awardees selected by the Student Nurses' Association (SNA) in the 1980-1981 academic year for outstanding service and academic performance within the School of Nursing at the University of North Alabama

Memorandum: Proposed Nursing Program At The University Of North Alabama, John F. Porter Jr., Ache (Alabama Commission On Higher Education) Staff

Correspondence

Annotated memorandums concerning the subcommittee on the proposed nursing program at the University of Alabama. The first memorandum was issued to the Council of University Presidents from John F. Porter Jr., Executive Director of the Alabama State Commission of Higher Education. Whereas the second was issued by the ACHE Staff to Members of the Alabama Commission on Higher Education.

'Access To Life' Begins Workshops, Kandis Steele

Documents

In the article, Dr. Ernestine Davis of the UNA School of Nursing addresses the concerns of the elderly through a workshop sponsored by the Southern Rural Health Care Consortium's Access to Life Program and the Home Extension office. The news article is derived from the Franklin County Times of Franklin County, Alabama.

Student Nurses Association Spring Awards Banquet, Program, University Of North Alabama, School Of Nursing

Documents

Program for the 1985 Spring Awards banquet of the University of North Alabama's Student Nurses' Association (SNA)

National League For Nursing: Certificates Of Membership, National League For Nursing, The Council Of Baccalaureate And Higher Degree Programs

Documents

Certificates of membership in the National League of Nursing issued to Florence State University and the University of North Alabama's School of Nursing for December 31 of 1974-76 and 1978 by the National League for Nursing and the Council of Baccalaureate and Higher Degree Programs

Daddies At Graduation And A Nurse In Uniform, William L. Mcdonald

Documents

The first article, "Daddies at Graduation" (1978), addresses the bittersweet experiences of local historian William Lindsey McDonald, while attending the graduation of his oldest daughter, Nancy McDonald Buttram, from the School of Nursing at the University of North Alabama.

The second article, "A Nurse in Uniform," (1979), features McDonald's reflection on his daughter's career in nursing.

Una School Of Nursing Pinning Ceremony, Program (Dec. 15, 1985), University Of North Alabama, School Of Nursing

Documents

Program for the Fall 1985 Pining Ceremony for the University of North Alabama's School of Nursing

Dens Invaginatus Prevalence In Maxillary Lateral Incisors In Egyptian Population: Cone Beam Computed Tomography 3-Dimensional Analysis, Marwa Ezz, Sherif Heidar, Mahinaz Reda Abdelhamed

Dentistry

Introduction: Dens invaginatus also called dens in dente is frequent developmental anomaly, most commonly affect maxillary lateral incisors. It can create an inflammatory and microbial pathway that may compromise pulp vitality. Once detected, intervention must be planned. Aim of the study : This study investigated Dens invaginatus prevalence in maxillary lateral incisors in Egyptian population and its categorization according to Oehlers classification using CBCT. Materials and Methods This study assessed 296 cone beam computed tomography scans including a total number of 592 maxillary lateral incisor. Two experienced examiners: an oral and maxillofacial radiologist and an endodontist, inspected Dens invaginatus in …

Planning For The Transition To Adulthood: Parent Perspectives On The Planning Process And Experiences Of Young Adults With Fragile X Syndrome, Leonard Abbeduto, Jessica Klusek Ph.D., Ccc-Slp, Julie Lounds Taylor, Angela John Thurman

Faculty Publications

Objectives

Relatively few young adults with fragile X syndrome (FXS) meet the normative expectations of adulthood, although there is heterogeneity in this regard. The present study examined the preparation for the transition to adulthood experienced by young adults with FXS and their parents.

Methods

Thirty-nine young adults with FXS and their primary caregiving parents participated. Those with FXS were in their last year of, or had recently left, high school or a formal transition program. Parents completed surveys about the formal transition planning process. We examined the role of the young adults’ adaptive behavior skills in transition planning.

Results

Among …

Powering Up Clinical Scholarship In Pain Management / Chronic Pain Fellowship, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This presentation introduces chronic pain fellows to clinical scholarship pathways in pain management, highlighting core literature search strategies, evidence‐based resources, and HSLIC services that support research, publishing, and teaching in chronic pain care.

A Rare Case Of Cutaneous Extramedullary Hematopoiesis In Chronic Myeloid Leukemia, Bennett Christie-Nguyen, Hanadi El Achi, Levani Iashvili, Amer Wahed, Brenda Mai, Jacob Armstrong

Faculty, Staff and Student Publications

Cutaneous extramedullary hematopoiesis (CEH) is a rare manifestation of extramedullary hematopoiesis (EMH), a process typically associated with fetal development or myeloproliferative neoplasms. EMH most commonly involves the spleen, liver, and lymph nodes, with CEH being exceedingly rare in chronic myeloid leukemia (CML). Here, we present a 34-year-old Hispanic male with multiple bilateral lower extremity lesions, right buttock and leg pain, fatigue, and splenomegaly, who was found to have chronic-phase CML. Punch biopsy of one of the skin lesions demonstrated dermal infiltration by maturing hematopoietic elements, including granulocytes, megakaryocytes, and erythroid precursors, with fluorescence in situ hybridization (FISH) testing confirming a …

A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink

Faculty, Staff and Student Publications

While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combination treatments with immunostimulatory molecules that can maximize anti-tumor responses. Cyclic dinucleotides (CDNs) are STING agonists that hold promise in combination approaches, but they require frequent intratumoral administration when used in both preclinical models of HNSCC and clinical trials. To reduce administration frequency, we have created a peptide hydrogel–liposome composite system, K2-Lip(CDN), for local and prolonged availability of CDN. We investigated the loading limits of cationic liposomes in both …

Therapeutic Potential Of Glp-1 Receptor Agonists For Smoking Cessation, Christian S Hendershot, W Kyle Simmons, Manish K Jha, Sherry A Mckee, Luba Yammine

Faculty, Staff and Student Publications

Glucagon-like peptide-1 (GLP-1) therapies are under investigation for a growing number of neuropsychiatric conditions, including substance use disorders. Cigarette smoking accounts for the largest proportion of substance use-related morbidity and mortality, in part reflecting increased risk for cardiometabolic disease among people who smoke. Given modest quit rates with approved smoking cessation therapies, medications with novel mechanisms of action are needed to expand the available monotherapy and combination treatment options. Treatments that prevent post-cessation weight gain could further reduce relapse and cardiometabolic risks following smoking cessation. Preclinical findings show that GLP-1 receptor agonists (GLP-1RA) modulate nicotine reward, reduce nicotine self-administration, and …

A Machine-Learning-Based Tool For Stroke Risk Prediction In Blunt Cerebrovascular Injury: Development And Preliminary Evaluation, Victoria Wagner, Joshua D Preston, Alejandro De Leon Castro, William F Mueller, Jonathan Nguyen, Manuel Garcia-Toca, Elizabeth R Benjamin, S Rob Todd, Jason D Sciarretta

Faculty, Staff and Student Publications

Purpose: Stroke risk correlates with the Biffl grading system in blunt cerebrovascular injury (BCVI). Although anti-thrombotic therapy is the mainstay of stroke prevention, no point-of-care clinical decision-support tool exists to guide timing for therapy. We sought to develop an interactive online calculator that incorporates patient-specific demographic and injury characteristics to estimate stroke risk and risk reduction with anti-thrombotic (AT) administration.

Methods: Data from BCVI patients (n = 1,197) at a Level I Trauma Center were retrospectively collected. Six machine learning methods were employed to predict stroke risk with and without AT therapy. Class imbalance was addressed using downsampling and/or class …

Etalanetug (E2814) In Dominantly Inherited Alzheimer's Disease: An Open-Label Phase 1b/2 Study To Assess Safety And Target Engagement In Participants With Mild To Moderate Cognitive Impairment, Erica Andreozzi, Kanta Horie, Nicolas R Barthélemy, Brian A Gordon, Shaney Flores, Tammie L S Benzinger, Eric Mcdade, Randall J Bateman, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Etalanetug (E2814) is designed to delay the clinical progression of Alzheimer's disease (AD) by binding to the microtubule binding region (MTBR) of tau implicated in seeding and spreading of tau pathology. Dominantly inherited Alzheimer's disease (DIAD) is a rare form of the disease (<  1%), having similar changes in the tau distribution and pathology to sporadic AD. Herein, we report the safety, pharmacology and biomarker results of the etalanetug Study 103 in DIAD patients.

METHODS: Study 103 enrolled participants with mild-to-moderate cognitive impairment due to DIAD who received etalanetug intravenously every 4 weeks escalating from 750 mg, 1500 mg, 3000 mg, to 4500 mg. After ascending to 4500 mg, patients received 4500 mg for up to 108 weeks. Tau pathology biomarkers, ptau217 and MTBR-tau243 were measured in CSF. Additional …

Loss Of Znrf3/Rnf43 Unleashes Egrfr In Cancer, Fei Yue, Amy T Ku, Payton D Stevens, Megan N Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin-Hua Feng, Galen Hostetter, Xiangwei Wu, Shixia Huang, Noah F Shroyer, Bing Zhang, Bart O Williams, Qingyun Liu, Xia Lin, Yi Li

Faculty, Staff and Students Publications

ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. Conventionally, their biological functions have been associated with regulating WNT signaling receptor ubiquitination and degradation. However, our proteogenomic studies have revealed EGFR as the protein most negatively correlated with ZNRF3/RNF43 mRNA levels in multiple human cancers. Through biochemical investigations, we demonstrate that ZNRF3/RNF43 interact with EGFR via their extracellular domains, leading to EGFR ubiquitination and subsequent degradation facilitated by the E3 ligase RING domain. Overexpression of ZNRF3 reduces EGFR levels and suppresses cancer cell growth in vitro and in vivo, whereas knockout of …

Constitutive Ampk Activation Prevents Hepatocellular Carcinoma Development Through Inhibition Of Hnf4Α Activity, Zhen Sun, Bernard Linares, Cassidy Urdiales, Fiyad Alsarmi, Boyuan Sang, Nagireddy Putluri, Jeanine L Van Nostrand

Faculty, Staff and Students Publications

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality and is largely driven by metabolic disorders such as obesity and type 2 diabetes. The AMP-activated protein kinase (AMPK) is a master regulator of metabolism, and its activation has been proposed as a therapeutic strategy for treating metabolic disorders. However, although AMPK activity is down-regulated in HCC, the precise role of AMPK in HCC development has not been clearly delineated. Here, we investigated the ability of constitutive AMPK activation to prevent HCC development using a constitutively active AMPK transgenic mouse model and a pharmacological AMPK activator. We observed that AMPK …

Single-Cell Tcr Mapping Reveals Spatially Coordinated T Cell States In Head And Neck Cancer, Kelli A Mccord, Emerald Kan, Sean Hyslop, Amanda Y Xia, Colby J Hofferek, James S Lewis, Andreas Wieland, David J Hernandez, Vlad C Sandulache, William H Hudson

Faculty, Staff and Students Publications

Current spatial T cell receptor (TCR) profiling approaches lack the resolution needed to link clonal identity, transcriptional state, and spatial positioning of individual T cells in the tumor microenvironment. Here, we introduce a spatial TCR profiling strategy that resolves individual T cell clones together with their transcriptional states at single-cell resolution and applied the method to human head and neck squamous cell carcinoma. Presumed tumor-specific T cells were broadly dispersed throughout the tumor microenvironment, and cells of the same clone occupied distinct transcriptional states in different locations: Immune-rich regions contained more plastic or progenitor cells, whereas tumor-dense regions were enriched …

A Tv-Bm3d Iterative Algorithm For Vmat-Ct Reconstruction, Chia-Lung Chien, Beibei Guo, Rui Zhang

Faculty, Staff and Students Publications

Volumetric modulated arc therapy-computed tomography (VMAT-CT), which is the CT reconstructed using the portal images collected during VMAT, can potentially be an effective onsite imaging tool. The goal of this study was to propose an iterative reconstruction algorithm that can further improve the image quality of VMAT-CT and reduce the number of failed reconstructions. An iterative algorithm combining total variation (TV) with block-matching and 3D filtering (BM3D) was proposed, addressing the L1-L2 regularization problem using the split Bregman method. We collected portal images from 67 VMAT cases including 50 phantom and 17 real-patient cases. Both Feldkamp-Davis-Kress (FDK) and TV-BM3D iterative …

Reirradiation Treatment Effects In The Clinic (Retec) Proposal - Proof Of Concept Based On Spinal Cord Dose Tolerance For Reirradiation With Stereotactic Body Radiotherapy, Jimm Grimm, Anand Mahadevan, Olusola Obayomi-Davies, Scott G. Soltys, Arjun Sahgal, Kristin J. Redmond, Michael T. Milano, Wolfgang A. Tomé, Kenneth Brooks, Scott Dodd, John Austin Vargo, Gopal Subedi, Jinyu Xue, Bisher Ebid, Felix Ehret, Byung-Han Andrew Rhieu, Christoph Fürweger, Rachel Grimm, Alexander Muacevic, Vitali Moiseenko, Shalom Kalnicki, Mark Mclaughlin, Lawrence R. Kleinberg, John R. Adler, Iris C. Gibbs

College of Health Professions Faculty Papers

BACKGROUND: Since the inception of spinal radiosurgery decades ago, the factors influencing spinal cord recovery have remained unclear. Elucidating these factors would aid in reirradiation planning and delivery. We describe modeling reirradiation normal tissue complication probabilities (NTCP) from compiled published data, akin to the collaborative Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) and High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic (HyTEC) projects.

PURPOSE: Simple dose-time recovery factors for the spinal cord serve as a basis to propose the Reirradiation Treatment Effects in the Clinic (ReTEC) project. ReTEC aims to define human organ recovery factors …

Supporting Holistic Wellness In Transitional Housing: Implementation Of A Wellness Program For Individuals Experiencing Homelessness, Ashley Lauren Kirk

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Housing insecurity and homelessness continue to increase in the United States, with over 771,480 individuals experiencing homelessness on a single night in 2024—an approximate 18% increase from 2023 (U.S. Department of Housing and Urban Development, 2024). Individuals facing homelessness often experience complex physical, mental, and emotional health challenges that can hinder successful community reintegration. The capstone site was a nonprofit organization that provides transitional housing through a relationship-centered model emphasizing individualized support and resource accessibility to those experiencing homelessness. The purpose of this project was to develop a comprehensive toolkit to educate residents on holistic wellness, provide practical strategies for …

Promoting Participation In Adults With Intellectual Disabilities (Id) Through Inclusive Theatre Education And A Professional Theatre Partnership, Lila R. Clark

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Intellectual Disabilities (ID) are characterized by a deficit in intellectual and adaptive function that affects between 1% and 3% of the general population (Patel et al., 2020). As young people age out of the school system between 18 and 21 years of age, opportunities for meaningful participation in their community drop drastically (Codd & Hewitt, 2020). This lack of opportunity can lead to decreased overall mental health and quality of life, possibly explaining why adults with ID are disproportionately affected by mental illness when compared to their typically developing peers (Hall, 2017; Pinals et al., 2022). The purpose of this …

Evaluating A Low-Burden, Client-Centered Home Activity Program For Stroke Survivors: A Mixed Feasibility Study, Latia A. Jones

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Importance

Stoke survivors often find it difficult to adhere to home exercise programs (HEPs), specifically those that are repetitive, impairment-based, or require technology, which can create barriers related to digital literacy, cognitive load, and access (Mahmood et al., 2019; Bol et al., 2018; Verma et al., 2022; Lang et al., 2007).

Objective

To evaluate the feasibility, usability and acceptability, and perceived usefulness of a low-burden, client-centered home activity program for adults with chronic stroke.

Design

A mix-methods feasibility study using structured quantitative measures and semi-structured qualitative interviews conducted after one week of home activity use.

Setting

MUSC Stroke Recovery Research …

Addressing Financial Toxicity In Student-Run Free Clinics (Srfcs) Through Development Of Inventory System And Community Resource Guide For Durable Medical Equipment (Dme), Samantha Boggess

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Student run free clinics (SRFC) provide care to uninsured or under insured patients with physical and mental health impairments. Under insured patients must make difficult decisions about their healthcare, not based on best practices, but on what they can reasonably afford.  For example, they may have to forego durable medical equipment (DME) (e.g., shower chairs, wheelchairs, and self-care equipment)or treatments due to high out-of-pocket costs.

Financial toxicity (FT) refers to the negative impact of medical expenses on patients’ health-related quality of life (HRQOL) and can lead to poor physical and mental health outcomes. FT is a new concept that has …