Medicine and Health Sciences Commons^™

In Vivo Demonstration Of Maturational Changes Of The Chronotropic Response To Α-Adrenergic Stimulation, Jorge Mccormack, Henry Gelband, Juan Villafañe, Hui Xu, Adrienne Stolfi, Arthur S. Pickoff

Medical Education Faculty Publications

In vitro studies suggest that neonates and adults may have different cardiac chronotropic responses to a-adrenergic stimulation. To investigate these differences in vivo, three groups of dogs were studied. Group I = 12 puppies, ages 3-7 days; group II = 12 puppies ages 8-15 days, and group III = seven adult dogs. Heart rate and blood pressure determinations were made in the control setting and then after combined β-adrenergic and parasympathetic blockade (propranolol 0.6 mg/kg and bilateral vagotomies). Alpha-stimulation was then achieved with phenylephrine given in doses of 0.5, 1.0, and 10.0 μg/kg/ min. A second, high dose of propranolol …

Pms Or Perifollicular Phase Euphoria?, Mary Guinan

School of Public Health Faculty Research

Why is it that so little is known about PMS? First of all, there is no agreement on what PMS is. If investigators are referring to different sets of symptoms, how can studies be comparable? In fact, they are not. Not only are the symptoms different, but the timing of symptoms is different, Some studies describe symptoms that occur 7 to 10 days before the onset of menses, while others include symptoms that begin 14 days before the onset of menses and continue for 7 days after onset. This definition suggests that women may have PMS-related symptoms during 21 days …

Cloning And Sequencing Of The Genes For Shiga Toxin From Shigella Dysenteriae Type 1, Nancy A. Strockbine, Matthew Jackson, Lawrence Sung, Randall Holmes, Alison D. O'Brien

United States Public Health Resources

The structural genes for Shiga toxin, designated stx A and stx B, were cloned from Shigella dysenteriae type 1 3818T, and a nucleotide sequence analysis was performed. Both stx A and stx B were present on a single transcriptional unit, with stx A preceding stx B. The molecular weight calculated for the processed A subunit was 32,225, while the molecular weight of the processed B subunit was 7,691. Comparison of the nucleotide sequences for Shiga toxin and Shiga-like toxin I (SLT-I) from Escherichia coli revealed that the genes for Shiga toxin and SLT-I were greater than 99% homologous; three nucleotide …

Biotechnology And The Law: Social Responsibility V. Freedom Of Scientific Inquiry?, George P. Smith Ii

Scholarly Articles

At American University in Washington, D.C., on November 20, 1973, Julius Stone presented the tenth annual Mooers Lecture, entitled, "Knowledge, Survival, and the Duties of Science."' The central question and thesis that he propounded could and, indeed, should be raised anew today; they form the very core of the province and function of law, science, and medicine. In our brave new world they point to the leeways of choice and patterns of discourse that exist in grappling with the central issue of social responsibility in scientific inquiry. Perhaps they will assist in forging a consensus opinion for a subsequent course …

La3+-Induced Fusion Of Phosphatidylserine Liposomes. Close Approach, Intermembrane Intermediates, And The Electrostatic Surface Potential, Joe Bentz, D. R. Alford, J. Cohen, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

The fusion of large unilamellar phosphatidylserine liposomes (PS LUV) induced by La3+ has been monitored using the 1-aminoapthalene-3,6,8-trisulfonic acid/p-xylenebis(pyridinium bromide) (ANTS/DPX) fluorescence assay for the mixing of aqueous contents. The fusion event is extensive and nonleaky, with up to 95% mixing of contents in the fused liposomes. However, addition of excess EDTA leads to disruption of the fusion products in a way that implies the existence of metastable intermembrane contact sites. The maximal fusion activity occurs between 10 and 100 microM La3+ and fusion can be terminated rapidly, without loss of contents, by the addition of excess La3+, e.g., 1 …

Department Of Radiology - Annual Report July 1, 1987-June 30, 1988, David C. Levin

Department of Radiology Administrative Documents and Reports

107 page Department of Radiology Annual Executive Summary Report, July 1, 1987 to June 30, 1988, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

Table of Contents:

Name of Department and Chairman 1

Department Divisions and Directors 1

Department Faculty 2

Radiology Residents and Fellows 6

Departmental Committees and Memberships 7

Department Organization Charts 9

State of the Department 11

Teaching Programs 23

- A. Teaching Programs for Medical Students and Non-Radiology House Staff 23

- B. Residency Program for Residents in Radiology 25

- C. Training Programs for Fellows 27

Continuing Medical Education (CME) Programs 28

Radiology Grand Rounds …

Conduct Disorder And Cognitive Functioning: Testing Three Causal Hypotheses, Irvin Sam Schonfeld, David Shaffer, Patricia O'Connor, Stephanie Portnoy

Publications and Research

Studied the relation between cognitive functioning, as evidenced by IQ and achievement test performance, and Diagnostic and Statistical Manual of Mental Disorders (DSM-III) categories of conduct disturbance, using data from Black adolescents who were members of collaborative perinatal project from birth to age 7 yrs. At age 17 yrs, Ss and their parents were administered a battery of instruments that included standardized psychiatric diagnostic interviews as part of a call-back study. Analyses were compatible with the hypothesis that deficiencies in cognitive functioning are causally related to adolescent conduct disorder as defined by DSM—III. Results suggest that the relation of cognitive …

A Controlled Evaluation Of Devotional Meditation And Progressive Muscle Relaxation, Charles R. Carlson, Panayiota E. Bacaseta, Dexter A. Simanton

CRVAW Faculty Journal Articles

The present study was conducted to determine the effects of devotional meditation (DM), defined as a period of prayer and quiet reading and pondering of biblical material, on physiological and psychological variables related to stress. It was hypothesized that religious persons engaging in DM experience physiological and psychological changes similar to those reported for persons using progressive relaxation (PR) exercises. Thirty-six participants, equally divided by sex into 3 groups: DM, PR, and a Wait List Control, underwent extensive psychophysiological assessment prior to and following a systematic introductio to either DM or PR. The hypothesis that DM could generate positive physiological …

Aftermath Of A Disaster: Psychological Response To The Russelville, Arkansas Mass Murder, Elizabeth Mary Smith, Carol S. North

FMHI Publications

No abstract provided.

Aftermath Of A Disaster: Psychological Response To The Indianapolis Ramada Jet Crash, Elizabeth Mary Smith, Carol S. North

FMHI Publications

No abstract provided.

A Response To "Two Puzzles", Carl E. Schneider

Book Chapters

In his stimulating paper, Professor Mnookin suggests that the legal issue of neonatal euthanasia may be seen in terms of two puzzles: First, what accounts for the ''striking dichotomy between the law on the books, which apparently outlaws such conduct, and the law in action, which apparently permits it"? Second, why has "the treatment of severely handicapped newborns . . . evoked such a violent storm in the last few years"? Professor Mnookin resolves the first puzzle by suggesting that the ''dichotomy between the law on the books and the law in action may serve as a pragmatic, although not …

Atrioventricular Nodal Function In The Immature Canine Heart, Jorge Mccormack, Henry Gelband, Hui Xu, Juan Villafane, Adrienne Stolfi, Arthur S. Pickoff

Medical Education Faculty Publications

Previous studies have suggested that the atrioventricular nodal functional refractory period in the neonate is equal to or shorter than that of the ventricle, providing little or no protection to the ventricle against rapid atrial rates and allowing closely coupled atrial beats to fall within the ventricular vulnerable period. We evalu­ated atrioventricular node function in 21 mongrel neonatal puppies, 3-15 days old, and 15 adult dogs utilizing intracardiac His bundle recording and stimulation techniques. The mean atrioventricular nodal functional refractory period (173.1 ± 20.0 ms) exceeded both the ventricular effective refractory period (139.5 ± 14.3) and ventricular functional refractory period …

Ethics In Academia, Diether H. Haenicke

Center for the Study of Ethics in Society Papers

This paper is based on a presentation made to the WMU Center for the Study of Ethics in Society, April 4, 1986.

Hemoglobin E B-Thalassemia In A Pakistani Family, Aftab Ahmed, Atiya Abbasi, Gerhard Braunitzer, Zafar H. Zaidi

Pharmacy Faculty Articles and Research

Hemoglobin E is a slow moving B chain variant of hemoglobin, first discovered by Itano¹. Characterized by Hunt et al² showed glutamic acid at B 26 to be replaced by lysine. It is a common variant of hemoglobin in the world and reported in high frequency from South-East Asia^3-6. Cases of Hb E, in combination with thalassemia have been reported on the basis of electrophoretic pattern only. In this communication a case of Hb E with B thalassemia is reported on the basis of amino acid sequencing of the abnormal peptide.

Baseball Media Guide 1988, Indiana State University

Intercollegiate Athletics

No abstract provided.

0482: Dr. Walter Freeman's Papers From Huntington State Hospital, 1897-1984, Marshall University Special Collections

Guides to Manuscript Collections

Please note: this collection does not contain individual patient hospital records or records about individuals who stayed here. The items in this collection come from a specific doctor who worked here and his research.

This collection consists of historical materials from the Huntington State Hospital during the period 1897 through 1984. The collection includes correspondence of hospital personnel and patients, administrative records, newspaper clippings, and a large number of photographs. Significant to the collection are files relating to transorbital lobotomies performed by Dr. Walter Freeman in the early 1950's as part of a larger lobotomy project in West Virginia. The …

The Detection, Pharmacokinetics And Behavioral Effects Of Diisopropylamine Dichloroacetate (Dada) In The Horse: A Preliminary Report, J.-M. Yang, W. E. Woods, T. J. Weckman, T. W. Wood, S.-L. Chang, J. W. Blake, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

1. Drug administration studies using diisopropylamine dichloroacetate (DADA) and diisopropylamine (DIPA) were conducted in Thoroughbred and Standardbred horses to assess physiological effects and develop detection methods.

2. Four horses received 0.08 mg DADA/kg body wt and showed no changes in heart and respiratory rates or body temperature as measured over a 1-hr period after administration. A transient diuretic effect was found to occur in 2 mares dosed with 0.80 mg DADA/kg body wt.

3. A qualitative detection method using thin-layer chromatography was developed to detect DIPA, the major metabolite of DADA in equine urine. A quantitative detection method (lower limit …

Properties Of Anti-Lyb-2-Mediated B-Cell Activation And The Relationship Between Lyb-2 Molecules And Receptors For B-Cell Stimulatory Factor-1 On Murine B Lymphocytes, Subbarao Bondada, Joan Morris, A. R. Baluyut

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The murine B-cell differentiation antigen Lyb-2 has been shown to be involved in B-lymphocyte activation and has been postulated by some to be related to a receptor for B-cell stimulatory factor I (BSF-1) (H. Yakura et al., J. Immunol. 137, 1475, 1986). Here we have demonstrated that monoclonal antibody (mAB) to Lyb-2 resembles BSF-1 in its ability to activate small resting B cells and enhancement of surface Ia. Anti-Lyb-2 antibodies bound B cells with very high avidity and were able to induce mobilization of cytosolic-free calcium. Anti-Lyb-2 mAB differs from BSF-1 in that BSF-1 but not anti-Lyb-2 is able to …

Impaired Autoreactive T Cell-Induced T Cell-T Cell Interaction In Aged Mice, Venkatachalam Udhayakumar, Subbarao Bondada, Aruna Seth, Mitzi Nagarkatti, Prakash S. Nagarkatti

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Self-Ia-reactive (autoreactive) L3T4⁺ T cell clones have been shown earlier to stimulate the proliferation of syngeneic naive L3T4⁺ T cells and initiate a T cell-T cell (T-T) interaction leading to the generation of immunoregulatory circuits. Since aging has been shown to be associated with a decline of the immune responsiveness, age-related alterations in the T-T interaction was investigated in the present study. Using several I-E^d-specific autoreactive T cell clones isolated from 2- to 3-month-old (young) DBA/2 mice as stimulators, it was observed that L3T4⁺ T cells from 22- to 24-month-old (aged) DBA/2 mice, failed to …

The Port Sudan Small Scale Enterprise Program, Eve Hall

Poverty, Gender, and Youth

Euro-Action ACORD (EAA) is a consortium of 20 European and Canadian aid agencies working in refugee farming settlements in Central and Southern Sudan, and with various rural development projects in other parts of Africa, which responded to a request from the Sudanese Commissioner of Refugees to work in Port Sudan. This was the first time the agency considered working with poor urban people, and staff were determined to understand the economic and social forces which governed life in the slums. The program noted a number of findings that will help determine its future: reaching out to women where they live …

Pcom Digest Article (Winter 1988) Featuring Dr. Koch, Philadelphia College Of Osteopathic Medicine

Koch Collection, Papers of Richard S Koch, DO

PCOM Digest Article (Winter 1988) Featuring Dr. Koch, the 1988 PCOM Founder's day laureate.

Biography, Philadelphia College Of Osteopathic Medicine

Koch Collection, Papers of Richard S Koch, DO

A brief biography of Richard S. Koch, DO, FAAO, featured in PCOM's 1988 Founder's Day Program.

Richard S Koch, Do, Selected Curriculum Vitae, Philadelphia College Of Osteopathic Medicine

Koch Collection, Papers of Richard S Koch, DO

Dr. Koch's Selected Curriculum Vitae excerpted from the 1988 Founders Day Program.

Improved Selective Medium For The Isolation Of Treponema Hyodysenteriae, Robert A. Kunkle, J. M. Kinyon

School of Veterinary and Biomedical Sciences: Faculty Publications

An agar medium with improved selection for Treponema hyodysenteriae was developed. Cultures of T. hyodysenteriae and T. innocens, feces from 11 clinically normal pigs, and colonic contents from 6 pigs with gross lesions consistent with swine dysentery were diluted in phosphate-buffered saline and plated on Trypticase soy agar (BBL Microbiology Systems, Cockeysville, Md.) with 5% citrated bovine blood (TSA), TSA with 400 ,ug of spectinomycin per ml (TSA-S400), TSA-S400 with 25 ,ug each of colistin and vancomycin per ml, and TSA with 5% pig feces extract and five antimicrobial agents (spiramycin, rifampin, vancomycin, colistin, and spectinomycin) (BJ). Viable numbers …

1988 Transactions, American Dental Association

ADA Transactions

This item is part of the Transactions of the ADA, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT). It is from the Transactions section, one of three subtitles that make up the full publication. Generally, the ADA Transactions are published in multiple volumes throughout the year. Pages from the Annual Reports and the Transactions are numbered consecutively (e.g. Annual Reports volume ends pg. 500 and Transactions volume starts at pg. 501). NOTE: All three subtitles are collectively known as the Transactions of the ADA or, alternatively, the ADA Transactions. Transactions refers …

1988 Annual Reports And Resolutions, American Dental Association

ADA Transactions

This item is part of the Annual Reports and Resolutions subtitle of the ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and Transactions. Generally, the ADA Transactions are published in multiple volumes throughout the year. Older versions include reports from all departments as subsections, while more recent versions include only those of councils, commissions, and committees.

1988 Supplement Vol. 1, American Dental Association

ADA Transactions

This item is part of the Supplements subtitle of The ADA Transactions, a serial publication of the annual activities of the ADA House of Delegates (HOD)/Board of Trustees (BOT) made up of three separate subtitles: Annual Reports and Resolutions, Supplements, and the Transactions. Generally, The ADA Transactions are published in multiple volumes throughout the year. The Supplements function like an appendix and are, in more recent editions, numbered separately with page numbers determined by HOD reference committee assignation. Items are described variously as "Supplement #", "Volume #", etc. throughout the series but have been labeled here as Vol. # for …

Mental Health Service Utilization By Child Victims Of Natural Disasters, Bill J. Locke

FMHI Publications

No abstract provided.

Variables Affecting Duty-Related Stress After An Air Crash Disaster, Don M. Hartsough

FMHI Publications

No abstract provided.

Grand Canyon Midair Collision, Don M. Hartsough

FMHI Publications

No abstract provided.