Medicine and Health Sciences Commons^™

Communication And Socialization Skills At Ages 2 And 3 In "Late-Talking" Young Children, Rhea Paul, Shawn S. Looney, Pamela S. Dahm

Communication Disorders Faculty Publications

Twenty-one apparently normal children between 18 and 34 months of age with slow expressive language acquisition were compared to a group of normally speaking children matched for age, SES, and sex ratio, on the Vineland Adaptive Behavior Scales (Sparrow, Balla, & Cicchetti, 1984). The late talkers (LTs) scored significantly lower not only in expressive communication, but also in receptive communication and socialization. A follow-up study of the same subjects, seen at age 3, showed nearly half the 3-year-olds with a history of LT remained delayed in expressive communication and socialization, while one third remained behind in receptive language. The data …

Current Concepts In The Diagnosis And Management Of Childhood Asthma, Z A. Bhutta

Department of Paediatrics and Child Health

No abstract provided.

Phenylbutyl Nitrone Compositions And Methods For Prevention Of Gastric Ulceration, Robert A. Floyd, John M. Carney

Pharmacology and Nutritional Sciences Faculty Patents

Compositions containing PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient, are disclosed for treating or preventing gastric ulceration caused by ingestion of non-steroidal anti-inflammatories. Based on animal studies, the dosage is in the range of 3 to 300 mg/kg and is administered prior to, simultaneously, or shortly after ingestion of the NSAID compound(s). In the preferred embodiment, the range is between 10 and 30 mg/kg, depending on the dosage unit required to protect the mucosa. The preferred method of administration is orally, alone or in combination with the non-steroidal anti-inflammatory. It is believed …

3-Hydroxy-N-Methylpyrrolidone And Use As Transdermal Enhancer, George A. Digenis, Walter J. Doll, Amale Hawi

Pharmaceutical Sciences Faculty Patents

The novel compound, 3-hydroxy-N-methylpyrrolidone, is effective as a transdermal enhancer for the absorption of drugs through the skin of humans and animals. The 3-hydroxy-N-methylpyrrolidone is prepared from delta-butyrolactone which is converted to methyl 2,4-dibromobutyrate, this intermediate is reacted with methylamine to form N-methyl-2,4-dibromobutyramide, this intermediate is converted to 3-bromo-N-methyl-2-pyrrolidone by ring closure, and the 3-bromo-N-methyl-2-pyrrolidone is reacted with an alkaline earth metal carbonate or alkaline metal carbonate to form 3-hydroxy-N-methyl-2-pyrrolidone.

Ua66/13 Newsletter, Issue #6, Wku Public Health

WKU Administration Documents

Newsletter created by and about WKU Public Health.

Female Condoms, An Urgent Need, Mary Guinan

School of Public Health Faculty Research

As of February 1991, more than 16,000 cases of AIDS in women had been reported in the United States, but the ". tidal wave of cases in women is yet to come. World Health Organization (WHO) estimates of the number of women infected with the human immunodeficiency virus (HIV) range from 1.5 million in Africa to I 00,000 in the United States. Within the next ten years, the majority of these women will develop AIDS and die. Some will live a bit longer, but all are eventually doomed to die prematurely. Most will not live to see their 40th year.

Use Morality As Basis For Animal Treatment, Kenneth J. Shapiro

Experimentation Collection

No abstract provided.

Ua66/13/3 Newsletter, Wku Public Health

WKU Administration Documents

Newsletter created by and about the WKU Public Health department.

The Calendar - July And August 1991, Nova University

The Calendar

No abstract provided.

The Management Of Aerosols With Airpolishing Delivery Systems, Caren M. Barnes

College of Dentistry: Faculty Publications

In summary. aerosol production is inherent with airpolishers. as well as other dental equipment such as handpieces, ultrasonic scalers, and air/water syringes. By practicing prudent infection control techniques and utilizing proper operating techniques, the clinician can continue to enjoy the time-efficient and efficacious benefits of airpolishers, while ensuring a maximum protection from aerosols for the patient and the operator.

A Comparison Of Competitive-Orientation Measures, Diane L. Gill, Betty C. Kelley, Jeffrey J. Martin, Christina M. Caruso

Kinesiology, Health and Sport Studies

We compared two sport-specific measures of competitive orientation, the Sport Orientation Questionnaire (SOQ; Gill & Deeter, 1988) and the Competitive Orientation Inventory (COI; Veasley, 1986), and an alternative 4-item version of the COI. Male and female athletes and nonathletes at two small colleges completed questionnaire packets. Competitive-orientation scores were similar to those reported in previous research. The 4-item measure correlated with the COI, and neither of those measures correlated with the SOQ. As in previous studies, males scored higher than females on SOQ competitiveness and win orientation, and athletes scored higher than nonathletes on all SOQ scores. Our results suggest …

Transcutaneous Bilirubinometry In Pakistani Newborns: A Preliminary Report, Z A. Bhutta, K Yusuf

Department of Paediatrics and Child Health

Neonatal hyperbilirubinemia is a frequently encountered problem in the neonatal period and carries a potential risk of encephalopathy. Early detection and quantification is important, and transcutaneous bilirubinometry (TcB) has been recommended as a non-invasive method for rapid screening. We prospectively compared the efficacy of TcB in 65 normal Pakistani jaundiced newborns undergoing simultaneous serum bilirubin measurements. Although the correlation between the two methods was significant (r = 0.66, P less than 0.01), the scatter was wide and the specificity only 53%. Although the technique offers the potential for non-invasive early screening of neonatal hyperbilirubinemia, it requires further validation in a …

A Clinicopathological Analysis Of Ovarian Tumours, M Saeed, K Khawaja, I Rizwana, Iffat Rizwana, J Rizvi, Imtiaz Malik, A Khan

Department of Obstetrics & Gynaecology

We performed a retrospective analysis of patients with ovarian tumors who were admitted to the Aga Khan University Hospital from January 1985 to December 1989. Sixty one cases were reviewed. Mean age of the whole group was 44 years. Majority of the patients presented with abdominal pain and distention. Most frequent physical finding was a palpable mass on pelvic or abdominal examination. Overall these patients had a higher incidence of breast cancer than expected in the general population. Two-thirds of the tumors were malignant. Comparison of the patients with malignancy against those with benign tumors failed to show any correlation …

Use Of Pollen Concentration In Paleopharmacology: Coprolite Evidence Of Medicinal Plants, Karl Reinhard, Donny L. Hamilton, Richard H. Hevly

Karl Reinhard Publications

Nearly 2,400 plant species have been documented ethnographically as having medicinal value among Native Americans. Therefore, it is not surprising that evidence of medicinal plants appears in some of the over 1,000 coprolites analyzed from the southwestern U.S. Three medicinal species identified in pollen analysis of coprolites are discussed. Willow (Salix) is the most common analgesic in the Native American pharmacopoeia. Prehistoric use of this plant is documented in coprolites from Bighorn Cave in the Black Mountains of Arizona and also in a burial from the Mimbres Valley, New Mexico. Historically, Mormon tea (Ephedra) served as …

Jefferson Alumni Bulletin – Volume Xl, Number 4, Summer 1991

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XL, Number 4, Summer 1991

Clinic presentations, page 9

Honoring our Dean and our Counselor, page 26

A research building for building research, page 28

“Health care: a right or a privilege?” Page 35

On campus, page 36

Class notes, page 38

Inclusion Of Data On Relatives For Estimation Of Allele Frequencies, R Chakraborty

Faculty, Staff and Student Publications

No abstract provided.

Department Of Radiology-Annual Report-July 1, 1990 To June 30, 1991, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1990 to June 30, 1991. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 84 pages.

Phenyl Butyl Nitrone Compositions And Methods For Treatment Of Oxidative Tissue Damage, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, which are active during ischemia in preventing ATP depletion of the cells which predisposes them to subsequent injury during reperfusion, and which are active during reperfusion as oxygen radical scavengers, in a suitable pharmaceutical carrier for systemic or local administration, especially to the CNS, spinal column and eyes. Based on animal studies, the dosage for treating damage due to stroke is in the range of 10 to 300 mg/kg. Similar dosages are useful in treating damage resulting from free radical generation during inflammation, either as a product …

The Effect Of Total-Body Irradiation On Corneal Neovascularization In The Fischer 344 Rat After Chemical Cauterization, M. W. Scroggs, A. D. Proia, C. F. Smith, E. C. Halperin, G. K. Klintworth

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.

The Calendar - June 1991, Nova University

The Calendar

No abstract provided.

Heterogeneity Of Methotrexate Binding In Human Colon Tumor Cells, M P. Iqbal, N Mehboobali, M A. Waqar, M Ahmed

Department of Biological & Biomedical Sciences

[3H]-methotrexate binding at pH 5.0 and pH 7.2 by the cytosol of tumor tissues and the surrounding normal areas of the gastrointestinal tract of patients suffering from colon or gastric cancer has been used to identify in these cells the presence of a binder of methotrexate having low-affinity for this drug in addition to the enzyme dihydrofolate reductase. Scatchard analysis of the [3H]-methotrexate binding data by a colon tumor sample also reveals that there are two binders of this drug present in the cytosol of these cells. The association constant (Kass) for one binder of methotrexate is = 5.6 x …

Crisis Intervention Services In Mental Health: A Review Of The Literature, Roger A. Lohmann, Ellen Neidermeyer

Faculty & Staff Scholarship

This paper is a review of the literature on mobile crisis services and other forms of modern crisis intervention services. It is the first part of a larger project, termed the North Central West Virginia Crisis Study. The purpose of this literature review is to identify recent published literature on crisis services, with particular attention to crisis response services. No attempt has been made to survey the voluminous literature on crisis intervention practice skills and techniques.

Introduction: The Right To Die After Cruzan, Diane E. Hoffmann

Faculty Scholarship

No abstract provided.

Effect Of Delays In Processing On The Survival Of Mycobacterium Avium-M. Intracellulare In The Isolator Blood Culture System., C. Fordham Von Reyn, Stephen Hennigan, Sandra Niemczyk, Nicholas J. Jacobs

Dartmouth Scholarship

Concentrations of Mycobacterium avium-M. intracellulare ranging from 10(-1) to 10(3) CFU/ml were added to blood, placed in Isolator tubes, and held at room temperature for intervals ranging from 4 h to 56 days before being processed (centrifugation and culture on Middlebrook 7H10 agar). At all concentrations tested, M. avium-M. intracellulare was recovered after hold times ranging from 4 h to 7 days; the number of final CFU actually increased progressively for hold times of 8 h or more. Hold times of up to 7 days did not increase the time from processing to the first appearance of visible colonies. At …

Mental Health Crisis: A Survey, Roger A. Lohmann, Ellen Neidermeyer

Faculty & Staff Scholarship

This paper is a research report on mobile crisis services and other forms of modern crisis intervention services. It is part of a larger project, termed the North Central West Virginia Crisis Study. This paper reports the results of a survey of mental health crisis incidents reported to a multi-county hotline.

Cytolytic And Ion Channel Forming Properties Of The N-Terminus Of Lymphocyte Perforin, David M. Ojcius, Pedro M. Persechini, Li-Mou Zheng, Paulo C. Notaroberto, Sandro C. Adeodato, John Ding-E. Young

All Dugoni School of Dentistry Faculty Articles

Perforin lyses cells by binding to the target cell membrane, where it polymerizes into large nonspecific pores. It is shown here that the first 34 amino acids of the N-terminal region of either human or murine perforin are soluble in aqueous medium and spontaneously insert into membranes. The N-terminal peptides lyse liposomes and nucleated cells, and they form ion channels in planar bilayers, some of which are comparable to those previously described for perforin. The lytic activity of the N-terminal domains does not require calcium, is independent of the lipid headgroup composition, and can be inhibited by heparin. Tumor cells …

Mapping The Transcriptional Transactivation Function Of Simian Virus 40 Large T Antigen., Jiyue Y. Zhu, Philip W. Rice, Michele Chamberlain, Charles N. Cole

Dartmouth Scholarship

T antigen is able to transactivate gene expression from the simian virus 40 (SV40) late promoter and from several other viral and cellular promoters. Neither the mechanisms of transactivation by T antigen nor the regions of T antigen required for this activity have been determined. To address the latter point, we have measured the ability of a set of SV40 large T antigen mutants to stimulate gene expression in CV-1 monkey kidney cells from the SV40 late promoter and Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter. Transactivation, although reduced, was retained by an N-terminal 138-amino-acid fragment of T …

Fulminant Hepatic Failure With Typhoid Fever In Childhood, Z A. Bhutta

Department of Paediatrics and Child Health

Although hepatic dysfunction has been described among adults with typhoid, there are few reports of significant hepatic functional impairment in children with typhoid. Of 355 children with culture proven typhoid seen at the Aga Khan University Hospital, hepatomegaly was noted in 118 (33%) and isolated right hypochondrial tenderness in 30 (8.5%). The liver function tests were normal in 78% and 47% of these children respectively and significant hepatic dysfunction was seen only in 26 (7.3%). However, children with typhoid and significant hepatic dysfunction had higher mortality (P less than 0.001) and two patients presented with a picture of fulminant hepatic …

Successful Eradication Of Flavobacterium Meningosepticum Neonatal Meningitis With Ceftizoxime, Z A. Bhutta, S H. Naqvi

Department of Paediatrics and Child Health

No abstract provided.

Of Mice But Not Men: Problems Of The Randomized Clinical Trial, Samuel Hellman, Deborah Hellman

Faculty Scholarship

No abstract provided.