Medicine and Health Sciences Commons^™

Appearance Of A Methotrexate Binding Plasma Protein During High Dose Methotrexate Therapy, M P. Iqbal, I Malik, N Mehboobali

Department of Biological & Biomedical Sciences

No abstract provided.

Mechanism Of Calcium Transport Stimulated By Chlorothiazide In Mouse Distal Convoluted Tubule Cells., Frank A. Gesek, Peter A. Friedman

Dartmouth Scholarship

Thiazide diuretics inhibit Na+ and stimulate Ca2+ absorption in renal distal convoluted tubules. Experiments were performed on immortalized mouse distal convoluted tubule (MDCT) cells to determine the mechanism underlying the dissociation of sodium from calcium transport and the stimulation of calcium absorption induced by thiazide diuretics. Control rates of 22Na+ uptake averaged 272 +/- 35 nmol min-1 mg protein-1 and were inhibited 40% by chlorothiazide (CTZ, 10(-4) M). Control rates of 36Cl- uptake averaged 340 +/- 50 nmol min-1 mg protein-1 and were inhibited 50% by CTZ. CTZ stimulated 45Ca2+ uptake by 45% from resting levels of 2.86 +/- 0.26 …

Predicting Alcohol Impairment: Perceived Intoxication Vs. Bac, Beverly S. Mahoney

Faculty Publications and Presentations

The purpose of this study was to report the relationship among perceived intoxication, performance impairment, and actual blood alcohol concentration (BAC) levels. Fifteen subjects, aged 21 to 40, completed both single- and double-dose sessions of alcohol consumption_ BACs, reaction and anticipation time, and perceived intoxication data were collected during both sessions. Analysis of data showed that perceived intoxication was significantly related to performance impairment, but the actual BAC was not.

Effects Of Dextro-Methamphetamine On Subjective Fatigue, C. A. Dejohn, Scott Shappell, D. F. Neri

Publications

Declining aircrew performance during periods of sustained flight operations (SUSOPs) has underscored the need to develop effective countermeasures. This paper reports on the ability of the central nervous system (CNS) stimulant d-methamphetamine to alleviate the detrimental effects of a simulated SUSOPs on subjective fatigue. Subjective fatigue was repeatedly measured by three questionnaires. The simulated SUSOP started at 1800 and consisted of a 9-h planning session followed by 4 h of rest and a 14-h mission. After 6 h of sleep, the 9/4/14 work/rest/work pattern was repeated. At 4 1/2 h into the second mission, 13 subjects were administered 10 mg …

Formation Of A Square-Planar Co(I) B12 Intermediate. Implications For Enzyme Catalysis, Mark R. Chance

Faculty Scholarship

X-ray edge and extended x-ray absorption fine structure (EXAFS) techniques provide powerful tools for analysis of local molecular structure of complexes in solution. We present EXAFS results for Co(I) B12 that demonstrate a four-coordinate (distorted) square-planar configuration. Comparison of EXAFS solutions for Co(I) and Co(II) B12 (collected previously; Sagi et al. 1990. J. Am. Chem. Soc. 112:8639–8644) suggest that modulation of the Co-N bond to the axial 5,6-dimethylbenzimidazole (DMB), in the absence of changes in Co-N (equatorial) bond distances, may be a key mechanism in promoting homolytic versus heterolytic cleavage. As Co-C bond homolysis occurs, the Co-N (DMB) bond becomes …

Mid-Atlantic Ethics Committee Newsletter, Summer 1992

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

The Calendar - July And August 1992, Nova University

The Calendar

No abstract provided.

Six Volleyball Skill Tests As A Predictor Of Game Performance, Donetta J. Cothran

Masters Theses & Specialist Projects

The purpose of this study was to investigate the relationship of six selected volleyball skill tests to actual volleyball game performance. The six skill test items were administered to 64 subjects, who were all members of a college level introductory volleyball course. Based on the ratings of a panel of experts, subjects were rated during game play as good, average, or poor performers.

The stepwise discriminant analysis was used to analyze the relationship between skill tests and game performance. Four of the six skill tests were identified as significantly contributing to group membership. These tests, in order of the magnitude …

Renal Angiomyolipoma: An Uncommon Tumour, Zafar Nazir, Jamsheer J. Talati

Section of Urology

No abstract provided.

Statement On Exercise: Benefits And Recommendations For Physical Activity Programs For All Americans - A Statement For Health Professionals By The Committee On Exercise And Cardiac Rehabilitation Of The Council On Clinical Cardiology, American Heart Association, Gerald F. Fletcher, Steven N. Blair, James Blumenthal, Carl Caspersen, Bernard Chaitman, Stephen Epstein, Harold Falls, Erika S. Sivarajan Froelicher, Victor F. Froelicher, Ileana L. Piña

Faculty Publications

No abstract provided.

Jefferson Alumni Bulletin – Volume Xli, Number 4, Summer 1992

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLI, Number 4, Summer 1992

Malignant bone tumors developing at sites of benign preexisting bone disease, page 13

An experience with a small rural hospital, page 15

The prevention of Turista and the enjoyment of foreign travel, page 16

The Nemours children’s clinic, page 17

The shoulder revisited, page 19

Jeff’s trauma program, page 20

The biochemical basis for diabetic nephropathy, page 21

Dealing with the media, page 23

Space motion sickness, page 24

Total joint replacement, page 25

Decision making and the doctor-patient relationship, 26

New endowed chair, page 30

Inaugural grandon lecture, page …

Competition Law And Anticompetitive Professional Behavior Affecting Health Care, Frances H. Miller

Faculty Scholarship

No abstract provided.

Department Of Radiology-Annual Report-July 1, 1991 To June 30, 1992, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1991 to June 30, 1992. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 72 pages.

Force Systems From T-Loop Orthodontic Space Closure Springs: The Effects Of Asymmetric Placement And Angulation On The Alpha-Beta Moment Differential, Andrew J. Kuhlberg

SoDM Masters Theses

No abstract provided.

National Health Insurance Proposals: An Ethical Perspective, Alan O. Kogan

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society, January 31, 1992.

The Calendar - June 1992, Nova University

The Calendar

No abstract provided.

Oesophageal Carcinoma Caused By Betel Nut, M Y. Sheikh, I H. Rizvi, I Ahmed

Department of Radiology

No abstract provided.

Immune Responses Of Systemic And Mucosal Lymphoid Organs To Pnu-Imune Vaccine As A Function Of Age And The Efficacy Of Monophosphoryl Lipid A As An Adjuvant, Manju Garg, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

A murine model system was established to study immune responses to the Pnu-Imune vaccine, which is made up of 23 different pneumococcal capsular polysaccharides. In this animal model, antibody-forming cell responses to 21 of 23 individual polysaccharides in the vaccine were detected. The Pnu-Imune vaccine elicited good antibody responses from the spleens and mesenteric lymph nodes (MLN) of young mice, whereas a variety of other peripheral lymph nodes were unresponsive. The immunoglobulin M plaque-forming cell (PFC) response in the spleen to the Pnu-Imune vaccine (given intraperitoneally or subcutaneously) decreased dramatically with increasing age. However, the spleen and MLN differed in …

Insulin Receptor And Epidermal Growth Factor Receptor Dephosphorylation By Three Major Rat Liver Protein-Tyrosine Phosphatases Expressed In A Recombinant Bacterial System, Naotake Hashimoto, Wei-Ren Zhang, Barry J. Goldstein

Department of Medicine Faculty Papers

Protein-tyrosine phosphatases (PTPases) play an essential role in the regulation of signal transduction mediated by reversible protein-tyrosine phosphorylation. In order to characterize individual rat hepatic PTPases that might have specificity for autophosphorylated receptor tyrosine kinases, we isolated cDNA segments encoding three PTPases (PTPase 1B, LAR and LRP) that are expressed in insulin-sensitive liver and skeletal muscle tissue, and evaluated their catalytic activity in vitro. The intrinsic PTPase activities of the full-length PTPase 1B protein and the cytoplasmic domains of LAR and LRP were studied by expression of recombinant cDNA constructs in the inducible bacterial vector pKK233-2 using extracts of …

Differentiation Of Renal Beta-Intercalated Cells To Alpha-Intercalated And Principal Cells In Culture., Geza Fejes-Tóth, Aniko Náray-Fejes-Tóth

Dartmouth Scholarship

The renal collecting duct is a heterogenous epithelium consisting of intercalated cells (ICC) and principal cells (PC). The origin of this cellular heterogeneity is not clear. To test the hypothesis that the two cell types might originate from one another, pure populations of ICC (beta subtype) and PC were isolated by fluorescence-activated cell sorting and grown on permeable supports. After the monolayers reached confluence, the expression of ICC- and PC-specific functions and antigens was monitored. Cultures of sorted beta-ICC, in addition to expressing ICC-specific functions (such as an electrogenic H+ secretion) and antigens, progressively acquired PC functions (amiloride-sensitive Na+ transport …

Differential Regulation Of Collagenase Gene Expression By Retinoic Acid Receptors--Alpha, Beta And Gamma, Luying Pan, Stephen H. Chamberlain, David T. Auble, Constance E. Brinckerhoff

Dartmouth Scholarship

The mechanisms involved in retinoic acid (RA)-mediated regulation of the collagenase gene in a rabbit synovial fibroblast cell line (HIG82) were investigated. When HIG82 cells are cotransfected with expression vectors containing cDNAs for retinoic acid receptor (RAR) α1, β2, or γ1 and collagenase promoter-driven CAT reporter constructs, only RAR-γ1 represses basal CAT expression upon RA treatment, while RAR-α1, β2, and γ1 all suppress phorbol-induced CAT expression. Thus, transcriptional regulation of collagenase by RA is mediated by RARs in an RAR-type specific manner. Using mutatlonal and deletional analysis, we find that interaction between elements within 182 bp collagenase promoter plays an …

Alternative Splicing Of Human Prostaglandin G/H Synthase Mrna And Evidence Of Differential Regulation Of The Resulting Transcripts By Transforming Growth Factor Beta 1, Interleukin 1 Beta, And Tumor Necrosis Factor Alpha., Arturo Diaz, Anthony M. Reginato, Sergio A. Jimenez

Department of Medicine Faculty Papers

Prostaglandin G/H synthase (PGG/HS) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and thromboxanes. We screened a human lung fibroblast cDNA library with an ovine PGG/HS cDNA and isolated a 2.3-kilobase clone (HCO-T9). Sequence analysis of this clone showed that (a) it contained the entire translated region of PGG/HS and (b) it displayed an in-frame splicing of the last 111 base pairs encoded by exon 9, which resulted in the elimination of the N-glycosylation site at residue 409. Polymerase chain reaction amplification with specific oligonucleotides of reverse-transcribed mRNA from diverse human tissues and cultured cells yielded …

Formation And The First Fifty Years Of The 6th District Illinois Nurses' Association, Brian T. Gegel '94

History

No abstract provided.

Ua66/14/3 Nursing Pinning Ceremony, Wku Nursing

WKU Administration Documents

Pinning ceremony program listing graduates of the WKU Nursing program.

Ua66/4/2 Ceremony Of Capping & Pinning, Wku Dental Hygiene

WKU Administration Documents

Program from capping & pinning ceremony.

Ua66/14/3 Nursing Pinning Ceremony, Wku Nursing

WKU Administration Documents

Pinning ceremony program listing graduates of the WKU Nursing program.

Randomised Comparison Of Oral Ofloxacin Alone With Combination Of Parenteral Antibiotics In Neutropenic Febrile Patients, I A. Malik, Z Abbas, M Karim

Section of Gastroenterology

Prompt treatment with empirical antibiotics in neutropenic febrile patients reduces morbidity and mortality. Most patients have been treated with parenteral combination antibiotics, but newer antibiotics with broad-spectrum bactericidal activity have made monotherapy feasible. Ofloxacin, a broad-spectrum fluoroquinolone, has the additional advantage that bactericidal concentrations can be achieved with oral administration. We have compared ofloxacin as an oral single agent with standard parenteral combination antibiotics for the management of neutropenic febrile patients in a prospective, randomised trial. Patients with severe neutropenia (absolute neutrophil count less than or equal to 0.5 x 10(9)/l), fever above 38 degrees C, and ability to take …

Information Interface - Volume 16, Issue 2 - May/June 1992, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Assertiveness As A Measure Of Satisfaction In The Physician-Patient Communication Process, Joan Delores Johnson

Masters Theses & Specialist Projects

In recent years medical societies have begun to recognize the effects and benefits of good communication between physician and patient. Like any other relationship, the exchange of information with fluent understanding creates a stronger bond of trust. Most applied research conducted in the area of physician-patient communication concentrates on physician behaviors which the patient views as problematic. This thesis focuses on patient assertiveness and its relationship to physician-patient satisfaction in the consultation process. Specifically, the study focuses on the relationship between patient assertiveness and physician-patient satisfaction.

For the study the researcher developed a patient questionnaire and pre- and post-physician questionnaires …

The Ratio Of Heinz Body Formation In Different Hemoglobin Zurich Subjects, Yenya Hu

Masters Theses & Specialist Projects

Hemoglobin Zurich is a hemoglobin anomaly that results when one amino acid (histidine) is substituted by arginine at position 63 in the beta chain of hemoglobin molecules [β 63 His—Arg]. When Hemoglobin Zurich individuals are exposed to sulfonamide medication, their hemoglobins denature and subsequently form Heinz bodies which attach to the surface of the plasma membrane.

Four Hemoglobin Zurich family members were the subjects of the current study. They included a splenectomized female subject, non-splenectomized female and male subjects, and a non-splenectomized female member without Hemoglobin Zurich as the control. The results collaborate that splenectomy increases the number of erythrocytes …