Medicine and Health Sciences Commons^™

Domestic Violence & Partner Notification: Implications For Treatment And Counseling Of Women With Hiv, Karen H. Rothenberg, Stephen Paskey, Melissa M. Reuland, Sheryl Itkin Zimmerman, Richard L. North

Journal Articles

No abstract provided.

The Risk Of Domestic Violence And Women With Hiv Infection: Implications For Partner Notification, Public Policy, And The Law, Karen H. Rothenberg, Stephen Paskey

Journal Articles

No abstract provided.

A Monoclonal Antibody To The Gp120-Cd4 Complex Has Differential Effects On Hiv-Induced Syncytium Formation And Viral Infectivity, Krystyna Konopka, Elizabeth Pretzer, F. Celada, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

A murine monoclonal antibody (MAb F-91-55) raised against the complex of soluble CD4 and human immunodeficiency virus type 1 (HIV-1) gp120 had previously been found to inhibit syncytium formation without inhibiting the interaction of CD4 with gp120, and its binding site was localized within the first two domains (D1/D2) of CD4. We investigated whether this antibody inhibited the infectivity of HIV-1 in the CD4+ T cell lines A3.01, Sup-T1 and H9. We also examined the effect of the antibody on syncytium formation between these cells and chronically infected H9 cells. Syncytium formation was found to depend critically on the incubation …

Mentorship Experiences In A Group Of Occupational Therapy Leaders., Ruth Levine Schemm, Theodore Bross

Department of Occupational Therapy Faculty Papers

OBJECTIVES: The development of occupational therapy leaders is a long-held goal of many members of the American Occupational Therapy Association and of state associations. The initiation of mentor programs is a common means to accomplish this goal. These programs take time and effort, and, although occupational therapists have described how mentorship programs work in the literature, there are few articles that describe the actual mentorship experiences of occupational therapy leaders.

METHOD: To study the experiences of elected occupational therapy leaders, a 30-item questionnaire was distributed at the annual meeting of the Committee of State Association Presidents and completed by 53 …

Dissociation Of Centrosome Replication Events From Cycles Of Dna Synthesis And Mitotic Division In Hydroxyurea-Arrested Chinese Hamster Ovary Cells, Ron Balczon, Liming Bao, Warren E. Zimmer, Kevin Brown, Raymond P. Zinkowski, B. R. Brinkley

University Faculty and Staff Publications

Relatively little is known about the mechanisms used by somatic cells to regulate the replication of the centrosome complex. Centrosome doubling was studied in CHO cells by electron microscopy and immunofluorescence microscopy using human autoimmune anticentrosome antiserum, and by Northern blotting using the cDNA encoding portion of the centrosome autoantigen pericentriolar material (PCM)-1. Centrosome doubling could be dissociated from cycles of DNA synthesis and mitotic division by arresting cells at the G1/S boundary of the cell cycle using either hydroxyurea or aphidicolin. Immunofluorescence micros-copy using SPJ human autoimmune anticentrosome antiserum demonstrated that arrested cells were able to undergo numerous rounds …

Certain Canine Weakly Β-Hemolytic Intestinal Spirochetes Are Phenotypically And Genotypically Related To Spirochetes Associated With Human And Porcine Intestinal Spirochetosis, Gerald E. Duhamel, Nagaraja Muniappa, Michelle R. Mathiesen, J. L. Johnson, J. Toth, R. O. Elder, A. R. Doster

School of Veterinary and Biomedical Sciences: Faculty Publications

Four canine weakly β-hemolytic intestinal spirochetes associated with intestinal spirochetosis (IS-associated WBHIS) were compared with IS-associated human and porcine WBHIS and the type species for Serpulina hyodysenteriae and S. innocens by using phenotypic and genotypic parameters. The IS-associated canine, human, and porcine WBHIS belonged to a phyletic group distinct from but related to previously described Serpulina type species.

The Role Of Aidose Reductase In Diabetic Retinopathy: Prevention And Intervention Studies, W. Gerald Robinson Jr., Nora M. Laver, Marjorie F. Lou

School of Veterinary and Biomedical Sciences: Faculty Publications

Diabetic retinopathy is the major ocular complication of diabetes, both in terms of incidence and irreversible visual impairment. In spite of modern procedures for strict blood glucose control (DCCT, 1993), laser treatment (ETDRS, 1991f; Aiello, 1994), vitrectomy (Gardner and Blankenship, 1994; Glaser, 1994b), and classical pituitary ablation (Kohner et al., 1976; Speakman et al., 1966; Poulsen, 1953), it is a serious threat to normal vision. It is mainly a vascular disorder, primarily involving microvessels (Garner, 1970). Retinal capillaries undergo multiple, extremely complex structural alterations in response to the unavoidable hyperglycemia of long-term diabetes. Because many of the angiopathies occur on …

Cluster Analysis Of The Coprolites From Antelope House: Implications For Anasazi Diet And Cuisine, Mark Q. Sutton, Karl Reinhard

Karl Reinhard Publications

This paper reports on a cluster analysis of 155 coprolites from Antelope House, a prehistoric Anasazi site in Canyon de Chelly, Arizona. The analysis revealed three primary clusters; whole kernel maize, milled maize, and nonmaize, which we believe to represent seasonal- and preference-related cuisine. Protein residue analysis on a subsample of the specimens added depth to the analysis.

Survey Of Omega-3 Fatty Acids In Diets Of Midwest Low-Income Pregnant Women, Nancy M. Lewis, Anne C. Widga, Janet S. Buck, Andrea M. Frederick

Department of Nutrition and Health Sciences: Faculty Publications

The objectives of this project were to detennine the omega-3 fatty acid (ω-3 FA) consumption of low-income pregnant women, and to identify food sources of ω-3 FA in their diets. Thirty women provided three days of dietary intake that were analyzed using the Food Processor Plus computer program. Mean daily consumption of ω-3 FA was 1.060 ± 0.030 g/day. The major form of the ω-3 FA was α-linolenic acid (α-LNA; 93%), with less from eicosapentanoic acid (EPA; 2%), and docosahexanoic acid (DHA; 5%). Foods that provided the most α-LNA were fats, oils, salad dressings, and milk products. EPA …

Effect Of Alcohol On The Postnatal Development Of Cerebellar Cortex In Rat Ii: Ultrastructural Study, Mansoor Saleh, Saadia Sayed, Entesar Saber

Haematology and Oncology, East Africa

In The present work, it was found that alcohol produced distinct changes in both Purkinje and granule cells during postnatal development. On the fifth day, the apical cones of the Purkinje cells were less developed and the cells showed an occasional somnatic spines but no somatic processes. At 21 days and adult stage these cells including their dendrites showed marked degenerative changes. The nuinber of basket cell axon synapses on Purkinje cell soma was reduced. There was also a reduction in the amount of basket fibers contributing to the pinceau around the intial seginent of the Purkinje cell axons. The …

Substitution Des Solvants En Milieu De Travail : Élaboration D'Un Outil Pour L'Intervention, Michel Gérin, Denis Bégin, Josée Goupil, René Garneau, Steven Sacks

Rapports de recherche scientifique

Les solvants sont parmi les substances toxiques que l'on retrouve le plus fréquemment en milieu de travail. La substitution peut servir à remplacer un solvant toxique ou inflammable par un produit moins dangereux. Elle peut aussi consister en un changement de procédé éliminant l'utilisation de la substance. Ce sont maintenant de plus en plus des considérations environnementales qui motivent la substitution (depletion de la couche d'ozone, smog photochimique). L'objectif de cette étude était de produire un bilan de connaissances sur la substitution des solvants. Une enquête dans le milieu industriel québécois a permis d'identifier les besoins prioritaires de substitution (peinture, …

The Resurgent Tuberculosis Epidemic In The Era Of Aids: Reflections On Public Health, Law, And Society, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

The resurgence of tuberculosis and the rise in drug-resistant cases is neither inexplicable nor unexpected, but rather is the predictable outcome of a complex configuration of biological, social, and behavioral factors that have converged in America over the past decade. This article examines the biological, social, and behavioral causes of the epidemic, and suggests a comprehensive public health strategy for curtailing tuberculosis and other infectious diseases. When thoughtfully conceived, public health strategies can be implemented that are consistent with the limitations that both constitutional law and disability law place on the authority of the state. While traditional concepts of public …

Phase Ii Trial Of Murine Monoclonal Antibody D612 Combined With Recombinant Human Monocyte Colony-Stimulating Factor (Rhm-Csf) In Patients With Metastatic Gastrointestinal Cancer, Mansoor Saleh, Michael Khazaeli, Richard Wheeler, Pat Bucy, Tiepe Liu, Michael Everson, David Mun, Jeff Schlom

Haematology and Oncology, East Africa

In a Phase II study, 14 patients with metastatic gastrointestinal cancer received the mAb D612 (40 mg/m2, days 4, 7, and 11) in combination with recombinant human monocyte colony-stimulating factor [(rhM-CSF) 80 ug/kg/days 1-14]. The combined treatment was well tolerated and resulted in characteristic biological activity associated with each of the agents. Thus, 10 of 14 patients experienced D612-associated secretory diarrhea, which responded to the prostaglandin inhibitor Indomethacin in 5 of 7 patients. rhM-CSF therapy was associated with peripheral mono- cytosis (peak absolute monocyte count, 1444 ±394/mm3) and thrombocytopenia (nadir count, 78 ±10/nim '). Monocyte surface marker analysis revealed a …

Jefferson Alumni Bulletin – Volume Xliv, Number 2, Winter 1994-1995

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIV, Number 2, Winter 1994-1995 College of allied health sciences and medical college collaborate, page 4 Diabetes prevention study, page 6 With outside funding, JeffCARES becomes part of curriculum, page 10 JeffMOMS Teaches freshmen, page 11 Students come by many routes to Jefferson, page 12 West Jersey health system joins Jefferson in healthshare group, page 15 Working on health care reform, page 22 Books, page 14 Bone marrow transplant center established under Flomenberg, page 16 Farber chairs board of trustees, page 16 Spitzer is pediatrics chair, page 17 Neurosensory institute’s unusual surgery saves infant, page …

Cd16+ Monocytes In Patients With Cancer: Spontaneous Elevation And Pharmacologic Induction By Recombinant Human Macrophage Colony- Stimulating Factor, Mansoor Saleh, Goldman Samuel, Lobuglio Albert, Beall Arthur, Sabio Hernan, Mccord Melissa, Minasian Lori, Alpaugh Katherine, Weiner Louis, Munn David

Haematology and Oncology, East Africa

The small subset of circulating monocytes that express the maturation- associated CD16 antigen has recently been reported to be elevated in patients with bacterial sepsis. We now show that this novel CD16+ monocyte population is also spontaneously expanded in patients with cancer. We studied 14 patients with metastatic gastrointestinal carcinoma enrolled in a clinical trial of recombinant human macrophage colony-stimulating factor (rhMCSF) plus monoclonal antibody D612. We found that before any cytokine treatment, 12 of 14 patients constitutively displayed significant elevations in both the percentage and the absolute number of CD16+ monocytes, as compared with both normal subjects and ill …

In Vitro Effects Of Two Silver Electrodes On Select Wound Pathogens, Linda Jean Laatsch-Lybeck, Poh Chye Ong, Luther C. Kloth

Physical Therapy Faculty Research and Publications

The use of electrical current to promote wound healing is well documented. However, little is understood about the effects of micro-amperage direct current (μADC) on growth of wound pathogens. The purpose of this project was to investigate the antibacterial effects of a silver wire/silver nylon electrode carrying μADC in vitro on several Gram positive and Gram negative bacteria. The current was delivered via silver wire and silver nylon electrodes at an amplitude of 100 μA for a 30-minute duration in an in vitro system. Results demonstrated that only silver wire carrying current inhibited bacterial growth around …

Student Evaluations Of Teaching Effectiveness: The Interpretation Of Observational Data And The Principle Of Faute De Mieux, B. Burt Gerstman

Faculty Publications

Student opinion surveys are important but widely misunderstood tools for evaluating teaching effectiveness. In this brief review, an analogy is drawn between the use and interpretation of observational data for public health and biomedical research and the use of student opinion data in evaluating teach ing effectiveness. Sources of systematic error in the form of selection bias, information bias, and confounding are defined and illustrated. Original data concerning intermittent "quid pro quo" confounding (i.e., the effect of expected grades on student evaluations of teaching) are presented. Finally, the principle of faute de mieux ("lack of anything better") and the interpretation …

Changes In Malaria Associated Morbidity In Children Using Insecticide Treated Mosquito Nets In The Bagamoyo District Of Coastal Tanzania, Zul Premji, P. Lubega, Y. Hamisi, E. Mchopa, J. Minjus, W. Checkley, C. Shiff

Pathology, East Africa

A community based malaria control intervention using insecticide treated mosquito nets (IMN) has been implemented and tested in 13 villages of the Yombo Division, Bagamoyo District in the Coastal Region, Tanzania, an area holoendemic for P. falciparum malaria. Following extensive sociological research into local perceptions of malaria, the programme was implemented. It was decided by consensus that village mosquito net committees would be the appropriate local level implementers. These were formed and provided with IMN's which were sold to villagers at subsidised cost. The income was invested for use by the committees for sustaining the activity. Use patterns were determined …

The Importance Of Religion For Parents Coping With A Chronically Ill Child, Carolyn M. Rutledge, Jeffrey S. Levin, David B. Larson, John S. Lyons

Ellmer School of Nursing Faculty Publications

This study examines differences in the stability and consequences of religious coping among parents (N = 102) of chronically ill children. Analyses revealed that changes in religious patterns due to a child's illness were reflected in changes in other, non-religious coping resources. Specifically, parents whose pre-illness religious patterns were satisfactory did not alter their use of other coping resources, whereas parents who reported changes in their religious patterns also made changes in their use of familial financial and social support systems.

Case Of Pelvic Relapse In A Child Suffering From Acute Lymphoblastic Leukemia, Karim Qamruddin, Sheema Hasan, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

We describe here a case of an eight years old child suffering from acute lymphoblastic leukemia. She developed pelvic infiltration of leukemic cells while in bone marrow remission and receiving maintenance chemotherapy: She also developed leukemic infiltration of Central Nervous System and died of complications resulting from massive pelvic relapse. With greater number of children in bone marrow and CNS remission, the issue ofpossible greater predisposition to extramedullary relapse has been discussed. The need for greater vigilance towards pelvic surveillance has been stressed.

Hiv-I Infection In A Family Blood Donor, S A Mujeeb, Naila Kayani, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

No abstract provided.

Life, Death And Public Policy, Larry I. Palmer

Faculty Publications

No abstract provided.

Pneumonia Caused By Nocardia Caviae In A Healthy Neonate, Perween Mufti, Bushra Jamil

Department of Medicine

Nocardia infections have been associated with patients of Aids, chronic granulomatous disease, recipient of organ transplant and malignancy Pulmonary nocardiosis in neo­nates is an unusual infection. A case of neonatal pulmonary nocardiosis mimicking miliaiy tuberculosis has been reported in the past. We report another case of pulmonary nocardiosis in a neonate presenting as consolidation with pleural effusion and cavitation.

Severe Thrombocytopenia In A Man With Prostatic Cancer, Saeed Hamid, Ata Khan, Haleem Khan, Roger Sutton, Ikram A. Burney, Mohammad Khurshid

Department of Medicine

A 66 year old gentleman was diagnosed to have metastatic adenocarcinoma of the prostate in 1990, following a CT scan of the abdomen and trans-uretheral resection of prostate (TLJRP). He was started on estrogen therapy (Fos­festerol sodium). Two years later he presented to the emer­gency room with breathlessness and edema of the left ann of a week’s duration. He admitted to persistence of symptoms of pmstatism and was found to have bilateral axillary lymphade­nopathy and pitting edema of the left arm. A doppler scan revealed left subclavian vein thrombosis. The patient was started on i.v. heparin and was maintained on …

Randomized Trial Of Erythromycin And Azithromycin For Treatment Of Chlamydial Infection In Pregnancy., M F Rosenn, G A Macones, N S Silverman

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: The purpose of this study was to compare erythromycin and azithromycin in the treatment of chlamydial cervicitis during pregnancy with regard to efficacy, side effects, and compliance.

METHODS: In a prospective manner, 48 pregnant patients with cervical chlamydial infections diagnosed by routine screening tests were randomly assigned to receive either erythromycin, 500 mg q.i.d. for 7 days (N = 24), or azithromycin, 1 g as a one-time dose (N = 24). All sexual partners were given prescriptions for doxycycline, 100 mg b.i.d. for 7 days. The treatment efficacy was assessed by follow-up chlamydia testing 3 weeks after the therapy …

Phonatory And Articulatory Changes Associated With Increased Vocal Intensity In Parkinson Disease: A Case Study, Christopher Dromey, Lorraine Olson Ramig, Antonia B. Johnson

Faculty Publications

This study examined changes in voice and speech production in a patient with Parkinson disease as he increased vocal intensity following 1 month of intensive voice treatment. Phonatory function and articulatory acoustic measures were made before and after treatment as well as 6 and 12 months later. Pre- to post-treatment increases were documented in sound pressure level in sustained phonation, syllable repetition, reading, and monologue. Consistent with mechanisms of intensity change reported in normal speakers, corresponding improvements were measured in estimated subglottal pressure, maximum flow declination rate, laryngeal airway resistance, open quotient, EGGW-25, harmonic-spectral slope, and maximum vowel duration. Measures …

The Immune System, Betty Bierut Gallucci, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Modern biotherapy has been in use for some 30 years. The first types of biotherapy were nonspecific stimulators of the immune response, but advances in genetic engineering are allowing the mass production of pure biological products which are now being tested as pharmaceutical agents. Biotherapy connotes the administration of products (1) that are coded by the mammalian genome; (2) that modify the expression of mammalian genes; or (3) that stimulate the immune system. In this chapter the discussion of the immune system will be limited primarily to topics relevant to cancer or autoimmune diseases. Because understanding the new biological agents …

Synergistic Effects Of Traumatic Head Injury And Apolipoprotein 4 In Patients With Alzheimer’S Disease, R. Mayeux, R. Ottman, Gladys E. Maestre, C. Ngai, M.-X. Tang, H. Ginsberg, M. Chun, B. Tycko, M. Shelanski

School of Medicine Publications

The apolipoprotein 4 allele increases the risk of Alzheimer’s disease (AD), but cerebral deposition of B-amyloid with age, a genetic mutation, or head injury may contribute to the pathogenesis of this disease. We examined the risks of AD associated with traumatic head injury and apolipoprotein 4 in 236 community-dwelling elderly persons. A 10-fold increase in the risk of AD was associated with both apolipoprotein 4a nd a history of traumatic head injury, compared with a two-fold increase in risk with apolipoprotein 4 alone. Head injury in the absence of an apolipoprotein 4 allele did not increase risk. These data imply …

Retiree Dies After Tractor Overturns Into Creek, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 58-year-old retired factory worker and part-time farmer was killed when the tractor he was operating overturned into a creek and pinned him. At the time of the incident, the victim was mowing a pasture along a creek bed. The tractor was not equipped with a Roll Over Protective Structure (ROPS) or a seat belt. Attached to the tractor was a five foot bush hog. About 3:00 pm the day of the incident, the victim began mowing a 30 acre bottom land pasture by entering a gate at the east of the pasture. The victim drove in a westward direction …

Ua66/14/3 Nursing Pinning Ceremony, Wku Nursing

WKU Administration Documents

Pinning ceremony program listing graduates of the WKU Nursing program.