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Articles 153331 - 153360 of 159953
Full-Text Articles in Medicine and Health Sciences
Ua61/1 Wku Nursing Class 1995, Wku Nursing
Ua61/1 Wku Nursing Class 1995, Wku Nursing
WKU Administration Documents
Members of the 1995 nursing class: Arika Atkerson, David Banahan, Michelle Barnard, Dawn Barton, Robey Blankenship, Beth Branstetter, Vicki Bryson, Amy Buckingham, Virginia Campbell, Carolyn Clemons, Nicole Coker, Brenda Crouch, Martina Crump, Lucena Davis, Erica Day, Jennifer Dickens, Julie Fentress, Dana Garrett, Meshel Goodman, Deborah Gravil, Tara Greenwell, Karyn Hahn, Amy Hampton, Karen Hanner, Deanna Hanson, Patricia Henderson, Jane Holkamp, Chritina Holthaus, Miranda Howard, Nina Hurt, Elizabeth Hyde, James Jenkins, Carol Johnson, Leigh Johnson, Reta Jolly, Ellen Kidder, Robert Ladd, Leigh Lindsey, Amanda Logue, Mark Massa, Tina McClanahan, Christiane McComble, Dixie Midkiff, Jennie Moich, Sandra Mosler, Patrick Moss, Ahsley Napier, …
An Overview Of The Effectiveness And Efficiency Of Hiv Prevention Programs, D. R. Holtgrave, Noreen L. Qualls, J. W. Curran, Ronald O. Valdiserri, Mary Guinan, William C. Parra
An Overview Of The Effectiveness And Efficiency Of Hiv Prevention Programs, D. R. Holtgrave, Noreen L. Qualls, J. W. Curran, Ronald O. Valdiserri, Mary Guinan, William C. Parra
School of Public Health Faculty Research
Because of the enormity of the HIV-AIDS epidemic and the urgency for preventing transmission, HIV prevention programs are a high priority for careful and timely evaluations. Information on program effectiveness and efficiency is needed for decision-making about future HIV prevention priorities. General characteristics of successful HIV prevention programs, programs empirically evaluated and found to change (or not change) high-risk behaviors or in need of further empirical study, and economic evaluations of certain programs are described and summarized with attention limited to programs that have a behavioral basis. HIV prevention programs have an impact on averting or reducing risk behaviors, particularly …
The Three Rs: The Way Forward, Michael Balls, Alan M. Goldberg, Julia H. Fentem, Caren L. Broadhead, Rex L. Burch, Michael F.W. Festing, John M. Frazier, Coenraad F.M. Hendriksen, Margaret Jennings, Margot D.O. Van Der Kamp, David B. Morton, Andrew N. Rowan, Claire Russell, William M.S. Russell, Horst Spielmann, Martin Stephens, William S. Stokes, Donald W. Straughan, James D. Yager, Joanne Zurlo, Bert F.M. Van Zutphen
The Three Rs: The Way Forward, Michael Balls, Alan M. Goldberg, Julia H. Fentem, Caren L. Broadhead, Rex L. Burch, Michael F.W. Festing, John M. Frazier, Coenraad F.M. Hendriksen, Margaret Jennings, Margot D.O. Van Der Kamp, David B. Morton, Andrew N. Rowan, Claire Russell, William M.S. Russell, Horst Spielmann, Martin Stephens, William S. Stokes, Donald W. Straughan, James D. Yager, Joanne Zurlo, Bert F.M. Van Zutphen
Experimentation Collection
This is the report of the eleventh of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM), which was established in 1991 by the European Commission. ECVAM's main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of laboratory animals. One of the first priorities set by ECVAM was the implementation of procedures which would enable it to become well-informed about the state-of-the-art of non-animal test …
How The Rat Turned White, Kenneth J. Shapiro
How The Rat Turned White, Kenneth J. Shapiro
Experimentation Collection
This is the first in a three-part series on the use of animals in psychological research. In it, I describe how animals got into laboratories in the first place, and their purpose and life there. In the second, I will describe animal model research, the strategy whereby psychologists' develop nonhuman animal models to study human psychopathology. In the concluding piece, I will present a critique of this enterprise, using original data I gathered. The three articles are based on a forthcoming book, Animal Models of Human Psychology: Science, Ethics, and Policy.
Computerized Patient Records And Np Practice., Polly A. Hulme
Computerized Patient Records And Np Practice., Polly A. Hulme
College of Nursing Faculty Publications
Computer-based patient records (CPRs) are becoming increasingly common in ambulatory settings. The advantages of computer-based patient records over paper records are multiple: they save space and time, help health care providers improve patient care, and provide clinical and managerial information quickly. Currently, however, this software is based on the medical model. The software for computer-based patient records was developed about 25 years ago in academic health care settings, but was never disseminated extensively into other types of ambulatory settings. Now, however, with the advent of more powerful personal computers (PCs), this innovation is commercially available for smaller ambulatory practices.
Sex And Temperament In Modern Society: A Darwinian View Of The “Glass Ceiling” And The “Gender Gap” In Compensation, Kingsley R. Browne
Sex And Temperament In Modern Society: A Darwinian View Of The “Glass Ceiling” And The “Gender Gap” In Compensation, Kingsley R. Browne
Law Faculty Research Publications
No abstract provided.
A National Survey Of The Arrangements Managed-Care Plans Make With Physicians, Marsha R. Gold , Sc.D., Robert Hurley , Ph.D., Timothy Lake , M.P.P., Todd Ensor, Robert Berenson , M.D.
A National Survey Of The Arrangements Managed-Care Plans Make With Physicians, Marsha R. Gold , Sc.D., Robert Hurley , Ph.D., Timothy Lake , M.P.P., Todd Ensor, Robert Berenson , M.D.
Health Administration Publications
Abstract
Background. Despite the growth of managed care in the United States, there is little information about the arrangements managed-care plans make with physicians.
Methods. In 1994 we surveyed by telephone 138 managed-care plans that were selected from 20 metropolitan areas nationwide. Of the 108 plans that responded, 29 were group-model or staff-model health maintenance organizations (HMOs), 50 were network or independentpractice–association (IPA) HMOs, and 29 were preferred-provider organizations (PPOs).
Results. Respondents from all three types of plan said they emphasized careful selection of physicians, although the group or staff HMOs tended to have more demanding requirements, …
Infections Associated With Bartonella Species In Persons Infected With Human Immunodeficiency Virus, Russell L. Regnery, James E. Childs, Jane E. Koehler
Infections Associated With Bartonella Species In Persons Infected With Human Immunodeficiency Virus, Russell L. Regnery, James E. Childs, Jane E. Koehler
Zoonotics and Wildlife Disease: Publications
Two members of the genus Bartonella, Bartonella quintana (formerly Rochalimaea quintana) and Bartonella henselae (formerly Rochalimaea henselae), have recently been recognized as agents of severe or fatal disease in patients infected with human immunodeficiencyv irus (HIV). The development of infection with B. henselae in HIV-infected individuals has been associated with traumatic contact with cats (scratches or bites), and domestic cats have been identified as a major reservoir for this organism. Specific information regarding the transmission of B. henselae to humans is not yet available, but common-sense precautions that minimize exposure to cat-associated organisms are appropriate. Preliminary accounts suggest that …
Rabies--Epidemiology, Prevention, And Future Research, John W. Krebs, Mark L. Wilson, James E. Childs
Rabies--Epidemiology, Prevention, And Future Research, John W. Krebs, Mark L. Wilson, James E. Childs
Zoonotics and Wildlife Disease: Publications
Rabies is caused by a single-stranded, negative-sense RNA virus, maintained in nature by a variety of animal reservoirs. Rabies virus infects the central nervous system, resulting in progressive encephalopathy and ultimately death in an infected human. Globally, the risk of contracting rabies for humans is greatest in regions of the developing world where dog rabies is enzootic. Where rabies in dogs has been eliminated or otherwise controlled through vaccination programs, the disease can be maintained by wildlife. Wildlife primarily involved in maintenance of transmission cycles are carnivores and bats. Persons having frequent contact with wildlife, such as mammalogists, are at …
Rodent-Borne Hemorrhagic Fever Viruses: A Special Risk For Mammalogists?, James E. Childs, James N. Mills, Gregory E. Glass
Rodent-Borne Hemorrhagic Fever Viruses: A Special Risk For Mammalogists?, James E. Childs, James N. Mills, Gregory E. Glass
Zoonotics and Wildlife Disease: Publications
We review two groups of taxonomically unrelated viruses that share similarities in host preference and transmission routes to humans and pose a risk for mammalogists working with rodents. The rodent-borne hemorrhagic fever viruses in the Arenaviridae and Bunyaviridae are widely distributed on most continents where rodents occur. Their geographic distribution usually exceeds the distribution of the recognized human diseases they cause and has resulted from either natural coevolutionary events or the dissemination of viral passengers traveling with introduced mammalian hosts. Diseases of humans caused by these agents are among the most severe and most frequently fatal of zoonotic diseases. These …
Site-Directed Mutagenesis Of Southern Bean Mosaic Virus (Cowpea Strain): In Search Of A Viral Protease, Alan Simmons
Site-Directed Mutagenesis Of Southern Bean Mosaic Virus (Cowpea Strain): In Search Of A Viral Protease, Alan Simmons
Masters Theses & Specialist Projects
The second and largest open reading frame within the southern bean mosaic virus (SBMV) genome encodes a 105 kDa polyprotein. Following translation, the polyprotein is cleaved to liberate various proteins necessary for SBMV replication. The elements within polyproteins of the picornavirus superfamily members have a conserved order: Vpg (viral protein, genome-linked)-protease-replicase. Amino acid sequence homologies indicate that the 105 kDa protein of SBMV contains a replicase very similar to those identified in polyproteins of the picorna-like viruses. The presence of a VPg covalently attached to the 5' end of the SBMV genome further suggests that SBMV may be considered a …
Ua66/4 Scrapbook, Class Of 1995
Ua66/4 Scrapbook, Class Of 1995
Student Organizations
Scrapbook created by the Dental Hygiene class of 1995.
Michigan's Deadlocked Commission On Death And Dying: A Lesson In Politics And Legalism, Joseph Ellin
Michigan's Deadlocked Commission On Death And Dying: A Lesson In Politics And Legalism, Joseph Ellin
Center for the Study of Ethics in Society Papers
Based on a presentation made to the WMU Center for the Study of Ethics in Society - September 21, 1994.
Ua60/5 Wku Dental Hygiene Class Of 1995, Wku Dental Hygiene
Ua60/5 Wku Dental Hygiene Class Of 1995, Wku Dental Hygiene
WKU Administration Documents
Members of the 1995 dental hygiene class: Leslie Abel, Airin Augsburg, Mari Byers, Laura Espy, Melinda Hamilton, Kristi Sanders, Judith Spidel, Lisa Logsdon, Jodi McCluskey, Angie Strode, Alice Mitchell, Gayle Mullins, Sonya Prater, Kimberly Tennison, Amy Thompson, Christy Vernon, Mary Walden, Carrie Reels, Marcia Ford, Angela Chase, Valerie Burrer, Angela Brown, Laura Blanton and Rachel Aulridge.
Methodological Issues In Occupational-Stress Research: Research In One Occupational Group And Its Wider Applications, Irvin Sam Schonfeld, Jaesoon Rhee, Fang Xia
Methodological Issues In Occupational-Stress Research: Research In One Occupational Group And Its Wider Applications, Irvin Sam Schonfeld, Jaesoon Rhee, Fang Xia
Publications and Research
The chapter addresses a number of important methodologic issues that are relevant to occupational-stress researchers. The issues addressed have arisen in the context of an ongoing research program involving cross-sectional and longitudinal studies of stress in teachers; the issues, however, apply to occupational research in general. The first issue involves measurement strategies required in operationalizing the stress process. The focal concern is the reduction of confounding in measures of the work environment. The second issue encompasses the question of whether to sample new or veteran workers. The third issue applies to types of job stressors. The chapter describes a …
Double Relative Deprivation: Combining The Personal And Political, Mindi D. Foster, Kimberley Matheson
Double Relative Deprivation: Combining The Personal And Political, Mindi D. Foster, Kimberley Matheson
Psychology Faculty Publications
Double relative deprivation, which has been virtually ignored in research on relative deprivation, was expected to predict women's collective action over and above egoistic and collective deprivation. The role of socio-political resources in perceiving deprivation and participation in action was also investigated. Female students (N=164) completed a questionnaire designed to assess their perceptions of egoistic, collective, double relative deprivation (defined as the interaction between egoistic and collective deprivation), resource availability and participation in collective action. Hierarchical regression analyses indicated that double relative deprivation predicted collective action over and above egoistic and collective relative deprivation, and that resource availability also uniquely …
Alcohol Prevention Programs, Laura Becker
Alcohol Prevention Programs, Laura Becker
Graduate Research Papers
Alcohol consumption is a problem on almost every college campus. The problem not only affects the drinkers, but also the roommates who have to put up with the behavior, the faculty who try to teach these students, and the support services staff who does what it can to reduce the behavior, or at least its negative effects
Because of the problem of drinking, many programs have been developed to try to get students to drink responsibly or to refrain from drinking. Despite these programs, the amount of drinkers on college campuses remains astoundingly high. What types of programs really do …
Pesticide Safety: A Photonovel, M. Susan Jones, The Kentucky Partnership For Farm Family Health & Safety
Pesticide Safety: A Photonovel, M. Susan Jones, The Kentucky Partnership For Farm Family Health & Safety
Nursing Faculty Publications
No abstract provided.
A Case-Control Study Of Hantavirus Pulmonary Syndrome During An Outbreak In The Southwestern United States, Paul S. Zeitz, Jay C. Butler, James E. Cheek, Michael C. Samuel, James E. Childs, Lee A. Shands, Richard E. Turner, Ronald E. Voorhees, John Sarisky, Pierre E. Rollin, Thomas G. Ksiazek, Louisa Chapman, Susan E. Reef, Kenneth K. Komatsu, Craig Dalton, John W. W. Krebs, Gary O. Maupin, Kenneth Gage, C. Mack Sewell, Robert F. Breiman, C. J. Peters
A Case-Control Study Of Hantavirus Pulmonary Syndrome During An Outbreak In The Southwestern United States, Paul S. Zeitz, Jay C. Butler, James E. Cheek, Michael C. Samuel, James E. Childs, Lee A. Shands, Richard E. Turner, Ronald E. Voorhees, John Sarisky, Pierre E. Rollin, Thomas G. Ksiazek, Louisa Chapman, Susan E. Reef, Kenneth K. Komatsu, Craig Dalton, John W. W. Krebs, Gary O. Maupin, Kenneth Gage, C. Mack Sewell, Robert F. Breiman, C. J. Peters
Zoonotics and Wildlife Disease: Publications
In May 1993, an outbreak of hantavirus pulmonary syndrome( HPS) occurred in the south-western United States. A case-control study determined risk factors for HPS. Seventeen case-patients were compared with 3 groups of controls: members of case-patient households( household controls), members of neighboring households( near controls), and members of randomly selected households ≥ 24 km away ( far controls). Investigators trapped more small rodents at case households than at near ( P = .03) or far control households( P = .02). After the number of small rodents was controlled for,case-patients were more likely than household controls to hand plow (odds ratio …
Guidelines For Working With Rodents Potentially Infected With Hantavirus, James N. Mills, Terry L. Yates, James E. Childs, Robert R. Parmenter, Thomas G. Ksiazek, Pierre E. Rollin, C.J. Peters
Guidelines For Working With Rodents Potentially Infected With Hantavirus, James N. Mills, Terry L. Yates, James E. Childs, Robert R. Parmenter, Thomas G. Ksiazek, Pierre E. Rollin, C.J. Peters
Zoonotics and Wildlife Disease: Publications
Because of the high morbidity and mortality associated with hantavirus pulmonary syndrome and the possibility of aerosol transmission of hantaviruses, persons handling known reservoir species in the field, laboratory, or classroom should take special precautions to minimize the risk of infection. We provide specific guidelines for personal safety while trapping, handling and releasing, transporting, sampling, and performing necropsy on potentially infected rodents or teaching field classes in areas occupied by reservoir species. Special consideration should be given to respiratory protection, choice and use of disinfectants, decontamination of instruments and traps, proper disposal of infectious wastes, and preservation and shipment of …
Visual Distinctiveness Can Enhance Recency Effects, Brian H. Bornstein, Craig B. Neely, Denny C. Lecompte
Visual Distinctiveness Can Enhance Recency Effects, Brian H. Bornstein, Craig B. Neely, Denny C. Lecompte
Department of Psychology: Faculty Publications
Experimental efforts to meliorate the modality effect have included attempts to make the visual stimulus more distinctive. McDowd and Madigan (1991) failed to find an enhanced recency effect in serial recall when the last item was made more distinct in terms of its color. In an attempt to extend this finding, three experiments were conducted in which visual distinctiveness was manipulated in a different manner, by combining the dimensions of physical size and coloration (i.e., whether the stimuli were solid or outlined in relief). Contrary to previous findings, recency was enhanced when the size and coloration of the last item …
Synapse, Alabama Health Libraries Association
Synapse, Alabama Health Libraries Association
Synapse - Newsletter of ALHeLa
This is the Fall, 1995 edition of the ALHeLa newsletter - Synapse.
Contents include:
- President's Notes - Tamara Lee
- Alabama Health Libraries association annual business meeting minutes - September 8, 1995
- Nominating Committee
- Alabama hospital libraries and the internet
- Expanded library services focus of new director of USA biomedical library
- T. Scott Plutchak, New director at UAB, Lister Hill Library
- Annual Report - 1995 Judy Burnham, Past president
- In and Out of the Comfort Zone: Medical libraries in transition
- Consumer Health Corner
- Patient education resources
- NN/LM SE/A region news
- Medical library association EBSCO/MLA annual meeting grant
Isolation And Characterization Of A B-D-Glucuronidase-Producing Strain Of Escherichia Coli Serotype O157:H7 In The United States, Peggy S. Hayes, Kristina Blom, Peter Feng, Jay Lewis, Nancy A. Strockbine, Bala Swaminathan
Isolation And Characterization Of A B-D-Glucuronidase-Producing Strain Of Escherichia Coli Serotype O157:H7 In The United States, Peggy S. Hayes, Kristina Blom, Peter Feng, Jay Lewis, Nancy A. Strockbine, Bala Swaminathan
United States Public Health Resources
A phenotypic variant of Escherichia coli serotype O157:H7 (G5101) was isolated from a patient with bloody diarrhea. Strain G5101 does not ferment sorbitol but is β-D-glucuronidase and urease positive. Serotyping and colony hybridization using a serotype-specific DNA probe confirmed that the isolate was O157:H7. G5101 produces Shiga-like toxins I and II and contains an eae gene that is highly conserved in the O157:H7 serotype. This strain would have been missed by laboratories that screen for the sorbitol-negative, β-D-glucuronidase- negative phenotype in isolating E. coli O157:H7 from clinical and food specimens.
Genetic Polymorphism Of The Ipah Multicopy Antigen Gene In Shigella Spps. And Enteroinvasive Escherichia Coli, Jerry M. Buysse, Antoinette B. Hartman, Nancy Strockbine, Malabi Venkatesan
Genetic Polymorphism Of The Ipah Multicopy Antigen Gene In Shigella Spps. And Enteroinvasive Escherichia Coli, Jerry M. Buysse, Antoinette B. Hartman, Nancy Strockbine, Malabi Venkatesan
United States Public Health Resources
The ipaH loci comprise a multicopy antigen gene family unique to Shigella species and enteroinvasive Escherichia coli (EIEC). DNA probes derived from the Shigella flexneri stereotype 5 ipaH7.8 gene were used to compare the molecular arrangement of ipaH alleles in a variety of Shigella and EIEC strains. Multiple copies of ipaH-homologous sequences were detected in all invasion plasmids examined. Oligonucleotide probes covering discrete 24 bp segments of the ipaH7.8 gene and sequences flanking the ipaH4.5 (probe H25) and ipaH2.5 (probe H24) loci were used to define the extent of homology among invasion plasmid copies of …
Fulminant Hepatic Failure: Summary Of A Workshop, Jay Hoofnagle, Robert Carithers Jr., Craig Shapiro, Nancy Ascher
Fulminant Hepatic Failure: Summary Of A Workshop, Jay Hoofnagle, Robert Carithers Jr., Craig Shapiro, Nancy Ascher
United States Public Health Resources
Fulminant hepatic failure (FHF) is defined by the appearance of severe liver injury with hepatic encephalopathy in a previously healthy person. There are an estimated 2,000 cases of FHF in the United States yearly, representing 0.1% of all deaths and, perhaps, 6% of liver related deaths. The causes of FHF are many, the chief ones in the United States being hepatitis A; B; non-A, non-B and drug induced liver disease. There are no specific therapies for FHF, however, liver transplantation is recommended for situations in which spontaneous recovery appears unlikely. Factors that are valuable in assessing the likelihood of spontaneous …
Bovine Tuberculosis In A Free-Ranging Mule Deer (Odocoileus Hemionus) From Montana, Jack Rhyan, Keith Aune, Brian Hood, Ryan Clarke, Janet Payeur, Jerald Jamagin, Larry Stackhouse
Bovine Tuberculosis In A Free-Ranging Mule Deer (Odocoileus Hemionus) From Montana, Jack Rhyan, Keith Aune, Brian Hood, Ryan Clarke, Janet Payeur, Jerald Jamagin, Larry Stackhouse
Michigan Bovine Tuberculosis Bibliography and Database
A survey of 41 mule deer (Odocolleus hemionus) and three white-tailed deer (O. virginianus) for bovine tuberculosis was conducted on a Montana (USA) cattle ranch from 2 November 1993 through January 1994. Gross and microscopic lesions typical of tuberculosis were present in tonsil and lymph nodes of the head, thorax, and abdomen of one adult female mule deer. Additionally, a single microgranuloma considered morphologically suggestive of tuberculosis was present in one lymph node of the head of a second mule deer. Mycobacterial isolates from lymph nodes of the head and thorax of the first deer were …
Genetic Variants Of Serum Alpha 1 Antitrypsin, Anjum Shahid, Anwar Ali Siddiqui, Mohammed Anwar Waqar, Sarwar J. Zuberi
Genetic Variants Of Serum Alpha 1 Antitrypsin, Anjum Shahid, Anwar Ali Siddiqui, Mohammed Anwar Waqar, Sarwar J. Zuberi
Department of Biological & Biomedical Sciences
Complete absence of data on alpha 1 antitrypsin in this country prompted us to determine serum levels using radial immunodiffusion (RID) and phenotypes by isoelectric focusing (IEF) in 100 healthy adults (52 males and 48 females). Mean serum alpha 1 antitrypsin concentration in healthy subjects was 2.47±0.08 g/l and the main phenotypes MM (70%), M1 M2 (28%) and FM 3(2%) are infrequent in our population (JPMA 45:245,1995).
Community-Based Aids Prevention And Care In Africa—Dissemination Of Phase I Findings: Report Of Five National Workshops, Population Council
Community-Based Aids Prevention And Care In Africa—Dissemination Of Phase I Findings: Report Of Five National Workshops, Population Council
HIV and AIDS
Given the constraints faced by the health care infrastructure in responding to the AIDS crisis in sub-Saharan Africa, and the limitations of traditional educational approaches in motivating people to modify their sexual behavior within the African context, community-based efforts at AIDS prevention, and care of those affected, are the first lines of defense against the disease. Thus, they deserve greater scrutiny, to learn from the experiences and to continue and expand their efforts. The “Community-Based AIDS Prevention and Care in Africa: Building on Local Initiatives” project is being carried out by the Population Council with support from Glaxo Wellcome. The …
Restructuring The Principle Of Medical Futility, George P. Smith Ii
Restructuring The Principle Of Medical Futility, George P. Smith Ii
Scholarly Articles
This essay surveys the need for a clear and objective definition of medical futility. It is urged that once agreement is obtained for structuring operational guidelines for determining futility, a three-tier decisional structure can be developed for testing whether a given treatment falls within the scope of these guidelines.
Under the first tier, the treating physician would be given the primary responsibility for the making the determination to withhold treatment on the grounds of futility. While the physician would be under a duty not to prescribe treatment deemed futile, he would be obliged to inform the patient and his family …
Therapy Of Mycobacterium Avium Complex Infections In Beige Mice With Streptomycin Encapsulated In Sterically Stabilized Liposomes, Pattisapu R.J. Gangadharam, D. R. Ashtekar, Diana L. Flasher, Nejat Düzgüneş
Therapy Of Mycobacterium Avium Complex Infections In Beige Mice With Streptomycin Encapsulated In Sterically Stabilized Liposomes, Pattisapu R.J. Gangadharam, D. R. Ashtekar, Diana L. Flasher, Nejat Düzgüneş
All Dugoni School of Dentistry Faculty Articles
Mycobacterium avium complex (MAC) causes serious opportunistic infections in AIDS patients. Previous studies with MAC-infected beige mice have indicated that weekly administration of liposome-encapsulated streptomycin can reduce significantly the CFU in the liver and spleen. We examined whether streptomycin encapsulated in recently developed sterically stabilized liposomes with prolonged circulation times would have a therapeutic effect in this animal model. Two liposome types with prolonged circulation (polyethyleneglycol-distearoylphosphatidylethanolamine [PEG-DSPE]- distearoylphosphatidylcholine [DSPC]-cholesterol [chol] or phosphatidylinositol [PI]-DSPC-chol) and conventional liposomes (phosphatidylglycerol [PG]-phosphatidylcholine [PC]-chol) encapsulating streptomycin and administered twice weekly were bactericidal to MAC strain 101 in the spleen when the level of infection after …