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Jefferson Alumni Bulletin – Volume Xlv, Number 4, September 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 4, September 1996

Commencement Addresses, Page 4

Clinic Presentations, Page 8

Annual Giving, Page 27

Bookstore, Page 54

Efficient Vasoactive Intestinal Polypeptide Hydrolyzing Autoantibody Light Chains Selected By Phage Display, Sonia Tyutyulkova, Qing-Sheng Gao, Austin Thompson, Stephen I. Rennard, Sudhir Paul

Journal Articles: Pulmonary & Critical Care Med

An immunoglobulin light chain (L chain) library derived from the peripheral blood lymphocytes of a patient with asthma was cloned into a phagemid vector. Phage particles displaying L chains capable of binding vasoactive intestinal polypeptide (VIP) were isolated by affinity chromatography. Two VIP binding L chains were expressed in Escherichia coli in soluble form and purified to electrophoretic homogeneity by metal chelating and protein L affinity chromatography. Both L chains catalyzed the hydrolysis of [tyr10-125I]VIP substrate. The catalytic activity eluted at the molecular mass of the monomer form of the L chain (28 kDa) from a gel filtration column. The …

Ms211: Kaznurse, Armin Weinberg

Works on Radiation Effects: 1990-2020

This document is a report by F. Curtiss Swezy, DrPH and Shanta Swezy about nursing reform in Kazakhstan being stimulated and supported by two AIHA partnerships. See more at Armin Weinberg, PhD Papers and its finding aid.

Front End Loader Overturns On Seed/Fertilizer Store Owner, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

A 53-year-old farmer and partner in a seed and fertilizer business was loading fertilizer for a customer. He was driving the store's old front end loader, which had no roll over protective structure (ROPS) or seatbelt. After coming around to the back of the building where fertilizer was stored, he failed to turn the loader into the bin; instead it continued forward almost 50 feet to a ditch. When the front tire went over the edge of the ditch, the loader overturned, coming to rest on top of the victim. He died within minutes.

In order to prevent similar incidents, …

Maintenance Worker Killed In 25-Foot Fall From I-Beam, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

A 25-year-old maintenance worker at a steel distribution company died as the result of a fall from a steel I-beam he had repeatedly climbed to reach the top of a disabled crane. This worker and another had been attempting to repair the crane, and had found it necessary to climb up and down several times for various reasons (see below). Each time the victim had shimmied down and back up the I-beam rather than using the fixed ladder some distance away. When the fall occurred, he was on his way back up and somehow lost his grip on the beam. …

Logs Roll Off Truck At Sawmill Killing The Truck Driver, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

A 64-year-old male (the victim) was killed while unloading logs at a sawmill. Since retiring from the mining industry several years ago, he had been working part-time driving a semi-trailer truck owned by a logger. As was his usual practice, the victim drove the truck alone, and on the day of the incident hauled a large load of logs on the trailer bed. The logs were approximately 12 inches in diameter and 20-25 feet long. Stakes on the sides of the trailer bed were four feet high; witnesses reported that the logs were stacked approximately four feet higher than the …

Information Interface - Volume 21, Issue 4 - August/September 1996, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

The Effects Of Lead Acetate On Host Susceptibility To Trypanosoma Cruzi, Tabitha Ellis

Masters Theses & Specialist Projects

Trypanosoma cruzi. a protozoan parasite, causes American trypanosomiasis or Chagas' disease. The infective stage of this parasite resides in the hindgut of the reduviid bug (family Reduviidae), which is both host and vector, and is transmitted to the mammalian host through fecal material released during a blood meal. Chagas' disease, an acute to chronic infection resulting in fever, malaise, and heart and liver enlargement, is becoming a concern in the United States due to the large increase in Latin American immigrants, and the lack of safe and effective therapeutic treatment and vaccination. Another growing concern in the United States involves …

Antibody Response To Heat Shock Proteins Of Trypanosoma Cruzi And Histopathology In Mice Infected And Maintained At Elevated Environmental Temperature, Ahmed Arif

Masters Theses & Specialist Projects

Trypanosoma cruzi is an obligate intracellular parasite infecting 18-20 million people in Latin America. It is the causative agent of Chagas' disease, commonly referred to as American Trypanosomiasis. The C3H murine model is widely used to study experimental Chagas' disease. It is well documented that when these highly susceptible mice are infected with the Brazil strain of T. cruzi and maintained at room temperature (RT), mice die between day 35-45 of infection. However, when held at an elevated temperature of 36°C, C3H mice survive an otherwise lethal infection with T. cruzi. When held at 36°C, the body temperature of the …

An Investigation Of Hexatylis Contracta Blomquist (Southern Heartleaf): Individuals, Hybrids, Populations And Species, Patrick Carroll

Masters Theses & Specialist Projects

Hexastylis contracta Blomquist is a rare herbaceous perennial plant endemic to southeastern North America. The plant exhibits a disjunct distribution, being found on the Cumberland Plateau of Tennessee and Kentucky and also 300 km east in the Blue Ridge Mountains of North Carolina. This plant was the subject of a population inventory supported through the Kentucky State Nature Preserves Commission (KNPC) which expanded the number of known populations of the species (28) by 68%, with 47 populations now known to exist. A morphological analysis of this species was done using principal components analysis. This analysis was used to answer questions …

Our Publication Series, Joseph Ellin

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society, September 28, 1995.

The Place Of Ethics Centers In Higher Education, Douglas Ferraro

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society, September 28, 1995.

The Effects Of Personal Health Assessments On Health Knowledge And Health Behavior Among Students Enrolled In An Undergraduate Personal Health Course, Jennifer Peeso

Masters Theses & Specialist Projects

The purpose of this research was to determine whether personal health assessments would increase Personal Health 100 students' health knowledge and healthy behaviors. This research is important because of the objectives set by Healthy People 2000 to promote health and because of the need for comprehensive school health education programs. By focusing on health promotion in the school setting, more effective preventive programs can be devised. The factors investigated included health knowledge and the following health behaviors: exercise, alcohol consumption, use of tobacco, sleep, breakfast, sexual activity, and seatbelt use. These factors were chosen based on a longevity theory. Data …

The First Ten Years, Michael Pritchard

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society, September 28, 1995.

Ethics At The End Of The Century: A Mosaic Form Genesis To Genetics, David H. Smith

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society, September 28, 1995.

The Ethics Center: Tenth Anniversary, Wmu Center For The Study Of Ethics In Society

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society, September 28, 1995.

Plasma Factor Xiii Binds Specifically To Fibrinogen Molecules Containing Γ‘ Chains, Kevin R. Siebenlist, David A. Meh, Michael W. Mosesson

Biomedical Sciences Faculty Research and Publications

The difference between peak 1 and peak 2 fibrinogen lies in their γ chains. Peak 1 molecules contain 2 γA chains; peak 2 molecules contain 1 γA and 1 γ‘ chain, the latter of which contains a 20 amino acid extension (γ‘ 408−427) replacing the carboxyl-terminal 4 amino acids of the γA chain (γA 408−411). While the existence of γ‘ chains in plasma fibrinogen molecules has been known for many years, their function remains unknown. When fibrinogen is purified from plasma, the factor XIII zymogen (A₂B₂) copurifies with it and is found only in the peak …

The Course Of Aggression In First-Grade Children With And Without Comorbid Anxious Symptoms, Nick Ialongo, Gail Edelsohn, Lisa Werthamer-Larsson, Lisa J. Crockett, Sheppard Kellam

Department of Psychology: Faculty Publications

We studied the course of aggressive behavior in an epidemiologically defined sample of first graders with and without comorbid anxious symptoms. Our primary purpose in doing so was to understand whether the stability of aggression in young children was attenuated or strengthened in the presence of comorbid anxiety. Previous studies of older children and adolescents had produced equivocal findings in this regard. Data on anxious symptoms were obtained through an interview of the children, whereas aggressive behavior was assessed through the use of a teacher interview and peer nominations. Assessments were performed in the fall and spring of first grade. …

Relationships Of Job And Family Involvement, Family Social Support, And Work–Family Conflict With Job And Life Satisfaction, Gary A. Adams, Lynda A. King, Daniel W. King

Management Faculty Research and Publications

A model of the relationship between work and family that incorporates variables from both the work-family conflict and social support literatures was developed and empirically tested. This model related bidirectional work-family conflict, family instrumental and emotional social support, and job and family involvement to job and life satisfaction. Data came from 163 workers who were living with at least 1 family member. Results suggested that relationships between work and family can have an important effect on job and life satisfaction and that the level of involvement the worker assigns to work and family roles is associated with this relationship. The …

Interleukin-10 Inhibits Tumor Metastasis Through An Nk-Cell Dependent Mechanism, Li-Mou Zheng, David M. Ojcius, F. Garaud, C. Roth, E. Maxwell, Z. Li, H. Rong, J. Chen, X. Y. Wang, J. J. Catino, I. King

All Dugoni School of Dentistry Faculty Articles

Interleukin-10 (IL-10) is a recently described pleiotropic cytokine secreted mainly by type 2 helper T cells. Previous studies have shown that IL-10 suppresses cytokine expression by natural killer (NK) and type 1 T cells, thus down-regulating cell-mediated immunity and stimulating humoral responses. We here report that injected IL-10 protein is an efficient inhibitor of tumor metastasis in experimental (B16-F10) and spontaneous (M27 and Lox human melanoma) metastasis models in vivo at doses that do not have toxic effects on normal or cancer cells. Histological characterization after IL-10 treatment confirmed the absence of CD8+ and CD4+ T cells and macrophages at …

Resistance Of Blastocystis Hominis Cysts To Chlorine, M Zaki, V Zaman, N A. Sheikh

Department of Pathology and Laboratory Medicine

No abstract provided.

Pneumococcal Sepsis In The Newborn--An Emerging Problem?, Z A. Bhutta

Department of Paediatrics and Child Health

No abstract provided.

Human Immunodeficiency Virus Type-1 (Hiv-1) Infection Increases The Sensitivity Of Macrophages And Thp-1 Cells To Cytotoxicity By Cationic Liposomes, Krystyna Konopka, Elizabeth Pretzer, Philip L. Felgner, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

Cationic liposomes may be valuable for the delivery of anti-sense oligonucleotides, ribozymes, and therapeutic genes into human immunodeficiency virus type 1 (HIV-1)-infected and uninfected cells. We evaluated the toxicity of three cationic liposomal preparations, Lipofectamine, Lipofectin, and 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide (DMRIE) reagent, to HIV-infected and uninfected cells. Monocyte/macrophages were infected with HTV-1(BaL) and treated with liposomes in medium containing 20% fetal bovine serum (FBS) for 4 h or 24 h at 37°C. Uninfected monocytic THP-1 cells and chronically infected THP-1/HIV-1(IIIB) cells were treated with phorbol 12-myristate 13-acetate (PMA) and exposed to liposomes in the presence of 10% FBS. Toxicity was …

Low Molecular Weight Thiocarbamates As Inhibitors Of Elastase, Uses And Method Of Synthesis, George Digenis, Nikolaos P. Rodis

Pharmaceutical Sciences Faculty Patents

To see this abstract, please download this patent.

Cloning Of The Mammalian Type Ii Iodothyronine Deiodinase. A Selenoprotein Differentially Expressed And Regulated In Human And Rat Brain And Other Tissues., Walburga Croteau, Jennifer C. Davey, Valerie Anne Galton, Donald L. St Germain

Dartmouth Scholarship

The deiodination of thyroid hormones in extrathyroidal tissues plays an important role in modulating thyroid hormone action. The type II deiodinase (DII) converts thyroxine to the active hormone 3,5,3'-triiodothyronine, and in the rat is expressed in the brain, pituitary gland, and brown adipose tissue (BAT). Complementary DNAs (cDNAs) for the types I and III deiodinases (DI and DIII, respectively) have been isolated and shown to code for selenoproteins. However, information concerning the structure of the mammalian DII remains limited, and the pattern of its expression in human tissues is undefined. We report herein the identification and characterization of rat and …

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Summer, 1996 edition of the ALHeLa newsletter - Synapse.

Contents include:

• President's Notes - Tamara Lee
• ALHeLA annual meeting
• Alabama Health Libraries association executive committee minutes
• CME meeting & MASA manual
• ALHeLA home page
• Committee reports
• ALHeLA home page and Listserv
• MASA workshop
• Alabama Medicine
• Consumer Health Corner
• USA biomedical library faculty and staff news
• Internet of Note

Method Of Tendon Repair, Bradley B. Hill

Surgery Faculty Patents

A method for repairing a transected or torn flexor or extensor tendon of a finger that has retracted proximally within its protective sheath includes the steps of: (a) visually locating a distal end of the tendon within the sheath; (b) engaging the distal end of the tendon, (c) pulling the tendon distally through the sheath to a tendon mending position; and (d) repairing the tendon.

Mid-Atlantic Ethics Committee Newsletter, Summer 1996

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

The Beat Newsletter, College Of Medicine

The Beat Newsletter

This is the July, 1996 edition of the Frederick P. Whiddon College of Medicine's newsletter - The Beat.

Contents include:

• Eye on Survival
• New chair of family practice and community medicine appointed
• New faculty
• Congratulations...
• College receives full accreditation
• Research! America an alliance for discoveries in health
• Basic medical science doctorates awarded
• Graduate medical education
• College chairs assume national positions
• Medical graduates challenged " TO ACCEPT DUTY AND LEAVE MEDICINE A BETTER PROFESSION"
• Honors convocation awards
• Class of 1996 residency appointments

Differential Expression Of The Toxr Regulon In Classical And E1 Tor Biotypes Of Vibrio Cholerae Is Due To Biotype-Specific Control Over Toxt Expression., Victor J. Dirita, Melody Neely, Ronald K. Taylor, Paul M. Bruss

Dartmouth Scholarship

The two major disease-causing biotypes of Vibrio cholerae, classical and El Tor, exhibit differences in their epidemic nature. Their behavior in the laboratory also differs in that El Tor strains produce two major virulence factors, cholera toxin (CT) and the toxin coregulated pilus (TCP), only under very restricted growth conditions, whereas classical strains do so in standard laboratory medium. Expression of toxin and TCP is controlled by two activator proteins, ToxR and ToxT, that operate in cascade fashion with ToxR controlling the synthesis of ToxT. Both biotypes express equivalent levels of ToxR, but only classical strains appear to express ToxT …