Medicine and Health Sciences Commons^™

Parasite Biodiversity And Emerging Pathogens: A Role For Systematics In Limiting Impacts On Genetic Resources, Eric P. Hoberg

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Emergence of pathogenic organisms continues as a threat to overall biodiversity and genetic resources. Macroparasites including helminths constitute a potential threat to economically important resources in agriculture and conservation biology. Limitation of this threat can be achieved through survey and inventory for biodiversity and the application of systematics to understand the host range , biogeography and history of faunas. Systematics constitutes the foundation for recognition of endemic and introduced elements of faunas and the basis for predicting the behavior of pathogens introduced to new ecological settings or host groups. The basis for emergence of pathogens has both a deep historical …

Mosques Against Malaria, M.S. Mfaume, P.J. Winch, A.M. Makemba, Zul Premji

Pathology, East Africa

In a community-based malaria control project covering a predominantly Muslim population in the United Republic of Tanzania, difficulty was encountered in motivating people to have their mosquito nets reimpregnated with insecticide at six-monthly intervals. Education on this subject was therefore provided in mosques during Friday noon prayers. People who attended these services considered them an appropriate forum for discussing health concerns and viewed them as a credible source of information.Insecticide-impregnated bednets help to control the spread of the malaria parasite Plasmodium falciparum. The Bagamoyo Bednet Project is a community-based scheme to develop a sustainable system for the distribution and promotion …

Developments In Client Information Systems, Marilyn Frenn

College of Nursing Faculty Research and Publications

No abstract provided.

Gender Differences: Exercise Beliefs Among Youth, Marilyn Frenn

College of Nursing Faculty Research and Publications

No abstract provided.

The Changing Economic Circumstances Of The Elderly: Income, Wealth, And Social Security, James P. Smith

Center for Policy Research

How is the economic status of the elderly changing and what are their prospects for the future? My portrait tells us how well off they are on average, but also about the vast disparities that exist among them. This description includes an often neglected measure of their economic well-being--the amount of wealth they control. Amazingly little is known about how much personal wealth older people have and how and what determines its distribution. But the conventional definition of household wealth ignores two critical components of wealth: the expected income flows from pensions and Social Security. For some elderly households, Social …

Private Commissions, Assisted Reproduction, And Lawyering, Larry I. Palmer

Faculty Publications

No abstract provided.

Interleukin-2 Fusion Protein: An Investigational Therapy For Interleukin-2 Receptor Expressing Malignancies, Jean Nichols, Foss Francine, Kuzel Timothy, Lemaistre Charles Fred, Platanias Leonidas, Ratain Mark, Rook Alain, Mansoor Saleh, Schwartz Gary

Haematology and Oncology, East Africa

DAB3s91L-2 is an interleukin-2 receptor (IL-2R) specific fusion protein with a molecular weight of 58 kD containing the enzymatic and translocation domains of diphtheria toxin (DT) and human IL-2. This fusion protein is able to direct the cytocidal action of the DT enzymatic region only to cells which bear the IL-2R. The human IL-2R exists in three forms: low, intermediate and high affinity. The high-affinity form is believed to be the biologically relevant form on mature, activated T-lymphocytes, B-lymphocytes and monocytes. DAB3sgIL-2 is able to bind selectively to the high-affinity IL-2R in a concentration-dependent manner, and once bound is internalised …

503 Phase I Radioimmunotherapy (Rit) Study Of 90y-Cc49 Monoclonal Antibody (Mab) Therapy In Patients With Advanced Non-Small Cell Lung Cancer (Nsclc), Francisco Robert, Ruby Meredith, Michael Khazaeli, Charles Russell, William Grizzle, John Newsome, Mansoor Saleh

Haematology and Oncology, East Africa

503 Phase I radioimmunotherapy (RIT) study of 90Y-CC49 monoclonal antibody (MAb) therapy in patients with advanced non-small cell lung cancer (NSCLC) × Close The Infona portal uses cookies, ie strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms …

Thirty Years And Going Strong, Beverly S. Mahoney

Faculty Publications and Presentations

No abstract provided.

Hazard Communication: A Review Of The Science Underpinning The Art Of Communication For Health And Safety, Barbara Sattler, B Lippy, T Jordan

Nursing and Health Professions Faculty Research and Publications

This report was commissioned by the United States Occupational Safety and Health Administration to review the state of scientific inquiry supporting our knowledge regarding key elements of chemical hazard communication programs: labeling, warnings, material safety data sheets, and worker training. This endeavor supports the international effort to harmonize laws, regulations, and consensus standards affecting the ways in which information about hazardous chemicals is communicated. The international effort can be divided into three major functions: classifying health and environmental hazards, classifying physical hazards; and communicating hazard information. This last component involves the determination of what information will be communicated to users …

Minor Physical Anomalies: Modifiers Of Environmental Risk For Psychopathology, Daniel S. Pine, David Shaffer, Irvin Sam Schonfeld, Mark Davies

Publications and Research

Tested the hypothesis that minor physical anomalies (MPAs) modify an adolescent's vulnerability to environmental risk factors for psychopathology. 118 male 17-yr-olds who had been evaluated as 7-year-olds received a comprehensive neuropsychiatric evaluation. The evaluation included standardized assessments of environmental risk factors for psychiatric impairment, neurological signs, IQ, MPAs, and psychiatric impairment. The relationship between psychiatric status and environmental risk was examined as a function of the MPA profile. There was a significant interaction between MPAs and environmental risk in predicting psychiatric status. Environmental risk was more predictive of psychiatric impairment at age 17 in Ss with high scores on the …

Peer Relations Of Children With Attention Deficit Hyperactivity Disorder, Joan Elizabeth Licari

Graduate Research Papers

This paper's main focus is on the peer relations of children with ADHD. Many interventions are used with children who have ADHD. One of the most widely used intervention is medication. The drug that is most associated with ADHD is methylphenidate or Ritalin. Medication, which can reduce some problematic behaviors associated with ADHD, has not been found to be very beneficial in peer relations.

Children who have ADHD are at risk for later psychopathology (mental disorders), among other problems, and thus early interventions are critical to reduce the onset of later pathologies.

This paper is intended to provide an overview …

Evaluation Of The Bunbury Chronic Pain Management Program, Samar Aoun, Carmen Gregg

Research outputs pre 2011

The objective of this study was to evaluate the effectiveness of a six-week program in pain management for patients with chronic pain referred by GPs in Bunbury, Australind, Harvey, Collie, and Donnybrook. The evaluation consisted of a retrospective analysis of patient data from the first 3 courses of the program (November 1996 to March 1997), and satisfaction surveys for 26 clients, 26 GPs and the 7 staff in the multidisciplinary team.

A comparison of pre-program and post-program pain inventory psychometric measures revealed a significant decrease in the amount pain interfered with general activity, social activities, normal work, sleep and mood. …

The Assessment Of The Health Care Needs Of The Community From A Consumer And Provider Perspective, Samar Aoun, Genevieve Stone

Research outputs pre 2011

This project aimed at identifying the health care needs of a community from a consumer and a provider perspective using a combination of quantitative and qualitative research methodologies.

As stated in the objectives, this needs analysis has provided information on:

-the characteristics of the community served the local Division of General Practice (Chapter 2).

-the health status of the community, in terms of disease patterns, healthy lifestyles ... (Chapter 3).

-the extent to which services exhibit qualities of convenient location, availability, equity of access, integrated care and providing education (Chapters 4 and 5).

-the various aspects concerning general practice interests, …

Computed Tomography In Staging Of Patients With Melanoma Metastatic To The Regional Nodes., T M Johnson, D J Fader, A E Chang, Alan M. Yahanda Md, Facs, J W Smith, K R Hamlet, V K Sondak

PCI Publications and Projects

BACKGROUND: This study addresses the yield and clinical impact of computed tomography (CT) imaging in otherwise asymptomatic patients with stage III melanoma metastatic to the regional nodes.

METHODS: The database from the University of Michigan Mutlidisciplinary Melanoma Clinic was reviewed and identified 127 asymptomatic patients with stage III melanoma (regional nodal disease) who received CT scans of the head, chest, abdomen, and/or pelvis. Scans were confirmed as true positive, false positive, and normal.

RESULTS: Four hundred twenty-six head and body CT scans were performed at the time of presentation of stage III disease. Twenty patients had a true-positive CT scan …

Acyclic Phosphonomethylether Nucleosideinhibitors Of Respiratory Viruses, Dale L. Barnard, N. Bischofberger, C. U. Kim, J. H. Huffman, R. W. Sidwell, J. P. Dougherty, W. Lew, M. A. Williams, W. Yang

Animal, Dairy, and Veterinary Science Faculty Publications

A series of acyclic phosphonomethylether nucleosides were synthesized and then evaluated for inhibitory activity against respiratory viruses of clinical significance using CPE inhibition, neutral red uptake and virus yield reduction assays. Of the 20 compounds synthesized, none significantly inhibited influenza A or B viruses or respiratory syncytial virus strains A2, Long or 18537; the selective indices (SI) were less than 10. A new compound, GS-2128 (2R, 5R-9-[2,5-dihydro-5-(phosphonomethoxy)-2-furanyl]adenine; D4API), selectively inhibited adenovirus 5 (SI>10) as did GS-0577 (9-(3-hydroxy-2-phosphonylmethoxypropyl)-adenine; HPMPA) and GS-0504 [(S)-1-[3-hydroxy-2-(phosphonylmethoxypropyl)]-cytosine; HPMPC]. The 50% effective concentrations (EC50) ranged from 8-100 μg mL-1 and 50% cell inhibitory concentrations (CC50) from …

The Ability Of Children With Specific Language Impairment To Participate In A Group Decision Task, Lee Robinson, Martin Fujiki, Bonnie Brinton, Valyne J. Watson

Faculty Publications

This study examined the ability of 6 children with specific language impairment (SLI), ages 8:10 to 12:5 (years; months), to participate in a group negotiation task. Each child interacted with two peers to select toys that children their age would enjoy. Performance was compared to both chronological age-similar (CS) peers and language similar (LS) peers performing the same task. Analyses of the resulting interactions indicated that subjects with SLI produced significantly fewer utterances than the other children in the triad. Similar differences were not observed in the CS or LS triads. Additionally, significantly fewer utterances were addressed to the children …

Return Of The Fourth Horseman: Emerging Infectious Diseases And International Law, David P. Fidler

Articles by Maurer Faculty

No abstract provided.

An Evaluation Of The Clinical Utility Of The College Adjustment Scales, Timothy B. Smith, Mark A. Nafziger, Gwenna C. Couillard

Faculty Publications

Comparisons of College Adjustment Scales (CAS) profiles with interview data from 748 clients generally supported the clinical usefulness of the CAS, although further refinements appear warranted.

Lactose Intolerance In Persistent Diarrhoea During Childhood: The Role Of A Traditional Rice-Lentil (Khitchri) And Yogurt Diet In Nutritional Management, Z A. Bhutta, S Q. Nizami, Z Isani

Department of Paediatrics and Child Health

Lactose intolerance is frequently encountered in children with persistent diarrhoea (PD). Selection of an appropriate milk-based formulation is a major management problem in the developing world. In a consecutive series of studies, we evaluated the role of feeding a traditional rice-lentil (khitchri) diet alone (KY) or in combination with either soy formula (KY-Soy) a dilute buffalo milk (KY-B), in children (age 6 months-3 years) with PD. Serial observations of stool output, caloric intake and weight gain of these children over a 14 day period indicated satisfactory tolerance of the KY diet with adequate weight gain. The weight gain and stool …

Paediatric Prescribing In Karachi, S Q. Nizami, I A. Khan, Z A. Bhutta

Department of Paediatrics and Child Health

To assess amount of drug overuse we studied drug prescribing for common childhood problems by 65 general practitioners (GPs) and 29 paediatricians. A total of 2433 encounters between GPs or paediatricians and children under five years of age were observed. The presenting complaints were fever in 18%, cough in 9%, both fever and cough in 21%, vomiting in 20% and diarrhoea in 41% of encounters. Antibacterials were prescribed in 49% of encounters, analgesics and antipyretics in 29%, antiemetics in 8% and injectables in 15%. Antidiarrhoeals were prescribed in 41% encounters with children reported to have diarrhoea. Ampicillin and cotrimoxazole were …

Immune Responses To Final Exams In Healthy And Asthmatic Adolescents, Duck-Hee Kang, Christopher L. Coe, Donna O. Mccarthy, William B. Ershler

College of Nursing Faculty Research and Publications

Immune responses to an academic stressor were examined in healthy and asthmatic adolescents with regard to their illness symptom reports. Eighty-seven high school students completed a health diary for 2 weeks and provided three blood samples during midsemester, final-exam, and postexam periods. During exam week, all students showed significant immunological alterations from baseline: Natural killer cell activity was significantly lower, whereas lymphocyte proliferation and neutrophil superoxide release were significantly higher. These immune changes tended to return toward baseline during the postexam period, but the enhanced neutrophil reactivity continued to rise. Overall, immunological responses were similar between asthmatic subjects and controls. …

Breast Cancer, The Genetic "Quickfix," And The Jewish Community: Ethical, Legal, And Social Challenges, Karen H. Rothenberg

Faculty Scholarship

No abstract provided.

The Ability Of Children With Specific Language Impairment To Access And Participate In An Ongoing Interaction, Lee Robinson, Martin Fujiki, Julie Campbell Spencer

Faculty Publications

This study investigated the ability of 6 children with specific language impairment (SLI), ages 8;10 to 12;5 (years;months), to enter and participate in an ongoing dyadic interaction. Performance was compared to that of 6 chronological age-matched (CA) peers and 6 language-similar (LS) peers. All children in the LS and CA groups successfully accessed the interaction, and most did so quickly. Two children from the SLI group did not access, and the 4 remaining subjects required varying amounts of time to access. Following successful access, the triadic interactions of subjects were examined. The accessing children with SU talked significantly less, were …

Prediction Of Stress Appraisals From Mastery, Extraversion, Neuroticism, And General Appraisal Tendencies, S. H. Hemenover, Richard A. Dienstbier

Department of Psychology: Faculty Publications

Several personality dimensions (mastery, extraversion, and neuroticism) and a new General Appraisal Measure were used to predict stress appraisals made by college students in specific situations. Using multiple-regression techniques, mastery and general appraisal tendencies predicted appraisals for an intellectual task. Path analysis supported a structural model with general appraisal tendencies as a mediator between mastery and specific appraisal. In the second study mastery, extraversion, neuroticism, and general appraisal tendencies predicted appraisals for an academic stressor. Path analysis again supported the mediational nature of general appraisal tendencies from personality variables to specific appraisal. We discuss a potential causal mechanism between personality …

Mill Owner Dies In Tractor Rollover, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 51-year-old mill owner (the victim) was killed while pulling a 16-foot log from the woods. He had reached the top of a 10-12-degree slope, turned slightly to the left and stopped, when the tractor he was driving turned over. It landed on the victim and then rolled again. The victim's partner, who was with him, ran to a nearby house where he had seen two men working outdoors earlier. He asked them to call 911 and then returned with a backhoe with which to lift the tractor. While he was doing this, emergency medical services (EMS) personnel arrived. The …

Ua66/14/3 Nursing Pinning Ceremony, Wku Nursing

WKU Administration Documents

Pinning ceremony program listing graduates of the WKU Nursing program.

Method For Obtaining Antifungal And Herbicidal Compounds That Target The First Committed Step In Shingolipid Long-Chain Base Biosynthesis, Robert C. Dickson, Robert L. Lester

Molecular and Cellular Biochemistry Faculty Patents

The invention provides the LCB1 and LCB2 genes of the yeast Saccharomyces cerevisiae that encode subunits of the enzyme serine palmitoyltransferase (SPT), the first enzyme leading to synthesis of the long-base component of the sphingolipids. The present specification describes the isolation of the LCB1 and LCB2 genes. The invention further relates to methods of using these genes to either inhibit SPT activity or to inhibit synthesis of the enzyme. Furthermore, the invention relates to methods for constructing strains of S. cerevisiae or other organisms that can be used to select and to test for compounds that either inhibit SPT activity …

Farmer Killed When Caught In Hay Baler, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 48-year-old part-time farmer was using a roll baler to bale hay on his farm around noon on a Saturday. Although there were no eyewitnesses to the event, it is believed that hay became clogged in the tines of the baler and he got off the tractor to try and force the hay in with his foot. His shoe or his pant leg became entangled in the tines of the baler and he was pulled into the machine.

In order to prevent similar incidents, FACE investigators recommend that

• machinery always be turned off before the operator dismounts or attempts to …

Welder Dies After 30-Foot Fall From Steel Structure, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

A 31-year-old welder working at a construction site died after falling 30 feet. The victim, along with two co-workers, was on an I-beam structure preparing to weld handrails when the incident occurred. The victim informed his two co-workers that he was going to talk with another person on the crew and left the area. He was wearing a hard hat, full-body safety harness with two shock-absorbing lanyards, and steel-toed shoes. He went down one level and crossed a roped-off area, stepping onto a steel-grate floor. The unsecured flooring moved, and the victim fell 30 feet to the dirt floor below. …