Medicine and Health Sciences Commons^™

Prp Genotypes And Experimental Scrapie In Orally Inoculated Suffolk Sheep In The United States, Katherine I. O'Rourke, G. R. Holyoak, W. W. Clark, J. R. Mickelson, S. Wang, R. P. Melco, T. E. Besser, W. C. Foote

Zoonotics and Wildlife Disease: Publications

One-hundred and three United States Suffolk sheep were inoculated orally with a scrapie agent preparation and monitored for clinical disease and histopathological lesions characteristic of scrapie. A retrospective study of the polymorphisms at codon 171 of the prion protein (PrP) gene was performed on these sheep. All 63 sheep that developed scrapie during the observation period were homozygous for the glutamine 171 (171-QQ) PrP allele. Twelve 171-QQ sheep failed to develop disease. All 5 sheep homozygous for arginine (171-RR) and all 23 heterozygous (171-QR) sheep remained free of scrapie.

Spongiform Encephalopathy In Free-Ranging Mule Deer (Odocoileus Hemionus), White-Tailed Deer (Odocoileus Virginianus) And Rocky Mountain Elk (Cervus Elaphus Nelsoni) In Northcentral Colorado, T. R. Spraker, M. W. Miller, E. S. Williams, D. M. Getzy, W. J. Adrian, G. G. Schoonveid, R. A. Spowart, Katherine I. O'Rourke, J. M. Miller, P. A. Merz

Zoonotics and Wildlife Disease: Publications

Between March 1981 and June 1995, a neurological disease characterized histologically by spongiform encephalopathy was diagnosed in 49 free-ranging cervids from northcentral Colorado (USA). Mule deer (Odocoileus hemionus) were the primary species affected and accounted for 41(84%) of the 49 cases, but six Rocky Mountain elk (Cereus elaphus nelsoni) and two white-tailed deer (Odocoileus virginianus) were also affected. Clinical signs included emaciation, excessive salivation, behavioral changes, ataxia, and weakness. Emaciation with total loss of subcutaneous and abdominal adipose tissue and serous atrophy of remaining fat depots were the only consistent gross findings. Spongiform encephalopathy …

Hydroxylation Of Saccharomyces Cerevisiae Ceramides Requires Sur2p And Scs7p, Dale Haak, Ken Gable, Troy Beeler, Teresa Dunn

Uniformed Services University of the Health Sciences

The Saccharomyces cerevisiae SCS7 and SUR2 genes are members of a gene family that encodes enzymes that desaturate or hydroxylate lipids. Sur2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramide, and Scs7p is required for the hydroxylation of the very long chain fatty acid. Neither SCS7 nor SUR2 are essential for growth, and lack of the Scs7p- or Sur2p- dependent hydroxylation does not prevent the synthesis of mannosyldiinositolphosphorylceramide, the mature sphingolipid found in yeast. Deletion of either gene suppresses the Ca²⁺-sensitive phenotype of csg2Δ mutants, which arises from overaccumulation of inositolphosphorylceramide due to …

Childhood Physical Or Sexual Abuse As A Possible Indicator Of Subsequent Adult Anxiety Disorders, Lynn Merry Cornwell

Graduate Research Papers

In recent years, there has been a growing acceptance that childhood physical and sexual abuse lead to higher rates of psychiatric morbidity in adulthood. Childhood abuse experiences have been reported to be highly prevalent among patients with anxiety disorders. Similarly, childhood incest victims have been found to suffer from a significantly higher rate of anxiety disorders in adulthood especially agoraphobia, than a non-victimized, matched comparison group. Epidemiology studies also support a relationship between childhood abuse and the subsequent development of anxiety disorders. Two separate community surveys found that childhood sexual victimization predicted the later onset of agoraphobia, obsessive-compulsive disorder, and …

An Analysis Of Critical Thinking At A Liberal Arts College, Amy Goebel

Honors Theses, 1963-2015

This study investigated the differences among first-year, sophomore, junior, and senior college students in critical thinking skills and dispositions as measured by the California Critical Thinking Skills Test and the California Critical Thinking dispositions Inventory. Tests were administered to college students from a small, private institution in a rural area of the Midwest enrolled in general education courses with a majority being first-year and senior students. Consistent with the hypothesis, critical thinking skills and dispositions differed significantly between first-year, sophomore, junior, and senior students. Scores on the two tests were significantly correlated with each other, and scores on the skills …

Association Between Plasma Homocysteine, Vitamin Status, And Extracranial Carotid-Artery Stenosis In The Framingham Study Population, Jacob Selhub, Paul F. Jacques, Andrew G. Bostrom, Ralph B. D'Agostino, Peter W. F. Wilson, Albert J. Belanger, Daniel H. O'Leary, Philip A. Wolf, David Rush, Ernst J. Schaefer, Irwin H. Rosenberg

United States Public Health Resources

Recent epidemiologic studies suggest that elevated homocysteine concentrations in plasma represent a risk factor for vascular disease and stroke. In the present study, we analyzed plasma samples from the 20th biannual examination of the Framingham Heart Study cohort to determine distribution of plasma homocysteine concentrations, with emphasis on relationships to vitamins that are involved in homocysteine metabolism and prevalence of carotid artery stenosis. Results showed that homocysteine was positively correlated with age. After controlling for age and sex, homocysteine exhibited strong inverse correlation with plasma folate, and weaker correlations with plasma vitamin B₁₂ and pyridoxal- 5' -phosphate. Homocysteine was …

Cystathionine Β-Synthase Deficiency: Metabolic Aspects, S. Harvey Mudd

United States Public Health Resources

Cystathionine β-synthase (CBS) deficiency was first demonstrated in 1964 in an eight-year-old mentally retarded girl with bilaterally dislocated optic lenses who excreted abnormally elevated amounts of homocystine in her urine. Patients with similar metabolic abnormalities and clinical findings had first been discovered 2 years earlier by Carson and her colleagues during a survey of mentally backward children in Northern Ireland. CBS deficiency has proven to be the most frequently encountered of the human genetic diseases causing homocystinuria and severe hyperhomocyst(e)inemia. Worldwide, it is detected with a frequency of about 1: 344,000 by screening programs of the newborn, but this is …

Blood Homocysteine Levels In The National Health And Nutrition Examination Survey (Nhanes Iii) In The United States: Preliminary Findings By Age And Sex, Irwin H. Rosenberg, Jacob Selhub, Paul F. Jacques, Barbara A. Bowman, Elaine W. Gunter, Clifford L. Johnson, R. S. Murphy

United States Public Health Resources

Evidence from scores of observational studies from many parts of the world have demonstrated an association between elevated blood total homocysteine levels and the risk of cardiovascular disease, peripheral vascular disease, and stroke. These conditions are more prevalent in males than in females in virtually all populations studied, and their prevalence increases with advancing age. A much smaller body of data exists that describes an increasing tendency to higher homocysteine levels with increasing age.

There have been no previous reports of blood homocysteine levels measured in a cross-sectional sample throughout the age spectrum from childhood through the elderly. However, the …

The Etiology Of Neural Tube Defects, J. M. Scott, D. G. Weir, A. Molloy, J. Mcpartlin, Leslie Daly, P. Kirke, M. Conley, J. Lee, J. Mills

United States Public Health Resources

Evidence continues to confirm that periconceptional ingestion of folic acid can prevent neural tube defects, although the basis of this prevention has been unclear. To further elucidate the mechanism by which this occurs, blood samples were collected from more than 50,000 pregnant women and the samples analyzed for red cell folate, plasma folate, plasma vitamin B12, and plasma homocysteine levels. Based on the results, it appears that the beneficial effect of folic acid is in overcoming a metabolic block in a folatedependent enzyme or transport process. It is likely that methionine synthase may be directly or indirectly involved.

The neural …

Cancer Mortality In Workers Exposed To Phenoxy Herbicides, Chlorophenols, And Dioxins, Manolis Kogevinas, Heiko Becher, Trevor Benn, Pier Alberto Bertazzi, Paolo Boffetta, H. Bas Bueno-De-No-De-, David Coggon, Didier Colin, Dieter Flesch-Janys, Marilyn Fingerhut, Lois Green, Timo Kauppinen, Margareta Littorin, Elsebeth Lynge, John D. Mathews, Manfred Neuberger, Neil Pearce, Rodolfo Saracci

United States Public Health Resources

The authors examined cancer mortality in a historical cohort study of 21,863 male and female workers in 36 cohorts exposed to phenoxy herbicides, chlorophenols, and dioxins in 12 countries. Subjects in this updated and expanded multinational study coordinated by the International Agency for Research on Cancer were followed from 1939 to 1992. Exposure was reconstructed using job records, company exposure questionnaires, and serum and adipose tissue dbxin levels. Among workers exposed to phenoxy herbicides contaminated with 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) or higher chlorinated dioxins, mortality from soft-tissue sarcoma (6 deaths; standardized mortality ratio (SMR) = 2.03, 95% confidence interval (CI) 0.75-4.43) …

Ambulatory Arthroscopic Knee Surgery Results Of Partial Meniscectomy, Muhammad Umar

Section of Orthopaedic Surgery

In an open prospective study the results of arthroscopic partial meniscectomy were reviewed in 188 knees. Group I comprised of 139 (65%) knees with pure meniscus lesions without any ligament laxity, the remaining 49 (35%) knees in group II had anterior cruciate ligament (ACL) deficiency in addition to meniscus lesions. In group I, 93% had excellent to good and 7% had fair results by criteria of Tapper and Hoover. In group II, 75% had excellent to good and 25% had fair results. Arthroscopic knee surgery was a good method of identifying patients in group II who required anterior cruciate reconstruction. …

Occupation As Spiritual Activity, Brenda S. Howard, Jay R. Howard

Scholarship and Professional Work - LAS

Although spirituality is rarely explicitly mentioned in the occupational therapy literature, it is implied as an interwoven part of the human system. This article explores the meaning of occupation in the context of sociological and Judeo-Christian theological frameworks and the meaning of spirituality in the occupational therapy clinic. A case is made for acknowledging spirituality in clinical reasoning as a centralizing component of the patients' motivation and assignment of meaning to life.

Analysis Of Phosphorescence In Heterogeneous Systems Using Distributions Of Quencher Concentration, A.S. Golub, A.S. Popel, L. Zheng, R.N. Pittman

Physiology and Biophysics Publications and Presentations

ABSTRACT

A continuous distribution approach, instead of the traditional mono- and multiexponential analysis, for determining quencher concentration in a heterogeneous system has been developed. A mathematical model of phosphorescence decay inside a volume with homogeneous concentration of phosphor and heterogeneous concentration of quencher was formulated to obtain pulse-response fitting functions for four different distributions of quencher concentration: rectangular, normal (Gaussian), gamma, and multimodal. The analysis was applied to parameter estimates of a heterogeneous distribution of oxygen tension (P02) within a volume. Simulated phosphorescence decay data were randomly generated for different distributions and heterogeneity of PO2 inside the excitation/emission volume, consisting …

Managing Depression In General Practice In Pakistan: Do We Need To Re-Invent The Wheel?, Hashim Reza, Murad M. Khan

Department of Psychiatry

No abstract provided.

Sites Other Than Nucleotide 234 Determine Cardiovirulence In Natural Isolates Of Coxsackievirus B3, Nora M. Chapman, Jose R. Romero, Mark A. Pallansch, Steven Tracy

United States Public Health Resources

The genetic site(s) that naturally determine the cardiovirulence phenotype of coxsackievirus B3 (CVB3) have yet to be mapped. Using two closely related CVB3 strains that differed in terms of cardiovirulence phenotype in mice, we previously reported the difference in phenotype mapped to a single site, nucleotide 234 (nt234) in the 58 non-translated region (NTR) of the CVB3 genome. When nt234 was C, the virus was attenuated and when U, the virus was cardiovirulent. To determine whether this finding was applicable to other strains of CVB3, we examined 13 different naturally occurring CVB3 strains isolated in different years in the United …

The Review - Winter 1997/1998

Jefferson Review

• A Standout OT Representative - 1
• PRO/CON on Managed Care and Physical Therapy - 5
• How to: Managing Dementia at Home - 6
• Biotechnology Opens With New Degree - 7
• Taking it to the Streets: CHP Community Service - 10
• Alumni Events - 12
• Alumni Notes - 14
• Donor List - 18

Late Onset Oesophageal Perforation Due To Gunshot Injury Of Chest: Successful Non-Operative Management In A Young Child, Asad Mian, Saima H. Khan, Naeem-Uz-Zafar Khan

Department of Emergency Medicine

Penetrating firearm injuries of the chest have become commonplace in children living in violent urban areas. Esophageal perforation may present as a late manifestation of peadiatric thoracic trauma due to gunshot injury. Opinion varies as to the surgical or nonsurgical management of such a patient. The authors report a case of a 12-year-old girl who presented with a similar dilemma and her successful conservative management, that they opted for; is discussed.

Ada News Daily - 1997 Day 1, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Ms211: Radefx Tm Registration 02261997, Armin Weinberg

Works on Radiation Effects: 1990-2020

Armin Weinberg, PhD Papers and its finding aid.

Twenty Years Later – What We Have Learned Since The Big Thompson Flood: Proceedings Of A Meeting Held In Fort Collins, Colorado, July 13-15, 1996, Natural Hazards Research And Applications Information Center

FMHI Publications

No abstract provided.

Indicator Bacteria Concentrations Of Two Northwest Arkansas Streams In Relation To Flow And Season, Dwayne R. Edwards, Mark S. Coyne, Tommy C. Daniel, P. F. Vendrell, J. F. Murdoch, P. A. Moore Jr.

Biosystems and Agricultural Engineering Faculty Publications

Concentrations of indicator bacteria such as fecal coliform (FC) and fecal streptococcus (FS) are often used to assess the suitability of waters for their intended use(s) and to allocate resources for water quality improvement measures. There is evidence, however, that concentrations of FC and FS can be influenced by variables such as season and flow rate during sampling, which could lead to biased results. The objective of this study was to assess the impacts of season and flow rate on concentrations of FC and FS. Fecal indicator bacteria concentrations were measured for approximately three years at five sites on two …

A Randomized Clinical Trial To Compare Selective Posterior Rhizotomy Plus Physiotherapy With Physiotherapy Alone In Children With Spastic Diplegic Cerebral Palsy, Paul Steinbok, Ann M. Reiner, Richard Beauchamp, Robert Armstrong, Douglas Cochrane

Paediatrics and Child Health, East Africa

A randomized controlled single-blind trial was performed to compare lumbo-sacral selective posterior rhizotomy (SPR) followed by intensive physiotherapy, with intensive physiotherapy alone in improving motor function in children with spastic diplegic cerebral palsy. Fifteen patients were randomly assigned to each treatment modality. Patients in the SPR group had rhizotomy within 1 month, followed by intensive outpatient physiotherapy for 9 months. Patients assigned to physiotherapy alone had identical intensive physiotherapy. There was a statistically significant and clinically important difference in improvement in motor function in favor of the SPR group, with a mean increase in total Gross Motor Function Measure (GMFM) …

An Assessment Of Community-Based Family Planning Programs In Kenya, Jane Chege, Ian Askew

Reproductive Health

Kenya has a long history of using community-based distribution (CBD) as an integral part of its family planning (FP) program. The purpose of this study was to assess the role of CBD programs in terms of providing information and services, to learn more about the determinants of program effectiveness, and to attempt to compare the programs’ cost-effectiveness. Fieldwork was undertaken in mid-1995 when data were collected from seven of the major CBD programs in Kenya. Four rural and three urban programs were included, as were programs that remunerated their agents and those that did not, and programs that had full-time …

Counseling The Husbands Of Postabortion Patients In Egypt: Effects On Husband Involvement, Patient Recovery And Contraceptive Use, Nahla G. Abdel-Tawab, Dale Huntington, Ezzeldin Osman Hassan, Hala Youssef, Laila Nawar

Reproductive Health

An ANE OR/TA Project qualitative study conducted in 1995 probed into women’s perceptions of abortion in Egypt, and the stress that postabortion patients experience during recovery. That study drew attention to the important role husbands can play in their wives’ recovery and subsequent use of contraception. This study was designed to test the effects of involving husbands in the postabortion medical-care process. Overall, the study indicates that providing counseling to husbands of postabortion patients is feasible, as the majority of husbands either accompanied their wife on admission or at discharge from the hospital. However, administrative changes are needed to enhance …

Translational Regulation Of Lipoprotein Lipase By Epinephrine Involves A Trans-Acting Binding Protein Interacting With The 3′ Untranslated Region, Gouri Ranganathan, Diane Vu, Philip A. Kern

Clinical and Translational Science Faculty Publications

To better characterize the translational regulation of lipoprotein lipase (LPL) by epinephrine, cytoplasmic extracts were prepared from 3T3-L1 adipocytes, 3T3-F442A adipocytes, and other nonadipocyte cell lines (C2 cells, 3T3 fibroblasts, and Chinese hamster ovary cells). After treatment with epinephrine, cell extracts from the adipocytes inhibited LPL translation in an in vitro translation assay, whereas extracts from the C2 cells and 3T3 fibroblasts did not affect LPL translation. To identify the region on the LPL mRNA that controlled translation, in vitro translation was carried out using constructs containing different LPL sequences. Specific deletion of the first 50 (1601-1650) nucleotides of the …

Student Handbook College Of Allied Health Hpd 1997-1998, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Social And Cultural Factors Affecting Rates Of Regular Retreatment Of Mosquito Nets With Insecticide In Bagamoyo District, Tanzania, P.J. Winch, A.M. Makemba, V.R. Makame, M.S. Mfaume, M.C. Lynch, Zul Premji, J.N. Minjas, C.J. Shiff

Pathology, East Africa

Insecticide-treated mosquito nets have an impact on mortality and morbidity in young children under controlled conditions. When integrated into larger control programs, there is the danger that rates of regular retreatment of the nets with insecticide will drop, greatly limiting their effectiveness as a public health intervention. In Bagamoyo District, Tanzania, rates of retreatment dropped significantly when payment for the insecticide was introduced. A series of neighbourhood (hamlet) meetings were held in all study villages to discuss people's concerns about the insecticide and ways to increase rates of retreatment. Although changes were made in the procedure for retreatment, rates of …

Tell Me A Story: Using Short Fiction In Teaching Law And Bioethics, Dena S. Davis

Law Faculty Articles and Essays

For some years now, I have been experimenting with the use of short stories. Despite rich resources for stories, there remains a void best filled by fiction. When discussing fiction, we can probe, criticize, and express ourselves freely without the constraints we feel when discussing real people. Good fiction lays bare the innermost thoughts and experiences of its characters, perhaps even their dreams and nightmares, in a way that would be intrusive, uncomfortable, or impossible, even in autobiography. When the entire class reads a short story, it provides a pool of shared experience, a fixed point for discussion. Just as …

Cochlear Implants And The Claims Of Culture: A Response To Lane And Grodin, Dena S. Davis

Law Faculty Articles and Essays

Because I reject the notion that physical characteristics constitute cultural membership, I argue that, even if the claim were persuasive that deafness is a culture rather than a disability, there is no reason to fault hearing parents who choose cochlear implants for their deaf children.

Genetic Dilemmas And The Child's Right To An Open Future, Dena S. Davis

Law Faculty Articles and Essays

In this paper, I examine three difficult issues raised by the Human Genome Project, and lay out an approach that takes seriously the interests of the child, present or future, while preserving the traditional commitment of professional geneticists to patient autonomy. The approach I take is based on Joel Feinberg's concept of "the child's right to an open future." In Part II, I describe the Human Genome Project, as well as the advances in assisted reproduction which give people ways to make use of the information engendered by the HGP. In Part III, I discuss the ethics of medical genetics, …