Medicine and Health Sciences Commons^™

Harnessing The Human Genome Through Legislative Restraint, George P. Smith Ii

Scholarly Articles

The awesome predictive power of genetic medicine promises great advancements in not only the treatment of identifiable conditions but the prevention of their pathological manifestations. At the same time, the release and dissemination of this genetic or medical information poses a distinct risk of loss of privacy and stigmatization to carriers of genetic disorders. In order to safeguard the individual right of autonomy, privacy, confidentiality and informed consent-yet accommodate the legitimate interests of employers and insurers to obtain medical information relevant to their professional needs and economic responsibilities a balance must be struck legislatively at the federal and state levels …

The Review - Fall/Winter 1998

Jefferson Review

IN THIS ISSUE

• Conference Explores Alternative Therapies for Healing and Health - 2
• Nursing Master's Graduates Choose from a Variety of Advance-Practice Opportunities - 3
• MSN Student Finds Satisfaction in Empowering Clients - 3
• Alumni-Owned Businesses - 4
• Project IMPART Increasing Minority Participation in Nursing Research Careers - 7
• Student Life Award Recipient Builds Awareness, Understanding of OT - 8
• Alumni Notes - 9
• Alumni Update - 10
• College Notes - 12
• Talk-Up Your Alma Mater - 13

Surveillance For Waterborne-Disease Outbreaks -- United States, 1995-1996, Deborah A. Levy, Michelle S. Bens, Gunther F. Craun, Rebecca L. Calderon, Barbara L. Herwaldt

Journal Articles: Epidemiology

PROBLEM/CONDITION: Since 1971, CDC and the U.S. Environmental Protection Agency have maintained a collaborative surveillance system for collecting and periodically reporting data that relate to occurrences and causes of waterborne-disease outbreaks (WBDOs).

REPORTING PERIOD COVERED: This summary includes data for January 1995 through December 1996 and previously unreported outbreaks in 1994.

DESCRIPTION OF THE SYSTEM: The surveillance system includes data about outbreaks associated with drinking water and recreational water. State, territorial, and local public health departments are primarily responsible for detecting and investigating WBDOs and for voluntarily reporting them to CDC on a standard form.

RESULTS: For the period 1995-1996, …

The Effect Of Sinoaortic Deafferentation On Renal Wrap Hypertension, J. Mark Van Ness, Teresa Craig, Carmen Hinojosa-Laborde, Joseph R. Haywood

College of the Pacific Faculty Articles

The purpose of this study was to determine whether sinoaortic deafferentation (SAD) alters the severity of hypertension or sympathoadrenal contribution to mean blood pressure (MAP) during renal wrap hypertension. Male Sprague-Dawley rats were implanted with radiotelemetry transmitters for 24-hour recording of MAP and heart rate. All rats underwent either SAD or sham SAD (Intact) surgery and were allowed to recover for 10 to 14 days. The rats were then assigned to a normotensive (Sham) group or a hypertensive (Wrap) group in which 1-kidney figure-8 renal wrap was performed. SAD increased the acute MAP response to renal wrap (Intact-Sham=5+/-1 mm Hg, …

Experiencing Physical Violence During Pregnancy: Prevalence And Correlates, Vilma E. Cokkinides, Ann L. Coker

CRVAW Faculty Journal Articles

Violence during pregnancy directly impacts the mental and physical health of pregnant women. We assessed the prevalence and correlates of physical violence around the time of pregnancy in a representative sample of 6,718 women in South Carolina. Physical violence, defined as "being physically hurt by husband or partner" or "being involved in a physical fight" was reported by 10.9% of recently pregnant women. These were correlates of violence: experiencing increased numbers of stressful life events, being unmarried, having increased parity, being on Medicaid, and having an unwanted pregnancy. Screening to identify violence in pregnancy in health care settings is vital …

Violence Against Women In Sierra Leone: Frequency And Correlates Of Intimate Partner Violence And Forced Sexual Intercourse, Ann L. Coker, Donna L. Richter

CRVAW Faculty Journal Articles

Violence against women is a significant public health problem which impacts women, men, and children. Little is known about the frequency or correlates of violence against women in Africa. In this cross-sectional study, we found that 66.7% of 144 women surveyed in a study of AIDS knowledge, attitude, and behaviours, report being beaten by an intimate male partner and 50.7% report having ever been forced to have sexual intercourse; 76.6% of women report either forced sex or intimate partner violence. Circumcised women were most likely to report intimate partner violence and forced sexual intercourse. To improve the health of women …

Chain Saw Hazard Alert, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Tractors/Logging

A review of 74 cases of chain saw injuries to Kentucky farmers revealed that most occurred while the farmers were clearing fence lines. Most of the injuries occurred in the spring, from March through April, and in the fall, from October through November. As for time of day, most happened in the morning, from 8:30 to 10, and in the early afternoon, from 12 to 3.

Described below are two representative incidents, followed by recommendations for prevention of similar injuries.

Complexities In Biomedical Decision-Making, George P. Smith Ii

Scholarly Articles

Within the contemporary debate over medical ethics, without question the most striking weakness found is the lack of a basic yardstick against which either the "rightness" or "wrongness" of a physician's actions may be measured. No general agreement is to be found among physicians or ethicists acknowledging what ethical determinant the physician should or should not follow in a particular case. Yet, despite this conflict of uncertainties, a framework for principled decisionmaking does exist and can be found within the rubric of medical ethics.

In Vitro Anti-Hepatitis B Virus Activities Of 5’-O-Myristoyl Analogue Derivatives Of 3’-Fluoro-2’,3’-Dideoxythymidine (Flt) And 3’-Azido-2’,3’- Dideoxythymidine (Azt), Keykavous Parang, Leonard I. Wiebe, Edward E. Knaus, Jyy-Shiang Huang, David L. Tyrrell

Pharmacy Faculty Articles and Research

The objective of this study was to evaluate a dual action prodrug concept wherein an unnatural myristic acid analogue is coupled via an ester moiety to the 5’-position of FLT or AZT. Subsequent intracellular cleavage of the prodrug ester would simultaneously release FLT or AZT that could inhibit reverse transcriptase (RT), and the myristic acid analogue that could inhibit myristoyl- CoA:protein N-myristoyltransferase (NMT). Methods: Cytotoxicity (2.2.15 cell culture), and antihepatitis B activity of 5’-O-myristoyl analogue prodrug derivatives of FLT and AZT (2-8) were evaluated in vitro using human liver hepatitis B virus (HBV) producing 2.2.15 cell lines. Results: The 5’- …

Manuel De Recherche Opérationnelle En Matière De Planification Familiale, Andrew A. Fisher, John E. Laing, John E. Stoeckel, John Townsend

Reproductive Health

Le Manuel de recherche opérationnelle en matière de planification familiale, publié pour la première fois en anglais par le Population Council en 1984, se basait sur des projets de recherche en Asie. Cette seconde édition contient des sections révisées et développées. Le cas échéant, des exemples d'Amérique latine et d'Afrique ont été ajoutés. Le chapitre d'introduction comprend une exposé actualisé sur le processus de la recherche opérationnelle (RO) en matière de santé et planification familiale. De nouveaux chapitres concernent le choix du type d’intervention à tester dans une étude RO ainsi que les principaux éléments constituant un programme d'intervention. Le …

Dual Diagnosis Treatment Models, Lauretta M. Cufr

Graduate Research Papers

The increase in the size of the identified Dual Diagnosis population and the increase in focus on cost effectiveness of treatment interventions and outcomes, has made clear the need for improvements in the knowledge base of treatment providers. Treatment models currently in use as partially developed approaches need to be studied in order to provide the DD population with the most effective treatment possible. (Minkoff, 1994).

This paper will examine literature pertaining to the three current treatment models: the serial, the parallel, and the integrated. It will also report findings regarding one innovative program currently under study for clients who …

Integrating Sti/Hiv Services Into Existing Mch/Fp Programs, Baker Ndugga, Ian Askew

Reproductive Health

The presence of certain STIs increases the risk of the sexual transmission of HIV. Thus, controlling STIs can reduce the incidence of HIV. Almost all women in the East and Southern African regions attend MCH/FP clinics regularly, and recent surveys have shown that the prevalence levels of many STIs, including HIV, can be high for women seeking FP and antenatal services, even though they are frequently asymptomatic. MCH/FP services are provided by medically trained staff with many of the same skills needed for managing STIs. Consequently, several MCH/FP programs have started looking for ways to integrate STI management strategies, such …

Reproductive Health Operations Research, 1995–1998, James R. Foreit, Federico R. Leon, Ricardo Vernon, Timothy D.N. King, Deborah L. Billings, A.B Friedman, Janie Benson

Reproductive Health

This book presents in-depth reports on promising new interventions that have been developed and important programmatic changes that have been achieved by operations research in Latin America between 1995 and 1998. The INOPAL III project has made advances in five areas including access and quality of services, integration of family planning and other reproductive health services, financial sustainability, post-abortion care, and emergency contraception. Each of these topics are represented by at least three studies conducted in two or more countries. The operations research projects discussed under each topic are not replications of a single study. They use different research designs …

Emergency Contraception In Zambia: Setting A New Agenda For Research And Action, Yusuf Ahmed, M. Ketata, John P. Skibiak

Reproductive Health

This report summarizes the activities and findings of the first phase of the operations research study, “Enhancing Access to Family Planning Services through the Introduction of Emergency Contraception.” Launched in September 1997, the study was designed to explore a broad range of issues relating to emergency contraception within a developing country context. With financial and technical support from the United States Agency for International Development, the World Health Organization, the Canadian Public Health Association, and the British Department for International Development (DFID), the study consists of an initial exploratory exercise and a subsequent research phase. The report is divided into …

Youth Centres In Ghana: Assessment Of The Planned Parenthood Association Of Ghana Programme, Evam Kofi Glover, Annabel Erulkar, Joana Nerquaye-Tetteh

Reproductive Health

The sexual and reproductive health of adolescents has become a major public concern, particularly with the advent of HIV/AIDS. Many organizations have tried to find strategies to reach youth with reproductive health (RH) information and services through various service delivery models. One such model has been the multipurpose youth center approach. Multipurpose youth centers typically include recreational or vocational services as entry points for RH and family planning (FP) information and services. There is some evidence in a variety of African settings (notably Kenya and Zimbabwe) suggesting that these centers are underutilized and not cost-effective. As a result, the Planned …

Peru Logistics Chain Analysis, Jeanne Noble, James R. Foreit

Reproductive Health

The inventory module of situation analysis, developed by the Population Council, has been adapted to help generate indicators of logistics system functioning suggested by the Evaluation Project and to provide an analytical framework that permits more accurate estimations of the frequency, location, and patterns of logistics problems. In 1996, the module was implemented in southern Peru. In 1997, the same module was implemented in the province of Santa and two provinces of Huancavelica. Comparable information was obtained from 149 service delivery points (SDPs) in four departments. Data include inventories of contraceptive supplies and materials required for safe delivery of contraception; …

Evaluation De La Stratégie De Distribution À Base Communautaire, Banza Baya, Georges Guiella, Christine Ouedraogo, Gabriel Pictet

Reproductive Health

Ce rapport d’évaluation de l’intervention de la DSF se base sur quatre séries d’enquête au Burkina Faso: l’enquête quantitative de base (avril-mai 1996), l’enquête qualitative de base (1996), et l’enquête de premier passage (avril-mai 1998) et l’enquête d’évaluation qualitative DBC (novembre 1998). L’intervention s’attachera à valider les hypothèses du Laboratoire de santé communautaire (LSC), à analyser la mise en œuvre de l’intervention, à tenter de saisir ses effets et d’étudier les mérites respectifs des deux stratégies testées dans le Bazèga, conformément au protocole d’évaluation proposé par l’UERD et validé par les partenaires du LSC (DSF, Population Council, Mwangaza Action et …

An Assessment Of The Zimbabwe Family Planning Programme: Results From The 1996 Situation Analysis Study, Lewis Ndhlovu, Hazel M.B. Dube, Caroline S. Marangwanda

Reproductive Health

Within the past ten years, the Zimbabwe National Family Planning Council (ZNFPC) has conducted two major studies for assessing the availability and quality of reproductive health services. The two studies, generally referred to as Situation Analysis studies, were conducted in 1991 and 1996. The 1996 survey collected data from 192 health facilities spread throughout Zimbabwe. During this exercise, an inventory of physical facilities, equipment, and educational materials was taken. In addition, 758 provider–client interactions of new and revisit clients were observed. Exit interviews were conducted with service providers, and with family planning and maternal and child health clients. In this …

Introduction Du Traitement Médical D'Urgence Ainsi Que Les Services Et Conseils Ultérieurs En Planification Familiale Pour Les Femmes Qui Souffrent De Complications Suite À Un Avortement Au Burkina Faso, Population Council, Jpiego

Reproductive Health

Cette étude de recherche opérationnelle a examiné la faisabilité et l'acceptabilité de la mise en place de services de soins après avortement (SAA) pour améliorer les soins cliniques et le suivi des patientes post-avortement dans deux sites pilotes au Burkina Faso. Une étude pré-test / post-test, sans groupe témoin, a été utilisée pour mesurer les effets d'une intervention qui a amélioré les compétences de communication clinique et interpersonnelle des médecins et des sages-femmes pour les soins aux patientes après avortement, y compris le conseil et la planification familiale. Les résultats de cette étude démontrent que l'introduction d'une approche plus globale …

Lack Of Effect Of Leptin On Glucose Transport, Lipoprotein Lipase, And Insulin Action In Adipose And Muscle Cells, Subramanian Ranganathan, Theodore P. Ciaraldi, Robert R. Henry, Sunder Mudaliar, Philip A. Kern

Clinical and Translational Science Faculty Publications

The effect of leptin on glucose transport, lipogenesis, and lipoprotein lipase activity was studied in cultured rat adipocytes and 3T3-L1 adipocytes. Leptin had no effect on basal and insulin stimulated glucose transport in isolated adipocytes from the rat and the genetically obese mouse. The incorporation of glucose into lipids was also unaffected. Lipoprotein lipase (LPL) activity remained unchanged in response to leptin in these cells, as well as in minced adipose tissue. Leptin also had no effect on both basal and insulin-stimulated glucose transport in cultured rat and human skeletal muscle cells. These studies showed that leptin had no effect …

Effects Of Tumor Necrosis Factor-Α On Glucose Metabolism In Cultured Human Muscle Cells From Nondiabetic And Type 2 Diabetic Subjects, Theodore P. Ciaraldi, Leslie Carter, Sunder Mudaliar, Philip A. Kern, Robert R. Henry

Clinical and Translational Science Faculty Publications

The effects of tumor necrosis factor-a (TNFα) on glucose uptake and glycogen synthase (GS) activity were studied in human skeletal muscle cell cultures from nondiabetic and type 2 diabetic subjects. In nondiabetic muscle cells, acute (90-Min) exposure to TNFα (5 ng/ml) stimulated glucose uptake (73 ± 14% increase) to a greater extent than insulin (37 ± 4%; P < 0.02). The acute uptake response to TNFα in diabetic cells (51 ± 6% increase) was also greater than that to insulin (31 ± 3%; P < 0.05). Prolonged (24-h) exposure of nondiabetic muscle cells to TNFα resulted in a further stimulation of uptake (152 ± 31%; P < 0.05), whereas the increase in cells from type 2 diabetics was not significant compared with that in cells receiving acute treatment. After TNFα treatment, the level of glucose transporter-1 protein was elevated in nondiabetic (4.6-fold increase) and type 2 (1.7-fold) cells. Acute TNFα treatment had no effect on the fractional velocity of GS in either nondiabetic or type 2 cells. Prolonged exposure reduced the GS fractional velocity in both nondiabetic and diabetic cells. In summary, both acute and prolonged treatment with TNFα up-regulate glucose uptake activity in cultured human muscle cells, but reduce GS activity. Increased skeletal muscle glucose uptake in conditions of TNFα excess may serve as a compensatory mechanism in the insulin resistance of type 2 diabetes.

Significance Of The Kccl Cytoplasmic Cooh-Terminal Fragment For The Ph Dependence Of K-Cl Cotransport In Transfected Human Embryonic Kidney Cells, Norma C. Adragna, Jin Zhang, Peter K. Lauf

Pharmacology and Toxicology Faculty Publications

No abstract provided.

College Of Medical Sciences Student Handbook, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

A Comparison Of Medicaid Managed Mental Health Care In Ahca Areas 6 & 4, M. Susan Ridgely, Julienne A. Giard, Kristen Snyder, Pat Robinson

Mental Health Law & Policy Faculty Publications

No abstract provided.

Asperger's Syndrome : A Review Of Literature, Tracy L. Gappa

Graduate Research Papers

This paper contains a review of literature on Asperger's Syndrome (AS). This disorder is characterized by deficits in social interaction skills and communication skills (such as the absence of eye contact or facial expressions). Individuals with AS also insist on routines in behaviors, and pursue a relatively narrow range of interests and activities. Etiology is thought to be multifactoral. Studies have indicated that AS may be influenced by genetic factors as well as pre-, peri-, and postnatal trauma. The disorder is also more common among boys than girls.

In this paper, the general clinical features of AS are reviewed, with …

Medicaid Managed Mental Health Care Arrangements In Ahca Area 6: Organizational, Financial And Clinical Structures, M. Susan Ridgely, Julienne A. Giard, Kristen Snyder

Mental Health Law & Policy Faculty Publications

This report, the first full report on the organizational, financial and clinical structures of the managed mental health care interventions in AHCA Area 6, is presented in the following sections. In Section 2 , we describe the methods used to identify, obtain and analyze information on the nine managed care plans operating in Area 6. In Section 3, we provide a chronology of events related to Medicaid managed care and then describe the Medicaid service delivery system in AHCA Area 6, providing contextual data on the number of Medicaid recipients enrolled in managed care plans, the number of MCOs and …

Quantitative Component Year One Report: Medicaid Enrollee Characteristics, Service Utilization, Costs, And Access To Care In Ahca Areas 4 And 6, Paul Stiles, Kristen Snyder, Mary R. Murrin

Mental Health Law & Policy Faculty Publications

No abstract provided.

Percutaneous Nephrostomy: A Non-Operative Management Of Urinomas: 2 Case Reports, Tanveer-Ul-Haq, I H. Rizvi, Z A. Khan, A A. Khan

Department of Radiology

No abstract provided.

Absence Of Detectable Pharmacological Effects After Oral Administration Of Isoxsuprine, J. Daniel Harkins, G. D. Mundy, S. Stanley, W. E. Woods, R. A. Sams, D. R. Richardson, S. C. Grambow, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To deflne the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCI (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin …

An Overview Of The Methylxanthines And Their Regulation In The Horse, J Daniel Harkins, W. Allen Rees, G. D. Mundy, Scott D. Stanley, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Caffiene, theophylline and theobromine are naturally occurring members of the methylxanthine family;pentoxfylline, dyphylline and enprofylline are structurally related synthetic pharmaceuticals. Caffiene has predominantly central nervous system effects, theophylline, dyphylline and enprofylline have predominantly bronchodilator effects, while theobromine is associated with diuretic responses. Pentoxfylline is thought to increase red cell deformability and facillitate blood flow through capillary beds. The methylxanthines are not highly potent agents; they are typically administered in gram doses and they tend to have relatively long half-lives. They remain detectable in plasma and urine for relatively long periods. Similarly, traces of the naturally occurring members of this family …