Medicine and Health Sciences Commons^™

Intelligent Support Of Gait Analysis, Kathy A. Johnson, Sheldon R. Simon, Philip J. Smith, Jack W. Smith

Faculty, Staff and Student Publications

No abstract provided.

Predicting The Risk Of Obesity Using A Bayesian Network, Christopher C. Bunn, Min Du, Keyi Niu, Todd R. Johnson, Walker S. Poston, John P. Foreyt

Faculty, Staff and Student Publications

No abstract provided.

Glass-Ionomer Adhesives In Orthodontics: Clinical Implications And Future Research Directions, T. Gerard Bradley, Daniel Camargo De Oliveira

School of Dentistry Faculty Research and Publications

During the past ten years significant advances have been made in the development of glass-ionomer bonding adhesives. The beneficial effects of fluoride are well documented and an agent which reduces or prevents a white spot lesion that commonly occurs clinically, is desirable. There has been a notable lack of randomized clinical trials to determine the prevalence of white spot lesions after orthodontic treatment although it is often reported in the literature. White spot lesions pose health and esthetic problems and their proper clinical management has yet to be resolved. The objective of this paper Is to review the literature in …

Anaesthetic Management Of Patients With Phaeochromocytoma And Uncontrolled Blood Pressure, Ursula Chohan, Fazal Hameed Khan

Department of Anaesthesia

No abstract provided.

Health And Educational Outcomes Of Children Who Experienced Severe Neonatal Medical Complications, Timothy B. Smith, Glenna C. Boyce, Glendon Castro

Faculty Publications

To determine the long-term developmental and educational outcomes of a sample of low birthweight infants with intraventricular hemorrhage (IVH), developmental assessments and interviews were conducted eight years after the initiation of an early intervention project. At the time of the follow-up, 62% of children were experiencing some developmental or behavior problems, with visual impairments, cerebral palsy, and attention deficits occurring most frequently. Grade of IVH and the number of days spent in the neonatal intensive care unit were the best predictors of later developmental delays. The sample also scored below average on school achievement; approximately 30% of those in school …

Transfection Of Human Macrophages By Lipoplexes Via The Combined Use Of Transferrin And Ph-Sensitive Peptides, Sérgio Simões, Vladimir Slepushkin, Elizabeth Pretzer, Paul Dazin, Rogério Gaspar, Maria C. Pedroso De Lima, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

The crucial function of macrophages in a variety of biological processes and pathologies render these cells important targets for gene therapeutic interventions. Commonly used synthetic gene delivery vectors have not been successful in transfecting these non-dividing cells. A combination strategy involving cationic liposomes to condense and carry DNA, transferrin to facilitate cellular uptake, and the pH-sensitive peptide GALA to promote endosome destabilization, resulted in significant expression of a luciferase gene. Transfection of macrophages was dependent on the degree of differentiation of the cells. The quaternary complexes of cationic liposomes, DNA, transferrin, and GALA exhibited a net negative charge, which may …

The Beat Newsletter, College Of Medicine

The Beat Newsletter

This is the January, 1999 edition of the Frederick P. Whiddon College of Medicine's newsletter - The Beat.

Contents include:

• Determining molecular mechanisms of Neoplastic transformation by targeting signal transduction pathways
• BAUGH returns to the college of medicine
• New faculty
• First Annual CHARLES M. BAUGH lecture in basic medical sciences
• AUBREY E. TAYLOR, PH.D. Texan Christian University distinguished alumnus award
• WERTELECKI to establish Ukrainian birth defects program
• New PH.D. graduates in basic medical sciences
• Medical curriculum update
• Institutional Review Boards (IRBs) Face Major Changes in the Research Environment
• Occupational Health Program
• Retirement
• Summer research program for medical students: Call for …

Plasmd Bearing A Cdna Copy Of The Genome Of Bovine Viral Diarrhea Virus, Chimeric Derivatives Thereof, And Method Of Producing An Infectious Bovine Wral Darrheavirus Using Sad Plasmid, Ruben O. Donis, Ventzislav B. Vassilev

School of Veterinary and Biomedical Sciences: Faculty Publications

A plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus (BVDV), chimeric derivatives of the plasmid and a method of producing an infectious bovine viral diarrhea virus using the plasmid are disclosed. The invention relates to a plasmid DNA molecule that replicates easily in E. coli and contains a sufficient portion of the genome of BVDV, cloned as cDNA, to be a suitable template to produce RNA in vitro which, upon transfection into bovine cells, gives rise to infectious BVDV. The BVDV created by the process of the invention can be engineered for use as a …

Conjunctivitis Caused By A Swine Chlamydia Trachomatis-Like Organism In Gnotobiotic Pigs, Douglas G. Rogers, Arthur A. Andersen

School of Veterinary and Biomedical Sciences: Faculty Publications

The objective of this study was to determine whether a chlamydial strain recovered from growing and finishing swine with conjunctivitis or keratoconjunctivitis could cause the same infections in gnotobiotic pigs. The strain shares biological characteristics with Chlamydia trachomatis. After propagation in Vero cells and preparation of the inoculum (107 inclusion-forming units/ml), chlamydial strain H7 was instilled into the ventral conjunctival sac (0.15 ml/sac) of 12 anesthetized 3-day-old gnotobiotic piglets. Four age-matched gnotobiotic piglets were anesthetized and sham infected with uninfected cell culture lysates. None of the principal piglets developed clinical symptoms of conjunctivitis or keratoconjunctivitis. Principal piglets necropsied 7 …

In Situ Hybridization For The Detection And Localization Of Swine Chlamydia Trachomatis, C. Chae, D.-S. Cheon, D. Kwon, O. Kim, B. Kim, J. Suh, D. G. Rogers, K. D. E. Everett, A. A. Anderson

School of Veterinary and Biomedical Sciences: Faculty Publications

Gnotobiotic piglets were inoculated intralaryngeally with swine Chlamydia trachomatis strain R33 or orally with swine C. trachmatis strain R27. Archived formalin-fixed, paraffin-embedded tissues from piglets euthanatized 4–7 days postinoculation were examined by in situ hybridization for C. trachomatis nucleic acid using a nonradioactive digoxigenin-labeled DNA probes that targeted specific ribosomal RNA or omp1 mRNA molecules of the swine C. trachomatis strains. Positive hybridization signals were detected in bronchial epithelial cells, bronchiolar epithelial cells, pneumocytes, alveolar and interstitial macrophages, and jejunal and ileal enterocytes. Chlamydia-infected cells had a strong signal that was confined to the intracytoplasmic inclusions. Positive hybridization signals were …

Affinity Chromatography: A Review Of Clinical Applications, David S. Hage

David Hage Publications

Affinity chromatography is a type of liquid chromatography that makes use of biological-like interactions for the separation and specific analysis of sample components. This review describes the basic principles of affinity chromatography and examines its use in the testing of clinical samples, with an emphasis on HPLCbased methods. Some traditional applications of this approach include the use of boronate, lectin, protein A or protein G, and immunoaffinity supports for the direct quantification of solutes. Newer techniques that use antibody-based columns for on- or off-line sample extraction are examined in detail, as are methods that use affinity chromatography in combination with …

The Biotech Century (Book Review), Philip A. Reed

STEMPS Faculty Publications

No abstract provided.

Aneuploidy Frequencies In Semen Fractions From Ten Oligoasthenoteratozoospermic Patients Donating Sperm For Intracytoplasmic Sperm Injection, Jerome Pfeffer, Myung-Geol Pang, Stanton F. Hoegerman, Christopher J. Osgood, M. W. Stacey, Jacob Mayer, Sergio Oehninger, William G. Kearns

Biological Sciences Faculty Publications

Objective: To determine aneuploidy frequencies in pellet and swim-up semen fractions from 10 infertile men with severe oligoasthenoteratozoospermia (OAT) who were donating sperm for intracytoplasmic sperm injection and to determine whether the swim-up isolation method would successfully separate aneuploid from haploid sperm.

Design: Prospective study.

Setting: Infertility clinic and molecular genetics laboratory.

Patient(s): Ten patients with severe OAT.

Intervention(s): Cytogenetic analyses by fluorescence in situ hybridization to determine aneuploidy frequencies for chromosomes 1, 13, 18, 21, X, and Y in sperm from swim-up and pellet fractions.

Main Outcome Measure(s): Gametic aneuploidy was scored in sperm fractions separated by the swim-up …

Uso De Una Escala Multidimensional Para Padres De Niños De 6 A 11 Años En El Diagnóstico De Deficiencia Atencional Con Hiperactividad [Use Of Multidimensional Scale For Parents Of Children Aged 6 To 11 For The Diagnosis Of Attention Deficit With Hyperactivity], David Pineda, R. W. Kamphaus, O. Mora, I. C. Puerta, L. G. Palacio, I. Jiménez, Silvia Mejia-Arango, M. García, J. C. Arango

School of Medicine Publications

Introduction: The BASC is a multidimensional approach to evaluate the child behavior and it has been validated on the diagnosis of ADD/+H in North American children.

Objective: Validating BASC-PRS 6-11 on the diagnosis of ADD/+H.

Patients and methods: We selected 25 male DSM IV-ADD/+H (combined type), 6 to 11-years-old children, and 25 age, gender, and socioeconomic status matched controls. Mean ages of both groups 8.16 (1.5), schooling of controls 2.64 (1.4), and cases 2.6 (1.9).

Results: On the Clinical Scale ADD/+H children had significant (Anova p < 0.01) higher scores in hyperactivity, conduct problems, and attention problems. On the Adaptive Scale only significant differences on social skills and leadership were found, with lower score in the ADD/+H group. A crosstab analysis between group code and each rating variable transformed into categorical (0 and 1) variable, cut-off point = 85 percentile, found that the case children's parents qualified as clinically in higher risk the variables attention problems (OR = 24.4; 95% CI = 4.5-130), conduct problems (OR = 9.0; 95% CI = 1.7-46.9) and hyperactivity (OR = 6.8; 95% CI = 1.6-28.5) (p < 0.01). A discriminant analysis selected attention problems as discriminant function (p < 0.0001). Classification capability 84% for each group.

Conclusion: Our results proved the validity of the BASC-PRS 6-11 questionnaire for the screening …

Development And Testing Of A Quantitative Food Frequency Questionnaire For Use In Gujarat, India, James R. Hébert, Prakash C. Gupta, Ramesh B. Bhonsle, Pesi N. Sinor, Hemali Mehta, Fali S. Mehta

Faculty Publications

Objective: To develop and test a quantitative, interviewer-administered food frequency questionnaire (FFQ) to ascertain nutrient intakes of individuals in northern India. Design: A 92-item FFQ was developed based on food use and market surveys of the study area. A validation study was conducted consisting of 24-h diet recalls (24HR) administered on 6 randomly selected days over 1 year. Two FFQs were administered, one each at the beginning and end of the 1-year period. FFQ and 24HR-derived nutrient scores were compared using correlation and regression analyses and by computing differences between nutrient intakes estimated by the two methods. Setting: Rural villages …

Managed Care And Mental Health: Clinical Perspectives And Legal Realities, Jesse Goldner

All Faculty Scholarship

Managed care is beginning to dominate the delivery of mental health services. The Article reviews limitations on managed care's ability to deal adequately with mental illness. It discusses empirical and other research examining the use of primary care providers as gatekeepers and it explores utilization review mechanisms, focusing particularly on providers' responses to UR. The impact on quality, access and continuity of care on discrete populations is analyzed. The article then surveys a variety of legal issues in the regulation of managed care, particularly as they apply to the provision of mental health services. These include ERISA, parity and liability …

Prise En Charge De La Sécurité Dans Les Petites Entreprises Des Secteurs De L'Habillement Et De La Fabrication De Produits En Métal, Danièle Champoux, Jean-Pierre Brun

Rapports de recherche scientifique

No abstract provided.

Decision Analytic Approach To Severe Head Injury Management., Harmanec D., Tze-Yun Leong, Sundaresh S., Poh K., Yeo T., Ng I., Lew T.

Research Collection School Of Computing and Information Systems

Severe head injury management in the intensive care unit is extremely challenging due to the complex domain, the uncertain intervention efficacies, and the time-critical setting. We adopt a decision analytic approach to automate the management process. We document our experience in building a simplified influence diagram that involves about 3000 numerical parameters. We identify the inherent problems in structuring a model with unclear domain relationships, numerous interacting variables, and real-time multiple inputs. We analyze the effectiveness and limitations of the decision analytic approach and present a set of desiderata for effective knowledge acquisition in this setting. We also propose a …

Alaska Native Cancer Survival Report, A.P. Lanier, P. Holck, J. Kelly, B. Smith, T. Mcevoy

Native Health Database Full Text

This report presents Alaska Native cancer survival rates and stage of disease at diagnosis. Data on survival and stage at diagnosis are given for all cancers combined, and for select primary cancer sites (the organ in which the cancer first began). Survival rates are given for only those cancers for which there were enough patients to calculate reliable estimates. The focus is on five-year relative survival rates because these rates are most commonly used in the cancer literature and most appropriate for comparisons between populations.

Native Outreach: A Report To American Indian, Alaska Native And Native Hawaiian Communities, C.S. Glover, F.S. Hodge

Native Health Database Full Text

The National Cancer Institute (NCI) is presenting a monograph written specifically for community leaders, health professionals and lay health workers serving Native American communities. Native Americans have higher mortality rates than the general U.S. population for several major cancer sites. This publication focuses on the need to reduce those rates through effective interventions at the grassroots level.

Patient Safety, Risk Reduction, And The Law, Larry I. Palmer

Faculty Publications

No abstract provided.

What Explains Wage Differences Between Union Members And Covered Nonmembers?, Edward J. Schumacher

Health Care Administration Faculty Research

An individual covered by a collective bargaining agreement but who is not a union member is estimated to earn about 13% lower wages than a union member. Sectors with relatively few covered nonmembers are associated with a large coverage differential, while sectors with high proportions of covered nonmembers are associated with small differentials. This suggests freeriders either weaken the bargaining position of the union or weak bargaining positions increase the incentive to freeride. Only a modest amount of this differential is accounted for by unmeasured ability, the probationary period associated with newly hired union workers, or union status misclassification.

Web Browser Implements Unobtrusive Randomized Comparisons Of Instruction In Health Informatics Classroom, Craig W. Johnson

Faculty, Staff and Student Publications

No abstract provided.

Xvii International Symposium On Biomechanics In Sports, June 30-July 6, 1999, Edith Cowan University, Perth, Western Australia: Fundamental Skills, Ross Sanders (Ed.)

Research outputs pre 2011

No abstract provided.

Isbs '99 : Xvii International Symposium On Biomechanics In Sports, June 30-July 6, 1999, Edith Cowan University, Perth, Western Australia: Acrobatics, Spiros Prassas (Ed.)

Research outputs pre 2011

No abstract provided.

Current Clinical Efficacy Of Chloroquine For The Treatment Of Plasmodium Falciparum Infections In Urban Dar Es Salaam, United Republic Of Tanzania, Zul Premji, C. Makwaya, J.N. Minjas

Pathology, East Africa

Reported is the use of a 14-day WHO protocol, which takes into account the clinical, parasitological and haematological responses to antimalarial drugs, to determine the efficacy of chloroquine in the treatment of uncomplicated malaria in young children (n = 200) in urban Dar es Salaam. Chloroquine failure was found in 43% of the children. Of these, 12.5% were considered to be early treatment failures and were given a single dose of sulfadoxine-pyrimethamine. Fever subsided in all children treated with sulfadoxine-pyrimethamine and there were no parasitological failures. In addition, children treated with sulfadoxine-pyrimethamine because of early treatment failure with chloroquine had …

Poor Performance Of Health And Population Welfare Programmes In Sindh: Case Studies In Governance Failure, Mehtab S. Karim, Shehla Zaidi

Community Health Sciences

Over the past few years, the issue of what is meant by “good governance” has generated increasing attention and debate both at the national and international level [Streeten (1997)]. The role of state and how that role is to be exercised is appearing high on the agenda of politicians, policy-makers and academicians in the developing world. Governance has been defined by the World Bank as “the manner in which power is exercised in the management of the country’s economic and social resources” [World Bank (1994)]. The somewhat narrow scope of this definition has been broadened in recent years to “the …

Healthcare Workers' Perceptions Of Occupational Exposure, Sunita Mutha, Donna B. Jeffe, Lynn E. Kim, Paul B. L'Ecuyer, Bradley A. Evanoff, Victoria J. Fraser

Occupational and Health Faculty Publications

No abstract provided.

Sistema De Evaluación Multidimensional De La Conducta. Escala Para Padres De Niños De 6 A 11 Años, Versión Colombiana [A System Of Multidimensional Behavior Assessment. A Scale For Parents Of Children From 6 To 11 Years Of Age. Colombian Version], David Pineda, R. W. Kamphaus, O. Mora, M. A. Restrepo, I. C. Puerta

School of Medicine Publications

Introduction: Behavioral Assessment System for Children (BASC) has demonstrated to be useful in the diagnosis of Attention Deficit Disorder (ADD).

Patients and methods: A randomized sample of 120 children, 6 to 11-year-old, participants from the school of the city of Medellín, Colombia, was selected. The sample was stratified by sex and two socioeconomic status (SES). Parents were asked to answer the BASC Parent Rating Scale (PRS) 6-11, authorized Spanish version.

Results: Cronbach's alpha coefficient was 0.85 for the clinical scale (9 items). It was 0.75 for the Adaptive Scale (3 items). A scale designed with 4 items to assess ADD …

International Law And Global Public Health, David P. Fidler

Articles by Maurer Faculty

No abstract provided.