Medicine and Health Sciences Commons^™

Serum Lipid Response To N-3 Fatty Acid Enriched Eggs In Persons With Hypercholesterolemia, Nancy M. Lewis, Kim Schalch, Sheila E. Scheideler

Department of Nutrition and Health Sciences: Faculty Publications

Consumption of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) is low among certain population subgroups in the United States, especially in people living in Midwestern states and those who dislike fish. Therefore, there is a need to identify acceptable food sources of n-3 PUFA. Vegetable oils, such as canola and soy, provide some n-3 fatty acids. However, these sources are high in n-6 fatty acids and there is concern that they may have detrimental side effects. Eggs enriched in n-3 PUFA can be produced by incorporating sources of these fatty acids into poultry rations. In acceptability studies, US consumers responded …

Jefferson Alumni Bulletin – Volume Xlix, Number 2, March 2000

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIX, Number 2, March 2000 Integrative medicine: Broadening the mainstream, page 4 Orthopaedics circa 2013, page 8 Doctoring a sickly system: medical errors, page 10 The two logos: university and health system, page 12 University expands neuroscience programs; Wills eye to construct sophisticated new building, page 14 Jeff hosts international medical students program, page 17 Rb2 gene therapy could shrink lung tumors, and may improve angioplasty, page 19 Gene repair could fix various inherited diseases, page 20 Alumni affairs: Events, notices, dates to remember, page 22

A Review Of Offenders In A State Psychiatric Hospital, L. E. C. Lim, L. L. Tan, M. Sung, K. L. Chan, M. I. Loh, Paulin T. Straughan

Research Collection School of Social Sciences

Patients remanded over a two-year period to Woodbridge Hospital by Court Order were studied retrospectively. Schizophrenia was the most common diagnosis, theft and robbery the most prevalent offences. Males greatly outnumbered females. There were important gender differences, with males tending to commit sexual offences and females, theft and mischief. Males were less likely to be acquainted with their victims but those who caused hurt were more likely to know their victims. Outrage of modesty and theft were more likely to be committed against strangers. The reconviction rate was 26%, with repeat offenders more likely to commit sexual offences and theft. …

Single-Channel Properties In Endoplasmic Reticulum Membrane Of Recombinant Type 3 Inositol Trisphosphate Receptor., D O Mak, S Mcbride, V Raghuram, Y Yue, Suresh K. Joseph, J K Foskett

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The inositol 1,4,5-trisphosphate receptor (InsP(3)R) is an intracellular Ca(2+)-release channel localized in endoplasmic reticulum (ER) with a central role in complex Ca(2+) signaling in most cell types. A family of InsP(3)Rs encoded by several genes has been identified with different primary sequences, subcellular locations, variable ratios of expression, and heteromultimer formation. This diversity suggests that cells require distinct InsP(3)Rs, but the functional correlates of this diversity are largely unknown. Lacking are single-channel recordings of the recombinant type 3 receptor (InsP(3)R-3), a widely expressed isoform also implicated in plasma membrane Ca(2+) influx and apoptosis. Here, we describe functional expression and single-channel …

Frequency Of Malignant Solid Tumors In Children, Sajid Hussain Shah, Shahid Pervez, Sheema H. Hassan

Department of Pathology and Laboratory Medicine

Objective: To find out the frequency of malignant solid tumors in children (cTl5 years).

Setting: All cases of pediatric malignant solid tumors which were diagnosed in the section of histopathology at the Aga Khan University Hospital, Karachi during the period of two years.

Methods: These tumors were initially evaluated on H&E stained sections and special stains were also performed whenever indicated. The undifferentiated tumors were evaluated immunohistochemically by using a panel of antibodies on sections from routinely processed, fornialin fixed, paraffin embedded tissu.e blocks.

Results: Of two hundred and fifty three (253) consecutive cases of paediatric malignant solid tumors, lyinphorna …

Technology Revolution’S Begun, And Stern Vows To Be First, Rick Burton

Sport Management - All Scholarship

No abstract provided.

Virus-Induced Neuronal Apoptosis Blocked By The Herpes Simplex Virus Latency-Associated Transcript, Guey-Chuen Perng, Clinton J. Jones, Janice Ciacci-Zanella, Melissa Stone, Gail A. Henderson, Ada Yukht, Susan M. Slanina, Florence M. Hofman, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler

School of Veterinary and Biomedical Sciences: Faculty Publications

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT^- virus but not with LAT⁺ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

Physician Connectivity: Electronic Prescribing, Robin J. Strongin

National Health Policy Forum

This issue brief focuses on physician connectivity — the electronic linking of physicians with online resources such as clinical databases and sophisticated formulary systems. As physician connectivity increasingly allows physicians to prescribe online via a handheld computer complete with formulary information as well as patient data and drug information, this issue brief examines the issues raised by this technological advance within the broader context of online prescribing.

Ada News - 02/21/2000, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

The Suggestibility Of Older Witnesses, Brian H. Bornstein, Christy J. Witt, Katie E. Cherry, Edith Greene

Department of Psychology: Faculty Publications

The present study compares younger and older adult witnesses’ susceptibility to misinformation. Previous research on the misinformation effect has not measured the relationship between the effect and individuals’ perceptions of their own memory abilities. Such perceptions, and general knowledge of one’s own memory processes, are referred to as “metamemory.” In order to examine the relationship between metamemory and the misinformation effect in the present study, participants also completed a questionnaire that assessed their perception of their memory functioning. Although older persons tend to perceive their memories as being faulty, the correlation between self-assessment of memory abilities and actual memory performance …

Interview No. 1625, John Hick Johnstone, Lady Ruth Johnstone

Combined Interviews

In this interview, conducted primarily with Dr. John Hick Johnstone (b. 1909), he discusses his World War II experiences as a physician traveling with the Advance Command Corps; in addition, he speaks at length on El Paso’s mid-twentieth-century medical scene, including the state of the hospitals and the practices of the medical community. At the start of the interview, both John Hick and Lady Ruth share memories of their early years and courtship in Eldorado, Illinois. On their 1940 honeymoon the couple passed through El Paso where they encountered some trouble at the international border due to the narcotics in …

Human Serum Albumin Enhances Dna Transfection By Lipoplexes And Confers Resistance To Inhibition By Serum, Sérgio Simões, Vladimir Slepushkin, Pedro Pires, Rogério Gaspar, Maria C. Pedroso De Lima, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

Cationic liposome-DNA complexes ('lipoplexes') are used as gene delivery vehicles and may overcome some of the limitations of viral vectors for gene therapy applications. The interaction of highly positively charged lipoplexes with biological macromolecules in blood and tissues is one of the drawbacks of this system. We examined whether coating cationic liposomes with human serum albumin (HSA) could generate complexes that maintained transfection activity. The association of HSA with liposomes composed of 1,2-dioleoyl-3-(trimethylammonium) propane and dioleoylphosphatidylethanolamine, and subsequent complexation with the plasmid pCMVluc greatly increased luciferase expression in epithelial and lymphocytic cell lines above that obtained with plain lipoplexes. The …

Efficient Gene Transfer By Transferrin Lipoplexes In The Presence Of Serum, Conchita Tros De Ilarduya, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

Cationic lipids are being used increasingly as reagents for gene delivery both in vitro and in vivo. One of the limitations to the application of cationic lipid-DNA complexes (lipoplexes) in vivo is the inhibition of gene delivery by serum. In this study, we have shown that transferrin (Tf)-lipoplexes, which had transferrin adsorbed at their surface via electrostatic interactions, are much more effective than plain lipoplexes in transfecting cells in the presence of relatively high concentrations (up to 60%) of fetal bovine serum (FBS). Serum even enhanced transfection by Tf-lipoplexes composed of 1,2-dioleoyl-3-(trimethylammonium) propane (DOTAP)/dioleoylphosphatidylethanolamine (DOPE)/pCMVLacZ at high lipid/DNA (+/-) charge …

Fungal Ipc Synthase Assay, Jeffery Radding, Robert C. Dickson, Robert L. Lester

Molecular and Cellular Biochemistry Faculty Patents

The presently-disclosed IPC synthase-inhibitor assays comprise the steps of: (1) expression of the IPC1 gene in a cell; (2) introducing labeled starting substrates for ceramide conversion as well as potential inhibitor(s) of such conversion to the expressed gene product in an environment which allows time and conditions for conversion, and (3) identifying those potential inhibitors which actually inhibit conversion. The present invention also provides methods to determine the ability of a test compound to inhibit fungal growth, comprising the steps of (1) presenting active inositolphosophotidylceramide synthase in a manner such that synthesis of inositolphosphotidylceramide can occur; (2) introducing ceramide and …

Ada News - 02/07/2000, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

A Mycobacterium Ulcerans Toxin, Mycolactone, Causes Apoptosis In Guinea Pig Ulcers And Tissue Culture Cells, Kathleen M. George, Lisa Pascopella, Diane M. Welty, P. L. C. Small

Public and Community Health Sciences Faculty Publications

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a tropical ulcerative skin disease. One of the most intriguing aspects of this disease is the presence of extensive tissue damage in the absence of an acute inflammatory response. We recently purified and characterized a macrolide toxin, mycolactone, from M. ulcerans. Injection of this molecule into guinea pig skin reproduced cell death and lack of acute inflammatory response similar to that seen following the injection of viable bacteria. We also showed that mycolactone causes a cytopathic effect on mouse fibroblast L929 cells that is characterized by cytoskeletal rearrangements and growth arrest …

A Comparison Of Service Delivery Models: Effects On Curricular Vocabulary Skills In The School Setting, Rebecca Throneburg, Lynn K. Calvert, Jennifer J. Sturm, Alexis A. Paramboukas, Pamela J. Paul

Faculty Research and Creative Activity

The present study evaluated the effectiveness of three service delivery models in the elementary school setting. Differences were investigated between (a) a collaborative approach, (b) a classroom-based intervention model with the speech-language pathologist (SLP) and classroom teachers working independently, and (c) a traditional pull-out model for children in kindergarten through third grade who qualified for speech or language services. The same curricular vocabulary targets and materials were used in all conditions. This study also examined the vocabulary skills of regular education children who participated in the collaborative approach, the independent classroom-based model, or received instruction from only classroom teachers, without …

A Comparison Of Service Delivery Models: Effects On Curricular Vocabulary Skills In The School Setting, Rebecca Throneburg, Lynn Calvert, Jennifer Sturm, Alexis Paramboukas, Pamela Paul

Faculty Research and Creative Activity

The present study evaluated the effectiveness of three service delivery models in the elementary school setting. Differences were investigated between (a) a collaborative approach, (b) a classroom-based intervention model with the speech-language pathologist (SLP) and classroom teachers working independently, and (c) a traditional pull-out model for children in kindergarten through third grade who qualified for speech or language services. The same curricular vocabulary targets and materials were used in all conditions. This study also examined the vocabulary skills of regular education children who participated in the collaborative approach, the independent classroom-based model, or received instruction from only classroom teachers, without …

Agonistic Behaviour And Biogenic Amines In Shore Crabs Carcinus Maenas, Lynne U. Sneddon, Alan C. Taylor, Felicity A. Huntingford, David G. Watson

Sentience Collection

To investigate the role of certain neurohormones in agonistic behaviour, fights were staged between pairs of size-matched male shore crabs Carcinus maenas, and blood samples were taken immediately after the contests had been resolved. Samples were also taken from these crabs at rest (before and after fighting) and after walking on a treadmill. A control group of crabs also had samples taken on each experimental day. Concentrations of tyramine, dopamine, octopamine, serotonin (5-HT) and norepinephrine were determined in each blood sample using a gas chromatography/mass spectrometry (GC-MS) system. Norepinephrine was not detectable in any of the samples, but the standards …

Wellness Center Healthletter - February 2000, Nova Southeastern University

Wellness Center Healthletter

No abstract provided.

Sequential Single Doses Of Cisapride, Erythromycin, And Metoclopramide In Critically Ill Patients Intolerant To Enteral Nutrition: A Randomized, Placebo-Controlled, Crossover Study, Robert Maclaren, David A. Kuhl, Jane M. Gervasio, Rex O. Brown, Roland N. Dickerson, Teresa N. Livingston, Kyle Swift, Stacey Headley, Kenneth A. Kudsk, John J. Lima

Scholarship and Professional Work – COPHS

Objective: To evaluate the comparative efficacy of enteral cisapride, metoclopramide, erythromycin, and placebo for promoting gastric emptying in critically ill patients with intolerance to gastric enteral nutrition (EN).

Design: A randomized, crossover study.

Setting: Adult medical intensive care unit at a university-affiliated private hospital and trauma intensive care unit at a university teaching hospital.

Patients: Ten adult, critically ill, mechanically ventilated patients not tolerating a fiber-containing EN product defined as a single aspirated gastric residual volume >150 mL or two aspirated gastric residual volumes >120 mL during a 12-hr period.

Interventions: Patients received 10 mg …

Impact Of Bovine Oocyte Maturation Media On Oocyte Transcript Levels, Blastocyst Development, Cell Number, And Apoptosis., A J Watson, P De Sousa, A Caveney, L C Barcroft, D Natale, J Urquhart, M E Westhusin

Obstetrics & Gynaecology Publications

The objectives were 1) to investigate the effects of oocyte maturation in serum-free and amino acid-supplemented defined media on oocyte transcript levels, blastocyst cell number, and apoptosis; 2) to investigate the influence of oocyte maturation culture atmosphere on blastocyst development, total cell number, and apoptosis; and 3) to examine the influence of epidermal growth factor (EGF) during oocyte maturation on blastocyst cell number and apoptosis. The results demonstrate that blastocysts derived from in vitro maturation, fertilization, and embryo culture protocols undergo apoptosis but that apoptotic levels are not greatly influenced by the oocyte maturation environment. Amino acid supplementation of oocyte …

Clinical Equipoise And Rct Design, Charles Weijer

Philosophy Presentations

This presentation addresses these questions:
• “Upon what ethical grounds may the physician offer RCT enrollment to a patient?”
• Which is the preferred moral basis of the RCT?

Disseminated Bipolaris Infection In An Immunocompetent Host: An Atypical Presentation, J A. Khan, S T. Hussain, S Hasan, P Mcevoy, A Sarwari

Section of Pulmonary & Critical Care

No abstract provided.

Correlates Of Physical Activity In Male And Female Youth, Timothy Bungum, Marsha Dowda, Anne T. Weston, Stewart G. Trost, Russell R. Pate

Faculty Publications

This study examined associations between psychosocial factors and physical activity in a group of youth (n=520). Students completed the Previous Day Physical Activity Recall and a survey of potential determinants of physical activity. Regression analyses of intentions to be physically active revealed that enjoyment and self-efficacy predicted intentions for both males and females. Attitudes predicted moderate to vigorous activity (MVPA), and enjoyment and self-efficacy predicted vigorous activity (VPA) for males. Self-efficacy predicted both MVPA and VPA for females. The findings suggest that intervention programs targeted at youth should include developmentally appropriate activities that are fun and promote physical …

The Differential Relations Of Parent And Peer Attachment To Adolescent Adjustment, Deborah J. Laible, Gustavo Carlo, Marcela Raffaelli

Department of Psychology: Faculty Publications

Whether or not close emotional relationships with parents and peers serve similar functions for adolescent adjustment is an issue of increasing interest. The present study was designed to examine the relations between parent and peer attachment and adolescent adjustment. Eighty-nine adolescents (M age = 16.1 years, SD = 1.8 years) completed self-report measures of parent and peer attachment, sympathy, academic efficacy, aggression, anxiety, and depression. Adolescents were divided into four groups on the basis of their parent and peer attachment scores: those high on both, those low on both, those high on peer but low on parent attachment, and those …

Diagnosis And Management Of The Neonatal Cloaca, A Samad, S Hussain, M Arshad, F Moazam

Department of Surgery Docs

No abstract provided.

The Effect Of Grandmultiparity On Pregnancy Related Complications: The Aga Khan University Experience, S Munim, M H. Rahbar, M Rizvi, N Mushtaq

Department of Obstetrics & Gynaecology

Background: Grandmultiparity has been associated with complications for both mother and the fetus.Objective: To evaluate if grandmultiparity is a risk factor in the presence of adequate antenatal care.
Setting: A tertiary care teaching hospital.
Methods: It was a retrospective study conducted in the department of Obstetrics & Gynecology at The Aga Khan University Hospital in Karachi. During this period 9253 women were delivered, out of these 143 booked grandmultiparas (GMP) served as cases. The outcome of these women was compared with 430 non-grandmultiparas (NGMP). Logistic regression model was used to adjust for potential confounders.
Results: Grandmultiparas had almost three times …

The Production Of Health And The Valuation Of Medical Inputs In Wage-Amenity Models, Edward J. Schumacher, John C. Whitehead

Health Care Administration Faculty Research

Using a hedonic wage-amenity model, this paper examines the valuation of medical inputs into the production of health. The data used in this study include the incomes, demographics and measures of human capital for households in eastern North Carolina with county level medical input supply. These data allow an estimate of the marginal value of medical care inputs such as the physician to population ratio and the availability of specialized services in an area of the country where the lack of available medical care has been of particular concern to policy makers. Our results indicate that while health care inputs …

Pulpal Tissue In Bilateral Talon Cusps Of Primary Central Incisors: Report Of A Case, H. Cem Güngör, Nil Altay, F. Figen Kaymaz

School of Dentistry Faculty Research and Publications

Talon cusp is a tooth anomaly that affects both the primary and the permanent dentitions. However, the occurrence of this anomalous cusp is rather infrequent in the primary dentition. Only 7 cases of bilateral talon cusps affecting the primary teeth have been reported in the dental literature. This is a case report of bilateral talon cusps on primary maxillary central incisors whose histologic evaluation revealed the existence of pulpal tissue in the anomalous cusps.