Medicine and Health Sciences Commons^™

Hemoglobin Concentration In Children In A Malaria Holoendemic Area Is Determined By Cumulated Plasmodium Falciparum Parasite Densities, H. Ekvall, Zul Premji, S. Bennett, A. Bjorkman

Pathology, East Africa

In malaria holoendemic areas children are anemic, but the exact influence of falciparum malaria on hemoglobin (Hb) concentration remains largely unsettled. Prospective data were therefore collected in children < 24 months of age during five months in a Tanzanian village. Children with mean asymptomatic parasitemia ≥ 400/μl had lower median Hb levels during the study than those with mean density < 400/μl. The difference was 9.7 g/L (95% confidence interval [CI] 2.8-17). In children with one or more clinical malaria episodes, the median Hb was 8.3 g/L (95% CI 0.9-16) lower than those without episode. If early treatment failure was recorded, the immediate effect on Hb was particularly important with a mean drop of 17 g/L. Interestingly, at study-end the Hb concentration represented a function of the area under the parasitemia curve (AUPC) during the previous five months, adjusting for age. In conclusion, stepwise deterioration in median Hb levels was found by asymptomatic parasitemia, clinical malaria episode, and most significantly, treatment failure.

Improved Compliance With Universal Precautions In The Operating Room Following An Educational Intervention, Lynn E. Kim, Donna B. Jeffe, Bradley A. Evanoff, Sunita Mutha, Brad Freeman, Victoria J. Fraser

Occupational and Health Faculty Publications

No abstract provided.

Engaging Parents In The Drug Education Of Their Pre-Adolescent Children : Practical Problems And A Promising Program, Shelley E. Beatty, Donna S. Cross

Research outputs pre 2011

No abstract provided.

Development And Testing Of An Assessment Tool For Integrated Learning, Z. Naqvi, R. Ahmed, Bushra Jamil

Department of Medicine

Objective: Development of integrated questions for undergraduate medical students and assessing students’ capability to retain and apply basic concepts in an integrated way.
Method: Multiple choice questions, attempting to probe understanding and application of different concepts, affiliated with different subjects and topics, were developed. As a pilot these were administered to the students of third year and final year at the end of their certifying examinations as a mock test. The following year these questions were introduced in the continuous assessments and subsequently the certifying examinations (in third year) as 33% of the whole examination. Difficult indices, item analysis and …

Relación Entre Monitoreo Ambulatorio De Presión Arterial De 24 Horas Y Alteraciones En La Memoria Reciente De Adultos Mayores De 55 Años [Ambulatory Blood Pressure Monitorization Statement With Recent Memory Disturbs In Adults Oldness Than 55 Years], Egle Silva, Aldrin Molero, Gloria Pino, Tulio Sulbarán, Gladys E. Maestre

School of Medicine Publications

We display a poblational and transversal cohort study with 402 male and female patients of 55 years old or than oldness, from Santa Lucía Maracaibo City Parroquial. Neuropsychologic essays were performs for recent memory evaluation; as a result we obtain two groups: with recent memory disturb and recent memory normal. Weight (kg), tall (m), body mass index (w/t2) and fortituos blood pressure with Dynamap Critikon were performs too. All patients were evaluated with an automatic engine for ambulatory blood pressure monitorization during vigil and sleep hours.

Our conclusions were: 1) Exist a relation of systolic blood pressure with recent memory …

How To Get The Calcium You Need, Unknown Unknown

All Current Publications

No abstract provided.

A Bayesian Decision Approach For Sample Size Determination In Phase Ii Trials, Denis H. Y. Leung, You-Gan Wang

Research Collection School Of Economics

Stallard (1998, Biometrics54, 279–294) recently used Bayesian decision theory for sample-size determination in phase II trials. His design maximizes the expected financial gains in the development of a new treatment. However, it results in a very high probability (0.65) of recommending an ineffective treatment for phase III testing. On the other hand, the expected gain using his design is more than 10 times that of a design that tightly controls the false positive error (Thall and Simon, 1994, Biometrics50, 337–349). Stallard's design maximizes the expected gain per phase II trial, but it does not maximize the rate of gain or …

Providing Services To Family Caregivers At Home: Challenges And Recommendations For Health And Human Service Professions, Susan Toth-Cohen, Laura N. Gitlin, Mary Corcoran, Susan Eckhardt, Pamalyn Kearney, Rosalyn Lipsitt

Department of Occupational Therapy Faculty Papers

The home represents a relatively new arena for practice for most service providers, especially those working with families of persons with dementia. This article describes four key factors to consider when working with caregivers of persons with dementia in their homes. The authors also discuss seven common challenges of service provision in the home and recommend strategies for addressing these challenges.

Dealing With Conflicts Of Interest In Biomedical Research: Irb Oversight As The Next Best Solution To The Abolitionist Approach, Jesse Goldner

All Faculty Scholarship

The author details the conflicts of interest facing individual investigators and research institutions and describes the current mechanisms, primarily focused at the relationship between the investigator and the research institution, to regulate these conflicts. The author finds these mechanisms insufficient and believes that the best approach is not to regulate conflicts, but to abolish them. The author acknowledges, however, that there is a lack of political will in an abolitionist approach. He proposes, therefore, institutional review board oversight at the level of the relationship between researcher and individual subjects as the next best solution.

Fluoroscopic Placement Of Double-Pigtail Ureteral Stents., Gregory L. Chen, Demetrius H. Bagley

Department of Urology Faculty Papers

Purpose: Double-pigtail ureteral stent is placed cystoscopically after ureteroscopy. We describe a technique for fluoroscopic placement of ureteral stents and demonstrate its use in a non-randomized prospective study.Materials and methods: Double-pigtail stents were placed either fluoroscopically or cystoscopically in 121 consecutive patients. In the fluoroscopic method, the stent was placed over a guide wire using a stent pusher without the use of cystoscopy. Conversely, stents were placed through the working channel of the cystoscope under vision. The procedure, stent length, width, type, method, ureteral dilation, and use of a retrieval string were noted.Results: A wide range of stent sizes were …

The Globalization Of Public Health: The First 100 Years Of International Health Diplomacy, David P. Fidler

Articles by Maurer Faculty

Global threats to public health in the 19th century sparked the development of international health diplomacy. Many international regimes on public health issues were created between the mid-19th and mid-20th centuries. The present article analyses the global risks in this field and the international legal responses to them between 1851 and 1951, and explores the lessons from the first century of international health diplomacy of relevance to contemporary efforts to deal with the globalization of public health.

Central Chemosensitivity, Sleep, And Wakefulness, E. E. Nattie, A Li

Dartmouth Scholarship

No abstract provided.

El Impacto De Las Nuevas Technologias En El Futuro De Las Technicas De Evaluacion Psicologica Clinica, Richard H. Dana, Isidro A. E. Sanz, Barry A. Ritzler, Jan Ivanouw

Regional Research Institute for Human Services

En este trabajo se presentan reflexiones desde distintas perspectivas acerca del futuro de la Evaluación Psicológica y el papel que las tecnologías informáticas tendráen ella. En la actualidad, es innegable la importancia que ha alcanzado la informática dentro de las actividades académicas y profesionales en tomo a la Evaluación Psicológica. La capacidad cada vez mayor de las computadoras facilitó las tareas de investigación, desarrollo, y aplicación de tests psicológicos. Parece altamente previsible que en el futuro la informática tendrá un lugar aún mayor en el auxilio del psicógicos evaluador. Algunas posibles consecuencias futuras son expuestas y debatidas por los diferentes …

Asian American Mental Health Clients: Effects Of Ethnic Match And Age On Global Assessment And Visitation, Richard H. Dana, Glenn Gamst, Aghop Der-Karabetian, Terry Kramer

Regional Research Institute for Human Services

Effects of client-counselor ethnic match (i.e., match, no match) and client age group (child, adult) on counselor-evaluated Global Assessment of Function (GAF) and visitation were investigated. The sample consisted of 253 Asian-American outpatient clients (24.9% children 75.1% adults) of a community mental health center. Unadjusted results indicated that ethnically matched clients had more positive GAF evaluations and more clinic visits than nonmatched clients. When adjusted for eight covariates, results showed ethnically matched clients continued to show higher levels of visitation. Analysis of separate diagnostic categories showed that ethnically matched mood-disorder clients had higher levels of visitation. Conversely, nonethnically matched anxiety …

Epidemiological Features Of Aplastic Anaemia In Pakistan, Salman Adil, G. N. Kakepoto, Mohammad Khurshid, I. A. Burney

Department of Pathology and Laboratory Medicine

Objective: To complete the data on the demographic features of patients diagnosed to have aplastic anemia at a single institution over a 7.5 years period. Methods: Demographic information was retrieved from the patients medical records retrospectively as well as prospectively of those patients who presented with features of aplastic anaemia. Their diagnosis was confirmed by performing a complete blood count and bone marrow trephine.
Results: One hundred and forty four patients were diagnosed to have aplastic anemia; there were 106 males and 38 females. Their ages ranged from 2 to 75 years, with a median of 17 years, …

Hard Cases For Autonomy, Respect, And Professionalism In Medical Genetics, Roger B. Dworkin

Articles by Maurer Faculty

No abstract provided.

Nasa Light Emitting Diode Medical Applications From Deep Space To Deep Sea, Harry T. Whelan, Ellen V. Buchmann, Noel T. Whelan, Scott G. Turner, Vita Cevenini, Helen Stinson, Ron Ignatius, Todd Martin, Joan Cwiklinski, Glenn A. Meyer, Brian D. Hodgson, Lisa J. Gould, Mary P. Kane, Gina Chen, James Caviness

School of Dentistry Faculty Research and Publications

This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program. LED-technology developed for NASA plant growth experiments in space shows promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. We present the results of LED-treatment of cells grown in culture and the effects of LEDs on patients’ chronic and acute wounds. LED-technology is also biologically optimal for photodynamic therapy of cancer and we discuss our successes using LEDs in conjunction with light-activated chemotherapeutic drugs.

Leptin In Children With Newly Diagnosed Type 1 Diabetes: Effect Of Insulin Therapy, Kenneth Mccormick, Gail J. Mick, Lisa Butterfield, Hugh Ross, Elaine Parton, Joan P. Totka

College of Nursing Faculty Research and Publications

No abstract provided.

Resistance Exercise Training Attenuates Wasting Of The Edl Muscle In Mice Bearing The Colon-26 Adenocarcinoma, Sadeeka Al-Majid, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Progressive wasting of skeletal muscle is a significant side effect of malignancy. Perturbations in protein metabolism contribute to this state of wasting. Resistance exercise increases protein synthesis and mass of healthy muscles and counteracts muscle wasting associated with several catabolic conditions. It is not known whether resistance exercise training can counteract cancer-induced muscle wasting. This study examined the effect of resistance exercise training on muscle mass and protein content in 9 mice bearing the colon-26 adenocarcinoma. The dorsiflexor (extensor digitorum longus [EDL] and tibialis anterior) and plantar flexor (soleus, plantaris, and gastrocnemius) muscles of 1 leg of the tumor-bearing and …

Cancer-Induced Fatigue And Skeletal Muscle Wasting: The Role Of Exercise, Sadeeka Al-Majid, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Fatigue is the most frequently reported symptom by cancer patients. Many of these patients perceive fatigue as the most distressing symptom associated with their illness because it imposes limitations on their physical activity level. Skeletal muscle wasting, which occurs as part of cancer cachexia, is one of the mechanisms that contribute to fatigue. Cancer induced skeletal muscle wasting may occur despite normal food intake and is not prevented by nutritional supplementation. Evidence suggests that endurance exercise ameliorates cancer-related fatigue. There is no compelling evidence to support that exercise induced reduction in fatigue is related to preservation of muscle mass. Resistance …

What Is Diabetes? Are You At Risk?, Laura Prestwich

All Current Publications

No abstract provided.

Healthy Lifestyle - Eating For You, Laura Prestwich

All Current Publications

No abstract provided.

Be In Control - Living With Diabetes, Laura Prestwich

All Current Publications

No abstract provided.

The Market For Medical Ethics, Maxwell Gregg Bloche

Georgetown Law Faculty Publications and Other Works

At the core of Kenneth Arrow’s classic 1963 essay on medical uncertainty is a claim that has failed to carry the day among economists. This claim—that physician adherence to an anti-competitive ethic of fidelity to patients and suppression of pecuniary influences on clinical judgment pushes medical markets toward social optimality—has won Arrow near-iconic status among medical ethicists (and many physicians). Yet conventional wisdom among health economists, including several participants in this symposium, holds that this claim is either naïve or outdated. Health economists admire Arrow’s article for its path-breaking analysis of market failures resulting from information asymmetry, uncertainty, and moral …

The Translational Regulation Of Lipoprotein Lipase In Diabetic Rats Involves The 3′-Untranslated Region Of The Lipoprotein Lipase Mrna, Gouri Ranganathan, Chunling Li, Philip A. Kern

Clinical and Translational Science Faculty Publications

Adipose tissue lipoprotein lipase (LPL) activity is decreased in patients with poorly controlled diabetes, and this contributes to the dyslipidemia of diabetes. To study the mechanism of this decrease in LPL, we studied adipose tissue LPL expression in male rats with streptozotocin-induced diabetes. Heparin releasable and extractable LPL activity in the epididymal fat decreased by 75-80% in the diabetic group and treatment of the rats with insulin prior to sacrifice reversed this effect. Northern blot analysis indicated no corresponding change in LPL mRNA levels. However, LPL synthetic rate, measured using [³⁵S]methionine pulse labeling, was decreased by 75% in …

Quarantine And Health Screening Protocols For Wildlife Prior To Translocation And Release Into The Wild, Michael H. Woodford

Zoonotics and Wildlife Disease: Publications

In recent years the translocation and release into the wild of wild-caught and captive-bred wild animals (mammals, birds, reptiles, amphibians and fish) has become a common practice, ostensibly for rehabilitation or conservation purposes. These wild animals comprise many varied taxa and the objectives of translocation and release may include:
(1) reintroducing a species that has become extinct in its natural range;
(2) restocking or reinforcing a population which has become depleted; and
(3) rehabilitating wild animals and birds which have been illegally captured and subsequently confiscated by Customs or national wildlife authorities. Welfare organizations also receive sick and injured wild …

Teams Of One Playing A Losing Game, Rick Burton

Sport Management - All Scholarship

No abstract provided.

Impaired Fast-Spiking, Suppressed Cortical Inhibition, And Increased Susceptibility To Seizures In Mice Lacking Kv3.2 K+ Channel Proteins, David Lau, Eleazar Vega-Saenz De Miera, Diego Contreras, Alan Chow, Richard Paylor, Christopher S. Leonard, Bernardo Rudy

NYMC Faculty Publications

Voltage-gated K(+) channels of the Kv3 subfamily have unusual electrophysiological properties, including activation at very depolarized voltages (positive to -10 mV) and very fast deactivation rates, suggesting special roles in neuronal excitability. In the brain, Kv3 channels are prominently expressed in select neuronal populations, which include fast-spiking (FS) GABAergic interneurons of the neocortex, hippocampus, and caudate, as well as other high-frequency firing neurons. Although evidence points to a key role in high-frequency firing, a definitive understanding of the function of these channels has been hampered by a lack of selective pharmacological tools. We therefore generated mouse lines in which one …

The Federal-State Medicaid Match: An Ongoing Tug-Of-War Over Practice And Policy, Karen Matherlee

National Health Policy Forum

Reviewing Medicaid match issues since the latter 1980s, this issue brief traces ways in which some states have used creative financing to get more Medicaid matching dollars than they otherwise would qualify for from the federal government. It explores the latest mechanism, states' use of so-called intergovernmental transfers of funds (to avoid established upper payment limits) to increase their matches, triggering efforts by the Senate Finance Committee and the federal Medicaid agency to ban such transfers.

Phosphonated Agents And Their Antiangiogenic And Antitumorigenic Use, Delwood C. Collins, Antonio Gagliardi, Peter Nickel

Obstetrics and Genecology Faculty Patents

Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown.