Medicine and Health Sciences Commons^™

Genes Encoding Several Poly (Adp-Ribose) Glycohydrolase (Parg) Enzymes, The Proteins And Fragments Thereof, And Antibodies Immnoreactive Therewith, Myron Jacobson, Elaine L. Jacobson, Jean-Christoph Amé, Winston Lin

Graduate Center for Nutritional Sciences Faculty Patents

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods …

Effect Of Non-Nicotinic Moist Snuff Replacement And Lobeline On Withdrawal Symptoms During 48-H Smokeless Tobacco Deprivation, Dennis E. Mcchargue, Frank L. Collins Jr., Lee M. Cohen

Department of Psychology: Faculty Publications

The present study investigated the effects of two herbal components (BACCOFF^TM and DIPSTOP ™) of a commercially available smokeless tobacco treatment program for reducing subjective withdrawal symptoms during deprivation. One component, BACCOFF™, is a non-nicotinic chew. The second component, DIPSTOP™, is a liquid containing the alkaloid lobeline, which to some extent mimics peripheral nicotinic effects. All participants (N = 22 males) were placed in four conditions: BACCOFF™ + DIPSTOP™, BACCOFF™ + placebo control, DIPSTOP™ only, and placebo control only. The conditions involved 48 h of deprivation, and subjects were exposed to one condition per week for 4 weeks. …

Construction Worker Dies After Being Struck By A Falling Excavator Bucket, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

A 44-year-old construction worker (victim) was killed when a 36-inch-wide bucket weighing more than 1000 pounds, detached from its quick release coupler and fell from an excavator, landing on him as he was working in a trench. The victim and another worker had been in the trench preparing it for a pre-formed concrete manhole that they were about to install. Their supervisor (the excavator operator) sat and waited in the excavator, with the engine running, and the bucket raised a few feet above ground level so that it would be out of the way. The second man in the trench …

Youth Riding As Passenger On Tractor Killed By Overturn, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 16-year-old female was killed after the tractor on which she was riding as a passenger overturned. She was a high school student; farmed on evenings and weekends. The tractor was driven by a 20-year-old friend while baling hay on a farm at dusk. The driver and the victim had been baling hay all day, and both were experienced farmers. The victim was seated on the fender to the left of the driver. The tractor was a 1969 tricycle-tired John Deere, which was well maintained but was not equipped with a Roll Over Protective Structure (ROPS) or a seatbelt. The …

Ada News - 05/20/2002, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Cyclosporin A Inhibits Caspase-Independent Death Of Ngf-Deprived Sympathetic Neurons: A Potential Role For Mitochondrial Permeability Transition., Louis K. Chang, Eugene M. Johnson

Open Access Publications

No abstract provided.

How Vulnerable Is The Nation's Food Supply? Linking Food Safety And Food Security, Robin J. Strongin

National Health Policy Forum

This paper reviews the food safety regulatory apparatus in place today, especially the activities of the two lead agencies in assuring food safety — the Food and Drug Administration within the Department of Health and Human Services and the Food Safety and Inspection Service within the Department of Agriculture. It examines the system's strengths and vulnerabilities, particularly in light of the post–September 11 environment that includes the heightened threat of terrorism. The paper also touches upon legislative and budgetary proposals aimed at improving food security, including the growing but debated interest in a single food safety agency.

Fibroblast Growth Factor–Specific Modulation Of Cellular Response By Syndecan-4, Arie Horowitz, Eugene Tkachenko, Michael Simons

Dartmouth Scholarship

Proteoglycans participate in growth factor interaction with the cell surface through their heparan sulfate chains (HS), but it is not known if they are otherwise involved in growth factor signaling. It appears now that the syndecan-4 core protein, a transmembrane proteoglycan shown previously to bind phosphatidylinositol 4,5-bisphosphate (PIP(2)) and activate PKC alpha, participates in mediating the effects of fibroblast growth factor (FGF)2 on cell function. Mutations in the cytoplasmic tail of syndecan-4 that either reduced its affinity to PIP(2) (PIP(2)(-)) or disrupted its postsynaptic density 95, disk large, zona occludens-1 (PDZ)-dependent binding (PDZ(-)) produced a FGF2-specific dominant negative phenotype in …

Ua66/14/3 Nursing Pinning Ceremony, Wku Nursing

WKU Administration Documents

Pinning ceremony program listing graduates of the WKU Nursing program.

Prevention Conference Vi: Diabetes And Cardiovascular Disease - Writing Group Iii: Risk Assessment In Persons With Diabetes, Rita F. Redberg, Philip Greenland, Valentin Fuster, Kalevi Pyörälä, Steven N. Blair, Aaron R. Folsom, Anne B. Newman, Daniel H. O'Leary, Trever J. Orchard, Bruce Psaty, J. Sanford Schwartz, Rodman D. Starke, Peter W. F. Wilson

Faculty Publications

No abstract provided.

Ada News - 05/06/2002, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Recession Has The Cure For Mlb's Ills, Rick Burton, Dennis Howard

Sport Management - All Scholarship

No abstract provided.

Keeping Your Cool When Feeling Hot Around The Collar!, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Other

No abstract provided.

We Want To Play Too, Peter J. Titlebaum, Kate Brennan, Tracy Chynoweth

Health and Sport Science Faculty Publications

The Americans with Disabilities Act (ADA) requires that persons with disabilities be integrated to the maximum extent possible, and that these persons cannot be excluded from participation. Intramural directors need to be proactive in this area. The benefits of intramural sports are vast, and they help many students become part of the college community.

Forming an alliance with the Disability Services on campus, the first step, is the most vital aspect of making these programs successful. It is important to remember the difference between what can be done and what must be done. Even with the best of intentions, it …

Information Interface - Volume 30, Issue 3 - May/June 2002, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

The Medicaid Buy-In Program: Lessons Learned From Nine "Early Implementer" States, Donna Folkemer, Allen Jensen, Robert Silverstein, Tara Straw

Center for Health Policy Research

For many individual Social Security Disability Insurance (SSDI) and Supplemental Security Income (SSI) recipients, the risk of losing Medicaid coverage linked to their cash benefits is a powerful work disincentive. Eliminating barriers to health care and creating incentives to work can greatly improve financial independence and well being. To support this goal, Congress included a Medicaid Buy-In option in the Balanced Budget Act of 1997 and enacted the Ticket to Work and Work Incentives Improvement Act (TWWIIA) in 1999. These laws authorized states to create Medicaid Buy-In programs to extend Medicaid coverage to persons with disabilities who go to work. …

Policy Frameworks For Designing Medicaid Buy-In Programs And Related State Work Incentive Initiatives, Allen Jensen, Robert Silverstein, Donna Folkemer, Tara Straw

Center for Health Policy Research

This report provides policy frameworks to assist stakeholders (such as Medicaid directors, state legislators, and cross-disability coalitions) design and implement Medicaid Buy-In programs and related work incentive initiatives to enhance the level of economic self-sufficiency of persons with significant disabilities. Of particular focus of the paper are the design decisions affecting enrollment, costs, and a state's fiscal exposure.

The policy frameworks describe the interrelationships between federal and state cash assistance programs (particularly SSDI, SSI, and state SSI supplementation programs) and health entitlements (particularly the Medicaid program). The policy frameworks are derived from the experiences of the nine early implementation states …

Timing Of New Black Box Warnings And Withdrawals For Prescription Medications, Karen Lasser, Paul D. Allen, Steffie Woolhandler, David U. Himmelstein, Sidney M. Wolfe, David H. Bor

Publications and Research

Context Recently approved drugs may be more likely to have unrecognized adverse drug reactions (ADRs) than established drugs, but no recent studies have examined how frequently postmarketing surveillance identifies important ADRs.

Objective To determine the frequency and timing of discovery of new ADRs described in black box warnings or necessitating withdrawal of the drug from the market.

Design and Setting Examination of the Physicians' Desk Reference for all new chemical entities approved by the US Food and Drug Administration between 1975 and 1999, and all drugs withdrawn from the market between 1975 and 2000 (with or without a prior black …

A Study Of The Relationships Among Secondary Traumatic Stress, Coping, And Years Of Service In Firefighter/Emergency Medical Service Personnel, Lynne S. Sanders

Faculty Dissertations

The purpose of this study is to examine relationships among stress, coping, and years of service in rescue personnel. One hundred sixteen voluntary subjects employed in Fire/EMS service in a small southern city participated in the study. Subjects completed a demographic questionnaire, The Davidson Trauma Scale (DTS), and The Coping Inventory for Stressful Situations (CISS).

The incidence of symptomatic stress for the sample was 19.8 percent, higher than the general population but comparable to rates found in other studies of rescue workers. Calls involving children were rated as most disturbing by the subjects. There was no relationship found between years …

Residential Radon Exposure And Lung Cancer: Variation In Risk Estimates Using Alternative Exposure Scenarios, R. William Field, Brian J. Smith, Daniel J. Steck, Charles F. Lynch

Physics Faculty Publications

The most direct way to derive risk estimates for residential radon progeny exposure is through epidemiologic studies that examine the association between residential radon exposure and lung cancer. However, the National Research Council concluded that the inconsistency among prior residential radon case-control studies was largely a consequence of errors in radon dosimetry. This paper examines the impact of applying various epidemiologic dosimetry models for radon exposure assessment using a common data set from the Iowa Radon Lung Cancer Study (IRLCS). The IRLCS uniquely combined enhanced dosimetric techniques, individual mobility assessment, and expert histologic review to examine the relationship between cumulative …

Distributive Justice And Punishment In Team Sports, David Bucur

Masters Theses & Specialist Projects

Distributive justice outcomes of punishment in an intercollegiate team sport setting were investigated. Male intercollegiate athletes (#=148) participating in the NAIA National Soccer Championship Tournament responded to one of eight scenarios and reported perceived fairness to player, fairness to teammates, deterrence to future player misconduct, and deterrence to future teammate misconduct. The results indicated that athletes perceive consistent distribution of punishment as more fair than conditional distribution of punishment; consistently distributed punishment is perceived to be more likely to deter future misconduct than conditional punishment; punishment, in general, is perceived as more fair when the violation committed is severe as …

Attitudes And Knowledge Of Nurses Regarding Herbal Medications, Janie Davis

Masters Theses & Specialist Projects

Much information has been published regarding herbal medication use. However, information is limited on how nurses incorporate this information into their practice, communicate information to the client, or collaborate with physicians to prevent drug/herbal interactions. The purpose of this study is to explore the attitudes and knowledge of nurses regarding the use of herbal remedies at various levels of practice. According to Henderson's Theory of Basic Care Components, the nurse has a responsibility to assess client needs, help clients meet health needs, and provide a safe environment for the client to perform activities unaided. These interventions help the client become …

Manténgase Fresco Cuando Tenga Calor!, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Other

No abstract provided.

Projected Smoking-Related Deaths Among U.S. Youth: A 2000 Update, Ellen J. Hahn, Mary Kay Rayens, Frank J. Chaloupka, Chizimuzo T.C. Okoli, Jun Yang

Nursing Reports

This paper projects the long term consequences of the rise in youth smoking in the 1990s by updating the state estimates for projected smoking-related deaths among youth in the U.S. using information from the Behavioral Risk Factor Surveillance System (BRFSS) 2000 and the U.S. Census 2000. This analysis is similar to that from an earlier study published by the Centers for Disease Control and Prevention (CDC), Office on Smoking and Health (MMWR, 45[44], November 8, 1996). The 1996 analysis used young adult smoking prevalence data from 1994 and 1995; whereas, the analysis presented here represents smoking prevalence data from 2000. …

Inside Unlv, Diane Russell, Betty Biodgett, Cate Weeks

Inside UNLV

No abstract provided.

Applying Managed Fee-For-Service Delivery Models To Improve Care For Dually Eligible Beneficiaries, Stuart Bratesman, Paul Saucier

Disability & Aging

No abstract provided.

Provider Type And Depression Treatment Adequacy, Thomas J. Kniesner, Regina H. Powers, Thomas W. Croghan

Center for Policy Research

We investigate the effect of initial provider (primary care physician, psychiatrist, or non-physician mental health specialist) on the adequacy of subsequent treatment for persons with depression. Our data are from MarketScan^®, a medical and pharmacy insurance claims database, which we use to estimate models of the likelihood of treatment for depression and the likelihood that any treatment received is adequate. Patients initially seeing psychiatrists are most likely to receive adequate treatment. Provider type has a statistically and medically significant effect on whether any treatment occurs but a smaller effect on treatment adequacy among treated patients. The results show …

Hla-Cw*04 And Hepatitis C Virus Persistence, Chloe L. Thio, Xiaojiang Gao, James J. Goedert, David Vlahov, Kenrad E. Nelson, Margaret Hilgartner, Stephen J. O'Brien, Peter Karacki, Jacquie Astemborski, Mary Carrington, David L. Thomas

Biology Faculty Articles

In studies of acute hepatitis C virus (HCV) infection, the early host immune response is one of the determinants of viral persistence. The class I human leukocyte antigens (HLA), which present foreign antigen to cytolytic T cells, are integral components of this response. We hypothesized that the highly polymorphic HLA genes affect the outcome of an HCV infection. To test this hypothesis, we molecularly typed 231 persons with well-documented clearance of an HCV infection and 444 matched persistently infected persons. HLA-A*1101 (odds ratio [OR], 0.49; 95% confidence interval [95% CI], 0.27 to 0.89), HLA-B*57 (OR, 0.62; 95% CI, 0.39 to …

Inhibition Of Apoptosis By Gamma Interferon In Cells And Mice Infected With Chlamydia Muridarum (The Mouse Pneumonitis Strain Of Chlamydia Trachomatis), Jean-Luc Perfettini, Toni Darville, Alice Dautry-Varsat, Roger G. Rank, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

The effect of gamma interferon (IFN-γ) on apoptosis due to infection by Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) was studied in epithelial cells in culture and in the genital tracts of mice. IFN-γ concentrations that induce the formation of aberrant, persistent chlamydiae inhibit apoptosis due to C. muridarum infection. In cells treated with an IFN-γ concentration that leads to the development of a heterogenous population of normal and aberrant Chlamydia vacuoles, apoptosis was inhibited preferentially in cells that contained the aberrant vacuoles. The inhibitory effect of IFN-γ appears to be due in part to expression of host …

Isolation And Characterization Of Endophytic Colonizing Bacteria From Agronomic Crops And Prairie Plants, Denise K. Zinniel, Patricia A. Lambrecht, N. Beth Harris, Zhengyu Feng, Daniel Kuczmarski, Phyllis Higley, Carol A. Ishimaru, Alahari Arunakumari, Raul G. Barletta, Anne K. Vidaver

School of Veterinary and Biomedical Sciences: Faculty Publications

Endophytic bacteria reside within plant hosts without causing disease symptoms. In this study, 853 endophytic strains were isolated from aerial tissues of four agronomic crop species and 27 prairie plant species. We determined several phenotypic properties and found approximately equal numbers of gram-negative and gram-positive isolates. In a greenhouse study, 28 of 86 prairie plant endophytes were found to colonize their original hosts at 42 days postinoculation at levels of 3.5 to 7.7 log₁₀ CFU/g (fresh weight). More comprehensive colonization studies were conducted with 373 corn and sorghum endophytes. In growth room studies, none of the isolates displayed pathogenicity, …