Medicine and Health Sciences Commons^™

Mere And Partial Means: The Full Range Of The Objectification Of Women, Carolyn Mcleod

Philosophy Publications

No abstract provided.

Differences In Percutaneous Injury Patterns In A Multi-Hospital System, Hilary M. Babcock, Victoria Fraser

Open Access Publications

No abstract provided.

Targeted Inactivation Of The Il-4 Receptor Α Chain I4r Motif Tromotes Allergic Airway Inflammation, Frank Blaeser, Paul J. Bryce, Nga Ho, Vidya Raman, Fatma Dedeoglu, Debra D. Donaldson, Raif S. Geha, Hans C. Oettgen, Talal A. Chatila

Open Access Publications

No abstract provided.

Interferon-Producing Cells Fail To Induce Proliferation Of Naive T Cells But Can Promote Expansion And T Helper 1 Differentiation Of Antigen-Experienced Unpolarized T Cells, Anne Krug, Ravi Veeraswamy, Andrew Pekosz, Osami Kanagawa, Emil R. Unanue, Marco Colonna, Marina Cella

Open Access Publications

No abstract provided.

Targeted Chemical Disruption Of Clathrin Function In Living Cells, Howard S. Moskowitz, John Heuser, Timothy E. Mcgraw, Timothy A. Ryan

Open Access Publications

No abstract provided.

Dispositional Hardiness And Women’S Well-Being Relating To Gender Discrimination: The Role Of Minimization, Mindi D. Foster, Kenneth L. Dion

Psychology Faculty Publications

Three studies examined whether personality-based hardiness would be associated with mental health benefits in contexts of gender discrimination. Hardy women encountering both a laboratory simulation and a hypothetical scenario of discrimination showed greater self-esteem and less negative affect than low hardy women. However, these benefits were mediated by the use of specific attributions, suggesting that the well-being in hardy women may have been achieved through minimizing the pervasiveness of discrimination. Study three showed this mediation pattern occurred only for participants exposed to higher threat scenarios versus lower threat scenarios of discrimination. Thus, minimizing the pervasiveness of discrimination may have been …

Monte Carlo Assessments Of Goodness-Of-Fit For Ecological Simulation Models, Lance A. Waller, David Smith, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

One often develops stochastic ecologic simulation models based on local interactions between individuals or groups and bases systemic conclusions on trends summarized over multiple data sets generated from the model. In many cases, such models generate data sets (“realizations”) each violating the usual assumptions associated with traditional statistical tests of goodness-of-fit, most notably that of independent observations. Monte Carlo hypothesis tests applied to multiple realizations from such models provide appropriate goodness-of-fit tests regardless of within-model peculiarities. The Monte Carlo tests address the question “Do the observed data appear consistent with the model?” in contrast to the usual question “Does the …

Abundant PrpCwd In Tonsil From Mule Deer With Preclinical Chronic Wasting Disease, Katherine I. O'Rourke, Dongyue Zhuang, Amy Lyda, Gabriel Gomez, Elizabeth S. Williams, Wenbin Tuo, Michael W. Miller

Zoonotics and Wildlife Disease: Publications

A monoclonal antibody dot-blot assay was used to evaluate detergent lysates of tonsil tissue from mule deer to detect PrP^CWD, the marker for the cervid transmissible spongiform encephalopathy chronic wasting disease (CWD). Samples of formalin-fixed brain and tonsil tissues from mule deer were examined for PrP^CWD using immunohistochemistry (IHC) with Mab F99/97.6.1, the gold standard for diagnosis of preclinical CWD. The contralateral tonsil from each of the 143 deer was prepared for confirmatory IHC and as a 10% (wt/vol) detergent lysate without purification or enrichment steps for monoclonal antibody dot-blot assay. PrP^CWD was detected by dot-blot …

Genealogical Relationships Influence The Probability Of Infection With Bovine Tuberculosis And Microgeographic Genetic Structure In Free-Ranging White-Tailed Deer, Julie Anne Blanchong

Michigan Bovine Tuberculosis Bibliography and Database

Zoonoses are of increasing importance to wildlife conservation and human health. It has become increasingly recognized that wildlife ecology plays a key role in disease transmission in wildlife populations. In domestic populations, contacts among individuals are controlled by humans and disease transmission is often density dependent. Unlike domestic animals, wildlife populations often have complex social systems in whch contacts among individuals are not solely density dependent, and can play an important role in the transmission and maintenance of disease.

Factor Structure Of The Coaching Behavior Questionnaire And Its Relationship To Athlete Variables, Jean M. Williams, Gerald J. Jerome, Laura J. Kenow, Tracie Rogers, Tessa A. Sartain, Greg Darland

Faculty Publications

Little research exists to identify optimal coaching behaviors and factors that influence the effectiveness of particular behaviors. The present study tested 484 athletes in order to determine sub-scales on the Coaching Behavior Questionnaire (CBQ). The CBQ measures athletes’ perceptions of coaching behaviors and evaluates their effectiveness in helping athletes play better and maintain optimal mental states and focus. A confirmatory factor analysis (CFA) supported the two-factor model (negative activation, supportiveness/emotional composure) derived from an exploratory factor analysis (EFA). Correlational analyses indicated that athletes with higher anxiety and lower self-confidence and compatibility with the coach were more likely to negatively evaluate …

A Prospective Evaluation Of The Relationships Between Smoking Dosage And Body Mass Index In An Adolescent, Biracial Cohort., Theodore Cooper, R. Klesges, L. Robinson, S. Zbikowski

Departmental Papers (Psych)

No abstract provided.

A Priori Prediction Of Disease Invasion Dynamics In A Novel Environment, Colin A. Russell, David L. Smith, Lance A. Waller, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

Directly transmitted infectious diseases spread through wildlife populations as travelling waves away from the sites of original introduction. These waves often become distorted through their interaction with environmental and population heterogeneities and by long-distance translocation of infected individuals. Accurate a priori predictions of travelling waves of infection depend upon understanding and quantifying these distorting factors. We assess the effects of anisotropies arising from the orientation of rivers in relation to the direction of disease-front propagation and the damming effect of mountains on disease movement in natural populations. The model successfully predicts the local and large-scale prevaccination spread of raccoon rabies …

Adolescent Sexuality: Behavior And Meaning, Lisa J. Crockett, Marcela Raffaelli, Kristin L. Moilanen

Department of Psychology: Faculty Publications

The emerging sexuality that accompanies adolescence poses fundamental challenges for young people. These include adjusting to the altered appearance and functioning of a sexually maturing body, learning to deal with sexual desires, confronting sexual attitudes and values, experimenting with sexual behaviors, and integrating these feelings, attitudes, and experiences into a developing sense of self. The challenge is accentuated by the unfamiliar excitement of sexual arousal, the attention connected to being sexually attractive, and the new level of physical intimacy and psychological vulnerability created by sexual encounters. Adolescents’ responses to these challenges are profoundly influenced by the social and cultural context …

Susceptibility Scoring In Family-Based Association Testing, Laila M. Poisson, Benjamin A. Rybicki, Steven W. Coon, Jill S. Barnholtz-Sloan, Gary A. Chase

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Family-based association testing is an important part of genetic epidemiology. Tests are available to include multiple siblings, unaffected offspring, and to adjust for environmental covariates. We explore a susceptibility residual method of adjustment for covariates.

Results

Through simulation, we show that environmental adjustments that down-weight persons who are "destined" to be affected decrease the power to detect genetic association. We used the residual adjusted method on the Framingham Heart Study offspring data, provided for Genetic Analysis Workshop 13, and got mixed results.

Conclusion

When the genetic effect and environmental effects are independent, a susceptibility residual method of adjustment …

Analysis Of Gene × Environment Interactions In Sibships Using Mixed Models, Jill S. Barnholtz-Sloan, Laila M. Poisson, Steven W. Coon, Gary A. Chase, Benjamin A. Rybicki

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Gene × environment models are widely used to assess genetic and environmental risks and their association with a phenotype of interest for many complex diseases. Mixed generalized linear models were used to assess gene × environment interactions with respect to systolic blood pressure on sibships adjusting for repeated measures and hierarchical nesting structures. A data set containing 410 sibships from the Framingham Heart Study offspring cohort (part of the Genetic Analysis Workshop 13 data) was used for all analyses. Three mixed gene × environment models, all adjusting for repeated measurement and varying levels of nesting, were compared for …

Educating Adolescents About Puberty: What Are We Missing?, Hatim A. Omar, Darby H. Mcelderry, Rana M. Zakharia

Pediatrics Faculty Publications

Adolescents undergo significant physical and cognitive changes during their pubertal development. These changes contribute to and impact their future development. Educating adolescents at an early age about their expected development decreases the possible anxiety associated with this period of life and also helps adolescents make better choices in regards to their sexuality. In order to assess the degree of education regarding pubertal development and sexuality, we conducted a survey of late adolescents (Median age 19 years) and parents of adolescents. A total of 409 adolescents (237 females, 172 males) and 124 parents completed the survey. 14.4% of teens (36.6% of …

Review Of Cure: A Story Of Cancer And Politics From The Annals Of The Cold War, John Brantley

Faculty & Staff Research & Creative Activity

No abstract provided.

Department Of Veterinary And Biomedical Sciences: Vbms Annual Report 2003

School of Veterinary and Biomedical Sciences: Information and History

Foreword
VBMS Faculty
VBMS Faculty and Staff, by Function and Unit
Honors. Awards and Recognitions
VBMS Committee Assignments
Faculty Profiles
VBMS Research Associates Profiles
VBMS Teaching Program
Great Plains Veterinary Educational Center (GPVEC)
VBMS Research Program
International Activities
Veterinary Extension Program
Nebraska Veterinary Diagnostic Laboratory Systems (NVDLS)
Grants and Contracts Program
Patents by VBMS Faculty
Publications by VBMS Faculty
Presentations by VBMS Faculty
Articles Regarding the Department
Selected Committees. Editorial and Other Appointments
Departmental Budget Summaries
Nebraska Agricultural Statistics

The Ascendancy Of Amblyomma Americanum As A Vector Of Pathogens Affecting Humans In The United States, James E. Childs, Christopher D. Paddock

United States Public Health Resources

Until the 1990s, Amblyomma americanum was regarded primarily as a nuisance species, but a tick of minor importance as a vector of zoonotic pathogens affecting humans. With the recent discoveries of Ehrlichia chaffeensis, Ehrlichia ewingii, and “Borrelia lonestari,” the public health relevance of lone star ticks is no longer in question. During the next 25 years, the number of cases of human disease caused by A. americanum-associated pathogens will probably increase. Based on current trajectories and historic precedents, the increase will be primarily driven by biological and environmental factors that alter the geographic distribution and intensity of …

Sodium Tanshinone Iia Sulfonate Mediates Electron Transfer Reaction In Rat Heart Mitochondria, Guangyin Zhou, Wen Jiang, Yan Zhao, Guangén Ma, Wenjuan Xin, Junjie Yin, Baolu Zhao

United States Public Health Resources

In this paper, an electron transfer reaction mediated by sodium tanshinone IIA sulfonate (STS) was studied in rat heart mitochondria. It was found that STS could stimulate mitochondrial NADH oxidation dose-dependently and partly restore NADH oxidation in the presence of respiratory inhibitor (rotenone or antimycin A or KCN). It was likely that STS could accept electrons from complex I similar to ferricyanide and could be converted to its semiquinone form that could then reduce oxygen molecule. The data also showed that cytochrome c (Cyt c) could be reduced by STS in the presence of KCN, or STS could transfer the …

A Preliminary Linkage Map Of The Hard Tick, Ixodes Scapularis, A. J. Ullmann, J. Piesman, M. C. Dolan, W. C. Black Iv

United States Public Health Resources

Blackwell Publishing Ltd. A linkage map of the Ixodes scapularis genome was constructed, based upon segregation amongst 127 loci. These included 84 random amplified polymorphic DNA (RAPD) markers, 32 Sequence-Tagged RAPD (STAR) markers, 5 cDNAs, and 5 microsatellites in 232 F₁ intercross progeny from a single, field-collected P₁ female. A preliminary linkage map of 616 cM was generated across 14 linkage groups with one marker every 10.8 cM. Assuming a genome size of ~ 10 ⁹ bp, the relationship of physical to genetic distance was found to be ~ 300 kb/cM in the I. scapularis genome.

Absence Of Interferon-Γ–Inducible Gene Igtp Does Not Significantly Alter The Development Of Chagasic Cardiomyopathy In Mice Infected With Trypanosoma Cruzi (Brazil Strain), A. P. De Souza, B. Tang, H. B. Tanowitz, S. M. Factor, V. Shtutin, J. Shirani, G. A. Taylor, L. M. Weiss, L. A. Jelicks

United States Public Health Resources

Interferon-γ (IFN-γ) contributes to host resistance during acute infection with Trypanosoma cruzi, the causative agent of Chagas’ disease. Inducibly expressed guanosine triphosphatase (IGTP), a 48-kDa guanosine triphosphatase (GTPase), is a member of a family of GTPase proteins inducibly expressed by IFN-γ. The expression pattern of IGTP suggests that it may mediate IFN-γ–induced responses in a variety of cell types. IGTP has been demonstrated to be important for control of Toxoplasma gondii infection but not for resistance against Listeria monocytogenes. We evaluated the role of IGTP in development of chronic chagasic cardiomyopathy in IGTP null mice and C57X129sv (wild …

Accuracy Of Six Commercially Available Systems For Identification Of Members Of The Family Vibrionaceae, Caroline M. O’Hara, Evangeline G. Sowers, Cheryl A. Bopp, Sarah B. Duda, Nancy A. Strockbine

United States Public Health Resources

Six commercially available bacterial identification products were tested with Vibrio alginolyticus (12 strains), V. cholerae (30 strains), Photobacterium (Vibrio) damselae (10 strains), V. fluvialis (10 strains), V. furnissii (4 strains), V. hollisae (10 strains), V. metschnikovii (9 strains), V. mimicus (10 strains), V. parahaemolyticus (30 strains), and V. vulnificus (10 strains) to determine the accuracy of each system for identification. The products included API 20E, Crystal E/NF, MicroScan Neg ID2 and Rapid Neg ID3, and Vitek GNI+ and ID-GNB. Each product was tested only with those species that were listed in its database. Overall, the systems correctly …

Estimated Risk Of Transmission Of The West Nile Virus Through Blood Transfusion In The Us, 2002, Brad J. Biggerstaff, Lyle R. Petersen

United States Public Health Resources

BACKGROUND: The West Nile virus (WNV) epidemic in 2002 in the US saw over 3300 reported human cases of WNV disease, with over 2300 reported cases of WNV encephalitis and meningitis. The first documented cases of transfusion transmission of WNV through voluntary blood donation also occurred.

STUDY DESIGN AND METHODS: Case onset dates from the 2002 WNV epidemic in the US were used to estimate the risk of transfusion-associated transmission with statistical resampling. An easily computed approximating formula for the mean risk was derived. Estimates were computed for six high-incidence states and metropolitan areas.

RESULTS: Mean and …

Incidence Of Ovarian Cancer By Race And Ethnicity In The United States, 1992–1997, Marc T. Goodman, Holly L. Howe, Ko Hui Tung, Joellyn Hotes, Barry A. Miller, Steven S. Coughlin, Vivien W. Chen

United States Public Health Resources

Ovarian cancer is the fifth most common cancer among U.S. women.¹ An estimated 23,400 new cases were expected to be diagnosed in the U.S. in 2001. As is the case for breast and endometrial cancers, ovarian cancer is more common among women in northern and central Europe, and North America compared with Africa, South America, and Asia.² In the U.S., substantial racial and ethnic variations also are observed in the incidence of ovarian cancer. rates reportedly are highest among non-Hispanic white and American Indian women, and are lower among Hispanic, Native Hawaiian, and Asian women.³ Among white …

Inhibition Of Markers Of Hepatic Stellate Cell Activation By The Hormone Relaxin, Robert G. Bennett, Kusum K. Kharbanda, Dean J. Tuma

United States Public Health Resources

Hepatic fibrois results from excess extracellular matrix produced primarily by hepatic stellate cells (HSC). In response to injury, HSC differentiate to a myofibroblastic phenotype expressing smooth muscle actin and fibrillar collagens. Relaxin is a polypeptide hormone shown to have antifibrotic effects in fibrosis models. In this study, activated HSC from rat liver were treated with relaxin to determine if relaxin can reverse markers of HSC activation. Relaxin treatment resulted in a decrease in the expression of smooth muscle actin, but had no effect on cell proliferation rate. The levels of total collagen and type I collagen were reduced, while the …

Ethanol Consumption Decreases The Synthesis Of The Mannose 6-Phosphatelinsulin-Like Growth Factor Ii Receptor But Does Not Decrease Its Messenger Rna, James Haorah, Richard Macdonald, Julie A. Stoner, Terrence M. Donohue, Jr.

United States Public Health Resources

The mannose 6-phosphatelinsulin-like growth factor I1 receptor (M6P/IGF-IIR) is a protein that facilitates the transport of acid hydrolases into the lysosome. We have shown that chronic ethanol consumption lowers the M6P/IGF-IIR content in rat hepatocytes. Here, we determined the steady-state level of mRNA encoding M6P/IGF-IIR, as well as the rate of receptor synthesis, to ascertain whether the ethanol-elicited reduction in receptor protein content is related to changes in either or both of these parameters. Rats were pair-fed the normal carbohydrate (NC) or low carbohydrate high-fat (LC) liquid diets containing either ethanol or isocaloric maltose-dextrin for 7-8 weeks. RNA was isolated …

Impaired Receptor-Mediated Endocytosis By The Asialoglycoprotein Receptor In Ethanol-Fed Mice: Implications For Studying The Role Of This Receptor In Alcoholic Apoptosis, Shana R. Dalton, Robert L. Wiegert, Cheryl R. Baldwin, Karen M. Kassel, Carol A. Casey

United States Public Health Resources

During receptor-mediated endocytosis (RME), extracellular molecules are internalized after being recognized and bound to specific cell surface receptors. In previous studies of the asialoglycoprotein receptor (ASGPR) in rats, we showed that ethanol impairs RME at multiple ASGPR sites. Ethanol administration has been shown to increase apoptosis, and we demonstrated increased sensitization to apoptotic induction in hepatocytes from ethanol-fed rats. Although a physiological role for the ASGPR has not been identified, investigators have shown its involvement in the uptake/clearance of apoptotic cells in vitvo. This suggests a potential role for the ASGPR in the removal of apoptotic cells, and the recent …

Acute Pesticide-Related Illnesses Among Working Youths, 1988–1999, Geoffrey M. Calvert, Louise N. Mehler, Rachel Rosales, Lynden Baum, Catherine Thomsen, Dorilee Male, Omar Shafey, Rupali Das, Michelle Lackovic, Ernest Arvizu

United States Public Health Resources

Objectives. The goal of this study was to describe acute occupational pesticide-related illnesses among youths and to provide prevention recommendations.
Methods. Survey data from 8 states and from poison control center data were analyzed. Illness incidence rates and incidence rate ratios were calculated.
Results. A total of 531 youths were identified with acute occupational pesticide-related illnesses. Insecticides were responsible for most of these illnesses (68%), most of which were of minor severity (79%). The average annual incidence rate among youths aged 15 to 17 years was 20.4 per billion hours worked, and the incidence rate ratio among youths vs adults …

Interferon Gamma Enhances Proteasome Activity In Recombinant Hep G2 Cells That Express Cytochrome P4502e1: Modulation By Ethanol, Natalia A. Osna, Dahn L. Clemens, Terrence M. Donohue Jr.

United States Public Health Resources

We tested the influence of IFNγ on proteasome activity in parental Hep G2 cells that do not metabolize ethanol, as well as in recombinant Hep G2-derived cells that express either or both alcohol dehydrogenase (ADH) and cytochrome P4502E1 (CYP2E1). IFNγ treatment increased proteasome activity in VL-17A (ADH⁺, CYP2E1⁺) and E-47 (CYP2E1⁺) cells, but not in Hep G2, VI-R2 (parental cells with empty vectors) or in VA-13 (ADH⁺) cells. Proteasome activation by IFNγ correlated positively with the level of CYP2E1 activity. Treatment of VL-17A cells with agents that inhibit CYP2E1 or the inducible …