Medicine and Health Sciences Commons^™

Regulation Of Human Col9a1 Gene Expression. Activation Of The Proximal Promoter Region By Sox9., Ping Zhang, Sergio A. Jimenez, David G Stokes

Department of Medicine Faculty Papers

The COL9A1 gene contains two promoter regions, one driving expression of a long alpha1(IX) chain in cartilage (upstream) and one driving expression of a shorter chain in the cornea and vitreous (downstream). To determine how the chondrocyte-specific expression of the COL9A1 gene is regulated, we have begun to characterize the upstream chondrocyte-specific promoter region of the human COL9A1 gene. Transient-transfection analyses performed in rat chondrosarcoma (RCS) cells, human chondrosarcoma (HTB) cells, and NIH/3T3 cells showed that the COL9A1 promoter was active in RCS cells but not HTB or NIH/3T3 cells. Inclusion of the first intron had no effect on promoter …

Knowledge And Attitudes Of Pharmacists In A Midwestern State Regarding Natural Products, Kevin A. Clauson, Cydney E. Mcqueen, Kelly M. Shields, Patrick J. Bryant

Pharmacy Faculty Scholarship

Objectives. The purpose of this descriptive investigation was to determine the perceived knowledge of and attitudes toward natural products by pharmacists in Missouri. Methods. A questionnaire was mailed to 2921 licensed pharmacists. Assessments were conducted regarding the venues and specific resources these pharmacists utilized in order to gain knowledge in the area of natural products. Results. Over half (56.9%) of those surveyed indicated that they received natural product questions on a weekly basis, but only a minority (2.4%) felt they could “always answer natural product questions.” The most commonly used means for education was printed continuing education (70.2%). Only 12.5% …

Natural Product Education In Schools Of Pharmacy In The United States, Kelly M. Shields, Cydney E. Mcqueen

Pharmacy Faculty Scholarship

Objective. The purpose of this study was to describe pharmacy school curriculum offerings in the areas of natural products and complementary/alternative medicine. Methods. Eighty-one schools of pharmacy in the United States were surveyed to determine the extent to which coursework addressing natural product or complementary/alternative medicine had been incorporated into their curriculum. Results. Usable responses were obtained from 64 schools (79 percent). Of these, 51 schools offered some exposure to these topics, while 40 offered courses exclusively on these topics. Most of these schools offered this instruction as an elective course focused primarily on natural products. Conclusion. These results indicate …

Healthnet News V.18:No.4 Winter 2003, Judith S. Kronick, Alberta Richetelle

Articles - Patient Care

A newsletter for public librarians and others interested in consumer health information services.

Measurements Of Phospholipases A2, C And D (Pla2, Plc And Pld) : In Vitro Microassays, Analysis Of Enzyme Isoforms, And Intact-Cell Assays, Ramadan I. Sha’Afi

UCHC Articles - Research

Phospholipases have been studied in great detail and their role in cell signaling has been established in the last 20 years. A role for phospholipases in mitogenesis has been described in terms of the products of their enzymatic reactions. Lysophosphatidic acid (LPA) is produced by the action of a phosphatidic acid (PA)-specific phospholipase A2 (PLA2). LPA is a potent mitogen for quiescent fibroblasts and triggers GTP-dependent phosphoinositide breakdown (1) through a membrane receptor (2). A phosphatidylcholine-specific PLA2 is responsible for the release of arachidonic acid in response to cell stimulation. Arachidonic acid is the precursor of biologically-active eicosanoids such as …

Diagnosis And Management Of The Painful Ankle/Foot. Part 2: Examination, Interpretation, And Management, P. Sizer, V. Phelps, G. S. Dedrick, R. James, O. Mattijs

Physical Therapy

No abstract provided.

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Winter, 2003 edition of the ALHeLa newsletter - Synapse.

Contents include:

• Information Resources
• ALHeLA Executive Committee 2003
• ALHeLA Executive Committee Meeting

Mid-Atlantic Ethics Committee Newsletter, Winter 2003-2004

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

Physical Wellness: The Relationship Between Motor Skill, Fitness And Physical Activity In Young Children, Beth P. Hands, Helen Parker

Health Sciences Conference Papers

The health benefits of adequate physical activity levels for children are well reported. However, we cannot assume that children will choose to be sufficiently active of their own accord. Motor competence and fitness are increasingly highlighted as key co-determinants of physical activity in young children (Hands, Parker, & Larkin, 2001) and where possible strategies to enhance these factors should be included in early childhood settings. However few studies have adopted an integrated view of the collective effects of these three factors on developing healthy children. This presentation explores interrelationships between measures of motor skill competence, fitness, and weekly physical activity …

Information Interface - Volume 31, Issue 1 - January/February 2003, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users. Includes articles on BioMed Central, Web of Science, understanding electronic holdings, and database search tips.

Functional Health Literacy In An Urban Primary Care Clinic, Nancy Trygar Artinian, M. Patricia Lange, Thomas Templin, Lynda G Stallwood, Christopher E. Hermann

Nursing Faculty Research Publications

The purpose of this study was to determine the level of functional health literacy in a sample of patients treated in 1of our 5 primary care clinics. A total of 92 randomly selected adults (mean age = 59 years) completed the TOFHLA while waiting for a scheduled appointment. Twenty eight percent of the sample had less than adequate levels of functional health literacy. Income, car ownership and education were significant and independent predictors of literacy level in this sample. Low levels of functional health literacy limit a patient's ability to read, understand and act on health information. It is essential …

Adefovir Dipivoxil For The Treatment Of Hepatitis B E Antigen–Positive Chronic Hepatitis B, Patrick Marcellin , M.D., Ting-Tsung Chang , M.D., Seng Gee Lim , M.D., Myron J. Tong , Ph.D., M.D., William Seivert , M.D., Mitchell L. Shiffman , M.D., Lennox Jeffers , M.D., Zachary Goodman , M.D., Ph.D., Michael S. Wulfsohn , M.D., Ph.D., Shelly Xiong , Ph.D., John Fry , B.Sc., Carol L. Brosgart , M.D.

Internal Medicine Publications

BACKGROUND

In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains.

METHODS

We randomly assigned 515 patients with chronic hepatitis B who were positive for hepatitis B e antigen (HBeAg) to receive 10 mg of adefovir dipivoxil (172 patients), 30 mg of adefovir dipivoxil (173), or placebo (170) daily for 48 weeks. The primary end point was histologic improvement in the 10-mg group as compared with the placebo group.

RESULTS

After 48 weeks of treatment, significantly more patients who received 10 mg or 30 mg of adefovir dipivoxil per day than …

The Mammography Screening Controversy: Who And What Is Heard In The Press?, Sonya Charles, Margaret Holmes-Rovner

Philosophy and Religious Studies Department Faculty Publications

The objective of this project was to analyze newspaper coverage of the January 2000 meta-analysis by Gotzsche and Olsen, “Is screening for breast cancer with mammography justified?” [Lancet 355 (2000) 129]. A content analysis was performed on a comprehensive set of newspaper clippings from the UK during the 2 weeks following publication of the Lancet article. The original authors were most quoted in Wave 1 (the first weekend); the screening programme was most quoted in Wave 2 (week 2). Screening programme description, and the “quality” of the Lancet article dominated Wave 1; patient testimonials increased in Wave 2. Newspaper articles …

Montessori-Based Activities For Dementia: A Walk Down Memory Lane, Janina C. Bognar

Case Studies from Age in Action

Educational Objectives

1. Familiarize readers with the Montessori method as used with participants who have dementia.

2. Demonstrate the role of Montessori-based activities for dementia in an adult day care setting.

The Value Of Multidisciplinary Care In Parkinson's Disease, Miriam Hirsch, Mark Baron

Case Studies from Age in Action

Educational Objectives

1. To recognize the signs and symptoms of Parkinson's disease (PD).

2. To identify key treatment and management strategies for PD.

3. To discuss the importance of multidisciplinary care and the need for individualized treatment of PD.

Abuse, Neglect, And Exploitation Of Vulnerable Elders, Sheila Crossen-Powell, Kira R. Holland, Marjorie L. Marker

Case Studies from Age in Action

Educational Objectives

1. To describe the variety and dynamics of self-neglect and abuse.

2. To illustrate cases of familial self-neglect and of financial exploitation.

3. To demonstrate the roles that Adult Protective Services (APS) plays in the investigation of adult abuse, neglect, and exploitation.

4. To describe the protections available to vulnerable adults in the Commonwealth.

Aging In Place -- Can Universal Design Make It A Reality?, Helen Eltzeroth

Case Studies from Age in Action

Educational Objectives

1. Comprehend the principles of universal design

2. Understand the barriers to aging in place

3. Learn what resources are available to facilitate aging in place

Severity Message From Hazard Alert Symbol On Caution Signs, Roger C. Jensen, Andrew M. Mccammack

Safety Health & Industrial Hygiene

Standards for the design of signal word panels specify different combinations of colors, signal words, and a hazard alert symbol. The warning sign standards of the American National Standards Institute specify a yellow signal word panel, with the word Caution and a hazard alert symbol, for signs marking people hazards. The same panel, without the symbol, is intended for property hazards. The purpose of this study was to determine if the presence or absence of the symbol effectively conveys the intended severity messages. A sample of 59 college students rated their impressions of a Caution sign with and without the …

Physiology And Prevention Of Heel Ulcers: The State Of Science, Vivian K. Wong, N. A. Stotts

Faculty Publications

The prevalence of heel ulcers across settings is high and is increasing. Prevention of ulcers requires knowledge of their etiology and the scientific basis for preventive care. The interaction between external pressure and the heel vasculature is central to the prevention of heel ulcers. This article focuses on the prevention of heel pressure ulcers. The physiology of heel tissue perfusion, the effect of external pressure on heel perfusion, as well as what is known about strategies to reduce external pressure and approaches to improve heel skin blood flow will be discussed. It is only through understanding of the physiology of …

Adaptive Multimodal Biometric Fusion Algorithm Using Particle Swarm, Kalyan Veeramachaneni, Lisa Ann Osadciw, Pramod K. Varshney

Electrical Engineering and Computer Science - All Scholarship

This paper introduces a new algorithm called “Adaptive Multimodal Biometric Fusion Algorithm”(AMBF), which is a combination of Bayesian decision fusion and particle swarm optimization. A Bayesian framework is implemented to fuse decisions received from multiple biometric sensors. The system’s accuracy improves for a subset of decision fusion rules. The optimal rule is a function of the error cost and a priori probability of an intruder. This Bayesian framework formalizes the design of a system that can adaptively increase or reduce the security level. Particle swarm optimization searches the decision and sensor operating points (i.e. thresholds) space to achieve the desired …

Sustainable Communities And Health Inequalities, Pierre Horwitz, Neil Drew, Neil Thomson, Meredith Green

Sciences Conference Papers

The goal of the Sustainable Communities Network is to seek effective interventions that address health inequalities in rural, remote and Indigenous communities through sustainable development and supporting sustainable communities. The Network is part of the Health Inequalities Research Collaboration, now known as the Health Inequalities Ministerial Advisory Committee, a Commonwealth Department of Health and Ageing initiative. Its goal is to enhance Australia’s knowledge of the causes of and effective responses to health inequalities, and to promote vigorously the application of this evidence to reduce health inequalities in Australia. This Committee was established in response to the increasing concern for health …

Assessing The Integrity Of Motivational Interviewing Interventions: Reliability Of The Motivational Interviewing Skills Code, Theresa Moyers, Tim Martin, Delwyn Catley, Kari Jo Harris, Jasjit S. Ahluwalia

Public and Community Health Sciences Faculty Publications

The motivational interviewing skills code (MISC) was used to review 86 audiotaped interactions between clinicians and patients participating in a smoking cessation intervention. Intraclass correlations (ICCs) were completed for two of the MISC elements: global evaluations and behavior counts. Results indicate 75% of the global ratings yielded ICCs in the good to excellent range, while only 44% of the behavior counts yielded this level of accuracy. Adherence scores were created to form overall ratings of clinician adherence to using motivational interviewing and 80% of these competence measures yielded ICCs in the good to excellent range. Specific recommendations regarding modifications for …

The Educational Interaction Between Physical Therapy And Occupational Therapy Students, Kimberly K. Cleary, Dana M. Howell

Occupational Science and Occupational Therapy Faculty and Staff Research

The objectives of this study were to identify the prevalence of shared learning in U.S. physical therapy (PT) and occupational therapy (OT) education programs; determine what terminology is used for these courses; and identify perceived barriers, benefits, and challenges of the educational interactions. A survey, designed to collect information about the educational interaction between PT and OT students, was mailed to all program directors (n = 206) at each of the academic institutions (N = 103) in the United States with accredited or developing entry-level programs in PT and OT. A census study was conducted, and the entire study population …

Environmental Planning, R. Steven Konkel

Environmental Health Science Faculty and Staff Research

Our understanding of the importance of healthy ecosystems and the impact of people on the natural and the built environment continues to grow. The need for stewardship to preserve, protect, and enhance the natural environment and promote healthy populations is increasingly seen as a universal responsibility of environmental health and safety (EHS) professionals.

Equilibrative Nucleoside Transporter Family Members From Leishmania Donovani Are Electrogenic Proton Symporters, Alex Stein, Gayatri Vaseduvan, Nicola S. Carter, Buddy Ullman, Scott M. Landfear, Michael Kavanaugh

Biomedical and Pharmaceutical Sciences Faculty Publications

Leishmania donovani express two members of the equilibrative nucleoside transporter family; LdNT1 encoded by two closely related and linked genes, LdNT1.1 and LdNT1.2, that transport adenosine and pyrimidine nucleosides and LdNT2 that transports inosine and guanosine exclusively. LdNT1.1, LdNT1.2, and LdNT2 have been expressed in Xenopus laevis oocytes and found to be electrogenic in the presence of nucleoside ligands for which they mediate transport. Further analysis revealed that ligand uptake and transport currents through LdNT1-type transporters are proton-dependent. In addition to the flux of protons that is coupled to the transport reaction, LdNT1 transporters mediate a variable constitutive proton …

College Of Osteopathic Medicine Student Handbook, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Drinking And The High School Student Brochure

Brochure

No abstract provided.

College Of Osteopathic Medicine Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Effects Of Cognitive Behavioral Treatment On Physical Health Status In Patients With Panic Disorder, Norman B. Schmidt, Beth T. Mccreary, John J. Trakowski, Helen T. Santiago, Kelly Woolaway-Bickel, Nicholas Ialongo

Uniformed Services University of the Health Sciences

The relationship between panic disorder and nonpsychiatric medical illness is complex, but some evidence suggests that panic disorder increases risk for a variety of nonpsychiatric medical conditions. Given the demonstrated efficacy of cognitive behavioral therapy (CBT) for panic disorder, we were interested in evaluating the effects of CBT for panic disorder on nonpsychiatric medical symptoms among these patients. Patients were randomized to a 12-week group-administered CBT protocol (n = 22) or a delayedtreatment conlrol (n = 24). Treated patients showed marked improvement in both anxiety symptoms and physical health symptom ratings that were evident at midtreatment and were …

Basics Of International Humanitarian Mission, Kevin M. Cahill, M.D.

Institute of International Humanitarian Affairs

This important book is a primer on the basics of humanitarian action. The ten chapters—each written by a leading professional—introduce the essential issues facing humanitarian workers as they confront both natural and man-made crises.

Designed for students, teachers, practitioners, policy-makers, journalists, and other professionals, Basics of Humanitarian Missions covers fundamental concepts, contexts, and problems, in settings that range from floods and earthquakes to medical emergencies, civil strife, and forced migration.