Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Specialties (53388)
- Medical Sciences (30411)
- Public Health (28946)
- Life Sciences (21147)
- Social and Behavioral Sciences (14585)
-
- Oncology (11371)
- Diseases (10733)
- Nursing (9590)
- Biomedical Informatics (7909)
- Bioinformatics (7575)
- Arts and Humanities (5819)
- Education (5697)
- Medical Genetics (5667)
- Physical Sciences and Mathematics (5437)
- Psychiatry and Psychology (5421)
- Pediatrics (5337)
- Medical Education (5124)
- Mental and Social Health (5116)
- Pharmacy and Pharmaceutical Sciences (5075)
- Sociology (4967)
- Rehabilitation and Therapy (4763)
- Genetic Phenomena (4603)
- Dentistry (4197)
- Surgery (4128)
- Neurology (3894)
- History (3536)
- Business (3510)
- Psychology (3183)
- Cardiology (3129)
- Institution
-
- The Texas Medical Center Library (24468)
- Thomas Jefferson University (11063)
- Washington University School of Medicine (10510)
- Aga Khan University (8059)
- University of Kentucky (5810)
-
- University of Nebraska - Lincoln (5194)
- Edith Cowan University (4304)
- Lehigh Valley Health Network (4062)
- Western Michigan University (3453)
- Himmelfarb Health Sciences Library, The George Washington University (3005)
- University of Texas Rio Grande Valley (2631)
- Population Council (2560)
- Western University (2535)
- Zucker School of Medicine at Hofstra/Northwell (2341)
- Old Dominion University (2238)
- Wright State University (2238)
- Marquette University (2186)
- Chapman University (2082)
- Wayne State University (2052)
- American Dental Association (1898)
- Georgia Southern University (1717)
- University of South Carolina (1687)
- City University of New York (CUNY) (1655)
- Western Kentucky University (1583)
- Virginia Commonwealth University (1552)
- Children's Mercy Kansas City (1532)
- University of Nebraska Medical Center (1436)
- LSU Health New Orleans (1425)
- Dartmouth College (1411)
- Technological University Dublin (1253)
- Keyword
-
- Humans (25933)
- Female (11902)
- Male (10571)
- Animals (7842)
- Adult (6115)
-
- COVID-19 (5718)
- Middle Aged (5272)
- ICTS (Institute of Clinical and Translational Sciences) (5267)
- Mice (5097)
- Aged (4573)
- Child (3269)
- Michigan (2871)
- Adolescent (2751)
- United States (2381)
- Retrospective Studies (2278)
- English (2245)
- Treatment Outcome (1884)
- Young Adult (1836)
- Infant (1636)
- Public health (1613)
- Pregnancy (1561)
- Risk Factors (1544)
- Neoplasms (1526)
- Biomarkers (1500)
- Obesity (1399)
- Thomas Jefferson University (1393)
- Mutation (1374)
- Tumor (1351)
- Brain (1282)
- Child, Preschool (1279)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (13671)
- Faculty, Staff and Students Publications (8118)
- 2020-Current year OA Pubs (7553)
- Research outputs 2022 to 2026 (2400)
- Journal Articles (2396)
-
- Faculty Publications (2317)
- School of Medicine Publications (1723)
- Research outputs 2014 to 2021 (1526)
- Publications and Research (1523)
- Manuscripts, Articles, Book Chapters and Other Papers (1471)
- Dartmouth Scholarship (1400)
- Reproductive Health (1317)
- Open Access Publications (1148)
- Articles (1027)
- Articles, Abstracts, and Reports (1025)
- School of Medicine Faculty Publications (1024)
- Rapports de recherche scientifique (980)
- Department of Medicine (969)
- College of Nursing Faculty Research and Publications (963)
- Patient Education Projects (960)
- Poverty, Gender, and Youth (856)
- Pharmacy Faculty Articles and Research (850)
- Watercooler Newsletter (744)
- Patient Care Services / Nursing (732)
- Historical Archives (705)
- Pediatrics Faculty Publications (699)
- Faculty Scholarship (683)
- Independent Study Project (ISP) Collection (676)
- Doctoral Dissertations and Projects (675)
- NYMC Faculty Publications (635)
Articles 149161 - 149190 of 160729
Full-Text Articles in Medicine and Health Sciences
Medicaid Prescription Drug Coverage: State Efforts To Control Costs, Dawn Gencarelli
Medicaid Prescription Drug Coverage: State Efforts To Control Costs, Dawn Gencarelli
National Health Policy Forum
This paper provides a brief summary of the Medicaid prescription drug benefit. It explains the mechanisms being used by states to control their prescription drug spending within the Medicaid program. The paper also highlights some of the concerns that have been expressed with these mechanisms and the litigation that has been initiated in several states as a result of these efforts. It takes a closer look at three states with cost containment strategies that have been the focus of increased scrutiny.
The Legal And Political Future Of Physician-Assisted Suicide, Larry I. Palmer
The Legal And Political Future Of Physician-Assisted Suicide, Larry I. Palmer
Popular Media
No abstract provided.
Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
Pharmaceutical Sciences Faculty Patents
Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.
Ada News - 05/05/2003, American Dental Association, Publishing Division
Ada News - 05/05/2003, American Dental Association, Publishing Division
ADA News
Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.
Ncaa Needs More Than Rules, Rewards, Rick Burton, James Terbrogs
Ncaa Needs More Than Rules, Rewards, Rick Burton, James Terbrogs
Sport Management - All Scholarship
No abstract provided.
Single Versus Multiple Drug Focus In Substance Abuse Clinical Trials Research, Nancy M. Petry
Single Versus Multiple Drug Focus In Substance Abuse Clinical Trials Research, Nancy M. Petry
UCHC Articles - Research
Complex patterns of multiple substance use pose clinical and methodological challenges for substance abuse clinical trials research. To increase measurement precision and internal validity, the modal approach has been to target both treatment interventions and outcome assessment to a single class of abused substance. This strategy warrants reconsideration because it entails limitations in recruitment feasibility and generalization of study findings. This report reviews pros and cons of single versus multiple targeted drugs, suggests guidelines for choosing between these strategies and outlines methods for broadening the scope of substance abuse clinical trails to take abuse of multiple substances into account. We …
The Effect Of Ultra Low Dose Epidural Analgesia On Newborn Breastfeeding Behaviors, Sharon Radzyminski
The Effect Of Ultra Low Dose Epidural Analgesia On Newborn Breastfeeding Behaviors, Sharon Radzyminski
Nursing Faculty Publications
Objective: To determine whether a difference in breastfeeding behaviors could be observed between newborns whose mothers received epidural analgesia for labor pain relief and those newborns whose mothers received no pain medication in labor. Design: There were two groups of neonates in this study. One group was born to mothers who received epidural analgesia, and one group was born to mothers who received no pain medication for labor. Both groups were observed for initial breastfeeding behaviors using the Premature Infant Breastfeeding Behavior Scale following birth and at 24 hours. Central nervous system functioning in the newborn was measured with the …
Water Quality Assessment In Cypress Creek Nature Preserve, Jason Flora
Water Quality Assessment In Cypress Creek Nature Preserve, Jason Flora
Masters Theses & Specialist Projects
Swamps are unique ecological communities that provide many valuable ecosystem services. In Kentucky, however, many swamps were altered by cypress removal and land development in their watersheds. Cypress Creek Swamp, which lies near Paducah in western Kentucky, is a good example of a swamp whose ecological integrity may be threatened by past and current nearby land use practices. This study was conducted to assess the water quality and macro- and microinvertebrate communities in the swamp. Three sites were monitored for temperature, dissolved oxygen, pH, specific conductivity, depth, phosphorus measured as orthophosphate, nitrite (NO2") and nitrate (NO3", NOx collectively), and ammonia …
Genescene: Biomedical Text And Data Mining, Gondy Leroy, Hsinchun Chen, Jesse D. Martinez, Shauna Eggers, Ryan R. Falsey, Kerri L. Kislin, Zan Huang, Jiexun Li, Jie Xu, Daniel M. Mcdonald, Gavin Ng
Genescene: Biomedical Text And Data Mining, Gondy Leroy, Hsinchun Chen, Jesse D. Martinez, Shauna Eggers, Ryan R. Falsey, Kerri L. Kislin, Zan Huang, Jiexun Li, Jie Xu, Daniel M. Mcdonald, Gavin Ng
CGU Faculty Publications and Research
To access the content of digital texts efficiently, it is necessary to provide more sophisticated access than keyword based searching. GeneScene provides biomedical researchers with research findings and background relations automatically extracted from text and experimental data. These provide a more detailed overview of the information available. The extracted relations were evaluated by qualified researchers and are precise. A qualitative ongoing evaluation of the current online interface indicates that this method to search the literature is more useful and efficient than keyword based searching.
Rpe "Drift" In Fit And Unfit Males Cycling In A Hot And Cool Environment, Robert Pritchett
Rpe "Drift" In Fit And Unfit Males Cycling In A Hot And Cool Environment, Robert Pritchett
Masters Theses & Specialist Projects
The potential influence of aerobic fitness on RPE estimations during extended exercise bouts is not well understood. The current study compared RPE-Overall, RPE-Legs and RPE-Chest between fit (n=7) and unfit (n=6) males. Subjects completed a graded cycling test and then, in a counterbalanced order, on two separate days cycled for 60min (intensity~90% of the Onset of Blood Lactate Accumulation (OBLA) - determined via gas exchange indices) at 30}1 degrees Wet Bulb Globe Temperature (WBGT) and 18}1 degrees WBGT. Heart rate (HR), rectal temperature (Tree) and overall and differentiated RPE estimations were collected every 5 minutes. Repeated measures analyses of variance …
Patterns Of Cocaine Consumption: A Sub-Analysis Of The Drugnet Survey, Nivedita Seerpi
Patterns Of Cocaine Consumption: A Sub-Analysis Of The Drugnet Survey, Nivedita Seerpi
Masters Theses & Specialist Projects
The myths and misconceptions that surround cocaine use lead to the over-estimation of the prevalence of cocaine addiction in society. Health education curricula and drug policy do not differentiate between cocaine use and abuse. This study describes the cocaine consumption patterns in a nonclinical, non-incarcerated sample of cocaine users. The resulting patterns are compared to those found by Cohen (1989) and Cohen and Sas (1993, 1994, 1995). DRUGNET is an online survey of recreational drug use by nondeviant adults via the WWW. Self-selected subjects completed a survey over the Internet between February and October 1997 (N= 701). This sample was …
Distributive Justice: Perceptions Of Star Player Treatment In Work Team Settings, Nadim Zaidy
Distributive Justice: Perceptions Of Star Player Treatment In Work Team Settings, Nadim Zaidy
Masters Theses & Specialist Projects
The present study examined the effects of punishment given to the most valued team member who has committed a company rule violation. The team is working on an important project where the contribution by that valued member is critical to project completion. The study assessed the effects of the severity of rule violation, the severity of the punishment, the consistency of the punishment, and who is impacted by the punishment. The results indicated that when a valued employee has committed a rule violation, applying consistent punishment is perceived as more fair and appropriate by the teammates. However, when that valued …
Effects Of Ethanol On Anti-Saccade Task Performance., Sarah A Khan, Kristen Ford, Brian Timney, Stefan Everling
Effects Of Ethanol On Anti-Saccade Task Performance., Sarah A Khan, Kristen Ford, Brian Timney, Stefan Everling
Brain and Mind Institute Researchers' Publications
It has been shown that saccade-related neurons in the superior colliculus (SC) display an increased level of prestimulus activity and a higher stimulus-related burst in action potentials preceding direction errors in the anti-saccade task compared with correct anti-saccades. From this, it has been hypothesized that errors occur when the incoming visual signal in the SC passes a threshold and triggers a reflexive saccade. This hypothesis predicts that an attenuated visual signal will reduce the number of direction errors. Since ethanol has been shown to have a suppressive effect on cortical visual event-related potentials (ERPs), the purpose of the present study …
The Ignored Disease: The Aids Epidemic 1981–1987, Heather L. Graff, Heather Graff Bloom
The Ignored Disease: The Aids Epidemic 1981–1987, Heather L. Graff, Heather Graff Bloom
College of Journalism and Mass Communications: Theses
Less than six months after Ronald Reagan was inaugurated as the 40th president of the United States, the federal Centers for Disease Control in Atlanta reported pneumocystis carinii pneumonia, in five gay men. In the United States, AIDS was first diagnosed among gay men in New York City and San Francisco. There were several media trends for AIDS coverage in the 1980s. In the early 1980s, AIDS was mainly thought of as a gay-related disease. In the mid- l 980s, AIDS cases were found in hemophiliacs, intravenous drug users and "celebrities." Coverage in the late 1980s focused on heterosexuals and …
Association Of Borrelia Garinii And B. Valaisiana With Songbirds In Slovakia, Klara Hanincova, Veronika Taragelova, Juraj Koci, Stefanie M. Schafer, Rosie Hails, Amy J. Ullmann, Joseph Piesman, Milan Labuda, Klaus Kurtenbach
Association Of Borrelia Garinii And B. Valaisiana With Songbirds In Slovakia, Klara Hanincova, Veronika Taragelova, Juraj Koci, Stefanie M. Schafer, Rosie Hails, Amy J. Ullmann, Joseph Piesman, Milan Labuda, Klaus Kurtenbach
United States Public Health Resources
In Europe, 6 of the 11 genospecies of Borrelia burgdorferi sensu lato are prevalent in questing Ixodes ricinus ticks. In most parts of Central Europe, B. afzelii, B. garinii, and B. valaisiana are the most frequent species, whereas B. burgdorferi sensu stricto, B. bissettii, and B. lusitaniae are rare. Previously, it has been shown that B. afzelii is associated with European rodents. Therefore, the aim of this study was to identify reservoir hosts of B. garinii and B. valaisiana in Slovakia. Songbirds were captured in a woodland near Bratislava and investigated for engorged ticks. Questing I. ricinus ticks …
European Mistletoe/Iscador® Faq , Clinic Staff
European Mistletoe/Iscador® Faq , Clinic Staff
Topics in Integrative Medicine
Mistletoe (Viscum album) may be the most commonly used complementary cancer therapy in Europe today. Background information and important questions are presented.
The Ethics Of Apology And The Role Of An Ombuds From The Perspective Of A Lawyer, Sharan Lee Levine, Paula A. Aylward
The Ethics Of Apology And The Role Of An Ombuds From The Perspective Of A Lawyer, Sharan Lee Levine, Paula A. Aylward
Center for the Study of Ethics in Society Papers
Papers presented for the Center of the Study of Ethics in Society Western Michigan University, March 20, 2003.
Effects Of Tensioning Errors In Split Transfers Of Tibialis Anterior And Posterior Tendons, Stephen J. Piazza, Matthew F. Moran, Neil A. Sharkey, Robert L. Adamson, James O. Sanders
Effects Of Tensioning Errors In Split Transfers Of Tibialis Anterior And Posterior Tendons, Stephen J. Piazza, Matthew F. Moran, Neil A. Sharkey, Robert L. Adamson, James O. Sanders
All PTHMS Faculty Publications
Background: Split transfers of the tibialis anterior and posterior tendons are commonly performed to address hindfoot varus deformities in patients with cerebral palsy, stroke, or brain injury. Poor outcomes from these procedures are often attributed to a failure to tension the transferred tendon properly, but the mechanical effects of this aspect of the procedure have not been quantified, to our knowledge. The purpose of the present study was to use a cadaver model to examine changes in the actions of these muscles that occur when the tensions in the halves of the split tendon are intentionally balanced or unbalanced to …
Hdl-Associated Estradiol Stimulates Endothelial No Synthase And Vasodilation In An Sr-Bi–Dependent Manner, Ming Gong, Melinda E. Wilson, Thomas Kelly, Wen Su, James Dressman, Jeanie Kincer, Sergey V. Matveev, Ling Guo, Theresa Guerin, Xiang-An Li, Weifei Zhu, Annette M. Uittenbogaard, Eric J. Smart
Hdl-Associated Estradiol Stimulates Endothelial No Synthase And Vasodilation In An Sr-Bi–Dependent Manner, Ming Gong, Melinda E. Wilson, Thomas Kelly, Wen Su, James Dressman, Jeanie Kincer, Sergey V. Matveev, Ling Guo, Theresa Guerin, Xiang-An Li, Weifei Zhu, Annette M. Uittenbogaard, Eric J. Smart
Pediatrics Faculty Publications
Cardiovascular diseases remain the leading cause of death in the United States. Two factors associated with a decreased risk of developing cardiovascular disease are elevated HDL levels and sex — specifically, a decreased risk is found in premenopausal women. HDL and estrogen stimulate eNOS and the production of nitric oxide, which has numerous protective effects in the vascular system including vasodilation, antiadhesion, and anti-inflammatory effects. We tested the hypothesis that HDL binds to its receptor, scavenger receptor class B type I (SR-BI), and delivers estrogen to eNOS, thereby stimulating the enzyme. HDL isolated from women stimulated eNOS, whereas HDL isolated …
Inside Unlv, Gian Galassi, Richard Morgan, Carol C. Harter
Inside Unlv, Gian Galassi, Richard Morgan, Carol C. Harter
Inside UNLV
No abstract provided.
Comparison Of Written And Oral Examinations In A Baccalaureate Medical-Surgical, Patricia Rushton, Dennis L. Eggett
Comparison Of Written And Oral Examinations In A Baccalaureate Medical-Surgical, Patricia Rushton, Dennis L. Eggett
Faculty Publications
Nursing students traditionally have been evaluated with an objective written examination. This method has shown some benefits and disadvantages. This project examined the value of oral examinations in evaluating nursing students. Five groups of students were evaluated with different forms of testing, some with only written tests, others with only oral examinations, some with a combination of both types of evaluations. The results showed that oral examinations can effectively evaluate the student's comprehension and application of clinical information in a clinical situation, as shown in higher test results, compared with oral written examinations, and positive student comments. Oral examination can …
Parent-Adolescent Communication About Sex: Retrospective Reports By Latino College Students, Marcela Raffaelli, Stephanie Green
Parent-Adolescent Communication About Sex: Retrospective Reports By Latino College Students, Marcela Raffaelli, Stephanie Green
Department of Psychology: Faculty Publications
Latina female (n = 97) and Latino male (n = 69) college students (M age =21.4 years) completed self-report surveys regarding family of origin experiences, including sexual communication with parents while growing up. Latino parents of this comparatively highly educated sample tended to use direct rather than indirect strategies for communicating about sexuality with their children. Young women reported higher levels of sexual communication with mothers while growing up than did young men, and respondents reported less communication with fathers than mothers. Among young women, sexual communication with mother was positively associated with non-Mexican origin and negatively associated with having …
Addressing The Decline In Reproductive Performance Of Lactating Dairy Cows: A Researcher’S Perspective, William J. Silvia
Addressing The Decline In Reproductive Performance Of Lactating Dairy Cows: A Researcher’S Perspective, William J. Silvia
Animal and Food Sciences Faculty Publications
No abstract provided.
Genomic And Proteomic Profiling Of Responses To Toxic Metals In Human Lung Cells, Angeline S. Andrew, Amy J. Warren, Aaron Barchowsky, Kaili A. Temple, Linda Klei, Nicole V. Soucy, Kimberly A. O'Hara, Joshua W. Hamilton
Genomic And Proteomic Profiling Of Responses To Toxic Metals In Human Lung Cells, Angeline S. Andrew, Amy J. Warren, Aaron Barchowsky, Kaili A. Temple, Linda Klei, Nicole V. Soucy, Kimberly A. O'Hara, Joshua W. Hamilton
Dartmouth Scholarship
Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expression following low-dose, acute exposures of cadmium, chromium, arsenic, nickel, or mitomycin C (MMC) in BEAS-2B human bronchial epithelial cells. Total RNA was isolated from cells exposed to 3 M Cd(II) (as cadmium chloride), 10 M Cr(VI) (as sodium dichromate), 3 g/cm2 Ni(II) (as nickel subsulfide), 5 M or 50 M As(III) (as sodium arsenite), or …
Thoracoscopic Intradiscal Spine Fusion Using A Minimally Invasive Gene-Therapy Technique, K. Daniel Riew, Jueren Lou, Neill M. Wright, Su-Li Cheng, Kyongtae T. Bae, Louis V. Avioli
Thoracoscopic Intradiscal Spine Fusion Using A Minimally Invasive Gene-Therapy Technique, K. Daniel Riew, Jueren Lou, Neill M. Wright, Su-Li Cheng, Kyongtae T. Bae, Louis V. Avioli
Open Access Publications
No abstract provided.
Lysosomal Membrane Permeabilization Induces Cell Death In A Mitochondrion-Dependent Fashion, Patricia Boya, Karine Andreau, Delphine Poncet, Naoufal Zamzami, Jean-Luc Perfettini, Didier Metivier, David M. Ojcius, Marja Jäättelä, Guido Kroemer
Lysosomal Membrane Permeabilization Induces Cell Death In A Mitochondrion-Dependent Fashion, Patricia Boya, Karine Andreau, Delphine Poncet, Naoufal Zamzami, Jean-Luc Perfettini, Didier Metivier, David M. Ojcius, Marja Jäättelä, Guido Kroemer
All Dugoni School of Dentistry Faculty Articles
A number of diseases are due to lysosomal destabilization, which results in damaging cell loss. To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two widely used quinolone antibiotics: ciprofloxacin (CPX) or norfloxacin (NFX). CPX or NFX plus UV light (NFX*) induce lysosomal membrane permeabilization (LMP), as detected by the release of cathepsins from lysosomes. Inhibition of the lysosomal accumulation of CPX or NFX suppresses their capacity to induce LMP and to kill cells. CPX- or NFX-triggered LMP results in caspase-independent cell death, with hallmarks of apoptosis such as chromatin condensation and phosphatidylserine exposure on …
Testing Search Skills In A Real-Time, Cased-Based Setting, Patricia Wilson, Alexandra Gomes, Anne Linton
Testing Search Skills In A Real-Time, Cased-Based Setting, Patricia Wilson, Alexandra Gomes, Anne Linton
Himmelfarb Library Faculty Posters and Presentations
Using the web-based course management system, Prometheus, the librarians of Himmelfarb Health Sciences Library gave a real-time skills testing exam to 48 medical students. This poster presentation explores the goals and results the exam.
Outbreak Of Sars, Ambreen Shakil, Muhammad Imran Omar, Saba Sohail
Outbreak Of Sars, Ambreen Shakil, Muhammad Imran Omar, Saba Sohail
Department of Radiology
No abstract provided.
Factors Influencing Treatment Patterns In Breast Cancer Patients Age 75 And Over, Arti Hurria, Denis H. Y. Leung, Kathleen Trainor, Patrick Borgen, Larry Norton, Clifford Hudis
Factors Influencing Treatment Patterns In Breast Cancer Patients Age 75 And Over, Arti Hurria, Denis H. Y. Leung, Kathleen Trainor, Patrick Borgen, Larry Norton, Clifford Hudis
Research Collection School Of Economics
To retrospectively determine the factors influencing treatment decisions in older breast cancer patients at a single center. Experimental Design: 216 patients age > or = 75 seen in post-treatment follow-up between January, 1997 and June, 2000 were identified in the Memorial Sloan-Kettering breast cancer database. Eligible patients were > or = 75 years old at diagnosis, had a diagnosis of stage I, II, or III breast cancer, and received their follow-up care at Memorial Sloan Kettering Cancer Center. A retrospective chart review was performed. Patients were stratified by: (1) prognostic factors (age (75-79 or > or = 80), Charlson comorbidity score, tumor size, …
Alpha-Toxin Is Required For Biofilm Formation By Staphylococcus Aureus, Nicky C. Caiazza, George A. O'Toole
Alpha-Toxin Is Required For Biofilm Formation By Staphylococcus Aureus, Nicky C. Caiazza, George A. O'Toole
Dartmouth Scholarship
Staphylococcus aureus is a common pathogen associated with nosocomial infections. It can persist in clinical settings and gain increased resistance to antimicrobial agents through biofilm formation. We have found that alpha-toxin, a secreted, multimeric, hemolytic toxin encoded by the hla gene, plays an integral role in biofilm formation. The hla mutant was unable to fully colonize plastic surfaces under both static and flow conditions. Based on microscopy studies, we propose that alpha-hemolysin is required for cell-to-cell interactions during biofilm formation.