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Articles 149131 - 149160 of 160729

Full-Text Articles in Medicine and Health Sciences

General Physicians' Perspective Of Sleep Apnea From A Developing Country, Syed Fayyaz Hussain, Sumaiya Zahid, Raana Haqqee, Javaid Ahmed Khan Jun 2003

General Physicians' Perspective Of Sleep Apnea From A Developing Country, Syed Fayyaz Hussain, Sumaiya Zahid, Raana Haqqee, Javaid Ahmed Khan

Section of Pulmonary & Critical Care

To assess the knowledge of general physicians about the diagnosis and management of obstructive sleep apnea (OSA), a self-administered questionnaire, containing 15 questions, was distributed to 160 doctors attending a pulmonary CME program in March 2002. After 15 minutes of response time, the questionnaires were collected. The data were entered and analyzed using SPSS (Version 10.0) software. One hundred and twenty (75%) questionnaires were returned. Only 41% of responders had ever read an article about OSA and 36% had suspected it at least once in their practice. The majority (61-77%) of responders were aware of the common symptoms of OSA, …

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Experience In 118 Consecutive Patients Undergoing Ct-Guided Stereotactic Surgery Utilizing The Cosman-Robert-Wells (Crw) Frame, G. R. Sharma, H. Siddiqui, Rashid Jooma Jun 2003

Experience In 118 Consecutive Patients Undergoing Ct-Guided Stereotactic Surgery Utilizing The Cosman-Robert-Wells (Crw) Frame, G. R. Sharma, H. Siddiqui, Rashid Jooma

Section of Neurosurgery

Aims: To evaluate the efficacy of CT-guided neurosurgical procedures done on patients operated by this modality.
Methods: Between January 1997 and March 2000, 118 patients undergoing CT-guided stereotactic procedures were recruited to the study. The CRW III stereotactic system (Radionics, USA) and the TSX-00ZA CT Scanner (Toshiba, Japan) were used for all the procedures in the series. These procedures were directed to symptomatic brain lesions or for the treatment of Parkinsonian tremor.
Results: Of 118 patients, 109 had intra-cranial lesions and 9 had Parkinson's Disease. The stereotactic procedures performed on these patients were: biopsies in 62, guided mini-craniotomies in 22, …

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Inside Unlv, Kevin Force, Gian Galassi, Carol C. Harter, Stuart Mann Jun 2003

Inside Unlv, Kevin Force, Gian Galassi, Carol C. Harter, Stuart Mann

Inside UNLV

No abstract provided.

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Identification Of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That Both Inhibit Apoptosis And Enhance The Spontaneous Reactivation Phenotype, Ling Jin, Weiping Peng, Guey-Chuen Perng, David J. Brick, Anthony B. Nesburn, Clinton J. Jones, Steven L. Wechsler Jun 2003

Identification Of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That Both Inhibit Apoptosis And Enhance The Spontaneous Reactivation Phenotype, Ling Jin, Weiping Peng, Guey-Chuen Perng, David J. Brick, Anthony B. Nesburn, Clinton J. Jones, Steven L. Wechsler

School of Veterinary and Biomedical Sciences: Faculty Publications

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for the high spontaneous and induced reactivation phenotype of HSV-1 in the rabbit ocular model and for the high induced reactivation phenotype in the mouse ocular model. Recently we showed that LAT has an antiapoptosis function, and we hypothesized that LAT’s ability to inhibit apoptosis played an important role in LAT’s ability to enhance the reactivation phenotype. Expression of just the first 1.5 kb of the 8.3-kb LAT gene is sufficient for both inhibition of apoptosis in an in vitro transient-transfection assay and the high spontaneous reactivation …

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Systemic Sclerosis: Current Views Of Its Pathogenesis., Chris T. Derk, Sergio A. Jimenez Jun 2003

Systemic Sclerosis: Current Views Of Its Pathogenesis., Chris T. Derk, Sergio A. Jimenez

Department of Medicine Faculty Papers

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immune abnormalities. Clinically, SSc is very heterogeneous, encompassing a spectrum ranging from mild limited forms of skin sclerosis with minimal internal organ involvement to severe skin and multiple internal organ fibrosis. Mortality and morbidity in SSc are very high and are directly related to the extent of the fibrotic and microvascular alterations. A better understanding of the pathogenesis of this incurable disorder will help to better target and design effective …

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Long-Term Care: Informed By Research, Francis G. Caro Jun 2003

Long-Term Care: Informed By Research, Francis G. Caro

Gerontology Institute Publications

Health services research has contributed to health policy and service developments that have led to major improvements in the quality of long-term care in the United States. This policy brief highlights a few areas in which publicly and privately funded research has informed the long-term care field.

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Jefferson Alumni Bulletin – Volume 52, Number 3, June 2003 Jun 2003

Jefferson Alumni Bulletin – Volume 52, Number 3, June 2003

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 52, Number 3, June 2003 Dean's Column by Dean Thomas J. Nasca ’75, page 4 Update on Transplant Surgery, page 5 The New Jefferson Hospital for Neuroscience and Farber Institute for Neurosciences, page 6 Researchers Show That Human Neural Stem Cells Can Become Dopamine-Making Brain Cells in the Lab, page 8 Evidence of Greater Sensitivity to Addictive Drugs in Adolescence, page 8 New Hope for Patients with Late Stage Parkinson's, page 10 Above and Beyond the Call: Three Alumni Heroes, page 11 The Mother in The Gross Clinic: A Medical Explanation of Her Hand, page …

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United Power For Action And Justice: Breaking The Cycle Of Homelessness Reports - Policy Brief, Center For Urban Research And Learning, Christine George, Chiara Sabina, Aparna Sharma Jun 2003

United Power For Action And Justice: Breaking The Cycle Of Homelessness Reports - Policy Brief, Center For Urban Research And Learning, Christine George, Chiara Sabina, Aparna Sharma

Center for Urban Research and Learning: Publications and Other Works

This is a story of two groups of determined people with intersecting interests. Group one: a dozen leaders within United Power for Action and Justice who set out to prove their conviction, that homelessness is one symptom of a complex of issues that destabilizes individuals and communities. Group two: persons who are homeless and struggle daily to “fit in” to a landscape that is, more and more, structured to shut them out. In 2000, a cluster of leaders within United Power organized member institutions in the north and northwest suburbs of Chicago, and initiated a relationship with Congressman John Porter …

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Brazil And The Development Of International Scientific Biosafety Testing Guidelines For Transgenic Crops, Deise Maria Fontana Capalbo, Angelika Hilbeck, David Andow, Allison Snow, Bui Ba Bong, Fang Hao Wan, Eliana M.G. Fontes, Ellie Onyango Osir, Gary P. Fitt, Jill Johnston, Josephine Songa, K. L. Heong, A. Nicholas E. Birch Jun 2003

Brazil And The Development Of International Scientific Biosafety Testing Guidelines For Transgenic Crops, Deise Maria Fontana Capalbo, Angelika Hilbeck, David Andow, Allison Snow, Bui Ba Bong, Fang Hao Wan, Eliana M.G. Fontes, Ellie Onyango Osir, Gary P. Fitt, Jill Johnston, Josephine Songa, K. L. Heong, A. Nicholas E. Birch

All Peer-Reviewed Publications

Under the umbrella of the International Organisation of Biological Control (IOBC), an international working group of public sector scientists entitled on "Transgenic Organisms in Integrated Pest Management and Biological Control" has been organized. The group will develop scientific principles and detailed scientific guidelines for biosafety testing of transgenic crops. The key elements of this project are: (1) An international initiative including expert scientists from leading research institutions in developed and developing countries; (2) coordination of the development and implementation of the guidelines as a dynamic process, which will include scientific and technical capacity building and communication among scientists and between …

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Residency Program At Michael E Debakey Department Of Surgery, Baylor College Of Medicine, F Charles Brunicardi Jun 2003

Residency Program At Michael E Debakey Department Of Surgery, Baylor College Of Medicine, F Charles Brunicardi

Faculty, Staff and Students Publications

No abstract provided.

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Care Management For Persistent Pain: An Introduction, Christine W. Hartmann, Neil I. Goldfarb, Susan S. Kim, Bhaskar R. Nuthulaganti, Raafat Seifeldin Jun 2003

Care Management For Persistent Pain: An Introduction, Christine W. Hartmann, Neil I. Goldfarb, Susan S. Kim, Bhaskar R. Nuthulaganti, Raafat Seifeldin

College of Population Health Faculty Papers

Persistent pain is a frequently occurring condition with significant economic, clinical, and humanistic implications, for both individuals and society. Current literature, however, points to unresolved issues with regard to its identification, assessment, diagnosis, and treatment, and a number of suggestions have been made for improving the quality of care for pain sufferers. Because persistent pain shares many of the salient features of other chronic conditions such as diabetes and congestive heart failure, it is reasonable to believe that the adoption of a coordinated approach to care management could substantially improve the quality of care. Several strategiesincluding identification, appropriate referral, education, …

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Donation After Cardiac Death: The Reinvention Of A Forgotten Procedure, Gloria Taylor, Karen Samartan, Kathryn Schroeter Jun 2003

Donation After Cardiac Death: The Reinvention Of A Forgotten Procedure, Gloria Taylor, Karen Samartan, Kathryn Schroeter

College of Nursing Faculty Research and Publications

No abstract provided.

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Editorial: Are You A Prime Mover?, Kathryn Schroeter Jun 2003

Editorial: Are You A Prime Mover?, Kathryn Schroeter

College of Nursing Faculty Research and Publications

No abstract provided.

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Review Of Molecular Infection Biology: Interactions Between Mircoorganisms And Cells By Jörg Hacker And Jürgen Heesemann, Jeffrey D. Cirillo Jun 2003

Review Of Molecular Infection Biology: Interactions Between Mircoorganisms And Cells By Jörg Hacker And Jürgen Heesemann, Jeffrey D. Cirillo

School of Veterinary and Biomedical Sciences: Faculty Publications

Pathogenesis is one potential outcome of the constant struggle between host defenses and the desire of microorganisms to acquire a privileged niche. This mutually competitive evolutionary process has resulted in interactions among complex and often elegant systems throughout the course of infections. The complexity of these interactions and the large number of infectious agents that exist makes the introduction of students to infectious diseases, as well as a comprehensive review of the field, an extremely daunting task. This book provides just such a comprehensive and timely description of the field in a manner that is easily understandable and enjoyable to …

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Doing It Rite: Exploring A Decade Of Health Coverage Innovation (Rhode Island), Jennifer Ryan, Ginger P. Parra May 2003

Doing It Rite: Exploring A Decade Of Health Coverage Innovation (Rhode Island), Jennifer Ryan, Ginger P. Parra

National Health Policy Forum

This site visit to the state of Rhode Island provided an opportunity to experience and understand the decade of health coverage innovation that has resulted in near universal coverage for children. Site visitors had the opportunity to interact with health care providers, state officials, and consumer advocates, as well as other leaders in health care community. The group also visited the Thundermist Health Center in Woonsocket; a school based health clinic at Woonsocket High School; the HELP Lead Safe Center in South Providence; and a local provider, St. Joseph’s Hospital for Specialty Care, that houses several preventive care clinics and …

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Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks May 2003

Synthases, Joe Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.

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Transdemal Delivery Of Opioid Antagonist Prodrugs, Audra L. Stinchcomb, Peter W. Swaan May 2003

Transdemal Delivery Of Opioid Antagonist Prodrugs, Audra L. Stinchcomb, Peter W. Swaan

Pharmaceutical Sciences Faculty Patents

A composition, a method and an apparatus for transdermally delivering an effective amount of opioid antagonists derived from prodrugs for treatment of eating disorders, narcotic dependence and alcoholism. In addition, the present invention relates to a composition, a method and an apparatus for transdermally delivering an effective amount of an opioid and opioid antagonist derived from an opioid agonist and one of an opioid antagonist and a prodrug for treatment of pain.

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Vam10p Defines A Sec18p-Independent Step Of Priming That Allows Yeast Vacuole Tethering, Masashi Kato, William Wickner May 2003

Vam10p Defines A Sec18p-Independent Step Of Priming That Allows Yeast Vacuole Tethering, Masashi Kato, William Wickner

Dartmouth Scholarship

YOR068c, termed VAM10 (altered vacuole morphology), lies within the VPS5 gene on the opposite DNA strand. VAM10 deletion causes vacuole fragmentation in vivo. The in vitro fusion of purified yeast vacuoles is stimulated by recombinant Vam10p and blocked by antibody to Vam10p. Vam10p acts early in the priming stage of fusion, independent of Sec18p. After priming, recombinant Vam10p will not stimulate fusion and anti-Vam10p antibodies will not inhibit; Vam10p provides a functional marker for this Sec18p-independent priming step. Pure Vam10p restores normal, Ypt7p-dependent tethering to vacuoles from a vam10Δ strain.

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Copper Chelation Represses The Vascular Response To Injury, Lazar Mandinov, Anna Mandinova, Stanimir Kyurkchiev, Dobroslav Kyurkchiev, Ivan Kehayov, Vihren Kolev, Raffaella Soldi, Cinzia Bagala, Ebo D. De Muinck, Volkhard Lindner, Mark J. Post, Michael Simons May 2003

Copper Chelation Represses The Vascular Response To Injury, Lazar Mandinov, Anna Mandinova, Stanimir Kyurkchiev, Dobroslav Kyurkchiev, Ivan Kehayov, Vihren Kolev, Raffaella Soldi, Cinzia Bagala, Ebo D. De Muinck, Volkhard Lindner, Mark J. Post, Michael Simons

Dartmouth Scholarship

The induction of an acute inflammatory response followed by the release of polypeptide cytokines and growth factors from peripheral blood monocytes has been implicated in mediating the response to vascular injury. Because the Cu2+-binding proteins IL-1alpha and fibroblast growth factor 1 are exported into the extracellular compartment in a stress-dependent manner by using intracellular Cu2+ to facilitate the formation of S100A13 heterotetrameric complexes and these signal peptideless polypeptides have been implicated as regulators of vascular injury in vivo, we examined the ability of Cu2+ chelation to repress neointimal thickening in response to injury. We observed that the oral administration of …

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Identifying Target Populations For Screening Or Not Screening Using Logic Regression, Holly Janes, Margaret S. Pepe, Charles Kooperberg, Polly Newcomb May 2003

Identifying Target Populations For Screening Or Not Screening Using Logic Regression, Holly Janes, Margaret S. Pepe, Charles Kooperberg, Polly Newcomb

UW Biostatistics Working Paper Series

Colorectal cancer remains a significant public health concern despite the fact that effective screening procedures exist and that the disease is treatable when detected at early stages. Numerous risk factors for colon cancer have been identified, but none are very predictive alone. We sought to determine whether there are certain combinations of risk factors that distinguish well between cases and controls, and that could be used to identify subjects at particularly high or low risk of the disease to target screening. Using data from the Seattle site of the Colorectal Cancer Family Registry (C-CFR), we fit logic regression models to …

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Improved Confidence Intervals For The Sensitivity At A Fixed Level Of Specificity Of A Continuous-Scale Diagnostic Test, Xiao-Hua Zhou, Gengsheng Qin May 2003

Improved Confidence Intervals For The Sensitivity At A Fixed Level Of Specificity Of A Continuous-Scale Diagnostic Test, Xiao-Hua Zhou, Gengsheng Qin

UW Biostatistics Working Paper Series

For a continuous-scale test, it is an interest to construct a confidence interval for the sensitivity of the diagnostic test at the cut-off that yields a predetermined level of its specificity (eg. 80%, 90%, or 95%). IN this paper we proposed two new intervals for the sensitivity of a continuous-scale diagnostic test at a fixed level of specificity. We then conducted simulation studies to compare the relative performance of these two intervals with the best existing BCa bootstrap interval, proposed by Platt et al. (2000). Our simulation results showed that the newly proposed intervals are better than the BCa bootstrap …

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Bootstrap Confidence Intervals For Medical Costs With Censored Observations, Hongyu Jiang, Xiao-Hua Zhou May 2003

Bootstrap Confidence Intervals For Medical Costs With Censored Observations, Hongyu Jiang, Xiao-Hua Zhou

UW Biostatistics Working Paper Series

Medical costs data with administratively censored observations often arise in cost-effectiveness studies of treatments for life threatening diseases. Mean of medical costs incurred from the start of a treatment till death or certain timepoint after the implementation of treatment is frequently of interest. In many situations, due to the skewed nature of the cost distribution and non-uniform rate of cost accumulation over time, the currently available normal approximation confidence interval has poor coverage accuracy. In this paper, we proposed a bootstrap confidence interval for the mean of medical costs with censored observations. In simulation studies, we showed that the proposed …

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Ada News - 05/19/2003, American Dental Association, Publishing Division May 2003

Ada News - 05/19/2003, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

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Trigeminal Somatosensory Innervation Of The Head Of A Teleost Fish With Particular Reference To Nociception, Lynne U. Sneddon May 2003

Trigeminal Somatosensory Innervation Of The Head Of A Teleost Fish With Particular Reference To Nociception, Lynne U. Sneddon

Veterinary Science and Medicine Collection

Trigeminal somatosensory receptors have not been characterised in teleost fish and studies in elasmobranchs have failed to identify nociceptors. The present study examined the trigeminal nerve of a teleost fish, the rainbow trout (Oncorhynchus mykiss) to determine what types of somatosensory receptors were present on the head of the trout specifically searching for nociceptors. Single unit recordings were made from receptive fields on the head of the fish innervated by the trigeminal nerve. Each receptive field was tested for sensitivity to mechanical, thermal and chemical stimulation. Five different receptor types were found: fast adapting receptors responding to mechanical stimulation; slowly …

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Disease Management To Population-Based Health: Steps In The Right Direction?, Lisa Sprague May 2003

Disease Management To Population-Based Health: Steps In The Right Direction?, Lisa Sprague

National Health Policy Forum

This issue brief reviews the evolution of the disease management model and the ways it relates to care coordination and case management approaches. It also looks at examples of population-based disease management programs operating in both the private and public sectors and reviews the evidence of their success. Finally, the paper considers the policy implications of adapting this model to a Medicare fee-for-service population.

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A Bootstrap Confidence Interval Procedure For The Treatment Effect Using Propensity Score Subclassification, Wanzhu Tu, Xiao-Hua Zhou May 2003

A Bootstrap Confidence Interval Procedure For The Treatment Effect Using Propensity Score Subclassification, Wanzhu Tu, Xiao-Hua Zhou

UW Biostatistics Working Paper Series

In the analysis of observational studies, propensity score subclassification has been shown to be a powerful method for adjusting unbalanced covariates for the purpose of causal inferences. One practical difficulty in carrying out such an analysis is to obtain a correct variance estimate for such inferences, while reducing bias in the estimate of the treatment effect due to an imbalance in the measured covariates. In this paper, we propose a bootstrap procedure for the inferences concerning the average treatment effect; our bootstrap method is based on an extension of Efron’s bias-corrected accelerated (BCa) bootstrap confidence interval to a two-sample problem. …

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Development Of Dose Coefficients For Radionuclides Produced In Spallation Neutron Sources, Phillip W. Patton May 2003

Development Of Dose Coefficients For Radionuclides Produced In Spallation Neutron Sources, Phillip W. Patton

Transmutation Sciences Physics (TRP)

A research consortium comprised of representatives from several universities and national laboratories has been established as part of this on-going project to generate internal and external dose conversion coefficients for radionuclides produced in spallation neutron sources. Information obtained from this multi-year study will be used to support the siting and licensing of future accelerator-driven nuclear initiatives within the U.S. Department of Energy complex, including the Spallation Neutron Source (SNS) and the Advanced Fuel Cycle Initiative (AFCI) Projects. Determination of these coefficients will also fill data gaps for several hundred radionuclides that exist in Federal Guide Report No. 11 and in …

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Regulation And Localization Of Endogenous Human Tristetraprolin, Anna-Marie Fairhurst, John E. Connolly, Katharine A Hintz, Nicolas J Goulding May 2003

Regulation And Localization Of Endogenous Human Tristetraprolin, Anna-Marie Fairhurst, John E. Connolly, Katharine A Hintz, Nicolas J Goulding

Dartmouth Scholarship

Tumor necrosis factor (TNF) has been implicated in the development and pathogenicity of infectious diseases and autoimmune disorders, such as septic shock and arthritis. The zinc-finger protein tristetraprolin (TTP) has been identified as a major regulator of TNF biosynthesis. To define its intracellular location and examine its regulation of TNF, a quantitive intracellular staining assay specific for TTP was developed. We establish for the first time that in peripheral blood leukocytes, express

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2003 Commencement For College Of Health Professions May 2003

2003 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

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Rhythmic Binding Of A White Collar-Containing Complex To The Frequency Promoter Is Inhibited By Frequency, Allan C. Froehlich, Jennifer J. Loros, Jay C. Dunlap May 2003

Rhythmic Binding Of A White Collar-Containing Complex To The Frequency Promoter Is Inhibited By Frequency, Allan C. Froehlich, Jennifer J. Loros, Jay C. Dunlap

Dartmouth Scholarship

The biological clock of Neurospora crassa includes interconnected transcriptional and translational feedback loops that cause both the transcript and protein encoded by the frequency gene (frq) to undergo the robust daily oscillations in abundance, which are essential for clock function. To understand better the mechanism generating rhythmic frq transcript, reporter constructs were used to show that the oscillation in frq message is transcriptionally regulated, and a single cis-acting element in the frq promoter, the Clock Box (C box), is both necessary and sufficient for this rhythmic transcription. Nuclear protein extracts used in binding assays revealed that a White Collar (WC)-1- …

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