Medicine and Health Sciences Commons^™

Distinct Roles For The Aaa Atpases Nsf And P97 In The Secretory Pathway, Seema Dalal, Meredith F.N. Rosser, Douglas M. Cyr, Phyllis I. Hanson

Open Access Publications

No abstract provided.

Dinitroanilines Bind Α-Tubulin To Disrupt Microtubules, Naomi S. Morrissette, Arpita Mitra, David Sept, L. David Sibley

Open Access Publications

No abstract provided.

Living Donor Liver Transplantation: Surgical Techniques And Innovations By Koichi Tanaka, Yukihiro Inomaka, And Satoshi Kaihara, Vivian Mcalister

Data and Test Instruments

Living-donor liver transplantation combines the techniques of hepatic resection and transplantation. The principal difference between living donation of liver and resection is the absolute requirement in the former to maintain the integrity of the liver on each side of the dividing line. To do this, the surgeon must retain the vascular supply and drainage of both sides throughout the dissection, up to the moment of graft removal. In this book, Tanaka and colleagues take us through the surgery in a manner that is at once detailed and exciting, through the generous use of magnificent electronic photography.

Review Of Surgical Limits: The Life Of Gordon Murray By Shelly Mckellar, Vivian Mcalister

Data and Test Instruments

Gordon Murray ranks as Canada’s greatest surgical pioneer, to whom history has been most unkind. Shelley McKellar has written a surgical biography that goes a long way toward explaining how this came about, and gives us a good opportunity to reassess Murray’s extraordinary career.

A Cost-Benefit Analysis Of Gown Use In Controlling Vancomycin-Resistant Enterococcus Transmission: Is It Worth The Price?, Laura A. Puzniak, Kathleen N. Gillespie, Terry Leet, Marin Kollef, Linda M. Mundy

Open Access Publications

No abstract provided.

Structural Basis For The Restoration Of Tcr Recognition Of An Mhc Allelic Variant By Peptide Secondary Anchor Substitution, Michael J. Miley, Ilhem Messaoudi, Beatrix M. Metzner, Yudong Wu, Janko Nikolich-Žugich, Daved H. Fremont

Open Access Publications

No abstract provided.

Treatment Of Terminal Peritoneal Carcinomatosis By A Transducible P53-Activating Peptide, Eric L. Snyder, Bryan R. Meade, Cheryl C. Saenz, Steven F. Dowdy

Open Access Publications

No abstract provided.

Ua60/5 Wku Dental Hygiene Class Of 2004, Wku Dental Hygiene

WKU Administration Documents

Members of the 2004 dental hygiene class: Heather Stone, fundraising chairman; Leslie Johnson, treasurer, Sarah Canty, secretary; Miki Hopkins, president; Stephanie Riehn, vice president; Penny Small, class representative; Lori Doss, class representative; Tyra Lindsey, historian, Erin Taylor, SADHA representative, Joanna Davis, SADHA representative, Stacey Chappius, historian; Cassie Alfrejd, Jamie Brawner, Lindsay Christy, Karen Dodson, Kristie Duncan, Jamie Green, Karrie McGrath, Jennifer Pace, Amy Pardue, Melanie Gutierrez, Cyndi Walker and Desirae Wilson.

Effect Of Day Length On Sleep Habits And Subjective On-Duty Alertness In Irregular Work Schedules, June J. Pilcher, Heather M. Teichman, Stephen Popkin, Krista Hildebrand, Michael Coplen

Publications

The human circadian system is sensitive to environmental conditions, such as those created by shift work, that affect the timing and duration of sleep. Previous research on the effects of shift work, however, has focused primarily on regularly scheduled shifts. Few studies have focused on irregular and unpredictable on-call shift systems, such as those found in much of railroad operations. The purpose of the current study was to examine the effect of irregular shift systems experienced by locomotive engineers on the length of sleep-wake periods and the effect of different length sleep-wake periods on self-reported sleep quantity, sleep quality, and …

Minimizing The Pervasiveness Of Women’S Personal Experiences Of Gender Discrimination, Mindi D. Foster, Lydia C. Jackson, Ryan Hartmann, Shannon Woulfe

Psychology Faculty Publications

Given the Rejection-Identification Model (Branscombe, et al., 1999) which shows that perceiving discrimination to be pervasive is a negative experience, it was suggested that there would be conditions under which women would instead minimize the pervasiveness of discrimination. Study 1 (N = 91) showed that when women envisioned themselves in a situation of academic discrimination, they defined it as pervasive but when they experienced a similar laboratory simulation of academic discrimination, its pervasiveness was minimized. Study 2 (N = 159) showed that women who envisioned themselves experiencing discrimination minimized its pervasiveness more so than women reading about discrimination …

When The Advantaged Become Disadvantaged: Men’S And Women’S Actions Against Gender Discrimination, Mindi D. Foster, Stacey Arnt, Jill Honloka

Psychology Faculty Publications

Intergroup theories suggest that different social identities will either discourage or encourage the taking of action against discrimination (Bartky, 1977; Jost & Banaji, 1994). However, research (e.g., Branscombe, 1998) has shown that discrimination is a less negative experience for men than for women. As such, it is possible that men may take greater action than women, regardless of identity. However, men’s responses to their perceived disadvantage has not yet been tested. Among those induced to ascribe to a gendered stereotype identity, men endorsed more action than women did.Among those induced to ascribe to an identity based on a gendered social …

The Role Of Hardiness In Moderating The Relationship Between Global/Specific Attributions And Actions Against Discrimination, Mindi D. Foster, Kenneth L. Dion

Psychology Faculty Publications

In this study, we proposed that individual differences in hardiness may moderate the relationship between global attributions and actions against discrimination. Specifically, global attributions were expected to predict decreased endorsement of actions to combat discrimination among low hardy women. In contrast, global attributions were expected to predict increased endorsement of actions among high hardy women. High and low hardy women were exposed to a laboratory situation of discrimination, and their attributions for, and responses to, discrimination were then assessed. Results showed the expected interaction, but in the opposite direction: among low hardy women, global attributions predicted stronger endorsement of action.Among …

The Effects Of Rapport-Building Style On Children’S Reports Of A Staged Event, Kim P. Roberts, Michael E. Lamb, Kathleen J. Sternberg

Psychology Faculty Publications

Three- to 9-year-old children (N = 144) interacted with a photographer and were interviewed about the event either a week or a month later. The informativeness and accuracy of information provided following either open-ended or direct rapport building were compared. Children in the open-ended rapport-building condition provided more accurate reports than children in the direct rapport-building condition after both short and long delays. Open-ended rapport-building led the 3- to 4-year-olds to report more errors in response to the first recall question about the event, but they went on to provide more accurate reports in the rest of the interview than …

A Comprehensive Evaluation Framework For Mental Health Consumer/Survivor Organizations: Values, Conceptualization, Design, And Action, Geoffrey Nelson, Joanna Ochocka, Rich Janzen, John Trainor, Shawn Lauzon

Psychology Faculty Publications

This article provides a framework for the evaluation of mental health consumer/ survivor organizations that consists of four main components: (a) participatory processes, (b) conceptualization of the activities and outcomes at the individual and systems levels of these organizations, (c) the combination of quantitative and qualitative methods for examining activities and outcomes, and (d) dissemination and action. We assert that these components form a comprehensive and holistic framework for evaluating mental health consumer/survivor organizations; we illustrate how these components can be put into action through a case study of four mental health consumer/survivor organizations in Ontario; and we reflect on …

Individual Telephone Support For Family Caregivers Of Seriously Ill Cancer Patients, Sandra M. Walsh, Griselle B. Estrada, Nancy S. Hogan

Nursing: School of Nursing Faculty Publications and Other Works

Medical-surgical nurses are an important source of information and guidance for family caregivers during health care crises. The concerns expressed by family caregivers to nurse interventionists during a supportive and informational telephone intervention are described in this study. An analysis of telephone call content using constant comparison methods identified major stressors of the family caregiver during the illness trajectory

Biology Of PrpSc Accumulation In Two Natural Scrapie-Infected Sheep Flocks, Patrick Caplazi, Katherine I. O'Rourke, Cynthia Wolf, Daniel Shaw, Timothy V. Baszler

Zoonotics and Wildlife Disease: Publications

Sheep scrapie is a prion disease that requires interaction of exogenous prions with host prion protein (PrP) supporting prion formation. Disease is associated with deposition of a host-generated conformational variant of PrP, PrP^sc, in a variety of tissues, including brain, resulting in fatal spongiform encephalopathy. Efficiency of PrP^sc formation is determined by polymorphisms in the PrP-coding sequence. This article adds to previous data of natural sheep scrapie, concentrating on the effect of host genotype and age on PrP^sc accumulation patterns during preclinical and clinical disease. Two entire scrapie-infected, predominantly Suffolk-cross, sheep flocks euthanized for regulatory purposes …

Cognitive-Behavioral Therapy, Light Therapy, And Their Combination In Treating Seasonal Affective Disorder, Kelly J. Rohan, Kathryn Tierney Lindsey, Katheryn A. Roecklein, Timothy J. Lacy

Uniformed Services University of the Health Sciences

Background: The need to develop supplementary or alternative treatments for seasonal affective disorder (SAD) is underscored by the significant minority (47%) of SAD patients that is refractory to light therapy, the persistence of residual symptoms despite light treatment, and poor long-term compliance with light use. Because preliminary studies suggest that cognitive and behavioral factors are involved in SAD, cognitive-behavioral therapy (CBT) warrants investigation as a possible treatment option. Methods: We piloted a 6-week randomized clinical trial to compare a standard light therapy protocol; a novel, SAD-tailored, group CBT intervention; and their combination in ameliorating and remitting a current SAD episode …

Functional Characterization Of The Arabidopsis Thaliana Orthologue Of Tsc13p, The Enoyl Reductase Of The Yeast Microsomal Fatty Acid Elongating System, Kenneth Gable, Sarah Garton, Johnathan A. Napier, Teresa M. Dunn

Uniformed Services University of the Health Sciences

The protein encoded by the Arabidopsis At3g55360 gene was selected as a candidate for the enoyl reductase of the microsomal elongase system based on its homology to the Tsc13p protein of S. cerevisiae. The studies presented here demonstrate that heterologous expression of At3g55360 functionally complements the temperature-sensitive phenotype of a yeast tsc13 mutant that is deficient in enoyl reductase activity. Furthermore, AtTSC13 is shown to interact physically with the Elo2p and Elo3p components of the yeast elongase complex. At3g55360 apparently encodes the sole enoyl reductase activity associated with microsomal fatty acid elongation in Arabidopsis. Consistent with this conclusion, …

Plant Cell-Based Intimin Vaccine Given Orally To Mice Primed With Intimin Reduces Time Of Escherichia Coli O157:H7 Shedding In Feces, Nicole A. Judge, Hugh S. Mason, Alison D. O'Brien

Uniformed Services University of the Health Sciences

Intimin is the primary adhesin of Escherichia coli O157:H7, the most common infectious cause of bloody diarrhea in the United States and the leading cause of acute kidney failure in children who develop hemolytic uremic syndrome. Cattle are the primary reservoir of E. coli O157:H7. Indeed, most cases of E. coli O157:H7 infection in the United States occur after ingestion of contaminated undercooked hamburger or produce that had contact with bovine manure. Because intimin is required for persistent colonization of neonatal calves and adult cattle, we hypothesized that an intimin-based vaccination strategy in calves would reduce colonization of cattle with …

Structure Of Shiga Toxin Type 2 (Stx2) From Escherichia Coli O157:H7, Marie E. Fraser, Masao Fujinaga, Maia M. Cherney, Angela R. Melton-Celsa, Edda M. Twiddy, Alison D. O'Brien, Michael N. G. James

Uniformed Services University of the Health Sciences

Several serotypes of Escherichia coli produce protein toxins closely related to Shiga toxin (Stx) from Shigella dysenteriae serotype 1. These Stx-producing E. coli cause outbreaks of hemorrhagic colitis and hemolytic uremic syndrome in humans, with the latter being more likely if the E. coli produce Stx2 than if they only produce Stx1. To investigate the differences among the Stxs, which are all AB₅ toxins, the crystal structure of Stx2 from E. coli O157:H7 was determined at 1.8-Å resolution and compared with the known structure of Stx. Our major finding was that, in contrast to Stx, the active site of …

Why Is She So Mean? Review Of Marion K. Underwood, Social Aggression Among Girls. New York: Guilford Press, 2003, Susan M. Swearer Napolitano

Department of Psychology: Faculty Publications

Review of Marion K. Underwood, Social Aggression among Girls. New York: Guilford Press, 2003, 300 pp. $44.00, ISBN: 1572308664 (cloth). $24.00, ISBN: 1-57230-865-6 (paper).

Bovine Tuberculosis In Swedish Farmed Deer: Detection And Control Of The Disease, Helene Wahlström

Michigan Bovine Tuberculosis Bibliography and Database

Bovine tuberculosis (BTB) was introduced into Swedish farmed deer herds in 1987. Epidemiological investigations showed that 10 deer herds had become infected (July 1994) and a common source of infection, a consignment of 168 imported farmed fallow deer, was identified (I).

As trace-back of all imported and in-contact deer was not possible, a control program, based on tuberculin testing, was implemented in July 1994. As Sweden has been free from BTB since 1958, few practicing veterinarians had experience in tuberculin testing. In this test, result relies on the skill, experience and conscientiousness of the testing veterinarian. Deficiencies in performing the …

Time Course Changes In Psychological Symptomatology In Women With Gynaecological Cancers, R W. Petersen, G Graham, Julie A. Quinlivan

Medical Conference Papers

The aim of this study was to explore the wider psychological symptomatology experienced by women with a new diagnosis of a gynaecological cancer at the point of diagnosis and 6 weeks later.

Idealization And Reality: Screening For Mother-Child Support Levels In Pregnancy And The Reality Experienced Six Months Postpartum, Julie A. Quinlivan

Medical Conference Papers

To evaluate to what extent teenage mothers are able to predict their postnatal support networks in the antenatal period, and the extent to which support correlates with social class and depressive symptomatology.

Developing And Implementing Statewide Prevention/Early Intervention, Victor Nossar, Pam Linke

Medical Conference Papers

Over the last decade it has been clearer that improvements in population health require different strategies, beyond the application of larger scale clinical interventions. Experience teaches that more focus needs to be given to the determinants of health and of health problems and to strategies that build systems to make a measurable difference in the outcomes for children. South Australia is in a relatively unique position, in Australia, of having a State wide child and family health service. This offers both opportunity and challenge to the development of a population based early intervention across metropolitan, regional and remote areas.

Relationship Between Early Feeding And Communication Development In Infants: Birth To 12 Months, S J. Massey, Kathryn Hird, K Simmer

Medical Conference Papers

Introduction: Anecdotal reports suggest that infants experiencing early feeding difficulties may have delays in communication development.

Methods: The first stage of the study involved the development of a theoretically based assessment protocol to test the hypothesis of linked or independent processes required for feeding and speech. The assessment protocol will be piloted on 10 full term and 10 preterm infants at birth, 4, 8 and 12 months post term age. Measures of inter-judge and intra-judge reliability will also be taken of the observation protocol. Observation of the infant's language, speech, environment and maternal relationship will also be conducted to determine …

Correlates Of Adherence With Transdermal Nicotine., Theodore Cooper, M. Debon, M. Stockton, T. Steenbergh, D. Sherrill-Mittleman, L. Jennings, R. Klesges

Departmental Papers (Psych)

No abstract provided.

Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Khan, Alan Watts

Departmental Papers (Biology)

No abstract provided.

Lack Of Chart Reminder Effectiveness On Family Medicine Resident Jnc-Vi And Ncep Iii Guideline Knowledge And Attitudes, Paul S. Echlin, Ross Eg Upshur, Tsveti P. Markova

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

The literature demonstrates that medical residents and practicing physicians have an attitudinal-behavioral discordance concerning their positive attitudes towards clinical practice guidelines (CPG), and the implementation of these guidelines into clinical practice patterns.

Methods

A pilot study was performed to determine if change in a previously identified CPG compliance factor (accessibility) would produce a significant increase in family medicine resident knowledge and attitude toward the guidelines. The primary study intervention involved placing a summary of the Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI) and the National Cholesterol …

Translation Research: From Accurate Diagnosis To Appropriate Treatment, Craig P. Webb, Harvey I. Pass

Wayne State University Associated BioMed Central Scholarship

Abstract

This review article focuses on the various aspects of translational research, where research on human subjects can ultimately enhance the diagnosis and treatment of future patients. While we will use specific examples relating to the asbestos related cancer mesothelioma, it should be stressed that the general approach outlined throughout this review is readily applicable to other diseases with an underlying molecular basis. Through the integration of molecular-based technologies, systematic tissue procurement and medical informatics, we now have the ability to identify clinically applicable "genotype"-"phenotype" associations across cohorts of patients that can rapidly be translated into useful diagnostic and treatment …