Medicine and Health Sciences Commons^™

Nerve-Independent Formation Of A Topologically Complex Postsynaptic Apparatus, Terrance T. Kummer, Thomas Misgeld, Jeff W. Lichtman, Joshua R. Sanes

Open Access Publications

No abstract provided.

Molecular Dynamics Simulations Of The O-Glycosylated 21-Residue Muc1 Peptides, A. Rubinstein, L. Kinarsky, S. Sherman

Journal Articles: Eppley Institute

The conformational propensities of the 21-residue peptide and its Oglycosylated analogs were studied by molecular dynamics (MD) simulations. This polypeptide motif comprises the tandem repeat of the human mucin (MUC1) protein core that is differently glycosylated in normal and cancer cells. To evaluate the structural effects of O-glycosylation on the polypeptide backbone, conformations of the nonglycosylated peptide and its glycosylated analogs were monitored during the 1 ns MD simulations. Radius gyration for whole peptide and its fragments, as well as root-mean-square-deviation between coordinate sets of the backbone atoms of starting structures and generated structures, were calculated. It was shown that …

Ada News - 03/15/2004, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Combined Tlr And Cd40 Triggering Induces Potent Cd8+ T Cell Expansion With Variable Dependence On Type I Ifn, Cory L. Ahonen, Christie L. Doxsee, Sean M. M. Mcgurran, Tony R. Riter, William F. Wade, Richard J. Barth, John P. Vasilakos, Randolph J. Noelle, Ross M. Kedl

Dartmouth Scholarship

Toll-like receptors are important in the activation of innate immunity, and CD40 is a molecule critical for many T and B cell responses. Whereas agonists for either pathway have been used as vaccine adjuvants, we show that a combination of Toll-like receptor (TLR)7 and CD40 agonists synergize to stimulate CD8⁺ T cell responses 10–20-fold greater than the use of either agonist alone. Antigen-specific CD8⁺ T cells elicited from combination CD40/TLR7 treatment demonstrated both lytic activities and interferon (IFN)γ production and an enhanced secondary response to antigenic challenge. Agonists for TLRs 2/6, 3, 4, and 9 also synergized with …

Use Of Hospitals, Physician Visits, And Hospice Care During Last Six Months Of Life Among Cohorts Loyal To Highly Respected Hospitals In The United States, J. E. Wennberg, Elliot S. Fisher, Therese A. Stukel, Jonathan S. Skinner

Dartmouth Scholarship

Objective: To evaluate the use of healthcare resources during the last six months of life among patients of US hospitals with strong reputations for high quality care in managing chronic illness.

Causal Inference In Hybrid Intervention Trials Involving Treatment Choice, Qi Long, Rod Little, Xihong Lin

The University of Michigan Department of Biostatistics Working Paper Series

Randomized allocation of treatments is a cornerstone of experimental design, but has drawbacks when a limited set of individuals are willing to be randomized, or the act of randomization undermines the success of the treatment. Choice-based experimental designs allow a subset of the participants to choose their treatments. We discuss here causal inferences for experimental designs where some participants are randomly allocated to treatments and others receive their treatment preference. This paper was motivated by the “Women Take Pride” (WTP) study (Janevic et al., 2001), a doubly randomized preference trail (DRPT) to assess behavioral interventions for women with heart disease. …

Necessary But Not Sufficient? Physician Volunteerism And The Health Care Safety Net, Eileen Salinsky

National Health Policy Forum

This paper examines the role of physician-sponsored charity care in meeting the health care needs of the uninsured. The paper provides an overview of current charity care levels by medical specialties and geographic regions, discusses limitations in available data, and describes the settings in which charity care is provided. The paper also summarizes the factors that motivate physicians to provide volunteer services, as well as the barriers that hinder volunteer activities, including malpractice insurance concerns. Also discussed are a range of public policies, both existing and considered, that support volunteer activities, with a particular emphasis on the expansion of Federal …

A Bayesian Hierarchical Approach To Multirater Correlated Roc Analysis, Tim Johnson, Valen Johnson

The University of Michigan Department of Biostatistics Working Paper Series

In a common ROC study design, several readers are asked to rate diagnostics of the same cases processed under different modalities. We describe a Bayesian hierarchical model that facilitates the analysis of this study design by explicitly modeling the three sources of variation inherent to it. In so doing, we achieve substantial reductions in the posterior uncertainty associated with estimates of the differences in areas under the estimated ROC curves and corresponding reductions in the mean squared error (MSE) of these estimates. Based on simulation studies, both the widths of confidence intervals and MSE of estimates of differences in the …

2,6-Disubstituted Piperidines As Modulators Of Nicotinic Acetylcholine Receptor Mediated Neurotransmitter Release, Uptake And Storage, Peter A. Crooks, Linda P. Dwoskin, Dennis Keith Miller, Vladimir P. Grinevich, Seth Davin Norrholm, Guangrong Zheng

Pharmaceutical Sciences Faculty Patents

Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder or for a CNS disease or pathology . . .

To see the remainder of this abstract, please download this patent.

The Tumor Suppressor Lkb1 Kinase Directly Activates Amp-Activated Kinase And Regulates Apoptosis In Response To Energy Stress, Reuben J. Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L. Hurley, Lee A. Witters, Ronald A. Depinho, Lewis C. Cantley

Dartmouth Scholarship

AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP ratio. Essential to activation of AMPK is its phosphorylation at Thr-172 by an upstream kinase, AMPKK, whose identity in mammalian cells has remained elusive. Here we present biochemical and genetic evidence indicating that the LKB1 serine/threonine kinase, the gene inactivated in the Peutz-Jeghers familial cancer syndrome, is the dominant regulator of AMPK activation in several mammalian cell types. We show that LKB1 directly phosphorylates Thr-172 of AMPKalpha in vitro and activates its …

Hearing Loss And Retarded Cochlear Development In Mice Lacking Type 2 Iodothyronine Deiodinase, Lily Ng, Richard J. Goodyear, Chad A. Woods, Mark J. Schneider

Dartmouth Scholarship

The later stages of cochlear differentiation and the developmental onset of hearing require thyroid hormone. Although thyroid hormone receptors (TRs) are a prerequisite for this process, it is likely that other factors modify TR activity during cochlear development. The mouse cochlea expresses type 2 deiodinase (D2), an enzyme that converts thyroxine, the main form of thyroid hormone in the circulation, into 3,5,3'-triiodothyronine (T3) the major ligand for TRs. Here, we show that D2-deficient mice have circulating thyroid hormone levels that would normally be adequate to allow hearing to develop but they exhibit an auditory phenotype similar to that caused by …

Gender Socialization In Latino/A Families: Results From Two Retrospective Studies, Marcela Raffaelli, Lenna L. Ontai

Department of Psychology: Faculty Publications

In this article, we present findings from 2 studies designed to explore gender-related socialization in Latino/a families. In Study 1, 22 adult Latinas (ages 20–45) completed in-depth interviews. In Study 2, 166 Latino/a college students (58% women; M age 21.4 years) completed self-report surveys. Study 1 findings suggest that many Latino/a parents socialize their daughters in ways that are marked by “traditional” gender-related expectations and messages. Results of Study 2, which included descriptive analyses and the creation of scales to explore family correlates of gender-related socialization, support and expand these findings. Male and female respondents described different experiences of household …

Photoreactive Bicyclic Amino Acids As Substrates For Mutant Escherichia Coli Phenylalanyl-Trna Synthetases, Thomas Bentin, Ramin Hamzavi, Jahan Salomonsson, Hervé Roy, Michael Ibba, Peter E. Nielsen

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Unnatural amino acids carrying reactive groups that can be selectively activated under non-invasive biologically benign conditions are of interest in protein engineering as biological tools for the analysis of protein-protein and protein-nucleic acids interactions. The double ring system phenylalanine analogues benzofuranylalanine and benzotriazolylalanine were synthesized, and their photolability was tested by UV irradiation at 254, 320, and 365 nm. Although both showed photo reactivity, benzofuranylalanine appeared as the most promising compound because this amino acid was activated by UVA (long wavelength) irradiation. These amino acids were also tested for in vitro charging of tRNA^Phe and for protein mutagenesis via …

Construction Laborer Dies From Heat Stroke At End Of Workday, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On June 27, 2003, a 41-year-old, male laborer died from heat stroke one day after being taken to the hospital. The laborer was working on an addition to a factory sawing boards to make concrete forms. He worked until 5:00 pm that day and was in the parking lot on his way to his vehicle when he apparently collapsed beside his vehicle. A worker on the second shift at the factory was taking scrap material outside to a dumpster when he found the laborer on the ground. The factory worker returned to the plant and told his supervisor there was …

Highway Construction Worker Dies When Struck By Semi-Tractor Trailer, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

At approximately 8:30 am on April 16, 2003, a 48-year-old male (decedent) highway construction laborer working in an interstate highway median, died when he was struck by an out-of-control double trailer (a semi-truck pulling two trailers). The laborer was speaking with the job foreman and another laborer in the median next to a grading machine. As the decedent looked toward the traffic, he saw a double trailer traveling on the right-hand shoulder swerve into the left-hand lane and drive into the median where all three men were standing. He told the other two to get out of the way as …

28-Year-Old Man Dies After Falling With Lift, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Falls

On June 27, 2003, a 28-year-old male sound technician died due to injuries received after falling approximately 50 feet from a lift. Three men (one chief sound engineer and two sound technicians) were sent to repair a sound system in a school gymnasium. Upon arriving and assessing the situation, the three diagnosed that a particular speaker, located in the rafters, should be removed from its location. Using a 30-year-old telescoping, self-leveling lift belonging to the school, the chief engineer used controls located at the base of the lift, to hoist the two sound technicians to the speaker in the rafter. …

Training Medical Providers To Conduct Alcohol Screening And Brief Interventions, Thomas F. Babor, John C. Higgins-Biddle, Pamela S. Higgins, Bruce E. Gould

UCHC Articles - Research

Although progress has been made in developing a scientific basis for alcohol screening and brief intervention (SBI), training packages are necessary for its widespread dissemination in primary care settings. This paper evaluates a training package developed for the Cutting Back^® SBI program. Three groups of medical personnel were compared before and after SBI training: physicians (n = 44), medical students (n = 88), and non-physicians (n = 41). Although the training effects were at times dependent on group membership, all changes were in a direction more conducive to implementing SBI. Physicians and medical students increased confidence in performing screening …

Self-Reported Memory Symptoms With Coronary Artery Disease: A Prospective Of Cabg Patients And Nonsurgical Controls, Ola A. Selnes, Maura A. Grega, Louis M. Borowicz, Jr., Sarah Barry, Scott L. Zeger, Guy M. Mckhann

Johns Hopkins University, Dept. of Biostatistics Working Papers

Background. Subjective memory complaints are common after coronary artery bypass grafting (CABG), but previous studies have concluded that such symptoms are more closely associated with depressed mood than objective cognitive dysfunction. We compared the incidence of self-reported memory symptoms at 3 and 12 months after CABG with that of a control group of patients with comparable risk factors for coronary artery disease but without surgery.

Methods. Patients undergoing CABG (n = 140) and a demographically similar nonsurgical control group with coronary artery disease (n = 92) were followed prospectively at 3 and 12 months. At each follow-up time, participants were …

Moral Callings And The Duty To Have Children: A Response To Jeff Mitchell, James Mcbain

Faculty Submissions

Jeff Mitchell argues that the good reason for having children is that parenthood is a “moral calling” and that one should heed the call out of a sense of duty and responsibility for the good of society. I argue such a “moral calling” account is mistaken, first, in that Mitchell problematically assumes the “basic intuition” is mistaken and, second, it fails to provide the epistemic conditions for the warranted belief that one would probably make a good parent (a central consideration of Mitchell’s). Thus, such a “moral calling” rationale for the having of children is not superior to rationales that …

Relationships Between Personality And Individual Perceptions Of Social Cohesion, James Garrett

Masters Theses & Specialist Projects

This research explored personality correlates of social cohesion. Groups of two were given a task to perform that required cooperation between the two team members. This task exposed each team member to the other's personality. Upon completion of the task, the individual perceptions of social cohesion were assessed by each individual. We hypothesized that extraversion, emotional stability, and agreeableness of one team member will correlate positively with the other team member's perception of social cohesion. These hypotheses were not supported. However an exploratory analysis showed that an individual's level of extraversion and conscientiousness were positively correlated to that same individual's …

The Relationship Between Stress, Satisfaction, And Emotional Intelligence In College Students, Jessica Largen

Masters Theses & Specialist Projects

The relationship between stress and satisfaction has been well documented. However, little is known about the possible mediating effect that emotional intelligence may have on that relationship. This study addressed the role emotional intelligence plays between stress and satisfaction. By collecting measures of stress, life satisfaction, satisfaction with school, and emotional intelligence, this researcher examined the question "Does emotional intelligence serve as a moderator in the relationship between satisfaction and stress?" Results indicated that, after removing the effects of stress, emotional intelligence and satisfaction demonstrated a positive significant relationship. Emotional intelligence was related to the Big Five factors of Conscientiousness, …

Esophageal Foreign Body In Neonates, Tasneem Fatima, M A M Khan, N Uddin

Section of Paediatric Surgery

No abstract provided.

Paraduodenal Hernia: A Case Report, A Munir, S M. Saleem, S Hussain

Section of Paediatric Surgery

No abstract provided.

Contributing Factors To Student Success In Anatomy & Physiology: Lower Outside Workload & Better Preparation., David E. Harris, Lynn Hannum, Sat Gupta

School of Nursing

Presents a study that examined the factors associated with the success in undergraduate Anatomy & Physiology coursework at Lewiston-Auburn College, University of Southern Maine in Lewiston. Details of the grading system used for the period of the study; Analysis of the independent variables that correlated significantly with the final course grades of the students; Relation between the amount of previous study of mathematics and science in both high school and college and the final course grades of the students.

Immune Responses Of Different Mouse Strains After Challenge With Equivalent Lethal Doses Of Toxoplasma Gondii, Y. H. Lee, L. H. Kasper

Dartmouth Scholarship

Most immunological studies that utilize different strains of inbred mice following T. gondii infection fail to compensate for differences in host susceptibility to the size of the parasite innoculum. To address this concern, susceptible C57BL/6 and resistant CBA/J mice were orally infected with either an equivalent 50 % lethal dose (LD₅₀) of brain cysts of the 76K strain of T. gondii (15 cysts in C57BL/6, 400 cysts in CBA/J) or the same dose of parasites in each mouse strain. C57BL/6 mice receiving 400 cysts (LD₅₀ of CBA/J mice) died post infection, whereas CBA/J mice that received 15 …

An Audit Of Head Trauma Care And Mortality, Arshad A. Siddiqui, Hasnain Zafar, S H. Bashir

Section of Neurosurgery

Objective: To analyze the factors contributing to deaths from head trauma by using standardized assessment parameters and to provide a peer-review of head injury deaths with focus on identifying deficiencies and analyzing contributory factors.
Design: Descriptive study.
Place and duration of study: The study was carried out at the Emergency, Aga Khan University Hospital during January 1998 to December 1999.
Subjects and method: One hundred and three patients above the age of 15 years presenting alive to the Aga Khan University Hospital (AKUH) emergency with head injury were included in this study. Identified deaths data was reviewed by the Hospital …

Fatal Tractor Overturns: Don't Let Them Roll Over You!, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Tractors/Logging

To prevent tractor injuries:

• All tractors should be equipped with a Roll Over Protective Structure (ROPS) and a seat belt.
• Tractors should be equipped with front-end counterweights and tractor wheels
• should be weighted to increase stability.
• Community farm safety training with safe operating procedures and hazard identification should be offered to novice or limited- experience operators.

The Influence Of Social Status On Token Women Leaders’ Expectations About Leading Male-Dominated Groups, Theodore W. Mcdonald, Loren L. Toussaint, Jennifer A. Schweiger

Public and Population Health Faculty Publications and Presentations

Prior research has shown that women report mostly negative expectations about being a gender-token in male-dominated work groups. We speculate that this is partially caused by the socially-ascribed status devaluation of women. In the present study we investigated the degree to which elevated social status may lessen negative expectations of gender-token women assigned to leadership positions. Sixty-three undergraduate women participated in one of three tokenism conditions: 1) nontoken, 2) gender-token, and 3) high-status gender-token. In all conditions participants were led to believe that they would be leading a group of men in a decision-making exercise. Leader expectations were then assessed. …

Depressed Type 1 Cytokine Synthesis By Superantigen-Activated Cd4+ T Cells Of Women With Human Papillomavirus-Related High-Grade Squamous Intraepithelial Lesions, Bang-Ning Lee, Michele Follen, De-Yu Shen, Anais Malpica, Karen Adler-Storthz, William T. Shearer, James M. Reuben

Faculty, Staff and Student Publications

Carcinoma of the cervix is causally related to infection with the human papillomavirus (HPV), and T cells play a pivotal role in the immune response of the host to rid itself of HPV infection. Therefore, we assessed the T-cell function of women with HPV-related cervical neoplasia against a superantigen, Staphylococcus enterotoxin B (SEB). Each woman provided a cervical brush specimen for HPV DNA testing and Papanicolaou (Pap) smears for the staging of cervical lesions. They also provided a blood specimen for determination of the ability of CD4(+) T and CD8(+) T cells to synthesize Th1 (interleukin-2 [IL-2], gamma interferon [IFN-gamma], …

The Influence Of Vibration On Muscle Activation And Rate Of Force Development During Maximal Isometric Contractions, Brendan Humphries, Geoff Warman, Jason Purton, Tim L.A Doyle, Eric Dugan

Research outputs pre 2011

At present there appears to be a need for research conducted on the effects of vibration on the contractile ability of skeletal muscle tissue. The aim of this study was to address this issue by examining the effects of a superimposed muscle/tendon vibration at 50.42±1.16 Hz (acceleration 13.24 ± 0.18ms^-2: displacement ≈5mm) on muscular activation and maximal isometric contraction. Sixteen participants with a mean age, body mass, and height of 22 ± 4.4 years, 73.2 ± 11.7 kg and 173.1 ± 9.7 cms, respectively, were recruited for this study. Electromyography and accelerometry from the rectus femoris, and maximal …