Medicine and Health Sciences Commons^™

A Review Of Selective Mutism In Immigrant Children [Poster], Lauren Cummings

Research in the Capitol

Selective mutism is an anxiety disorder that is characterized by a child’s lack of verbal communication in certain situations where there is an expectation of speech. Children who are diagnosed with selective mutism typically have communication or cognitive difficulties and later display higher rates of psychiatric disorders in early adolescence and adulthood. The overall prevalence of selective mutism is debated, but there is clear evidence that immigrant children are at least three times more likely to be diagnosed with selective mutism than the general population. As the number of immigrant children in the United States continues to rise, it is …

Maternal Mortality In The United States: Focusing On Societal Impacts And Potential Solutions [Poster], Grace Petrzelka

Research in the Capitol

This research project explores the available literature on maternal mortality in the United States, and examines social, environmental, and cultural factors for their impact. With a public health focus, included are discussions on forming safer maternal health practices in our country, comparison of statistics on maternal and infant deaths, and using the available data to create potentially life-saving solutions. Specific topics include race, biology, health policy and legislation, insurance coverage, infant mortality, and family planning. This research project covers a span of academic disciplines, and was created to bring these areas together to promote awareness to a sobering, but meaningful …

Seizure Prediction In Epilepsy Patients, Gary Dean Cravens

NSU REACH and IPE Day

Purpose/Objective: Characterize rigorously the preictal period in epilepsy patients to improve the development of seizure prediction techniques. Background/Rationale: 30% of epilepsy patients are not well-controlled on medications and would benefit immensely from reliable seizure prediction. Methods/Methodology: Computational model consisting of in-silico Hodgkin-Huxley neurons arranged in a small-world topology using the Watts-Strogatz algorithm is used to generate synthetic electrocorticographic (ECoG) signals. ECoG data from 18 epilepsy patients is used to validate the model. Unsupervised machine learning is used with both patient and synthetic data to identify potential electrophysiologic biomarkers of the preictal period. Results/Findings: The model has shown states corresponding to …

A Systematic Review To Propose An Evidence-Based Nutrition Protocol In Depression, Camilla A. Mirkin, Nicole Koci

NSU REACH and IPE Day

Background: Rates of depression have been rising steadily over the last several decades with more than 264 million people affected, making it one of the top three burdens globally. The pandemic has brought on a greater risk of depression. Forty-two percent of individuals surveyed in December 2020 by the US Census Bureau reported depressive symptoms. Many factors, including poor diet quality, play a role in the development of depression during traumatic events like the pandemic. A low-quality dietary pattern has been associated with obesity, low-grade chronic inflammation, dysbiosis, increased cortisol levels and monoamine neurotransmitter deficiency. Among others, these factors have …

The Role Of Healthcare Workers In The Care Of Human Trafficking Survivors, Darisel N. Ventura Rodriguez

NSU REACH and IPE Day

Purpose/Objective: Highlight the importance of increasing awareness among healthcare professionals on the identification and treatment of human trafficking victims. Background/Rationale: In the state of Florida, human trafficking (HT) remains a significant public health issue affecting hundreds of victims each year. Miami-Dade and Broward Counties reported 351 cases in 2019 alone. More than 50% of HT victims encounter healthcare providers while being exploited. For this reason, healthcare providers must be trained to recognize and treat victims of HT. The goal of this project was to educate healthcare providers and students on the identification of HT victims and how to provide trauma-informed …

Using Complex Medical Devices: Icu Nurses' Safety Perceptions, Violet Rhagnanan-Kramer

NSU REACH and IPE Day

Purpose: The purpose of this study was to gain insight into ICU nurses’ safety perceptions and explore continuing educational strategies for improving nurses’ technological competence. Background: Medical errors are the third leading cause of death in America. Over 10,000 medical errors occur daily, with an estimated financial impact of preventable mistakes is 20 billion dollars annually. Increasing the use of multifarious sophisticated medical technologies in the Intensive Care Unit (ICU) poses a risk of medical errors and unintentional harm to patients. However, limited empirical evidence exists regarding ICU nurses’ perspectives. Methods: This research featured an online mixed methods descriptive exploratory …

A Pilot Research Project To Enhance Inquiry-Based Learning By Mapping The Microbiome Of The Southern Appalachian Region, Shivam Patel

Tennessee Posters at the Capitol [2022]

As humans continue to advance healthcare resources, we face a growing threat of nosocomial multidrug-resistant bacteria. The rise of these antibiotic-resistant microorganisms has been placed on the World Health Organization’s watchlist as one of the biggest threats to global health. We continue to have a shortage of effective antibiotics with the rise of these “superbugs”. With the growing number of deadly pathogens, the future of medicine relies on scientific findings to combat multidrug-resistant bacteria. Appalachia could be the answer to combat this new health threat. As the most biodiverse temperate forest region in North America, our beautiful backyard in the …

Using Polymicrobial Interactions To Identify Possible Novel Targets In Staphylococcus, Bacillus, And Candida, Sheyda Amirfaiz

Tennessee Posters at the Capitol [2022]

Microbes all compete for the same limited nutrients, space, and resources; therefore, they show competitive relationships. There is a component of Alcaligenes faecalis that inhibits the growth of Staphylococcus aureus, a gram-positive bacterium that causes many clinical diseases. We are interested in finding what genetic factors in Alcaligenes faecalis are responsible for killing Staphylococcus aureus. Transposon mutagenesis was used to interrupt certain gene segments by introducing a foreign piece of DNA into the Alcaligenes faecalis genome. By creating mutants of Alcaligenes faecalis, we were able to test these against Staphylococcus aureus to find those that can no …

Generalized Estimating Equations (Gee) Approach For Clustered Binary Data With Application To Covid-19 Treatment., Sadixa Sanjel

SDSU Data Science Symposium

Clustered binary data frequently occur in epidemiology and other applied fields such as clinical trial studies, where observations within the respective samples are correlated. In such situations, the standard logistic regression method is not valid as logistic regression requires the observations to be independent of one other. This situation arises when treating COVD-19 patients. Patients from certain clusters, such as geographic areas or the same family, are highly correlated, and we need to fit the model using the GEE approach. In this paper, Standard Logistic Regression (LS), Generalized Linear Models (GENMOD), and GEE procedures have been utilized for comparison purposes. …

General Adversarial Networks In Tumor-Related Research: A Review And Agenda For Moving Forward, Andrew James Behrens, Cherie Noteboom

SDSU Data Science Symposium

Recent advances in Generative Adversarial Networks (GANs) have led to many new variants and uses of GANs. The latest advancements have allowed researchers and practitioners to apply this technique to tumor-related problems with limited data. One of the trends in this problem domain is to develop different variants of GANs suited explicitly to particular problems. The variants of GANs are numerous but share a common characteristic of expanding the dataset by creating synthetic data from the original dataset. This paper aims to develop a research agenda through a systematic literature review that investigates practitioners' and researchers' emerging issues and current …

Poster Session, Emma Beeler, Maddison Caldwell, Mackenzie Paul, Shirli Salihaj, Sara Lynn Sligh, Stephen Trest

Mississippi Undergraduate Honors Conference

Video provided is of MacKenzie Paul's presentation.

Abstracts

Humanities

Emma Beeler, Mississippi University for Women

Adultery and Fidelity in the Lais of Marie de France

Using both literary and historical analysis, I will examine contrasting depictions of adultery and fidelity within the lais written by 12th-century poet Marie de France. A lai is a type of narrative poem, ranging in length from 118 to 1184 lines. Many of Marie de France’s lais follow the literary trope known as courtly love; however, the reader is encouraged to sympathize with different characters depending on the lai. In some lais, the reader …

Oral Presentations: Stem, Zithlaly Amezquita

Mississippi Undergraduate Honors Conference

Each oral presentation of 15 minutes is followed by Q&A.

Title: Implementing And Evaluating A Farmer's Market Incentive And Nutrition Education Program For Families With Children, Raven Barleston, Kendra Oonorasak, Tammy Stephenson, Makenzie Barr

Posters-at-the-Capitol

1 in 6 children face food insecurity and experience limited access to healthy foods in Kentucky. The Power of Produce (POP) Club is a farmer’s market incentive and nutrition education program for families with children aged between 3 and 14. This project is a 10-week pilot study in Lexington, Kentucky and it aims to improve fruit and vegetable consumption by engaging children in the local food system through educational activities, interactions with farmers, and exposure to new local fruits and vegetables through taste-testing. Every week, each child engaging in POP Club activities received a $2 farmer’s market voucher that can …

Breadth Of Vaccinated Cancer Patient Humoral Response To Sars-Cov-2 Spike Protein And Rbd Variants, Julia Corman, Joey Breckenridge Jr., Adrienne M. Bushau-Sprinkle, Krystal T. Hamorsky, Joshua L. Fuqua

Posters-at-the-Capitol

SARS-CoV-2, the virus responsible for the COVID-19 of which several variants have emerged, such as the B.1.351 SARS-CoV-2 variant. The Receptor Binding Domain (RBD), located within the Spike protein is an immunogenic epitope for potent neutralizing antibodies. Current mRNA vaccines encode for the Spike protein, allowing the body to build antigen-specific antibodies. Assays measuring protective antibodies are essential to manage the COVID-19 pandemic and can be used as a platform for variant screening. RBD-foldon 2.2 is a novel antigen produced by fusing RBD with the trimerization domain Fibritin from Bacteriophage T4. Its amino acid sequence is based on the original …

The Effect Of A Vegetation Buffer On Sound Levels, Madison Cicha

Posters-at-the-Capitol

Noise pollution is a growing concern in the environmental health community. Unlike other common exposures, such as air and water pollution, noise is uniquely difficult for an individual to protect themselves from. Studies have shown multiple adverse health outcomes resulting from exposure to noise pollution, including hearing impairment, negative social behavior and annoyance, sleep disturbance, along with a strong association between noise pollution and high cardiovascular risk. It is important, then, to look for solutions to this exposure. This study is designed to assess the effects of a tree barrier in reducing traffic noise. Noise monitoring was conducted at Saint …

A Novel Chelator For Pb-212/Bi-212-Based Alpha-Particle Radiotherapy For Cancers, Eric Doorn, Mengshi Li, Brianna Cagle, Nicholas Baumhover, Zhiming Dai, Dijie Liu, Ivy Vance, Frances Johnson, Michael K. Schultz

Summer Research

Lead-212 ( 212Pb) has been identified as a promising candidate for alpha(α)- particle radiotherapies for cancers in preclinical and clinical studies. Using a low molecular weight peptide, the radiotherapy will target with high affinity selective markers highly expressed in cancer cells but found in low concentration in healthy tissue. A radiometal is coupled to a chelator moiety linked to the peptide to deliver the α-particle radiation destroying cancer cells.

To develop a novel Pb specific chelator (PSC) that will provide high affinity to Pb212 and improve the in vitro and in vivo binding pharmacokinetics and stability of progeny of the …

The Impact Of Summer Program Intervention Strategies On Girls' Knowledge And Health Behaviors, Olivia Cerny, Dzifa Agbossey-Dimado, Awayinooluwa Seriki, Adejoke Ayoola

Summer Research

The well-being of youth in the United States is being threatened by physical inactivity, poor nutrition, and a range of health risk behaviors (Pierce et al., 2017). According to the U.S. Center for Disease Control and Prevention, there are worsening trends in youth health behaviors (Pierce et al., 2017). Sepúlveda and Hutton (2019) suggest with evidence that summer programs effectively reduce drug use, decrease violent crime arrests, increase safe sex practices and dispositions, maintain physical fitness, prevent excessive weight gain, and reduce anxiety

Sustainability In Biomedical Engineering, Kyle Borror, Christopher Hartemink

Summer Research

Boston Scientific (BSC) is a biomedical engineering company that specializes in designing and manufacturing devices that are used to help diagnose or treat health conditions in the human body. Primarily based in Europe and North America, BSC has recently been faced with the need to adhere to new sustainability protocols. Many of these protocols are addressed through a product accounting system called a Life Cycle Analysis (LCA), which is a standardized method for analyzing a product life cycle. A product life cycle for a medical device typically includes material extraction and refinement, component manufacturing, assembly, storage and distribution, use, and …

Preknop Research: The Benefits Of Educating Women About Reproductive Health, Alysa Runhaar, Joyce Jun, Adejoke Ayoola

Summer Research

In the United States, there are high rates of unplanned pregnancies. Many women are not educated on how to plan for, prevent or detect pregnancies and these unexpected life changes have negative outcomes such as sexually transmitted diseases, inadequate prenatal care, postpartum depression, premature birth with birth complications and high cost of delivery, and maternal mental health problems later in life. The purpose of this research is to examine the benefits of educating women about their reproductive health and about contraceptive use and effectiveness. This education is important for women’s health and the wellness of newborns and children.

Complex Regional Pain Syndrome: Not A Catch-All, Amanda Shulski

Capstone Showcase

Complex Regional Pain Syndrome (CRPS) is prolonged and disproportionate neuropathic pain and inflammation which presents after surgery, fracture, or trauma to a limb. This phenomenon has been recognized in the literature since the civil war but the pathophysiology has only become clear over the last 20 years. There are no diagnostic tests for CRPS and it is a relatively rare condition with only about 20 cases in 100,000 people per year. CRPS is then under-recognized by some providers but over-diagnosed by others. Occasionally, providers use CRPS as a catch-all for unexplained pain rather than a recognized condition with specific diagnostic …

Vaccine Hesitancy Among Healthcare Workers In The Covid-19 Era, Gabriella Checchi

Capstone Showcase

Vaccination against harmful, deadly pathogens have been an essential tool in the scientific world and have shaped our community as we know it today. They have allowed us to live in a society where members of the community are protected from certain severe disease and can help to decrease the death toll of these diseases. Vaccines have allowed us to eradicate smallpox, a disease that ravaged the world and killed over 300 million people. They have been a one of the most useful advances in medical science so far. And yet today, as SARS-CoV-2 continues to spread rampantly throughout the …

Initial Antihyperglycemic Options For Populations With Type 2 Diabetes Who Cannot Take Metformin, Rena Ogino

Capstone Showcase

Type 2 diabetes is a common disease in the United States that can result in life-threatening cardiac, vascular, and/or renal complications. The treatment of type 2 diabetes includes but is not limited to exercise, diet, multi-disciplinary approaches, and pharmaceuticals. Metformin is the first line pharmaceutical for newly diagnosed type 2 diabetes, however patients may be unable to tolerate metformin. With more than seven different antihyperglycemic drug classes and over twenty antihyperglycemic drugs, clinicians may have difficulty choosing the best agent for patients when metformin is not tolerated. This article compares common anti-hyperglycemic pharmaceutical agents and their drug classes, focusing on …

Percutaneous Coronary Intervention Using Second Generation Drug-Eluting Stents Vs Coronary Artery Bypass Graft In Left Main Coronary Artery And Multivessel Coronary Artery Disease, Eric Kim

Capstone Showcase

Many of the studies that are used in reference to the clinical decision making between PCI vs CABG use BMS or first-generation DES as a comparison. With the advancement of stent technology, second-generation DES have emerged with improved efficacy and overall outcome rates compared to BMS and first-generation DES. Some of the newer studies such as EXCEL1-2 , demonstrated noninferiority of second-generation DES to CABG but there are limited studies that support this conclusion. Currently, the studies remain divided in the impact of newer-generation PCIs, and 10-year follow up studies may be required to further validate noninferiority before it can …

Clinical Pearls To Diagnosing Lyme Arthritis, Chandelle Keller

Capstone Showcase

Arthritis is one of the most common long term sequelae of Lyme disease infection in humans. Although the pathophysiology for Lyme arthritis is not concretely understood, there are several key features that are helpful in diagnosing Lyme disease as the culprit for the arthritic symptoms that an individual is experiencing. With a thorough history of an individuals’ age, geographic location, recent travel history and common outdoor recreational activities engaged in, a differential can be narrowed down. With the knowledge of how various arthritides present in the body, along with the use of diagnostic testing with ELISA and Western immunoblot, any …

The Benefit Of Bdnf Modification In The Treatment Of Post-Stroke Depression, Christine Gordynskiy-Ageyev

Capstone Showcase

Neuroplasticity has been a rapidly expanding area of research, and its findings have elucidated the potential of taking advantage of some of its components for the treatment of various neural pathologies. Stroke is the most common cause of long-term disability, and it is a disease process that affects many people. There are many rehabilitation programs that seek to restore a patient’s motor and cognitive functions after stroke; if not fully, then at least partially. Unfortunately, mental health changes contribute in large part to the overall disability of a patient, but these changes are not always targeted in these programs. In …

A Case Of Irritable Bowel Syndrome In The Setting Of Generalized Anxiety Disorder, Stephen Driscoll

Capstone Showcase

Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder characterized by a relapsing-remitting course of abdominal discomfort and change in stool form and/or frequency in the absence of any structural or biochemical abnormalities. Currently there is debate on its pathogenesis but there is no definitive conclusion. Treatment consists of primarily playing symptomalogic catch-up with anti-spasmodics, anti-diarrheals, stool softeners, or laxatives depending on which symptoms the patient is currently experiencing. Patients with IBS typically struggle to control their symptoms long term, like the patient described in this case study. This case study explores a possible link between IBS and its’ most …

The Effectiveness Of Probiotics In Adults With Depressive Symptoms, Brianna Rees

Capstone Showcase

Introduction: Depression affects over 21 million adults in the United States and continues to rise, affecting more people due to the recent pandemic. Because the prevalence of this debilitating mental health disease is increasing, it is even more crucial to find additional therapeutic treatments to alleviate depressive symptoms in adults whose depression is not controlled on current anti-depressant medication or therapy. Depression has been shown to be linked to the gut-brain axis, meaning gut health is connected to our mental health. Therefore, probiotics may be effective in altering the gut microbiome, and ultimately affecting cognitive patterns in the brain.

Methods: …

Quality Of Life Before And After Cosmetic Surgery: Should Body Dysmorphic Disorder Be Considered An Absolute Or Relative Contraindication For Cosmetic Surgery?, Lindsay Conlisk

Capstone Showcase

Body Dysmorphic Disorder (BDD) has historically been regarded as a strong contraindication for cosmetic plastic surgery. New research now suggests that the contraindications to cosmetic surgery in patients with BDD may not be so absolute. This paper reviews diagnostic criteria, diagnostic challenges, and current standard of treatment of BDD. It then presents the idea of insight analysis in the BDD patient as a significant factor in determining if patients with BDD may or may not benefit from cosmetic surgery or procedures.

Treatment Of Hypothyroidism: Desiccated Thyroid Extract, Aimee Fong

Capstone Showcase

The treatment of hypothyroidism with Levothyroxine (T4) has been well studied and FDA approved. However, many patients continue to have signs and symptoms of hypothyroidism while on Levothyroxine treatment despite reaching appropriate thyroid levels. An additional thyroid treatment known as desiccated thyroid extract (DTE) is made from dried pig thyroid glands and is advertised as a “natural” alternative to Levothyroxine. Despite lack of FDA approval and studies surrounding DTE, clinicians have prescribed DTE to patients, many of whom reported relief of their symptoms. The following poster highlights the approach to the treatment of hypothyroidism with Levothyroxine and DTE and outlines …

Queer Patients: An Underserved And At Risk Population, Joshua Schmidt

Capstone Showcase

Queer patients in America have faced a history of discrimination as both a community and as individuals. As such, this marginalization acts as a barrier to resources, including healthcare. Clinicians must be aware of said barrier and actively work towards dismantling it within their interactions with queer patients. This article makes a case for increasing sexual health conversations in order to assess queer patients and encourage a stronger patient-provider relationship for a community that is reluctant to seek medical attention, and also more likely to participate in higher risk behaviors.