Medicine and Health Sciences Commons^™

Gastrointestinal Fibromatosis: A Case Of Successful Oral Tyrosine Kinase Inhibitor Delivery To An Infant With Proximal Duodenal Obstruction, Darius Blanding

Research Days

Background: Infantile myofibromatosis (IM) is a rare disorder characterized by the fibrous proliferation of the skin, bone, muscle, and viscera that usually presents at birth, or soon after. Although IM is a benign condition, significantly higher morbidity and mortality have been reported when the viscera is involved. This case report is of a 6-week-old female who presented with poor feeding along with subcutaneous nodules that were diagnosed as IM. Upper and lower endoscopy were performed for worsening feeding intolerance showing marked nodularity throughout the gastrointestinal (GI) tract, including partial obstruction of the proximal duodenum by biopsy-proven myofibromas, confirming visceral IM …

Subclinical Status Epilepticus In The Setting Of An Acute Covid-19 Infection, Thomas Rieth

Research Days

Background: While COVID-19 commonly presents as an upper respiratory infection, acute COVID infections has the potential to have multisystem involvement. Neurological symptoms, which have mainly been reported in adults, are rare in children and are not well recognized. Better understanding of the neurological manifestations of COVID-19 in children can lead to earlier detection of COVID-19 and help with medical decision making and treatment.

Objectives/Goal: To describe an unusual presentation of COVID-19 in a previously healthy female and explore the neurological presentations of COVID-19.

Results: A 10 year old previously healthy female presented with a 1 day history of altered mental …

Soft Palate Teratoma: 5 Month Old Presenting With Failure To Thrive And Severe Obstructive Sleep Apnea, Anna Lawrence

Research Days

Introduction: Oropharyngeal teratomas are an extremely rare congenital tumor. They are often diagnosed prenatally and can cause significant airway obstruction and feeding difficulties at birth. We present a 5-month old female that was diagnosed with a palatal teratoma that presented with failure to thrive, difficulty feeding and eventually with severe obstructive sleep apnea.

Case Description: We present a 5 month old term, otherwise healthy female who initially was breastfeeding well. After an episode of RSV at one month old she become stridulous and had difficulties with feeding. She was seen by an otolaryngologist at 3 months old who performed both …

A Case Of Fibrous Hamartoma In Term Neonate, Elizabeth Perry

Research Days

Case report abstract: Fibrous hamartoma of infancy (FHI) is a rare, benign lesion characterized as a tumor of myofibroblastic origin that has characteristic features of triphasic histology. FHI was first described in 1956 by Reye and formally named by Enzinger in 1965 (1, 2). The lesion is defined as a hamartoma due to the histologic presentation of disorganized mesenchymal, fibrous, and adipose tissue with absence of mitotic figures; this combination of derived tissue without evidence of anaplasia is diagnostic for FHI. These lesions typically arise as a single, solitary mass, are most commonly located on the extremities, trunk, sacrum, or …

Early Onset Obesity In A 4-Year-Old Female Found To Have Variants In Both The Single-Minded Homolog 1 And Sh2b Adaptor Protein 1 Genes, Erica Zarse

Research Days

No abstract provided.

Markerless Tumor Tracking Using Kalman Filter And Deep Learning, Anisha Kapoor, Mark Albert

Computer Science Research Seminars and Symposia

According to the Center for Disease Control, more people die from lung cancer than any other cancer in the United States. A complication that arises from lung cancer treatment, radiation therapy, is radiation pneumonitis. Radiation pneumonitis can be fatal and affects over 23% of patients.

What Is The Prevalence Of Dirofilaria Immitis (Dog Heartworm) In Invasive Aedes Mosquitoes?, Leen Yousef, Johan Espinoza Corrales, Daniela H. Dolar, Taylor K. Trieu, Aisha Popalzai, Agamchat Dhami

Pacific Undergraduate Research and Creativity Conference (PURCC)

No abstract provided.

Medial Edge Chondrification Of The Vocal Folds Of E. Pustulosus And Its Function In Sexual Selection, Helena Soon Czochanski

Pacific Undergraduate Research and Creativity Conference (PURCC)

No abstract provided.

Florida Healthcare Workers Responses To Covid-19, Kristen K. Hicks-Roof

Showcase of Faculty Scholarly & Creative Activity

These two articles were published to describe the landscape of Florida healthcare professionals' responses to COVID-19. These data were collected in mid-2020 when times were unpredictable. These findings shed a lot of light on how we need to better train healthcare professionals on telehealth, interprofessional collaboration and communication among each other and patients.

Increased Risk Of Mental Illness Due To Epigenetic Alteration Of The Nr3c1 Gene After Early Life Adversity., Erin Mccue

Thinking Matters Symposium

Early life adversity (ELA), such as malnutrition, abuse, and economic disparity, is an issue commonly seen in adolescents, a group already facing increased risk for stress-related disorders. This review of current literature reveals that gestational stress exposure, as well as variations in maternal care during postnatal development, cause latent effects on the epigenome, specifically impacting the glucocorticoid receptors (GRs) encoded by the NR3C1 gene. GRs bind to glucocorticoids to regulate the body’s neuroendocrine stress response. However, in those with a history of ELA, the number of GRs is reduced, generating dysregulation within the hypothalamic-pituitary-adrenal (HPA) axis. Rodent studies are utilized …

Mourning The Marathon: Black Men Rappers, Homicide Survivorship Bereavement, And The Rap Tribute Of Nipsey Hussle, Melvin L. Williams, Justin K. Winley, Justin Causey

Far West Popular Culture Association Annual Conference

Eritrean-American rapper Ermias “Nipsey Hussle” Asghedom’s murder represented a cultural cataclysmic event that startled the hip-hop community and triggered previous memories of Black men’s homicidal deaths in rap and Black American urban communities. Nipsey Hussle’s death inspired touching rap tribute songs by Black men rappers, who sought to commemorate his cultural legacy and express their bereavement pains as homicide survivors. Rap tribute songs occupy a significant history, as rappers historically employed them to honor hip-hop’s fallen soldiers, communicate their homicide survivorship bereavement processes, and speak about social perils in the Black community. Framed by critical race (CRT) and gender role …

Covid Susceptibility And Severity Correlation With The Ace2 Gene, Natalie Taylor

Thinking Matters Symposium

A wide spectrum of susceptibility and severity of infection has been observed among COVID-19 patients. While some individuals remain unaffected by the Sars-Cov-2 virus, others have contracted the virus multiple times with varying levels of severity. This poster reviews some of the research demonstrating a link between the susceptibility of the Sars-Cov- 2 virus and the severity of infection, and a specific gene called ACE2. The ACE2 gene encodes an angiotensin-converting enzyme that acts as a functional receptor for the spike glycoprotein receptor binding domain of the coronavirus and severe acute respiratory syndrome coronaviruses. ACE2 presents numerous amino acid variants …

Literature Review: Antibody Production In Mice In Response To Aspergillus Fumigatus Inhalation, Jenica Hancock, Courtney Folk

Student Academic Conference

Aspergillus fumigatus is a commonly inhaled respiratory fungal pathogen and an allergen found in flooded indoor environments, household dust, soil, and plant matter. Inhalation of A. fumigatus poses a threat to weakened immune systems due to the potential of infection in the lungs or sinuses which can spread to other areas of the body. The mouse genome is 99% similar to the human genome, and therefore they serve effectively in modeling the effects of inhaled A. fumigatus. A comprehensive literature search of antibody production in mice in response to A. fumigatus inhalation was conducted utilizing PubMed and the search terms …

Assessing Onu Students Perspective On Sexual Health, Dakota L. Roberts

ONU Student Research Colloquium

Background: It is important for college students to understand sexual health to prevent sexually transmitted infections, help to plan future pregnancies, and support overall well-being. The American College Health Association (ACHA) has released guidelines titled “Best Practices for Sexual Health Promotion and Clinical Care in College Health Settings” as guidance for universities and services to provide. However, it is not known what students at Ohio Northern University know about sexual health and whether they are aware of or desire helpful/useful sources on campus to improve knowledge and ensure the best outcomes.

Methods: A 10-question survey was developed and designed based …

Pharmacists Provision Of Non-Dispensing Services In Health Professional Shortage Areas, Haley L. Kessinger, Emily R. Landis

ONU Student Research Colloquium

Background: Individuals living in primary care health professional shortage areas (PCHPSAs) experience health inequities. Community pharmacists are healthcare professionals with an opportunity to provide care to underserved populations. The objective of this study was to compare non-dispensing services provided by Ohio community pharmacists in PCHPSAs and non-PCHSPAs.

Methods: An electronic, IRB-approved 19-item survey was sent to all community pharmacists practicing in full PCHPSA counties and a random sample practicing in non-PCHPSA counties in Ohio (n=324). Questions assessed current provision of non-dispensing services as well as interest and barriers regarding such services.

Results: Seventy-three usable responses were received (23% response rate). …

Checklist Based Vap Bundle, Molly Van Gorp

ONU Student Research Colloquium

Problem: Ventilator Associated Pneumonia (VAP) is the leading cause of death of all hospital acquired infections. VAP bundles have been researched and utilized throughout hospitals. However, there is a gap that exists between physical practice and knowledge.

Purpose: This proposed study aims to implement a checklist based VAP Bundle into the ICU to increase nurse adherence to bundle and thereby decrease rates of VAP.

Methods: This project is a three phase quasi-experimental research design taking place in an ICU. The first phase is a retrospective data collection over five months. The second phase will take place over two months. This …

Quality Improvement Initiative To Improve Door To Needle Time In Acute Stroke Patients, Lauren N. Trace

ONU Student Research Colloquium

Problem: A stroke is when a blockage occurs in the blood vessels to the brain or when a blood vessel bursts in the brain, creating a lack of oxygen supply to keep the brain functioning effectively. The earlier a stroke patient is treated, the better the outcomes will be. Door to needle time is the time difference between when the patient arrives to the time treatment is given.

Purpose: The purpose of this project is to determine if implementing a one call notification system can decrease door-to-needle (DTN) time.

Methods: A quasi-experimental approach will be used for this study. Five …

Ensuring Safety During Behavioral Health Emergencies In Emergency Rooms, Allison Logue

ONU Student Research Colloquium

Problem: Psychiatric patient emergencies and behavioral outbursts are increasingly present in nonmental health units. With the associated increase in complexity and acuity of mental health emergency room visits, there is an associated increase in risk that they will become agitated, posing a risk to themselves and others. The yelling, manipulating, physical outbursts, and verbal or physical threats that can be associated with this patient population increases the risk of injury for staff and patients.

Purpose: The purpose of this project is to determine if the implementation of a behavioral health/aggressive patient bundle will decrease the number of staff injuries by …

End Of Life Simulation Education For Nurses, Shaun T. Wagner

ONU Student Research Colloquium

Problem: End of Life (EOL) care requires skilled nursing skills. Many nurses report negative experiences and attitudes related to End of life care. This may lead to negative patient and family EOL outcomes. Simulation education may be one method to improve nurses attitudes toward EOL care.

Purpose: The purpose of this project is to determine if simulation based EOL education leads to improved nurse attitudes.

Methods: This quasi-experimental quality improvement project will include registered nurses who receive EOL simulation training. Participant attitudes of EOL care will be measured prior to and following simulation using the Frommelt Attitude Toward Care …

Trauma Related Stress On Nursing Care, Karsen Bresnahan

ONU Student Research Colloquium

Problem: ED nurses are faced with critical unexpected traumas daily. Nurses must be able to cope with traumatic patient events to provide care to other assigned patients. The inability to cope may lead to burnout and medical mistakes. Mindfulness is a coping strategy that can be used to decrease stress.

Purpose: The purpose of this quality improvement study is to determine if educating nurses on the use of mindfulness after experiencing a patient trauma decreases nurses’ physical and mental stress.

Methods: This will be a quantitative, quasi-experimental study comparing the stress levels of nurses who received mindfulness training to nurses …

Reducing Musculoskeletal Injuries In Nurses, Ashlie R. Miller

ONU Student Research Colloquium

Problem: Nurses across the nation are being affected by an epidemic that often leads to severe, chronic pain. This is not an infectious disease, but mass amounts of preventable musculoskeletal injuries caused by repetitive movements such as lifting, repositioning, and transferring patients. These injuries lead to time away from work and increased costs for healthcare facilities. Education on proper lifting techniques provides nurses with the tools to reduce risk for injury.

Purpose: The purpose of this study is to determine if reeducating nurses about proper lifting techniques reduces the occurrence of musculoskeletal injuries.

Methods: This study will be a cross …

The Effects Of Oral Care In Reducing The Incidence Of Ventilator-Associated Pneumonia In Mechanically Ventilated Patients In The Icu, Alexandra Ann Waugh

ONU Student Research Colloquium

Problem: Ventilator-Associated Pneumonia (VAP) is a severe complication that occurs within mechanically ventilated patients. Despite initiatives to decrease complications of mechanical ventilation, VAP continues to occur in critically ill patients.

Purpose: The purpose of this study is to evaluate the effectiveness of oral care in reducing the number of patient’s in the ICU who develop VAP.

Methods: This project uses a three part quasi-experimental retrospective study design. The participants include mechanically ventilated patients in the ICU and the nurses taking care of them. The oral care kits used in this study consists of chlorhexidine, suction swabs, suction brushes, and mouth …

Diminishing The Doubts: A Mental Health Education Initiative, Megan Breier, Joey Sidoti

ONU Student Research Colloquium

According to the Substance Abuse and Mental Health Services Administration, poor mental health and suicide rates amongst people ages 18-25 years old continues to increase. Given these statistics, it is reasonable to assume that mental health education needs to be implemented during regular school hours. It is imperative that students understand the warning signs of poor mental health prior to entering higher education or entering the workforce. By creating an Online Mental Health Resource Archive (OMHRA) filled with resources (i.e. infographics, podcasts, TED Talks, etc.), participants have a central location to browse resources and educate themselves about mental health. The …

Implementing A Healthy Recipe Book In A Rural Area To Promote Healthy Lifestyles, Avery Ballinger, Han Pham

ONU Student Research Colloquium

Nutrition and obesity were leading health indicators included in Healthy People 2020¹. In Hardin County, 21.7% of residents live in poverty, ⅓ of residents are considered overweight, and 44% of residents are at risk for high blood pressure². The purpose of this project is to improve health promotion in a group of adults in a rural setting, as these environments have been found to have high rates of obesity and chronic disease risks. This study will evaluate the impact of a comprehensive recipe book on nutrition knowledge, self-efficacy, and willingness to adjust health-related behaviors such as lifestyle changes in diet …

Student Self-Developed Wellness Goals Before And During Covid, Han Pham, Dalen Foster

ONU Student Research Colloquium

Background: This study aims to investigate the change over time in student developed well-being related goals based on the definition of “The 8 dimensions of wellness”. It is expected that the changes experienced by students during the COVID 19 pandemic will impact the type of wellness goals students develop for themselves.

Method: All pharmacy students at ONU are required to complete an annual goal setting assignment as part of their co-curricular requirement each academic year. Personal goals were extracted from submissions from 2019 to 2021. The goals were classified into 8 categories (emotional, financial, intellectual, occupational, physical, social, spiritual, and …

Exchange Protein Directly Activated By Camp (Epac1) Protects Human Endothelial Cells From Tumor Necrosis Factor-⍺ (Tnf-⍺) Induced Cell Death, Anh Luu, Abigail Carpenter, Rosetta Tolley

ONU Student Research Colloquium

Millions of people are affected by diseases involving inflammatory states such as sepsis. Sepsis is associated with elevated tumor necrosis factor alpha (TNF-⍺) which mediates inflammation. Excessive TNF-⍺ contributes to death of endothelial cells (EC) with subsequent disruption of vascular endothelial function. Exchange Factor Directly Activated by cAMP (EPAC1) is a cyclic-AMP (cAMP) sensor that regulates multiple EC functions. We hypothesized that EPAC1 activation affects the response of EC to TNF-a. Microvascular EC were pretreated for 45 minutes with 100 mM 8-pCPT-2′-O-Me-cAMP (8-CPT, specific EPAC1 activator) or 10 mM forskolin (adenylyl cyclase activator that increases cAMP), then exposed to 5 …

Cinnamon Extract Alters Mcf7 Cell Morphology, Madison M. Anderson

ONU Student Research Colloquium

Cancer prevention is one area of research that has gained interest in recent years. The anti-cancer effects of polyphenols and other nutraceuticals show great promise in prevention as well as therapeutics. In cancers that occur due to epigenetic modifications, molecules that provide these modifications are useful for both the prevention and reversal of disease. Our lab studies the effects of cinnamon extract on cell viability, growth and morphology. Cinnamon extract has high polyphenolic content and is believed to regulate a variety of transcription factors as well as epigenetic modifications. Our observations suggest that a significant change in morphology occurs in …

Evaluating The Use Of Nintendo Labo As A Rehabilitation Tool, Jacob Colwell, Logan Suiter, Amanda Wells

ONU Student Research Colloquium

Serious gaming is the practice of using video games, either commercial or specifically designed, for physical rehabilitation. Serious games have emerged in the last decade as a way to increase patient involvement in rehabilitation, increase the likelihood of patients continuing treatment after progress stalls, and generally increase mental health during treatment. However, the current literature has not kept pace with the evolution of technology and therefore the use of next-generation consoles for serious gaming is underdeveloped.

The Nintendo Switch could provide new avenues for serious gaming because of the advanced sensing ability of its controllers (Joy-Cons) and the engaging ways …

Short-Term Muscle Fatigue And Recovery In Different Types Of Athletes, Morgan D. Morris, Jayson C. Sumner, Aaron F. Valenti

ONU Student Research Colloquium

Having poor grip strength can cause an increase of injuries and difficulty to perform day to day tasks. The goal of this IRB approved research was to investigate how athletic sport activities impact muscle fatigue and recovery in grip strength. The study consisted of ten males between the ages of 18 and 24 from four different collegiate sport teams: (1) wrestlers, (2) football players, (3) e-sports players, and (4) basketball players, at Ohio Northern University. For each athlete, grip strength (pounds per square inch) was measured before and after squeezing a 60 kg. grip strengthener 30 times to induce muscle …

Ohio Northern University Students Connect With Kenton Hardin Health Department For Project Dawn (Deaths Avoided With Naloxone) Training, Kelly Kern

ONU Student Research Colloquium

Background:

In partnership with the Kenton Hardin Health Department, Project DAWN training was offered to Ohio Northern University students. Project DAWN is a public health program offered within Ohio. The goal of the program is to provide education and training related to opioid overdoses and to distribute naloxone kits.

Methods:

Two sessions of Project DAWN training provided by the county Health Department was completed by 77 Ohio Northern University students. At the sessions students filled out a survey on student demographics (college, class, major), and reasons for attending.

Results:

Of the students that attended: 57 (pharmacy majors), 9 (engineering majors), …