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Articles 4141 - 4170 of 11649
Full-Text Articles in Medicine and Health Sciences
Improving Inpatient Hyperglycemia Through An Internal Medicine Resident And Pharmacy Audit And Feedback Quality Improvement Project, Hector Arredondo, Lina Pedraza Sanchez, Chelsea Chang, Alfarooq Alshaikhli, Alcibiades Fleires, D. Bazan, Diana Gavilanes, Don Rajan, F. Cabral, J. Cantu, J. Trejo, K. Oliveira, R. Verduzco
Improving Inpatient Hyperglycemia Through An Internal Medicine Resident And Pharmacy Audit And Feedback Quality Improvement Project, Hector Arredondo, Lina Pedraza Sanchez, Chelsea Chang, Alfarooq Alshaikhli, Alcibiades Fleires, D. Bazan, Diana Gavilanes, Don Rajan, F. Cabral, J. Cantu, J. Trejo, K. Oliveira, R. Verduzco
Research Symposium
Background: Although the advantages of proper glycemic control in hospitalized patients with diabetes are well-established, a variety of barriers limit accomplishment of blood glucose targets. Inpatient hyperglycemia is associated with an increase in morbidity and mortality, number of re-hospitalizations, and length of hospitalization. Our aim was to decrease the number of glucose values above 180mg/dl in non-critical care hospitalized patients using an audit and feedback intervention with pharmacy and internal medicine residents.
Methods: A resident-led multidisciplinary team implemented the quality improvement (QI) project including conception, literature review, educating residents, iterative development of audit and feedback tools, and data analysis. The …
Outcomes Following Total Hip Arthroplasty For Hip Dysplasia In Older Adults. Are They Comparable To Those With Osteoarthritis?, Cesar Sevilla Jr., Vanessa Lopez, Ruthvik Allala, Isabella Amado, Yin Xi, Nicholas Fey, Avneesh Chhabra, Joel Wells
Outcomes Following Total Hip Arthroplasty For Hip Dysplasia In Older Adults. Are They Comparable To Those With Osteoarthritis?, Cesar Sevilla Jr., Vanessa Lopez, Ruthvik Allala, Isabella Amado, Yin Xi, Nicholas Fey, Avneesh Chhabra, Joel Wells
Research Symposium
Background: Complications from hip dysplasia during infancy and childhood can be prevented with an early diagnosis and immediate treatment. However, those who delay interventions have an increased risk of developing secondary osteoarthritis in adulthood. We sought to investigate and compare the pre-and postoperative outcomes of primary total hip arthroplasty (THA) in older adults with hip dysplasia to those with end-stage osteoarthritis (OA).
Methods: A prospectively collected database from a single institution dating from September 1st, 2016 to October 31st, 2021 was used to identify 323 unilateral THA patients who were 50 years or older and then separated into 2 …
Effect Of Third Dose Pfizer/Biontech Covid-19 And Moderna Mrna Vaccine On Igg Antibody Titers, Thao A. Khuc, Gregery Pequeno, Monica M. Betancourt-Garcia, Adrienne M. Casciato, Marissa Gomez-Martinez, Carlos D. Arroyo, Bill Pope, Shravan Narmala, Sohail Rao
Effect Of Third Dose Pfizer/Biontech Covid-19 And Moderna Mrna Vaccine On Igg Antibody Titers, Thao A. Khuc, Gregery Pequeno, Monica M. Betancourt-Garcia, Adrienne M. Casciato, Marissa Gomez-Martinez, Carlos D. Arroyo, Bill Pope, Shravan Narmala, Sohail Rao
Research Symposium
Background:With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, there has been increasing concern for another COVID-19 crisis. In response, the Centers for Disease Control and Prevention (CDC) authorized the third dose of the Pfizer-BioNTech (BNT162b2) vaccine to enhance protection against the SARS-CoV-2 virus. The purpose of our study was to investigate the impact of administering the third dose of the Pfizer/BioNTech COVID-19 vaccine on the incidence and severity of SARS-CoV-2 infections.
Methods: We enrolled 189 participants, including healthcare workers, adults aged 65 years or older, and medically immunocompromised patients in the Rio Grande Valley. Blood …
Choroid Plexus Morphology In Substance Abuse, Angelica Pham, Alan N. Francis
Choroid Plexus Morphology In Substance Abuse, Angelica Pham, Alan N. Francis
Research Symposium
Background: The choroid plexus (CP), a highly vascularized organ that lines the ventricles of the brain, serves several important functions that maintain homeostasis of the cerebrospinal fluid (CSF) surrounding the brain and protects the brain from harm by acting as part of the blood-cerebrospinal fluid barrier. Dysfunction in CP morphology and function has recently been associated with various conditions such as stroke, aging, neoplasms, hydrocephalus, Alzheimer’s disease, depression, and psychosis. This systematic review explores the morphological changes in the CP associated with substance abuse, which poses a significant problem worldwide.
Methods: A comprehensive literature search was performed to find …
Axial Fat Relationship With Development Of Pathologic Metabolic Disease, Allison Podsednik Gardner, Ryan Ketan Ajgaonkar, Yossef Alsabawi, Paul Berry
Axial Fat Relationship With Development Of Pathologic Metabolic Disease, Allison Podsednik Gardner, Ryan Ketan Ajgaonkar, Yossef Alsabawi, Paul Berry
Research Symposium
Background: Increasing BMI is related to development of pathologic metabolic syndromes including insulin resistance, type 2 diabetes mellitus, and non-alcoholic fatty liver disease. The present study aims to provide a review on the current data in literature assessing the relationship between axial fat and development of metabolic disease states while also exploring the long-term effects of liposuction.
Methods: We conducted a literature search using OVID, PubMed, Google Scholar, and Plastic and Reconstructive Surgery using search terms including “axial fat” and “truncal fat” in combination with disease states of interest including “insulin resistance,” “diabetes,” and “non-alcoholic fatty liver disease.”
Results: …
Description Of A New Technique: Utilizing A De-Epithelialized Inferior Mastectomy Skin Flap To Preserve The Nipple-Areolar Complex In Patients With Stage Ii And Iii Breast Ptosis, Allison Podsednik Gardner, Annalisa M. Lopez, Aidee Nunez, Mauricio De La Garza
Description Of A New Technique: Utilizing A De-Epithelialized Inferior Mastectomy Skin Flap To Preserve The Nipple-Areolar Complex In Patients With Stage Ii And Iii Breast Ptosis, Allison Podsednik Gardner, Annalisa M. Lopez, Aidee Nunez, Mauricio De La Garza
Research Symposium
Background: Breast cancer is the most common malignancy in women aside from non-melanoma skin cancer. Skin Sparing Mastectomy (SSM) and preservation of the nipple areolar complex (NAC) are increasing in popularity due to improved cosmesis and low rate of tumor recurrence. Relative contraindications to nipple-sparing mastectomies (NSM) include grade II and III breast ptosis, even if oncologically feasible to keep the nipple, due to concerns of vascular compromise. For some women, maintaining their own, natural nipples is an important part of the reconstructive process. This paper describes a technique which is intended to preserve the NAC in those with …
Investigating The Significance Of Muc13 In Hepatocellular Carcinoma Development, Shabnam Malik, Mohammed Sikander, S. Mishra, Daniel Zubieta, Murali M. Yallapu, S. K. Jain, Parvez Khan, Deepshikha Pande Katare, Meena Jaggi, Subhash C. Chauhan
Investigating The Significance Of Muc13 In Hepatocellular Carcinoma Development, Shabnam Malik, Mohammed Sikander, S. Mishra, Daniel Zubieta, Murali M. Yallapu, S. K. Jain, Parvez Khan, Deepshikha Pande Katare, Meena Jaggi, Subhash C. Chauhan
Research Symposium
Background: Hepatocellular carcinoma (HCC) has a poor prognosis due to ineffective therapeutic modality and lack of early diagnostic marker. Accumulating studies have shown that elevated expression of mucin 13 as potential oncogene and predictive biomarker for various cancer. However, very little is known about its expression and function for development and progression of HCC.
Objective: To investigate mucin 13 expression in chemically induced hepatocellular carcinoma model.
Methodology: Diethyl nitrosamine (DEN) and 2-Acetylaminofluorene (2-AAF) induced method was employed for the development of hepatocellular carcinoma in Male Wistar rats. Serum and tissues were collected at regular interval of time and routinely …
Development Of Cross-Linked Tannic Acid-Based Nanoparticle For Lung Cancer Treatment, Rahul Tiwari, Vivek K. Kashyap, Eswara Naga Hanuma Kumar Ghali, Subhash C. Chauhan, Murali M. Yallapu
Development Of Cross-Linked Tannic Acid-Based Nanoparticle For Lung Cancer Treatment, Rahul Tiwari, Vivek K. Kashyap, Eswara Naga Hanuma Kumar Ghali, Subhash C. Chauhan, Murali M. Yallapu
Research Symposium
Background: Lung cancer is a predominant cause of cancer-related morbidity and mortality across the world including in the United States. Treatment modalities for lung cancer include surgery, chemotherapy, radiotherapy, and/or targeted therapies depending on the cancer stage. Despite the survival benefits of chemotherapy, its value is offset by severe systemic side effects such as renal and/or hepatic toxicity or insufficient amounts of drug reaching to the target site. Such pitfalls can be handled by inhalable therapy which avoids first-pass metabolism and increases patients' compliance. In this study, we have investigated the inhalable therapy of cross-linked tannic acid-based nanoparticles (CTA NPs) …
Therapeutic Efficacy Of Novel Brominated-Ormeloxifene (Br-Orm) Against Cervical Cancer, Mohammed Sikander, Shabnam Malik, John Apraku, Sonam Kumari, Parvez Khan, Daniel Zubieta, Hassan Mandil, Aditya Ganju, Bhavin Chauhan, Maria C. Bell, Man Mohan Singh, Sheema Khan, Murali M. Yallapu, Fathi T. Halaweish, Meena Jaggi, Subhash Chauhan
Therapeutic Efficacy Of Novel Brominated-Ormeloxifene (Br-Orm) Against Cervical Cancer, Mohammed Sikander, Shabnam Malik, John Apraku, Sonam Kumari, Parvez Khan, Daniel Zubieta, Hassan Mandil, Aditya Ganju, Bhavin Chauhan, Maria C. Bell, Man Mohan Singh, Sheema Khan, Murali M. Yallapu, Fathi T. Halaweish, Meena Jaggi, Subhash Chauhan
Research Symposium
Aberrant activation of β-catenin signaling is strongly associated with cancer proliferation, invasion, migration, and metastasis, thus small molecules that can inhibit this pathway might have great clinical significance. Our molecular modeling studies suggest that Ormeloxifene (ORM), a triphenylethylene molecule docks with β-catenin, and its brominated analogue (Br-ORM) bind more effectively with relatively less energy (-7.6 kcal/mol) to the active site of β-catenin as compared to parent ORM. Herein, we report the synthesis and characterization of a Br-ORM by NMR and FTIR, as well as its anti-cancer potential in cervical cancer models in vitro and in vivo. Br-ORM treatment effectively inhibited …
Human Ipsc Derived Neural Stem Cells: An In-Vitro Model To Investigate Snake Venom Neurotoxicity, Miriam Aceves, Jose C. Granados, Ana C. Leandro, Juan M. Peralta, Sarah Williams-Blangero, Jacob Galan, John Blangero, Joanne E. Curran, Satish Kumar
Human Ipsc Derived Neural Stem Cells: An In-Vitro Model To Investigate Snake Venom Neurotoxicity, Miriam Aceves, Jose C. Granados, Ana C. Leandro, Juan M. Peralta, Sarah Williams-Blangero, Jacob Galan, John Blangero, Joanne E. Curran, Satish Kumar
Research Symposium
Background: The World Health Organization (WHO) has recognized snakebite as a neglected tropical disease that affects nearly 2.7 million people per year and causes both long-term morbidity and substantial mortality. The multifunctionality of snake venom and the diversity of cellular responses to snake venom insult are well recognized. However, the neurotoxic effects of snake venom insult on the human nervous system are not yet fully understood. Therefore, a robust cell model that is easily reproducible and scalable to a larger sample size is required to aid the discovery of molecular mechanisms involved in the neurobiology of snake envenomation in humans. …
The Mechanisms Of N-Acetylcysteine Protect Against Cobalt Chloride Induced 661w Cone Photoreceptor Cell Toxicity., Lili Guerra, Benxu Cheng, Andrew Tsin
The Mechanisms Of N-Acetylcysteine Protect Against Cobalt Chloride Induced 661w Cone Photoreceptor Cell Toxicity., Lili Guerra, Benxu Cheng, Andrew Tsin
Research Symposium
Purpose: Proliferative diabetic retinopathy (PDR) is the leading cause of blindness due to the apoptotic death of the photoreceptors among working age adults. Photoreceptors are the most common and metabolically demanding cells inl the retina thus oxygen is vital for retinal function. Hypoxia induced metabolic stress leads to photoreceptor atrophy and retinopathy. However, the protection of hypoxia-induced cytotoxicity in cone photoreceptor cells has not been investigated extensively. The aim of the present study was to further characterize the biochemical changes in cultured 661W photoreceptor cells during hypoxic exposure and to investigate the protective mechanisms of N-acetyl cysteine (NAC) against hypoxia-induced …
An Investigation Of Porous Pcl Scaffolds And Osteogenic And Angiogenic Inducing Mirnas For Bone Tissue Engineering, Lauren Serra, E. Lozoya, S. D. Vidal, D. M. Enriquez, M. A. Arriaga, Sue Anne Chew
An Investigation Of Porous Pcl Scaffolds And Osteogenic And Angiogenic Inducing Mirnas For Bone Tissue Engineering, Lauren Serra, E. Lozoya, S. D. Vidal, D. M. Enriquez, M. A. Arriaga, Sue Anne Chew
Research Symposium
Background: Trauma, infection, fracture, tumor resection, disease, or congenital abnormalities can cause bone defects. Small defects can self-regenerate, but larger ones or those with poor vascularized areas require intervention. Autografts involve transferring bone from one area to the damaged site. Although considered the current gold standard for treatment, this method is associated with limitations such as pain, infection risk, rejection and difficulty in finding the correct size, shape and volume of bone needed. Bone tissue engineering may be a promising alternative which combines multipotent cells, scaffolds, and bioactive factors to induce bone regeneration. The objectives of the study were to …
Differences In Female Re6productive Cycles Dependent On Age And The Effects On Short Term Memory In The Syrian Hamster (Mesocricetus Auratus), Laura Emma Garcia, Mariela Garcia, Fernando Dominguez, Mario Gil
Differences In Female Re6productive Cycles Dependent On Age And The Effects On Short Term Memory In The Syrian Hamster (Mesocricetus Auratus), Laura Emma Garcia, Mariela Garcia, Fernando Dominguez, Mario Gil
Research Symposium
The female reproductive system plays an important role in cognitive function, and the status of it affects memory and many other health issues, including mental. For this reason, it is important to continue studying its effects by using as a model, the female Syrian hamster. Like the human female menstrual cycle, the female hamster has shown inconsistencies in their cycles and changes in it as they age. The female hamsters’ estrus cycle consists of a 4-day cycle. Dr. Orsini’s protocol focusing on vaginal secretion, published in 1961, describes day 1 discharge of the cycle as translucent (TS), day 2 as …
Co-Culture Of Retinal Pericytes And Retinal Endothelial Cells, Laura Valdez, Lili Guerra, Richard Lebaron, Andrew Tsin
Co-Culture Of Retinal Pericytes And Retinal Endothelial Cells, Laura Valdez, Lili Guerra, Richard Lebaron, Andrew Tsin
Research Symposium
Background: Human retinal pericytes (HRP) are contractile cells adjacent to and provide support for retinal endothelial cells (REC) of retinal capillaries. One of the earliest events of diabetic retinopathy (DR) is the loss of RP through apoptosis. Pericytes share a common basement membrane with endothelial cells and are most prominent in retinal capillaries in comparison with capillaries in other tissues in the body. The loss of HRP leads to the development of advanced-stage pathology including angiogenesis. In this present study, human HRP and REC in coculture were examined in order to evaluate effects of their interactions and response to exogenous …
Investigating The Ability Of Foxo Factors To Regulate The Notch Pathway, Larissa Barroso, A. M. Reyes, S. Rios
Investigating The Ability Of Foxo Factors To Regulate The Notch Pathway, Larissa Barroso, A. M. Reyes, S. Rios
Research Symposium
Background: Initial studies show that forkhead box (FOXO) transcription factors support maintenance in embryonic, hematogenic, and neural stem cells. Myoblasts, embryonic precursors of myocytes, are essential for forming and maintaining skeletal muscle tissue, which can fuse to form with multinucleated myotubes. In the presence of activated PI3K-AKT pathway, FOXO factors are inactive in muscle and liver cells; however, this regulatory mechanism is bypassed in stem/stem-like cells. FOXO factors directly interact with stem-related genes like OCT4 and SOX2, facilitating their expression. Nevertheless, our understanding of the full range and conservation of FOXO transcription factor function in stem cell environments remains incomplete, …
Investigating The Post-Treatment Mechanisms Underlying Prolonged Effect Of Niclosamide And Camptothecin On Glioblastoma Cells, X. Fang, B. Cheng, R. Lara, J. B. Osho, Josue Fonseca
Investigating The Post-Treatment Mechanisms Underlying Prolonged Effect Of Niclosamide And Camptothecin On Glioblastoma Cells, X. Fang, B. Cheng, R. Lara, J. B. Osho, Josue Fonseca
Research Symposium
Background: Glioblastoma is the most common malignant brain tumor characterized by its aggressive and highly proliferative nature. Although GBM rarely metastasizes to distant organs, it presents unique characteristics that challenge chemo- and radio-therapeutic efforts. Previous studies have attributed glioblastoma's prominent level of resistance to its involvement in multiple signaling pathways. To counter this, current promising treatments, such as Niclosamide and Camptothecin (CPT), have been evaluated and subsequently combined for their synergistic effect, targeting the multiple pathways that glioblastoma upregulates. The current study provides further insight into the duration of effect in with the usage of such promising treatments. The lasting …
Assessing The Post-Treatment Morphological Effects Of Niclosamide And Camptothecin On Glioblastoma Cells, X. Fang, B. Cheng, R. Lara, J. B. Osho, Josue Fonseca
Assessing The Post-Treatment Morphological Effects Of Niclosamide And Camptothecin On Glioblastoma Cells, X. Fang, B. Cheng, R. Lara, J. B. Osho, Josue Fonseca
Research Symposium
Background: Glioblastoma is the most common malignant brain tumor characterized by its aggressive and highly proliferative nature. Due to its poor prognosis, high recurrence, and lack of a permanent cure, current therapy is directed toward extending survival. Recent studies have provided insight into the anticancer effects of the anti-helminthic drug, Niclosamide, and the naturally occurring alkaloid, Camptothecin (CPT). Our lab previously observed how co-administration of Niclosamide and CPT resulted in increased suppression of cell proliferation, as well as higher rates of cell apoptosis compared to usage of each treatment alone. The present study examines the impact of the different chemotherapies …
Gaba Expression In The Monodelphis Domestica And Relevance To Neuropsychiatric And Neurological Disorders, Jatziry Luna, Truc Le, Esperanza I. Zacarias, Mario Gil
Gaba Expression In The Monodelphis Domestica And Relevance To Neuropsychiatric And Neurological Disorders, Jatziry Luna, Truc Le, Esperanza I. Zacarias, Mario Gil
Research Symposium
Background/Purpose: Gamma-aminobutyric acid (GABA) is an amino acid that serves as the central nervous system's (CNS) main inhibitory neurotransmitter. By preventing nerve transmission, it works to lower neuronal excitability. Altered GABA levels have been associated with a variety of psychiatric disorders for example Epilepsies, Parkinson’s Disease and Schizophrenia. However, it is also imperative to study the role GABA transmission relates with drug addiction and substance disorders including alcohol misuse. GABAergic neurons can be identified and quantified using antibodies that target GAD65 and GAD67. GAD65 is mostly abundant in axon terminals and is linked to synaptic vesicles while GAD67 is found …
Electrosprayed Minocycline-Loaded Plga Microparticles For The Treatment Of Glioblastoma, Jaqueline Quintanilla, A. Rodriguez, J. Amieva, J. Ledezma, M. A. Arriaga, I, Davila, Karen S. Martirosyan, Sue Anne Chew
Electrosprayed Minocycline-Loaded Plga Microparticles For The Treatment Of Glioblastoma, Jaqueline Quintanilla, A. Rodriguez, J. Amieva, J. Ledezma, M. A. Arriaga, I, Davila, Karen S. Martirosyan, Sue Anne Chew
Research Symposium
Background: Around 12,340 patients in the US are diagnosed with glioblastoma multiforme (GBM) yearly, and despite the current treatment options, such as chemotherapy, radiotherapy, surgical resection, or a combination of them, the median survival is only about 15 months after initial diagnosis. Minocycline, a tetracycline antibiotic, has shown to inhibit U87 glioblastoma cell death and inhibit angiogenesis, or the creation of new blood vessels as is often needed by the tumor to grow. The utilization of biomaterials such as poly lactic-co-glycolic acid (PLGA) can better sustain the release and bioactivity of loaded drugs. The use of polyethylene glycol (PEG), a …
The Significance Of Reactive Oxygen Species In Physiological Processes And Hematological Disorders: Insights Into Cardiovascular And Cerebrovascular Diseases, Alex Zuo, Hector Trejo, Anthony Alanis
The Significance Of Reactive Oxygen Species In Physiological Processes And Hematological Disorders: Insights Into Cardiovascular And Cerebrovascular Diseases, Alex Zuo, Hector Trejo, Anthony Alanis
Research Symposium
Background. Reactive oxygen species (ROS) have a double role on biomedicine: they are molecular commodities in cellular biochemistry and signaling, but also corrosive threats to other cellular elements with their damaging or directly oxidizing effect. This poster seeks to discuss the relevance of ROS in different physiological processes and diseases of cardiovascular disease (including hypertension), hematological diseases related to cerebrovascular accident.
Methods. We have thoroughly studied over 60 most recent or related literature to the topic and determine important roles of ROS in various biological systems, cardiovascular and cerebrovascular diseases.
Results. ROS are fundamental for cell signaling and …
Investigating The Behavioral Effects Of Microinjecting Hormones Into The Brain Of The Syrian Hamster (Mesocricetus Auratus), Fernando Dominguez, J. Chapa, A. Hinojosa, E. Alaniz, G. Padilla, Mario Gil
Investigating The Behavioral Effects Of Microinjecting Hormones Into The Brain Of The Syrian Hamster (Mesocricetus Auratus), Fernando Dominguez, J. Chapa, A. Hinojosa, E. Alaniz, G. Padilla, Mario Gil
Research Symposium
Background: Hormones are important modulators of physiological functions, behaviors, emotions, and cognition; however, most neuroscientists focus on neurotransmitters and how these chemicals affect the brain and behavioral outcomes. Studies have shown that arginine-vasopressin (AVP), a hormone that is typically known for its regulation of kidney function, microinjected in the anterior hypothalamus (AHA) induces flank marking and aggressive behaviors in Syrian hamsters (Mesocricetus auratus). In the present study, we investigated the behavioral effects of two hormones, AVP and angiotensin, microinjected into the interfascicular nucleus (IF) and the bed nucleus stria terminalis (BNST), respectively, in the Syrian hamster.
Methods: Eleven hamsters (8 …
One-Step Simultaneous Liquid Phase Exfoliation-Induced Chirality In Graphene And Their Chirality-Mediated Microrna Delivery, Pranav, Eswara Naga Hanuma Kumar Ghali, Neeraj Chauhan, Rahul Tiwari, Subhash C. Chauhan, Murali M. Yallapu
One-Step Simultaneous Liquid Phase Exfoliation-Induced Chirality In Graphene And Their Chirality-Mediated Microrna Delivery, Pranav, Eswara Naga Hanuma Kumar Ghali, Neeraj Chauhan, Rahul Tiwari, Subhash C. Chauhan, Murali M. Yallapu
Research Symposium
Background: Graphene (G) has been established as an exciting prospect for a broad range of applications owing to its remarkable properties. As the molecular structure of G itself is achiral thus introducing chirality in G by simple attachment of a functional group (a chiral ligand) on the G nanosheet may result in more diverse applications. The recent innovations of G chiral nanosystems have been extended to drug delivery. Herein, we have developed a novel and facile synthesis method for producing chiral G for its application in the chirality-dependent microRNA delivery.
Methods: L-graphene and D-graphene were produced in a single …
Examining Apoe Gene Associated With Diabetes And Hypertension Of The Hispanic Population In The Rio Grande Valley., Erika Guajardo, Daniela Gamez, Aida Galvan Gutierrez, Kesheng Wang, Chun Xu
Examining Apoe Gene Associated With Diabetes And Hypertension Of The Hispanic Population In The Rio Grande Valley., Erika Guajardo, Daniela Gamez, Aida Galvan Gutierrez, Kesheng Wang, Chun Xu
Research Symposium
Background: In the United States, 11.3% of the population has diabetes. Diabetes is a group of chronic health conditions that affects blood sugar uptake into cells for energy. There are different types of diabetes characterized by different pathophysiologies, with the most common being Type 1 Diabetes Mellitus where there is a total lack of insulin, and Type 2 Diabetes Mellitus where peripheral tissues become insulin resistant. Over time, these conditions can cause many different health issues that decrease the quality of life. In addition, Hispanic people are twice as likely to develop Type 2 diabetes than non-Hispanic White people. In …
Apoe Gene Associated With Dementia Related Traits, Depression And Anxiety In The Hispanic Population., Daniela Gamez, Erika Guajardo, Aida Galvan Gutierrez, Victoria I. Padilla, Stephanie Lozano, Mario Gil, Gladys E. Maestre, Kesheng Wang, Chun Xu
Apoe Gene Associated With Dementia Related Traits, Depression And Anxiety In The Hispanic Population., Daniela Gamez, Erika Guajardo, Aida Galvan Gutierrez, Victoria I. Padilla, Stephanie Lozano, Mario Gil, Gladys E. Maestre, Kesheng Wang, Chun Xu
Research Symposium
Background: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders that has been associated with a strong genetic component. In addition, AD is often comorbid with neuropsychiatric conditions, some of which are early indicators of the disease. Specific demographic factors and genetic variants have been identified as risks in non-Hispanic populations; however, there are limited studies observed on the Hispanic population. Therefore, in our current study, we focused on investigating a known gene, APOE, that is associated with AD-related phenotypes and two psychiatric diseases (depression and anxiety) within the U.S. Hispanic population.
Methods: A total of 1,382 …
Cucurbitacin D Suppresses Benzo[A]Pyrene-Induced Liver Injury By Modulating Nrf2 Signaling, Shabnam Malik, Mohammed Sikander, Daniel Zubieta, Anyssa Rodriguez, Murali M. Yallapu, Fathi T. Halaweish, Meena Jaggi, Subhash Chauhan
Cucurbitacin D Suppresses Benzo[A]Pyrene-Induced Liver Injury By Modulating Nrf2 Signaling, Shabnam Malik, Mohammed Sikander, Daniel Zubieta, Anyssa Rodriguez, Murali M. Yallapu, Fathi T. Halaweish, Meena Jaggi, Subhash Chauhan
Research Symposium
Background: Accumulating studies have shown strong correlation of HCC and co-morbidity factors including smoking. Tobacco smoke contains benzo[a]pyrene, which is extremely carcinogenic and contributes to liver damage. Cucurbitacin, a triterpene, has a wide range of biological activities, including antioxidant, anti-inflammatory, and anti-cancer properties. However, their hepatoprotective effects remain poorly understood. In the current study, we examined the hepatoprotective activity of cucurbitacin D, a novel analog of cucurbitacin, against benzo[a]pyrene-induced liver injury in human HepG2 cells.
Method: To investigate the hepatoprotective effect of cucurbitacin D against benzo[a]pyrene-induced liver damage, proliferation, clonogenicity, migration, invasion, Western blotting, and qPCR analyses were performed. …
Differential Expression Of Irbp By Cultured Rod And Cone Cells In Hypoxia And Hyperglycemia, Arianna Rodriguez, Elias Martinez, Laura Valdez, Kevin Abraham, Federico Gonzalez-Fernandez, Andrew Tsin
Differential Expression Of Irbp By Cultured Rod And Cone Cells In Hypoxia And Hyperglycemia, Arianna Rodriguez, Elias Martinez, Laura Valdez, Kevin Abraham, Federico Gonzalez-Fernandez, Andrew Tsin
Research Symposium
Background: Interphotoreceptor-Retinoid-Binding-Protein (IRBP, RBP3) is a 124 kDa glycolipoprotein secreted by rods and cones. IRBP traffics and protects visual cycle retinoid and has significant free radical scavenging activity. Its expression is reduced in early stages of diabetes. Interestingly, an increased level of IRBP is protective against diabetic retinopathy (DR). We reported that that hypoxia increases VEGF expression by 661W cone photoreceptors in culture, suggesting a role of photoreceptors in proliferative DR (PDR) (Rodriguez et al, Arch Clin Exp. Ophthal 3:23,2021). Here, we compare hypoxia and VEGF on IRBP expression between rods and cones in high and low glucose.
Methods: Y79 …
Development Of An Experiential Learning Lab Activity On Skeletal Muscle Physiology In Undergraduate Md Pre-Clerkship Curriculum, Angela Martinez, Daniel Salinas, Kelsey Potter-Baker, Amin Shah
Development Of An Experiential Learning Lab Activity On Skeletal Muscle Physiology In Undergraduate Md Pre-Clerkship Curriculum, Angela Martinez, Daniel Salinas, Kelsey Potter-Baker, Amin Shah
Research Symposium
Background: Experiential learning is an important part of the medical education curriculum. Our goal was to establish an experiential learning skeletal muscle physiology lab activity that would improve undergraduate MD pre-clerkship students’ skill to collect muscle force measurements using a hand-held dynamometer (HHD) and understanding of core physiological concepts.
Methods: The authors developed and incorporated lab activity in the Musculoskeletal and Dermatology (MSKD) Module in the undergraduate MD pre-clerkship year 2 curriculum. Before lab sessions, students reviewed the HHD guide, watched videos on how to use a HHD to measure the force, and reviewed the Arm Angle strength data sheet. …
Cellular And Molecular Mechanisms Of Neurodegeneration In Early-Stage Diabetic Retinopathy, Andrew Callan, Sonal V. Jha, Laura Valdez, Andrew Tsin
Cellular And Molecular Mechanisms Of Neurodegeneration In Early-Stage Diabetic Retinopathy, Andrew Callan, Sonal V. Jha, Laura Valdez, Andrew Tsin
Research Symposium
Background: Diabetic retinopathy (DR) remains the leading cause of blindness in working age Americans. There has yet to be any effective treatment to prevent the onset of the condition, only to treat late-stage disease. Research on early signs of disease have shown that changes in neural layers of the retina are the earliest signs of disease, preceding the vascular changes that currently define DR. This has sparked interest in the pathogenesis of the neurodegeneration involved in DR. This review explains the current understanding of the cellular and molecular mechanisms of neuronal degeneration in DR, as well as the potential pharmacological …
Enhancing The Tribological Performance Of Prosthetic Implants: An Investigation Of Cnc Surface Micro-Texturing On Uhmwpe, Javier Ortega, J. Perez, N. Perez
Enhancing The Tribological Performance Of Prosthetic Implants: An Investigation Of Cnc Surface Micro-Texturing On Uhmwpe, Javier Ortega, J. Perez, N. Perez
Research Symposium
Background: Annually, there are over a million joint replacement procedures and more than 250,000 revision surgeries in the United States. The typical lifespan of a joint replacement ranges from 7 to 15 years, often curtailed by complications such as excessive implant wear leading to infections and joint dislocations. Given that most joint replacement recipients are between the ages of 50 and 70, the later part of their lives is often marred by repeated surgeries and discomfort. Presently, the predominant material used in joint replacements is medical-grade Ultra-High Molecular Weight Polyethylene (UHMWPE) with smooth surfaces. While these smooth surfaces are believed …
Primary Care Behavioral Health Partnerships Advancing & Transforming Health Sciences (Pcbh Paths), Kristan Diaz-Rios, Deepu George, Salvador Arellano Iii, Maria Hernandez, Myrna Ruiz
Primary Care Behavioral Health Partnerships Advancing & Transforming Health Sciences (Pcbh Paths), Kristan Diaz-Rios, Deepu George, Salvador Arellano Iii, Maria Hernandez, Myrna Ruiz
Research Symposium
Purpose: Primary Care Behavioral Health Partnerships Advancing & Transforming Health Sciences (PCBH PATHS) is a workforce development pipeline project aimed at permanently augmenting UTRGV’s institutional capacity to address shortage of an Integrated Behavioral Health (IBH) competent workforce locally, regionally and nationally. Our initiative, aligned with UTRGV strategic priorities and key initiatives, will integrate basic(model specific strategy and operational elements), mid-level (role identity and profession specific behavioral competencies specific to each health profession), and advanced (behavioral medicine clinical skills) applications of the evidence based PCBH model of delivery. A PCBH focused delivery system (clinical and educational), in which primary care providers …