Medicine and Health Sciences Commons^™

Role Of Mumio In Periodontal Wound Healing–An In Vitro Study On Human Pdl Cells, Jagadish Hosmani, Abdullah Alqarni, Abdullah Alqahtani, Nasser Alhamid

Annual Research Symposium

Mumio, used in ancient medicine for almost 4000 years, is the gold standard of traditional medicine. Mumio, a tar-like compound made from rock dissolved minerals and degraded organic matter, takes a century to form. Dibenzo-alpha-pyrones, humic acid, and fulvic acid are important in Mumio, which includes 60–80% humus, benzoic acid, fatty acids, ichthyol, ellagic acid, resin, triterpenes, sterol, aromatic carboxylic acids, bioactive 3,4-benzokoumarins, amino acids, phenol Active chemicals improve Mumio's antioxidant effects. Despite its anti-ulcerogenic, anti-inflammatory, antioxidant, immunomodulatory, memory-enhancing, and anxiolytic characteristics, mumio has been studied rarely on oral tissues. The present study examined the cytotoxic, antioxidant, anti-inflammatory, and reparative …

Efficacy Of Concentrated Growth Factor Membrane Versus Collagen Membrane In Treating Gingival Recession, Shazneen Kandawalla

Annual Research Symposium

Creating a beautiful smile has always been a cornerstone of dental practice. Gingival recession, characterized by a downward shift of the gum line, causing uneven gum margins and an unattractive appearance.

The Vestibular Incision Subperiosteal Tunnel Access (VISTA) technique, introduced by Zadeh in 2011, offers an innovative solution for root coverage. Concentrated Growth Factor Membrane (CGF) further enhances dental repair.

Spatial Analysis Of Maxillary Central Incisors In Relation To The Nasopalatine Canal And Surrounding Alveolar Bone, Harnoor Dhillon

Annual Research Symposium

The use of mini-implants in orthodontics has enabled greater retraction of incisors than previously achievable. This change underscores the need to understand how incisors relate to the alveolar bone and nasopalatine canal. The varying labiolingual inclination of incisors during orthodontic treatments may influence these anatomical relationships. Our study aimed to assess the spatial relationship between maxillary central incisors and the surrounding alveolar bone and nasopalatine canal.

Interplay Of Periodontal Bacterial Metabolites In The Progression Of Coronary Artery Disease: A System Biological Approach, Janakiraman V

Annual Research Symposium

Purpose:

The purpose of this study is to investigate the intricate relationship between periodontal disease (PD) and coronary artery disease (CAD), as evidenced by epidemiological associations. Metalloproteinase inhibitor (TIMP1) plays a pivotal role in cellular signaling, differentiation, cell death, and migration by binding to target metalloproteinases, forming complexes with other molecules (collagenases) to inactivate them. However, the expression of TIMP1 is reduced in both PD and CAD, leading to an upregulation of other metalloproteinases. This research explores the hypothesis that metabolites released from (Porphyromonas gingivalis), a prevalent bacterium in atherosclerotic patients, may inhibit TIMP1, thereby influencing CAD progression. …

Implementation Of Best Practice When Collecting Blood Cultures In The Emergency Department (Ed), Parker Grossman

Annual Research Symposium

The purpose of this study is to compare blood culture contamination rates in the ED before and after educational in-services on best practice.

Overlooked Dental Disease In Cbct Imaging And The Impact Of Oral Radiologist Interpretation, Jared Fausnaught

Annual Research Symposium

This study aims to underscore the necessity for a comprehensive interpretation of Cone Beam Computed Tomography (CBCT) volume images obtained by dentists. The research demonstrates and quantifies potentially overlooked dental pathology, categorizing incidental findings into three groups: 1) requiring some form of treatment or follow-up, 2) necessitating follow-up (monitoring) only, and 3) demanding no further treatment or follow-up.

Photodynamic Therapy Effects In The Treatment Of Residual Periodontal Pockets, Kade Janes

Annual Research Symposium

This systematic review examined the adjunctive effect of photodynamic therapy to treat residual pockets.

Sulforaphane Pre-Treatment Improves Cytoprotection Against Opportunistic Pathogens, Robert Darby, Nathan Clark

Annual Research Symposium

Alcohol is associated with increased mortality and morbidity globally. Pulmonary infections with opportunistic pathogens can occur in healthy humans; however, binge alcohol intoxication (≥ 0.08% BAC) is a major risk factor. We have previously shown that a single dose of alcohol comparable to binge alcohol intoxication increases infection by reducing alveolar macrophage function in vivo. The aim of this study was to 1) test the therapeutic potential of the phytonutrient sulforaphane (SFN) given as a pre-treatment, and 2) test the alcohol-induced effects on phagocytic function in murine and human macrophages in vitro.

Impact Of Non-Surgical Periodontal Treatment On Salivary Hif-1Α In Gingivitis & Periodontitis Patients, Srijanani S

Annual Research Symposium

To estimate and compare the level of salivary HIF-1α in periodontally & systemically healthy volunteers, generalized chronic gingivitis & periodontitis patients before and after non-surgical periodontal treatment.

Exploring The Resilience Of Two Commercial Suturing Materials Subjected To Thermocycling And Chlorhexidine Immersion: An In Vitro Study, Devadharshini Chandrasekar

Annual Research Symposium

To evaluate the durability of two commercially available suture materials (non absorbable Black Braided Silk and absorbable polyglactin 910) subjected to thermocycling after immersing in Chlorhexidine mouthwash.

Euglycemic Diabetic Ketoacidosis Secondary To Sodium Glucose 2 Transport Inhibitor: A Case Report, Alexis Duevel, Edward Ramirez

Annual Research Symposium

The purpose of this case report is to highlight the emergence of a rare adverse drug reaction (ADR), euglycemic diabetic ketoacidosis (EDKA), associated with the use of sodium glucose transport 2 (SGLT2) inhibitors.EDKA is a rare and often misdiagnosed condition, due to the absence of hyperglycemia, but represents a life-threatening emergency. We present a unique case of a 35-year-old female patient with a past medical history of diabetes and recent diagnosis of Hashimoto’s thyroiditis. The primary objective is to provide valuable insights and education to the medical community regarding this infrequent yet significant complication. Ultimately, the goal is to enhance …

Impact Of Smoking And Drinking Habits On Lipid Profiles In Diabetic And Non-Diabetic Individuals & Their Oral Implications, Dinraj Kulkarni

Annual Research Symposium

The rising prevalence of lifestyle-related diseases, notably diabetes mellitus and cardiovascular diseases (CVD), underscores the importance of investigating modifiable risk factors such as smoking and alcohol consumption. These habits are known to influence lipid profiles, crucial indicators of cardiovascular health. Main aim of this study To investigate & evaluate the effect of smoking and drinking habits on lipid profiles of diabetic and non-diabetic individuals and their oral implications.

Detection And Relative Quantitation Of Changes In Gene Expression Of Hippo Proteins In Doxorubicin-Exposed Human Cells By Rt-Qpcr, Lillian Fleisher, Tricia Domingo, Christopher So, Stephen Lee

Annual Research Symposium

The HIPPO signaling pathway plays a key role in cell proliferation and tumor suppression. It consists of serine/threonine kinase cascades, including MST1/2, LATS1/2, YAP, and TAZ. When the HIPPO pathway is activated, gene expression is altered. Dysfunction of the activity of this cascade may contribute to cancer development and chemoresistance. FAT4 is an intracellular protein that may regulate the HIPPO signaling. The purpose of this study is to determine the relative changes of mRNA of the HIPPO pathway members and FAT4 in doxorubicin-treated and vehicle-treated in vitro cell lines.

Dentofacial Effects Of Radiotherapy On Pediatric Population With Retinoblastoma, Kristi Truong

Annual Research Symposium

This literature review investigates the dentofacial consequences of radiotherapy in young patients with retinoblastoma by referencing current research. In addition, the management and rehabilitation of the dentofacial abnormalities, highlighting orthodontic, surgical, and prosthetic approaches, is examined. By understanding the changes of dentofacial development due to retinoblastoma treatment, effective management techniques can be implemented to resolve significant issues, relating to dental and skeletal relationship and facial appearance.

Referral Patterns Of Neonatal Healthcare Professionals For Cleft Lip And Palate Patients, Alyssa Morrow

Annual Research Symposium

Cleft Lip and Palate patients are some of the most vulnerable and complex orthodontic patients. They face a myriad of health challenges including psychological, nutritional, auditory, speech, airway, skeletal, and dental. Ideal comprehensive treatment for CLP patients is provided via multidisciplinary teams of healthcare providers. However, there is currently limited access to proper multidisciplinary care for CLP patients in the US, partly due to lack of education regarding available resources. For the most effective treatment and optimal outcomes, it is essential that coordinated care starts at birth and that parental education begins as soon as CLP is detected in utero. …

Quantifying Community-Based Pharmacy Student Operational And Clinical Rotation (Ippe) Activities., Kenneth Kunke, Phillip Lawrence, C. Leiana Oswald, Erin Johanson, Michelle Hon

Annual Research Symposium

The purpose of this study is to identify and describe trends in the quantity and proportion of operational and clinical activities performed by students on introductory (IPPE) rotations.

Multimode Point Spectroscopy For Food Authentication, Sayed Asaduzzaman, Nicholas Mackinnon, Hossein Kashani Zadeh

SDSU Data Science Symposium

Enhancing food quality measurement is a necessity to guarantee food safety and adherence to health regulations. Current methods involve lab testing which are time-consuming, costly, destructive and require skilled workers. Spectroscopy has the potential to overcome these challenges. This study employs a multi-mode point spectroscopy method to distinguish food products according to their spectral characteristics,. The system records fluorescence, excited at 365 and 405 nm, visible-near infrared (Vis-NIR) and short-wave infrared (SWIR) spectra. The three main subjects of the study are olive oil, milk, and honey. Samples were kept in a transparent cell culture pot, and Gray and White Spectralon …

Comparing The Trends Of Postpartum Depression Screening Scores During And Before The Covid-19 Pandemic, Elif S. Duran, Dung Dang, Tony Ogburn

Research Colloquium

Introduction: Postpartum depression includes major and minor depressive disorder affecting women in the time period after childbirth. The studies reviewed in our literature found that the COVID-19 pandemic has increased the risk of postpartum depression for women. Our study location, the Rio Grande Valley is one of the hardest hit locations by the COVID-19 pandemic in the United States. Our patient population is also one with the higher risk factors for postpartum depression. As such, we are expecting the psychological impact of the pandemic to be even more magnified and thus, actions need to be taken to support the vulnerable …

3rd Annual Hu Research Symposium Program 2021, Akeisha Belgrave, Erica Ward, Rebekah Harriger

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

3rd Annual HU Research Symposium program and schedule of presenters. Presentations were held April 21st, 2021 virtually on the Teams platform.

2018 2nd Place: Identifying The Effectiveness Of Plant Extracts For Treating Biofilms Of Escherichia Coli And Myxococcus Xanthus, Micah Burton

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

Antibiotic resistance is a topic that is of growing concern in the field of medicine. Antibiotics act as growth blockers or act as toxins, killing the organism they affect. These biological weapons generate selective pressure leading to the current antibiotic crisis. This selective pressure causes resistant organisms to begin to emerge and over generations antibiotic resistance can develop and be spread among a bacterial population.

One of the key factors contributing to antibiotic resistance in bacteria is the ability for some bacteria to form and shield themselves within biofilms. Biofilms are masses of bacteria protected by a polysaccharide/ extracellular DNA …

Identification Of Predictive Gene Signatures And Molecular Interactions Underlying Opioid Use Disorder In Brain Tissues And Peripheral Blood, Kashish Kumar

Research Symposium

Background: Opioid use disorder (OUD) is a chronic and relapsing condition influenced by genetic and environmental factors. OUD is associated with altered gene expression and epigenetic modifications in BA9 and the greater prefrontal cortex affecting regional function and connectivity. OUD may also involve the downregulation of genes related to synaptic transmission and neurogenesis in the amygdala, impairing its adaptability. In addition to the brain, peripheral blood can serve as a source of molecular markers for OUD as it is easily accessible and may reflect systemic and chronic inflammation changes prompted by OUD. Understanding the molecular mechanisms dysregulated by OUD may …

In-Silico Approach For Identifying Metabolic Proteins And Their Pathways Involved In Neurodegenerative Disorders Rna-Seq Data, Asmita Bharti, Parvesh Bubber

Research Symposium

Background: Neurodegeneration is a pathological condition where progressive loss of neuronal cells occurs in the brain. Neurodegenerative disorders have become more prevalent and by 2050, it is predicted that they will be the primary cause of ageing worldwide. Globally, the prevalence of neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD) has been increasing tremendously. It has been identified that various proteins, such as APP, Tau, -synuclein, and TAR DNA-binding protein 43, are some of the main causative factors of dementia in older patients. Several studies have supported the idea that in-silico analyses using high-throughput RNA-seq data are …

Performance Of Color Plates For M. Tuberculosis Detection And Drug Resistance Screening In Mexican Tb Clinics Across The Texas Border, Sean Monday, Doris Ayala, Genesis P. Aguillón-Durán, America Cruz-Garcia, Alyssa Schami, Amberlee Hicks, Juan Ignacio Garcia, Jordi B. Torrelles, Blanca I. Restrepo

Research Symposium

Purpose: Populations along the U.S.-Mexico border have a high prevalence of risk factors for TB such as low socioeconomic status, overcrowding and migration, and consequently, higher TB incidence (up to 12 and 44/100,000) when compared to their corresponding national averages in each country. TB control in border regions is further challenged by limited access to cost-effective tests to diagnose TB and assess drug resistance (DR). We evaluated the performance of a novel, simple and low-cost culture plate technology for isolation and DR testing of Mtb in TB clinics on the Mexican border with Texas.

Methods: We conducted an observational study …

Skin Conditions And Villainous Depictions In Anime Films: Exploring Unconscious Bias In Patient-Provider Interactions, Patricia Guzman

Research Symposium

Background: Film and artistic media have the ability to influence societal perception of dermatological conditions. Literature describes how both live-action and animated films tend to depict villainous characters with a disproportionately greater number of skin conditions, thus contributing to the stigma surrounding skin conditions and their association with moral deficiency. However, the majority of literature tends to examine films of cultural, historic, and aesthetic significance in Western canon. This study seeks to include perspectives from East Asian cinema by evaluating dermatological findings of heroes and villains in popular anime films and assessing whether an increased number of skin conditions …

The Effects Of Partner Support On Breastfeeding In Underserved Nicu Latina Mothers Living Along The Us-Mexico Border, Mia Honrubia, Kassandra Garcia, Andrea P. Almaguer-Botero

Research Symposium

Introduction: Mothers of very low birthweight infants undergo many obstacles initiating, and then continuing breastfeeding. The AAP (2022) recommends exclusive breastfeeding for the first 6 months of life. A Level III NICU along the US-Mexico border, cares for over 140 VLBW infants per year. Hidalgo County is an underserved-underrepresented Latino community. 97% of our mothers live near or at the poverty level. Mothers who are newly emigrated from Mexico are often disenfranchised from our medical community and proper health care (Galvan et al. 2021). The incidence of maternal anxiety and depression in the NICU maternal population is high, adding stress …

Driscoll Children's Heart Center (Dchc): Pediatric Cardiothoracic Surgical Outcomes In Previously Underserved, Underrepresented Latino Patients Living In The Rio Grande Valley (Rgv), Kassandra Garcia, Mia Honrubia, Vincent Honrubia, Stephen M. Langley

Research Symposium

Introduction: Children are born every year with heart conditions that can range in levels of severity and differ in impact to quality of life. The Driscoll Children’s Heart Center (DCHC) comprehensively cares for children with heart conditions beginning with in utero care and follow-up through adulthood. DCHC manages all different types of Cardiac Defects including Hypoplastic Left heart Syndrome, Valve Dysfunction, Single Ventricle heart disease, transposition of the great arteries, atrioventricular septal defects and tetralogy of Fallot.

The DCHC quality data: low mortality and complication rates, and short length of stay (LOS) are cornerstones to driving quality improvement. The RGV, …

Safety And Feasibility Of Oral Pharyngeal Human Milk Therapy In Latino Vlbw Babies In A Large Level Iii Neonatal Intensive Care Unit Along The Us- Mexico Border, Kassandra Garcia, Mia Honrubia, Belen Martinez, Dynio Honrubia

Research Symposium

Introduction: The Doctors Hospital at Renaissance-Neonatal Intensive Care Unit (DHR-NICU) in Edinburg, is a large Level III/IV Regional NICU, admitting 140 Very Low Birth Weight (VLBW) babies per year. The population is 99% Latino, historically underserved and underrepresented; the unit is located 10 miles from the US- Mexico Border.

Background: Very Low Birth Weight (VLBW) infants are born too immaturely to feed human milk. In utero, the fetus continuously swallows amniotic fluid which provides growth stimulus and immune protective components. Human milk can provides essential antimicrobial agents and immune protective components to infants born prematurely, reducing the risk of major …

Prevalence Of Alternative Treatments In Patients In The Oncology Area In Northeastern Mexico, Hadassa Y. Martínez-Padrón, Hernán Uziel Vargas-Ruiz, Domingo Vargas-Gonzalez, Araní Casillas-Ramírez, J M. Guerrero-Nava

Research Symposium

Background: The treatment against cancer depends of the type of cancer and the stadium that is found, the treatment consist in the application of one or various methods, according to the American Institute for Cancer Research, the principals methods used are the following: surgery, radiotherapy, chemotherapy, immunotherapy, driven therapy, hormonal therapy, mother cells transplant, biomarker test, etc. Mexico has more than 4500 medicinal plants, and only 11% of those plants had chemical, pharmacological and biomedical efficacy. For the above, in the country stands out the use of herbalist treatment for different types of cancer, however, the published articles in this …

Prevalence Of Anxiety And Depression In Young People From Northern Tamaulipas, In The Context Of The Covid-19 Pandemic, Teresa Velázquez-Loredo

Research Symposium

Background: From the beginning of the confinement due to the Covid-19 pandemic, the prevalence of depression was >22%, while ENSANUT 2018 survey reported a prevalence of 13.6%. The pandemic had an adverse impact on young people, affecting employment, their professional future, education, training and, therefore, their mental well-being. Early studies show that young people have higher levels of anxiety and depression than adults and older adults.

Methods: We evaluated the impact of the COVID-19 pandemic on the mental health of students from the upper secondary and higher education levels of northern Tamaulipas, Mexico, measuring the prevalence of anxiety and depression …

Risk Factors For Arterial Hypertension In High School Students From Miguel Aleman And Gustavo Díaz Ordaz, Tamaulipas, Mexico, Teresa Velázquez-Loredo, Netzahualcoyotl Mayek-Pérez

Research Symposium

Background: Although arterial hypertension (AHT) in adolescents is not an important cause of morbidity and mortality, it is a public health problem that is rapidly increasing in Mexico, due to changes in lifestyle and diet that generate overweight and obesity in the population and will later impact significantly in adulthood. The earlier AHT develops the risk of acute myocardial infarctions, cerebrovascular accidents; then disabilities should be increased. These conditions have repercussions at social and economic levels.

Methods: Observational, descriptive, and cross-sectional study in students of the CBTIS 220 of Gustavo Díaz Ordaz (N = 423; women = 190, men = …