Medicine and Health Sciences Commons^™

Relationship Among Cognitive Performance, Physical Activity (Pa), Demographic, And Individual Lifestyle Characteristics Among Aging Hispanic Population, Ulku Karabulut, Bryan Mixumi, Imtiaz Masfique Dowllah, Murat Karabulut

Research Symposium

Purpose: To investigate the association among different intensity and duration of physical activity (PA), cognitive domains (executive function, processing speed, and memory), and demographic and lifestyle characteristics of aging Hispanic population. PA has been identified as a promising non-pharmaceutical preventative intervention for Alzheimer disease and other dementias. This study aims to provide a better understanding of the effects of different intensities of PA on cognitive performances of aging Hispanic population.

Methods: For this study, 441 Hispanic (age ≥60) participants’ data from NHANES (20112014) were analyzed. The protocol was approved by the NCHS Research Ethics Review Board, and all data …

Proteomic Analysis Of Stress Associated Factor Overexpression In Hepatocellular Carcinoma, Mohammad Shabir Hussain, Sophia Leslie, Amayrani Sanchez, Samantha Lopez, Kyle Doxtater, Manish Kumar Tripathi

Research Symposium

Background: Hepatocellular carcinoma (HCC) constitutes a substantial portion, accounting for 85% to 90% of liver cancers worldwide. Notably, within the Hispanic population, liver cancer mortality rates are notably higher, particularly evident in regions like the South Texas Rio Grande Valley (RGV), where nearly 90% of the populace is Latino/Hispanic. This region grapples with poverty affecting nearly 30% of its residents, coupled with elevated rates of obesity, diabetes, and low-income households, thereby fostering a prevalent environment of stress. Stress can profoundly impact cancer outcomes by compromising immune functionality and triggering inflammatory responses, potentially impairing surveillance against oncogenic triggers. The activation of …

Reactive Oxygen Species In Acute Coronary Syndrome, Fernando Cisneros, Alex Zuo

Research Symposium

Reactive oxygen species (ROS) are formed in metabolism, cellular signaling, immune response, antimicrobial defense, and detoxification. Oxidative damage through overproduction of ROS or dysregulation of ROS regulation may result in oxidative stress associated with DNA damage, protein damage, mitochondrial dysfunction, and lipid peroxidation. Additionally, the accumulation of dysfunction of cellular components may manifest as diseases that contribute to the predisposition of acute coronary syndrome (ACS). This poster meticulously explores the significance of ROS in various cardiovascular stressors, including hypertension, thrombogenesis, vascular remodeling, lipid peroxidation, cellular proliferation, atherogenesis, and vasoconstriction. These stressors collectively contribute to ACS associated with ischemia. Furthermore, autophagic …

Piperlongumine Nanoformulation Attenuates Pancreatic Tumor Desmoplasia And Alter Tumor Immune Responses, Vivek Kumar Kashyap, Neeraj Chauhan, Mohammed Sikander, Eswara N. H. K. Ghali, Bilal Hafeez, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan

Research Symposium

Pancreatic cancer (PanCa) is characterized by lack of early diagnosis, poor response to available therapeutic modalities and chemoresistance. Gemcitabine (GEM) is currently considered the most effective therapy for PanCa; however, it shows only a marginal survival benefit of 6 months. This poor drug response has been attributed to desmoplasia, causes suboptimal drug delivery, alters tumor microenvironment (TME), which includes tumor surrounding blood vessels, fibroblasts, immune cells, extracellular matrix, and other signaling molecules and induces chemo-resistance in tumors. To overcome these existing issues associated with chemotherapy, identification and development of novel therapeutic modalities are a pressing need. Piperlongumine (PL) is a …

Oxidative Stress, A Culprit In Cardiovascular Diseases And Resveratrol As A Potential Therapeutic Agent, Alyssa Sepulveda, Justin Z. Heckman, Grace Ochoa, Amin Shah

Research Symposium

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Oxidative Stress (OS) is one of the pathophysiological mechanisms of CVDs such as hypertension, atherosclerosis, myocardial infarction (MI), ischemia reperfusion (I/R) injury, and heart failure. Resveratrol, a natural polyphenol compound has cardioprotective effects acting via several molecular mechanisms including reduction of OS in cardiovascular system. Our goal was to provide an updated overview of the pathophysiological role of OS in CVDs. Furthermore, we explored the cardiovascular effect of resveratrol and its mechanism of actions involved, especially focusing on its role as an antioxidant molecule in CVDs.

Methods: We searched …

Oral Administration Of Ph-Responsive Polymeric Nanoparticles Based On Zein And Their Therapeutic Potential On Cancer., Bruno Alejandro Valades-Aguilar, José Raúl Rangel-López, Jennifer Citlally Leos-Rivera, Moisés Armides Franco-Molina, María Cristina Rodríguez-Padilla, Diana Ginette Zárate-Triviño

Research Symposium

Background: Zein is a water-insoluble protein extracted from the endosperm of corn seeds, this polymer is an attractive matrix to encapsulate hydrophilic compounds because of its high proportion of hydrophobic amino acids, making it a potential smart delivery material for several treatments in the biopharmaceutical industry. nanoparticles have been used as drug delivery systems for the improvement of oral bioavailability; however, the strategies of nanoparticle obtention need the addition of stabilizers. in this study, a modified method to obtain zein nanoparticles was developed.

Methods: Zein nanoparticles (ZNps) were made by a thermal treatment and precipitated into ovalbumin at a ratio …

Optimization Of Gait Analysis System For Clinical Applications, Gerardo Medellin, Katherine S. Bolado, Daniel Salinas, Kelsey Potter-Baker

Research Symposium

Background: Adequate gait function is pivotal for many activities of daily living and high quality of life. Following many neurodegenerative diseases, such as Parkinson’s Disease, gait abnormalities can manifest and range from reduced stride length, inability to turn, foot drop or shuffling. To track and monitor such changes in gait, gait analysis techniques are gaining clinical popularity and have the ability to gather a range of data in a short duration. Gait analysis techniques go beyond simple visual observation and include instrumental gait analysis and weight distribution of the gait cycle. Here, we sought to optimize the gait analysis …

Nursing Education And The Emerging Artificial Intelligence, Somi Nagaraj, Nancy J. Macmullen

Faculty Research Events

The emerging artificial intelligence (AI) is transforming patient care across all domains of nursing practice, including administration, clinical care, education, policy, and research. Nursing researchers are exploring the potential influences of AI health technologies (AIHTs) on nursing in general and on nursing education more specifically. ChatGPT, a trending Artificial Intelligence (AI) tool developed by Open AI. The impact of ChatGPT on the nursing education is profound. The technological evolution in healthcare is advancing. The complexity of curricular revision can create challenges in the face of rapid practice change.

This PowerPoint presentation explains the meaning of Artificial Intelligence (AI), the history …

Desolation, Kiara Adelina Hernandez Padron

UNO Student Research and Creative Activity Fair

Desolation was made in mind with my late aunt's mental illness, schizophrenia. Though I don't know what it's like having it, listening to her in the past and others about her hardships made me think about her mindset constantly throughout her whole life. This sculpture was made by digitally mapping out the composition, cutting out individual pieces of wood with each layer representing the depth of the many heads of emptiness.

Knyaw/Karen Womanhood, Generational Healing And The Interplay Of Faith, Genocide, Gender Roles, And Education In The Face Of Health Diagnosis, Moo Law Eh Soe

UNO Student Research and Creative Activity Fair

During the fall semester of 2023, my honors project aimed to provide representation and shed light on the challenges Knyaw/Karen women encounter as part of their womanhood in traditional and Western communities. The issues are emphasized when these women receive life-altering health diagnosis that not only alters their identities but also requires them to step beyond the invisible parameters of what it means to be a Knyaw/Karen woman. It's worth noting that all the women I interviewed were immigrants from the Thai-Burma Border refugee Camps where Indigenous Knyaw people have been facing at least 70 years of genocide. The project …

Optimization Of Baseline Values For The Bionik Inmotion Arm/Hand Rehabilitation Robot, Marysol Cabello, Diego Rojano, Daniel Salinas, Ramiro Oquita, Victoria Cuello, Kelsey Potter-Baker

Research Symposium

Background: Clinical studies utilizing the Bionik InMotion Arm/Hand robot are increasing in recent years. However, there is a lack of standardized values from healthy participants that can be used to compare to patients with stroke or other neurodegenerative disorders. We aim to create this standardized set of values by employing the new Bionik InMotion Arm/Hand robot on healthy participants. Establishing normative values will allow our lab, and other laboratories, to have a baseline that can be used to track rehabilitation progress in patients with neurological disorders, such as stroke. Creating this standardization may also allow for more tailored rehabilitative approaches …

Ongoing Study Of The Association Of Apoe Gene Polymorphisms With Cognitive Impairment In The Rio Grande Valley Hispanic Population, Jaime Miguel L. Saveron, Daniela Gamez, Chun Xu

Research Symposium

Background: Alzheimer's disease (AD), a prevalent neurodegenerative disorder, exhibits a significant genetic component. In addition, mild cognitive impairment (MCI) is a key risk factor for AD. While certain demographic factors and genetic variants associated with AD and cognitive impairment have been identified in non-Hispanic populations, limited research exists on this subject within the Hispanic population, particularly in the Rio Grande Valley. This study aims to investigate the relationship between the APOE gene, specifically its ε4 allele, and cognitive impairment in the Hispanic population of the Rio Grande Valley.

Methods: A total of 269 Hispanic subjects, aged 60 and above, with …

Novel Strategy To Make Kras Targeted Therapies More Effective For Pdac Treatment, Ana I. Martinez Bulnes, Melissa Elizondo, Orlando Garcia, Poornima Devi Shaji, Swathi Holla, Nirnoy Dan, Anupam Dhasmana, Swati Dhasmana, Shabnam Malik, Murali Yallapu, Stephen Behrman, Subhash Chauhan, Sheema Khan

Research Symposium

Introduction: Pancreatic Ductal Adenocarcinoma (PDAC) patients exhibit extremely poor prognosis. KRAS mutation on codon-12 is present in 70–95% of PDAC cases and it drives PDAC growth and progression. Galectin-1 (Gal-1) is present in both PDAC and stromal cells, being involved in tumor microenvironment, immune cell activation and metastasis. Therefore, this study discusses the efficiency of combined inhibition of mutated KRASG12D and Gal-1 inhibition to effectively suppress PDAC growth and progression. For this we have delivered KRASG12D inhibiting siRNA (siKRASG12D) using a superparamagnetic iron oxide nanoparticle (SPION) and a galectin inhibitor.

Methods: SPION nano-formulation was used to deliver siKRASG12D and investigate …

Newly Diagnosed Ulcerative Colitis In A Young Hispanic Mexican Female At South Texas: A Case Report, Elimar Gonzalez Morales, Jose Gomez Casanovas, Shreel Patel, Khairiya Haj-Yahya

Research Symposium

Introduction: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by recurring episodes of inflammation limited to the mucosal layer of the colon. Traditionally, this disease has been associated mostly with white Americans, however in recent years, an increase incidence has been reported in minorities in the US and around the world. In Hispanic population, cases are frequently underdiagnosed, and literature is scarse. In this case, we present a young patient without past medical history who presented with what appeared to be an infectious gastroenteritis and found to have a severe UC.

Case Presentation: A 22-year old Hispanic …

Nebulization Based Inhalation Nanomedicine For Lung Cancer Treatments, Rahul Tiwari, Meghana Kolli, Neeraj Chauhan, Eswara Naga Hanuma, Vivek Kashyap, Subhash Chauhan, Murali Yallapu

Research Symposium

Background: Lung cancer is reported to have a high incidence rate and first leading cause of cancer-related morbidity and mortality across the world including in the United States. Noninvasive nebulized inhalation is a promising delivery strategy for lung, which can enhance the targeting efficiency and detention time interval of nanoparticles in the lung tissue, thus elevating the therapeutic index of therapeutic agent(s) at lower dosages. The aim of this study is to develop inhalable nanoparticles (INPs) for effective delivery of therapeutic agents in lung cancer cell lines and ex vivo models.

Methods: The inhalation nanoparticles (INPs) were prepared by solvent …

Modern Neurosurgical Techniques For Surgical Excision Of Neoplasms, Kevin A. Garcia Valdez, Sonya Bhatia, Natasha Bell, Anesu Karen Murambadoro, Victoria Elizondo, Fernando Cisneros, Kory Punch, Alan N. Francis

Research Symposium

Background: Neurosurgical excision of brain tumors is still regarded as the first line treatment for multiple neoplasms, including meningiomas, gliomas, and metastatic tumors. Advances in technology have allowed neurosurgeons to utilize various approaches that significantly reduce mortality and surgical morbidity. However, the high risk of neurological deficit and tumor recurrence remains. Here, we analyze three neurosurgical approaches: craniotomy, microsurgery with tubular retraction, and tumor ablation. While craniotomy remains as the first line treatment for most brain tumors, we hypothesize that microsurgery and ablation will show greater success of tumor removal with fewer complications.

Methods: Published literature was reviewed from PubMed …

Deficient Dietary Folic Acid And Systemic Dsp-4 Induced Locus Coeruleus Loss Assessed As Neurodegenerative Cognitive Model In Adult Cb57/J6 Mice, Gabriel Kong, Aristotle Zeng, Theo Helm, Simon Khorani, Rohan Rampal, Smayana Kurapati, Riva Ranier, Aidan Schmidt, Maximilian Doane, David B. Green Phd, Susan E. Helm Phd

Seaver College Research And Scholarly Achievement Symposium

DEFICIENT DIETARY FOLIC ACID AND SYSTEMIC DSP-4 INDUCED LOCUS COERULEUS LOSS ASSESSED AS NEURODEGENERATIVE COGNITIVE MODEL IN ADULT CB57/J6 MICE Gabriel Kong, C. Foster Graf, Aristotle Zeng, Theodore Helm, Simon Khorani, Rohan Rample, Smayana Kurapati, Riva Rainier, Aidan Schmidt, Maximilian Doane, David B. Green, and Susan E. Helm Chemistry and Nutritional Science, Pepperdine University, Malibu, California

Dietary deficiency of folic acid (FA) shortened nerve lengths as much as 50% in hippocampal dentate gyrus (DG). Locus coeruleus (LC) is largest noradrenergic nucleus in central nervous system with neurogenic projections widely dispersed in the brain and, notably, a major norepinephrine source in …

Exploring The Impact Of Trusted Patient-Physician Relationship And Effective Health Communication On Patient Empowerment, Mingming Song

UNO Student Research and Creative Activity Fair

Abstract

Empowered patients actively participate in their healthcare decision making, clearly understanding their health conditions, and effectively managing their health care plan. Traditionally, health education has served as the primary method for educating and empowering patients within the healthcare services model, including the care provided by physicians....

Effect Of Three-Month Use Of Assistive Shoes On Gait In Patients With Peripheral Artery Disease, Jonathan Kirkland

UNO Student Research and Creative Activity Fair

Effect of Three-Month Use of Assistive Shoes on Gait in Patients with Peripheral Artery Disease

Comparison Of Marker-Based And Marker-Less Motion Capture On Kinematic Outcomes; Comparison Of Lower Limb 3d Kinematic Outcomes Between Markerless And Marker-Based Systems During Overground Walking In Children With Cerebral Palsy (Cp) (Irb:8022-21-Ep), Jutharat Poomulna

UNO Student Research and Creative Activity Fair

The Gait Deviation Index (GDI) serves as a summary measure to evaluate gait pathology in children with cerebral palsy (CP), with a score ≥ 100 denoting typical gait and each 10-point difference representing one standard deviation from the mean. While marker-based (MB) motion capture, the gold standard for 3D gait analysis, has limitations for widespread clinical use, leading to the exploration of video-based markerless motion capture, specifically Theia3D. Theia3D has been validated for accuracy and reliability in healthy adults; however, its clinical applicability is limited. This study aims to compare the impact of different motion capture systems on GDI scores …

Idiopathic And Neuromuscular Scoliosis In A Female College Basketball Player Requiring Spinal Correction Surgery, Magan Kim

UNO Student Research and Creative Activity Fair

The purpose of this report is to present the case of a 20-year-old female collegiate basketball player who was diagnosed with a combination of idiopathic and neuromuscular scoliosis. Patient underwent thoracic spinal fusion surgery when she was 15 to resolve her extreme scoliosis. The uniqueness of this case stems from the athlete’s urgency to have to undergo a life-altering spine operation and still be able to successfully contribute to a collegiate basketball team. Athletic trainers should be knowledgeable and aware of how to maintain treatment/rehabilitation for athletes with scoliosis, operative or non-operative. Scoliosis should no longer be a reason to …

Materials And Methods Developed For The Recording And Analysis Of Behavior In The Common Marmoset (Callithrix Jacchus)., Christian Wintle

UNO Student Research and Creative Activity Fair

Materials and methods developed for the recording and analysis of behavior in the common marmoset (Callithrix jacchus).

Christian J. Wintle^a, Jordan B. Hernandez^a,b,c, Dobromir Dotov^d, and Jonathan B. Clayton^a,b,e,f,g

^aDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA

^bNebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, USA

^cDepartment of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, NE, USA

^dDepartment of Biomechanics, University of Nebraska at Omaha, Omaha, NE, USA

^eDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, …

Methotrexate-Induced Pancytopenia: A Call For Mindful Medication Practices, Eunbee Cho, Jessica Marcela Daza, Jiye A. Park, Shreel Patel, Seokwon Choi, Daniel Farray

Research Symposium

Introduction: Methotrexate(MTX) is a widely used disease-modifying antirheumatic drug for various conditions including autoimmune diseases or malignancies. Pancytopenia as an adverse effect of methotrexate is rarely reported but sometimes fatal, and requires more attention. This case report shows a 76-year-old woman with a history of rheumatoid arthritis(RA) on MTX therapy, presenting with severe pancytopenia and oral lesions, and highlights the importance of safe medication practices especially in elderly patients with poor health literacy and compliance.

Case Presentation: A 76-year-old female with rheumatoid arthritis presented to the emergency department with a worsening oral lesion. She had been on an unspecified maintenance …

Metagenomic Analysis Unveils The Microbial Landscape Of Pancreatic Tumors, Sheema Khan, Goutam Banerjee, Saini Setua, Daleniece Jones, Anupam Dhasmana, Bhavin Chauhan, Pratik Banerjee, Murali M. Yallapu, Stephen Behrman, Subhash Chauhan

Research Symposium

Background: The composition of resident microbes in the human body is linked to various diseases and their treatment outcomes. Although studies have identified pancreatic ductal adenocarcinoma (PDAC) associated bacterial communities in the oral and gut samples, herein we hypothesize the prevalence of microbiota in pancreatic tumor tissues is different as compared to their matched adjacent, histologically normal appearing tissues and these microbial molecular signatures can be highly useful for PDAC diagnosis/prognosis.

Methods: In this study, we performed comparative profiling of bacterial populations in pancreatic tumors and their respective adjacent normal tissues using 16S rRNA-based metagenomics analysis.

Results: This study …

Mechanistic Investigation Of C—C Bond Activation Of Phosphaalkynes With Pt(0) Complexes, Roberto M. Escobar, Abdurrahman C. Ateşin, Christian Müller, William D. Jones, Tülay Ateşin

Research Symposium

Carbon–carbon (C–C) bond activation has gained increased attention as a direct method for the synthesis of pharmaceuticals. Due to the thermodynamic stability and kinetic inaccessibility of the C–C bonds, however, activation of C–C bonds by homogeneous transition-metal catalysts under mild homogeneous conditions is still a challenge. Most of the systems in which the activation occurs either have aromatization or relief of ring strain as the primary driving force. The activation of unstrained C–C bonds of phosphaalkynes does not have this advantage. This study employs Density Functional Theory (DFT) calculations to elucidate Pt(0)-mediated C–CP bond activation mechanisms in phosphaalkynes. Investigating the …

Little Bit About Liddle: Big Improvement In Blood Pressure, Shreel Patel, Roy Kondapavuluru, Eunbee Cho, Fatimah Bello, Jian Garcia Cruz

Research Symposium

Background: Liddle syndrome is a rare autosomal dominant disorder associated with abnormalities in function of the collecting tubule sodium channel, also called the epithelial sodium channel (ENaC). ENaC function is increased in the Liddle’s syndrome leading to the manifestations of mineralocorticoid excess symptoms, such as hypertension, hypokalemia, and metabolic alkalosis. The diagnosis is made when these features are seen with low renin and low plasma or urinary aldosterone. Genetic testing is not required for the diagnosis of Liddle syndrome. Liddle's syndrome has an excellent response to amiloride.

Case Presentation: A 56-year-old gentleman, with longstanding uncontrolled hypertension was seen for functional …

Lncrna Impact On Regorafenib Resistance In Colorectal Cancer, Ricardo Pequeno Bracho, Kyle Doxtater, Dennis Kwabiah, Yamile Abuchard Anaya, Sophia Leslie, Mohammad Shabir Hussain, Manish Tripathi

Research Symposium

Cancer metastasis is one of the deadliest aspects of the disease, with about 90% of all cancer-related deaths due to its development at different sites within the body. Colorectal cancer (CRC) is the second leading cause of cancer mortality in the United States, with 40-50% of all patients developing metastasis at some point during their fight with the disease. With the approval of Regorafenib for treating metastatic colorectal cancer, steps have been taken to combat metastasis in colorectal cancer. A vital aspect of the development of metastasis is the development of resistance to first-line chemotherapy. Regorafenib is an oral small-molecule …

Leveraging A Human-Centered Design Framework To Improve Longitudinal Care At A Student Free Clinic : A Quality Improvement Initiative, Rosa E. Martinez, Alexis De Montfort Shepherd, Sahana Prabhu, Katie Se, Krishna Hariprasad, Sanika Mhatre

Research Symposium

Background: Founded in 2009, the CD Doyle Clinic is a student-run free clinic with a mission to provide high-quality equitable care to those in need, regardless of their background. Since 2020, our clinic has served residents at the Esperanza community, a state-sanctioned encampment for people experiencing homelessness in Southeast Austin. The majority of the patients that we serve navigate complex medical and psychosocial conditions. Our clinic operates as an ambulatory care center, primarily addressing acute care and psychiatric concerns. Recognizing our limits as a free clinic, we collaborate alongside community partners, such as Travis County’s CommUnityCare Mobile Health Team, to …

La1-Xsrxcoo3 Perovskite Nanomaterial: Synthesis, Characterization, And Its Biomedical Application, Adhira Tippur, Anyet Shohag, Luke Franco, Ahmed Touhami, Swati Mohan, Mohammed Uddin

Research Symposium

Early cancer detection is paramount for effective treatment and potential cures. This research explores the application of perovskite materials, specifically Sr2+-doped Lanthanum Cobaltite (La1-xSrxCoO3) nanomaterials, in cancer detection, with a focus on rats as an experimental model. The ferroelectric nature of these materials, synthesized through a combination of sol-gel and molten-salt processes, was examined at varying Sr2+ doping levels (1-20 wt%). Rigorous characterization, employing X-ray diffraction and scanning electron microscopy, confirmed the uniform morphology of nano cubes, laying the foundation for subsequent investigations. The magnetic properties of the perovskite nanoparticles were probed, suggesting their potential as a diagnostic tool for …

Jungle Fever: Navigating Malaria In Immigrant Travelers Patient At South Texas: A Case Report, Elimar Gonzalez Morales, Eunbee Cho, Jose Gomez Casanovas, Khairiya Haj-Yahya

Research Symposium

Introduction: Malaria is a severe mosquito-borne illness that can be life-threatening. This infection continues to be a significant global health concern, most prominent in tropical and subtropical regions. Malaria's clinical manifestations exhibit a striking diversity, influenced by geographical variables, the individual's immunity, and age. Diagnosing and treating malaria early is crucial to preventing severe complications and fatalities. This heterogeneity poses unique challenges to its diagnosis and treatment, making it a subject of continuous study and innovation. In this case, we present a case of a patient traveling from an endemic area to a non-endemic area. In this comprehensive examination of …