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Full-Text Articles in Medicine and Health Sciences

Bone And Joint Infections: A Retrospective Chart Review Of The Medically Underserved Rio Grande Valley, Blake C. Martin, Chloe Harris, Manoj Peiris Mar 2025

Bone And Joint Infections: A Retrospective Chart Review Of The Medically Underserved Rio Grande Valley, Blake C. Martin, Chloe Harris, Manoj Peiris

Research Symposium

Background: The Rio Grande Valley (RGV) is a demographically unique region that is impoverished and medically underserved. Because of its unique patient population, this community may be at increased risk for bone and joint infections and the morbidity and mortality that follows. The goal of this study was to analyze individuals with osteomyelitis, septic arthritis, and periprosthetic joint infections and determine which infectious bone or joint conditions are most prevalent in the Rio Grande Valley and determine if there were any demographic disparities between the various types of bone and joint infections and healthy individuals. We hypothesized that age and …


Association Of Joint Disease With Demographic Factors In Clinical Populations Of The Rio Grande Valley, Blake C. Martin, Devian D. Baez, Juan C. Lopez-Alvarenga Mar 2025

Association Of Joint Disease With Demographic Factors In Clinical Populations Of The Rio Grande Valley, Blake C. Martin, Devian D. Baez, Juan C. Lopez-Alvarenga

Research Symposium

Background: The Rio Grande Valley (RGV) is a medically underserved, demographically unique population that warrants the exploration of various conditions, including joint conditions, such as osteoarthritis (OA), rheumatoid arthritis (RA), gout, ankylosing spondylitis (AS), psoriatic arthritis (PA), juvenile idiopathic arthritis (JIA), and septic arthritis (SA). We sought to determine the demographic disparities between the different types of common joint conditions in this community. We hypothesized that OA would follow national trends and be the most common joint condition in the Rio Grande Valley. We hypothesized that the demographics between the various joint conditions would vary depending on age, sex, BMI, …


Using Network Pharmacology To Systematically Deduce The Molecular Mechanism Of The Selective Perinucleolar Compartment Inhibitor Ml246, Bhuvnesh P. Sharma, Himanshu N. Singh, Bhupesh Singh, Deepak Parashar, Kuldeep K. Roy, Murali M. Yallapu, Subhash C. Chauhan, Vivek K. Kashyap Mar 2025

Using Network Pharmacology To Systematically Deduce The Molecular Mechanism Of The Selective Perinucleolar Compartment Inhibitor Ml246, Bhuvnesh P. Sharma, Himanshu N. Singh, Bhupesh Singh, Deepak Parashar, Kuldeep K. Roy, Murali M. Yallapu, Subhash C. Chauhan, Vivek K. Kashyap

Research Symposium

Metarrestin (ML246) is an orally bioavailable synthetic molecule that selectively disrupts the perinucleolar compartment (PNC) structure, and it has showed promise in preclinical studies for metastatic cancer therapy. However, the precise molecular mechanism of ML246 remains poorly understood. We investigated the topological and protein interaction network (PIN) analyses of ML246 to determine the molecular mechanism of ML246. To determine the regulatory effect of ML246 on the rewired PIN of ML246, an intercom was constructed using 25 oncogenic key proteins. These proteins were selected using the reverse pharmacophore matching approach (based on a fit score > 0.502) using the STRING database and …


Trpv1 And Its Co‑Expressed Genes Are Associated With The Progression Of Hepatocellular Carcinoma, Bhuvnesh P. Sharma, Himanshu N. Singh, Sanjay Kumar, Deepak Verma, Deepak Parashar, Murali M. Yallapu, Everardo Cobos, Subhash C. Chauhan, Vivek K. Kashyap Mar 2025

Trpv1 And Its Co‑Expressed Genes Are Associated With The Progression Of Hepatocellular Carcinoma, Bhuvnesh P. Sharma, Himanshu N. Singh, Sanjay Kumar, Deepak Verma, Deepak Parashar, Murali M. Yallapu, Everardo Cobos, Subhash C. Chauhan, Vivek K. Kashyap

Research Symposium

Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective Ca2+ channel protein widely expressed and plays a significant role in cancer initiation and progression. However, the biological significance of TRPV1 in HCC has not been systematically and comprehensively investigated. This study used deep data mining and transcriptomics analyses to describe the significance of TRPV1 expression and its association with HCC prognosis.

Methods: Download the RNA expression of TRPV1 from the Cancer Genome Atlas (TCGA), Genotype Tissue Expression Atlas (GTEx), Tumor Immune Estimation Resource (TIMER), and the UALCAN …


A Review Of Key Music Therapy Approaches To Unlocking Recovery From Stroke And Traumatic Brain Injury, Bethany Woolman, Nina Mourao, Joshua K. Elliott, Shizue Mito, Ney Alliey-Rodriguez Mar 2025

A Review Of Key Music Therapy Approaches To Unlocking Recovery From Stroke And Traumatic Brain Injury, Bethany Woolman, Nina Mourao, Joshua K. Elliott, Shizue Mito, Ney Alliey-Rodriguez

Research Symposium

Background: Strokes and traumatic brain injuries are neuronal injuries that can impact the motor, sensory, and cognitive abilities of an affected individual, and may necessitate therapy of multiple forms to regain back total or partial functionality and independence in their daily lives. Music assists in stimulating multiple brain regions, and when incorporated into rehabilitation, it has the potential to impact stroke and traumatic brain injury recovery. This literature review focuses on the efficacy of two novel music therapy approaches, melodic intonation therapy (MIT) and rhythmic auditory stimulation (RAS), on recovery from aphasia and restoration of gait, respectively, to assess whether …


Machine Learning Quantification Of High-Resolution Tissue Microarray (Tma) Image On Muc13 Ihc Analysis, Beibei Huang, Aiko Yamaguchi, Jianbo Wang, Shilpa Sharma, Zhiwen Liu, Henry Charles Manning Mar 2025

Machine Learning Quantification Of High-Resolution Tissue Microarray (Tma) Image On Muc13 Ihc Analysis, Beibei Huang, Aiko Yamaguchi, Jianbo Wang, Shilpa Sharma, Zhiwen Liu, Henry Charles Manning

Research Symposium

Background High-resolution tissue microarray (TMA) technology allows prompt molecular profiling of multiple tissue specimens, making it ideal for analyzing candidate biomarkers quickly and effectively [1, 2]. Integrating TMA with digital pathology and machine learning enhances high-throughput, cost-effective studies, offering advanced image analysis and improved diagnostic accuracy. MUC13 (Mucin 13) is a transmembrane glycoprotein frequently overexpressed in colorectal cancer (CRC) [3]. MUC13 contributes to colonic tumorigenesis, progression and metastasis [4, 5], making it an attractive target for antibody-guided radiotheranostics in CRC. This study investigates the expression pattern of MUC13 and its association with patients' clinical characteristics in primary and metastatic CRC …


Acute Heart Failure Secondary To Coxsackie Dilated Cardiomyopathy In An Immunocompetent Adult: A Case Report From A Social Disparities Perspective, Barbara Malaga-Espinoza, Donnel Dockery-Joseph, Jessica Daza, Oscar Lopez, Andres Suarez Parraga Mar 2025

Acute Heart Failure Secondary To Coxsackie Dilated Cardiomyopathy In An Immunocompetent Adult: A Case Report From A Social Disparities Perspective, Barbara Malaga-Espinoza, Donnel Dockery-Joseph, Jessica Daza, Oscar Lopez, Andres Suarez Parraga

Research Symposium

Introduction: Cardiomyopathies (CM) are defined as myocardial disorders in the absence of coronary artery disease, hypertension, valvular or congenital heart conditions. Dilated CM is characterized by dilation and impaired contraction of one or both ventricles. The prevalence of this condition is underestimated because of variable disease expression and challenging diagnosis. We present the case of an undocumented and immunocompetent patient who debuted with acute heart failure after being exposed to significant environmental stressors.

Case Presentation: A 44-year-old Hispanic gentleman with a history of untreated hypertension presented to the ED with severely persistent left-sided chest pain at rest associated with frontoparietal …


A Case Of Rhabdomyolysis Complicated By Acute Compartment Syndrome After A Ground-Level Fall, Barbara Malaga-Espinoza, Khairiya Haj-Yahya, Corey Haines Mar 2025

A Case Of Rhabdomyolysis Complicated By Acute Compartment Syndrome After A Ground-Level Fall, Barbara Malaga-Espinoza, Khairiya Haj-Yahya, Corey Haines

Research Symposium

Introduction: Rhabdomyolysis is the breakdown of skeletal muscle tissue that results in the release of intracellular contents such as myoglobin, CK, and electrolytes into the surrounding interstitium and circulation. Rhabdomyolysis is commonly precipitated by trauma, excessive physical exertion, infection, or drug toxicity. Compartment syndrome can be a complication of severe rhabdomyolysis, characterized by increased pressure in a closed anatomical space which can lead to compromised perfusion and ischemia. Timely identification and early surgical intervention are crucial to improving outcomes. Here we present a case of rhabdomyolysis complicated by acute compartment syndrome of the leg in the setting of prolonged poor …


Prognostic Determinants Of Liver And Intrahepatic Bile Duct Carcinomas: A Seer Database Analysis, Aura Calderon, Ivan Mogollon, Everardo Cobos Mar 2025

Prognostic Determinants Of Liver And Intrahepatic Bile Duct Carcinomas: A Seer Database Analysis, Aura Calderon, Ivan Mogollon, Everardo Cobos

Research Symposium

Introduction: The incidence of liver and intrahepatic bile duct carcinomas has risen significantly in the United States, necessitating a deeper understanding of survival outcomes and prognostic determinants. This study examines survival rates based on disease stage at diagnosis and explores the influence of demographic factors such as sex, race, ethnicity, and age.

Objectives: The primary objective is to evaluate survival rates stratified by disease stage and demographic variables using data from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2021.

Methods: Data were extracted from the SEER database for patients diagnosed with primary hepatic and intrahepatic bile …


Muc13-Driven Molecular Interactions In Pancreatic Cancer Cell Lines, Anupam Dhasmana, Swati Dhasmana, Rajasekhar Baru, Shweta Singh, Abigail Gomez, Sheema Khan, Murali M. Yallapu, Subhash Chauhan Mar 2025

Muc13-Driven Molecular Interactions In Pancreatic Cancer Cell Lines, Anupam Dhasmana, Swati Dhasmana, Rajasekhar Baru, Shweta Singh, Abigail Gomez, Sheema Khan, Murali M. Yallapu, Subhash Chauhan

Research Symposium

Background: MUC13, a recently identified oncoprotein, is aberrantly expressed in pancreatic ductal adenocarcinoma (PDAC) tumors and cells but absent in normal pancreatic tissues. Our laboratory has extensively documented its critical role in pancreatic cancer progression. Despite numerous studies, the molecular interactions mediated by MUC13 that contribute to cancer progression and metastasis remain poorly understood. A significant knowledge gap exists regarding the specific proteins that interact with MUC13. To address this, we conducted a comprehensive molecular interaction study using immunoprecipitation combined with liquid chromatography-mass spectrometry (IP-LCMS) to identify functional interactors of MUC13. Understanding these interactions is essential to elucidate the …


Wernicke-Korsakoff Syndrome: A Current Perspective, Astrid-Ines Foamkom, Maria Sophia Zaraspe Malbas, Kory D. Punch, Victor A. Bob-Yellowe, Allison J. Mcadams, Julia Paz, Karina Zamora, Kelsey Baker, Ihsan Salloum, Ney Alliey-Rodriguez Mar 2025

Wernicke-Korsakoff Syndrome: A Current Perspective, Astrid-Ines Foamkom, Maria Sophia Zaraspe Malbas, Kory D. Punch, Victor A. Bob-Yellowe, Allison J. Mcadams, Julia Paz, Karina Zamora, Kelsey Baker, Ihsan Salloum, Ney Alliey-Rodriguez

Research Symposium

Background: Wernicke-Korsakoff syndrome (WKS) is a debilitating neuropsychological condition characterized by the profound loss of thiamine (vitamin B1). The neuropsychological presentation of WKS has been increasingly refined since its discovery in the nineteenth century, leading to a more robust understanding of the condition. In general, it has been shown that WKS causes differ amongst individuals but the main causes for the condition include chronic alcoholism, immunodeficiency, genetic disorders, malnutrition, drug-induced thiamine deficiency, and hyperemesis gravidarum. However, it remains unclear how demographic, environmental, and ethnic differences may influence WKS etiology and severity. Here, we sought to conduct a systematic review of …


Dog Bite Prevalence And Severity Within Demographics: Age, Ethnicity, And Sex., Ashlyn Holubar, Jocelyn Torres, Mary Arden Guillory, Saloni Saldhi, Isabella Ortigoza Martinez, Shalika Padhi, Kelsey Baker Mar 2025

Dog Bite Prevalence And Severity Within Demographics: Age, Ethnicity, And Sex., Ashlyn Holubar, Jocelyn Torres, Mary Arden Guillory, Saloni Saldhi, Isabella Ortigoza Martinez, Shalika Padhi, Kelsey Baker

Research Symposium

Dog bites are the most common animal bite injuries treated in emergency departments. Studies have shown a disproportional distribution of dog bites within demographics such as age group, ethnicity, and sex. This study aimed to identify the demographic groups with the highest prevalence of dog bites, analyze the relationship between injury type and gender, and explore the association between injury location and gender. Data from the Texas Department of State Health Services (2018-2022) were analyzed using ICD-10 code W54.0XXA, specific for dog bite incidents. Demographic factors such as age, sex, and ethnicity were extracted, and chi-square tests with Benjamini-Hochberg adjustments …


The Influence Of Environmental Neurotoxins On Parkinson's Disease, Arjun Bellamkonda, Amin Ibrahim, Hugo Zamarron, Kelsey Potter-Baker Mar 2025

The Influence Of Environmental Neurotoxins On Parkinson's Disease, Arjun Bellamkonda, Amin Ibrahim, Hugo Zamarron, Kelsey Potter-Baker

Research Symposium

Background: Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. PD is the second most common neurodegenerative disease, after Alzheimer’s Disease, with global prevalence increasing by 74.3% between 1990 and 2016. The majority of PD can be classified as primary or secondary parkinsonism. Differentiating secondary parkinsonism, which is caused by medications or environmental toxins, from other forms of PD requires careful exclusion of alternative causes and identification of red flags. Here, we sought to review literature concerning the effects of environmental neurotoxin exposure on the severity of PD.

Methods: We conducted a systematic review …


Ai Driven Detection Of Common Carotid Artery For Emergent Cardiac Procedures, Arjun Bellamkonda, Nneka Ede, Marc Abdallah, Alaukik Gupta, Gilmar Ortega, Bharathi S. Gadad Mar 2025

Ai Driven Detection Of Common Carotid Artery For Emergent Cardiac Procedures, Arjun Bellamkonda, Nneka Ede, Marc Abdallah, Alaukik Gupta, Gilmar Ortega, Bharathi S. Gadad

Research Symposium

Background: Visualizing the common carotid artery is a crucial step during ECMO (Extracorporeal Membrane Oxygenation) and ECPR (Extracorporeal Cardiopulmonary Resuscitation) procedures where timely and accurate cannulation is essential to sustain a patient’s vital functions. These procedures often involve critical time-sensitive scenarios where every second can make a significant difference in survival outcomes. Current cannulation techniques, such as the open cannulation method and the semi-Seldinger technique, are not only time-intensive but also require a high degree of precision to ensure proper arterial access. Delays or inaccuracies in identifying the common carotid artery can compromise the efficacy of these life-saving interventions. Recognizing …


Exploring The Effects Of Serotonin And Ssris On The Neurological, Behavioral, And Cardiovascular Systems Under Induced Stress –Using The Animal Model Of The Syrian Hamster, Ariana V. Hinojosa, Esperanza I. Alaniz, Esmeralda Lopez-Garcia, Giselle Padilla, Fernando Dominquez, Mario Gil Mar 2025

Exploring The Effects Of Serotonin And Ssris On The Neurological, Behavioral, And Cardiovascular Systems Under Induced Stress –Using The Animal Model Of The Syrian Hamster, Ariana V. Hinojosa, Esperanza I. Alaniz, Esmeralda Lopez-Garcia, Giselle Padilla, Fernando Dominquez, Mario Gil

Research Symposium

Background: Serotonin is a neurotransmitter that has been found to have a wide range of effects on not just the neuropsychological processes but has also been found to exert effects outside the central nervous system (CNS); regulating numerous biological processes, such as metabolism, gastrointestinal system, reproductive function, and even the cardiovascular system. However, there is still a limited understanding of how serotonin affects all these systems due to its complexity and ability to regulate homeostasis. This project aims to create a stronger foundation of knowledge about serotonin and its influence on the interaction between the CNS, behavior, and cardiac function …


Gene Co-Expression Networks And Descriptive Statistical Patterns In Cancer Subtypes, Arely Solis, Marzieh Ayati Mar 2025

Gene Co-Expression Networks And Descriptive Statistical Patterns In Cancer Subtypes, Arely Solis, Marzieh Ayati

Research Symposium

There are many cancers that are affecting the human population, with some being more common and studied than others. These cancers have mostly been studied individually until 2012 when scientists began studying through comparison analysis of different cancers to see possible connections on the genomic and molecular level and have resulted in the categorization of tumors into types. The result from molecular analysis has re-classified types of tumors into new clusters, which aid doctors in deciding the optimal way of treating tumors. In this study, we analyze a dataset comprising over 2,000 cancer samples, focusing on six cancer types: breast, …


Uncovering The Mechanisms Of Glioblastoma Relapse Prevention With Niclosamide And Camptothecin Treatment, Xiaoqian Fang, Araely Ruiz, Eunseo Yang, Brianna Morin, Kimberly Herrera-Toscano, Megan Szobody, Josue Fonseca, John-Beloved Osho, Raquel Lara Mar 2025

Uncovering The Mechanisms Of Glioblastoma Relapse Prevention With Niclosamide And Camptothecin Treatment, Xiaoqian Fang, Araely Ruiz, Eunseo Yang, Brianna Morin, Kimberly Herrera-Toscano, Megan Szobody, Josue Fonseca, John-Beloved Osho, Raquel Lara

Research Symposium

Background: Glioblastoma multiforme (GBM) is the most common and lethal malignant primary brain tumor for which the development of efficacious chemotherapeutic agents remains an urgent need. In our previous studies, we demonstrated that niclosamide and camptothecin (CPT) synergistically suppressed the proliferation in human glioblastoma U87 MG cells. Recently, we observed that U87 MG cells failed to resume growth after the combined treatment was removed, a phenomenon not seen with either agent alone. We aimed to explore the sustained anti-tumor effects of niclosamide and CPT in GBM.

Methods: Human glioblastoma U87 MG cells were treated with 5 mM niclosamide, 5 mM …


Muscle Force Analysis In Patients With Forefoot Amputees And Healthy Subjects During Walking, Anthony Melgar, Dumitru Caruntu, Javier La Fontaine, Luis Venegas, Hafizur Rahman Mar 2025

Muscle Force Analysis In Patients With Forefoot Amputees And Healthy Subjects During Walking, Anthony Melgar, Dumitru Caruntu, Javier La Fontaine, Luis Venegas, Hafizur Rahman

Research Symposium

Forefoot amputation, a type of partial foot amputation, involves the surgical disarticulation of either the interphalangeal or metatarsophalangeal joints. This procedure not only removes critical joint structures but also alters the positioning of associated muscles. Forefoot amputations significantly affect gait patterns and redistribute plantar pressure maps across the plantar surface of the foot. The phalanges are crucial in absorbing and redistributing plantar pressure during the gait cycle. The absence of phalanges and the loss of metatarsophalangeal joints alter the normal pressure distribution maps, possibly shifting peak pressure from one local foot region to another region of the foot. This research …


Use Of Marker-Less Motion Capture Systems In Community Care Settings, Anjana Ganesh, Kelsey Baker Mar 2025

Use Of Marker-Less Motion Capture Systems In Community Care Settings, Anjana Ganesh, Kelsey Baker

Research Symposium

Background: Marker-less motion capture systems have improved the assessment of human movement by allowing for a non-invasive, affordable, quantitative data collection useful in clinical settings. However, their use in real-world community care settings is largely underexplored, presenting a unique opportunity to bridge the gap between controlled laboratory environments and the complexity of providing care in diverse, everyday contexts. Here, we sought to review the current state of marker-less motion capture systems applied in community care, specifically for the monitoring and management of neurodegenerative diseases.

Methods: A systematic review was conducted using databases including PubMed, Web of Science, MEDLINE …


Utilidad De La Combinación De Los Biomarcadores: Procalcitonina, Proteína C Reactiva Y Volumen Plaquetario Medio En El Diagnóstico Temprano De Sepsis Neonatal [Usefulness Of The Combination Of Biomarkers: Procalcitonin, C-Reactive Protein And Mean Platelet Volume In The Early Diagnosis Of Neonatal Sepsis], Oscar Manuel Berlanga Bolado Jr, Patricia Rivera Vazquez, Arely Socorro Hernández García, Angelica Lizbeth Martinez Ortiz Mar 2025

Utilidad De La Combinación De Los Biomarcadores: Procalcitonina, Proteína C Reactiva Y Volumen Plaquetario Medio En El Diagnóstico Temprano De Sepsis Neonatal [Usefulness Of The Combination Of Biomarkers: Procalcitonin, C-Reactive Protein And Mean Platelet Volume In The Early Diagnosis Of Neonatal Sepsis], Oscar Manuel Berlanga Bolado Jr, Patricia Rivera Vazquez, Arely Socorro Hernández García, Angelica Lizbeth Martinez Ortiz

Research Symposium

Introducción: La sepsis neonatal es una causa frecuente de morbilidad y mortalidad infantil. Se le ha definido como un síndrome clínico caracterizado por signos sistémicos de infección, acompañado de bacteriemia en el primer mes de vida. Por lo tanto, el diagnóstico temprano es fundamental.

Objetivo: Conocer la sensibilidad y especificidad de la combinación de biomarcadores séricos como procalcitonina, proteína C reactiva y volumen plaquetario medio en el diagnóstico temprano de sepsis neonatal.

Material y métodos: Estudio clínico, de tipo prospectivo, predictivo, observacional, analítico, longitudinal y conveniencia. Se analizaron los biomarcadores como PCT, PCR, VPM para diagnosticar sepsis neonatal. Se incluyeron …


Gut-Spine Connection: Unexplored Pathways To Improving Outcomes In Spinal Health And Disease, Anesu K. Murambadoro, Julia Saifetiarova, Priya Kale, Victor A. Bob-Yellowe, Paul Bonilla, Aun A. Bangash, Isabella Ortigoza, Anjana Ganesh, Mohammed S. Razzaque Mar 2025

Gut-Spine Connection: Unexplored Pathways To Improving Outcomes In Spinal Health And Disease, Anesu K. Murambadoro, Julia Saifetiarova, Priya Kale, Victor A. Bob-Yellowe, Paul Bonilla, Aun A. Bangash, Isabella Ortigoza, Anjana Ganesh, Mohammed S. Razzaque

Research Symposium

Introduction: Lumbar spinal fusion is among the most expensive procedures in the Medicare system, with costs exceeding $33 billion annually. Improving recovery outcomes for these procedures is critical, and emerging research suggests that microbiome-targeted therapies could play a key role. There is growing evidence linking spinal health with gut microbiota alterations, particularly through the gut-spine axis, which involves the gut-disc, gut-bone, and gut-immune interactions. This bidirectional relationship between gut microbiota and spinal health offers a novel approach for understanding recovery mechanisms. Additionally, magnesium deficiency, which is prevalent, may exacerbate both gut dysbiosis and poor bone health, contributing to chronic skeletal …


Evaluating Industry Relationships And Transparency: Insights From Orthopedic Surgeons In The Cms Open Payments Database, Anesu K. Murambadoro, Mario Keko, Edward Rodriguez, John J. Wixted Mar 2025

Evaluating Industry Relationships And Transparency: Insights From Orthopedic Surgeons In The Cms Open Payments Database, Anesu K. Murambadoro, Mario Keko, Edward Rodriguez, John J. Wixted

Research Symposium

Introduction: Industry payments to physicians may risk introducing bias into patient care. The Open Payments (OP) database, established by Physician Payments Sunshine Act, reports these payments to promote transparency. Orthopedic surgeons receive the highest industry payments especially in the category of royalties/licensing, prompting questions about conflicts of interest and whether the database accurately reflects the status across the specialty. We hypothesize that the OP database underrepresents the relationships that orthopedic surgeons have with industry. We seek to assess the validity of reported industry payments, particularly in the categories of royalties and licensing payments to determine how to improve transparency and …


Evaluating Longitudinal Research Modules: Enhancing Pre-Clerkship Medical Students' Research Skills And Performance, Anesu K. Murambadoro, Kevin Garcia Valdez, Chloe Harris, Meyer Maddox, Blake Martin, Nina Mourao, Elias Arellano Villanueva, Juan C. Lopez-Alvarenga, Chelsea Chang, Beatriz Tapia, Kelsey Baker, Bharathi S. Gadad Mar 2025

Evaluating Longitudinal Research Modules: Enhancing Pre-Clerkship Medical Students' Research Skills And Performance, Anesu K. Murambadoro, Kevin Garcia Valdez, Chloe Harris, Meyer Maddox, Blake Martin, Nina Mourao, Elias Arellano Villanueva, Juan C. Lopez-Alvarenga, Chelsea Chang, Beatriz Tapia, Kelsey Baker, Bharathi S. Gadad

Research Symposium

Background: Less than 7% of medical students publish research articles. Factors contributing to delays in student engagement include perceived time limitations, lack of enthusiasm, poor facilities, and insufficient supervisory support. Although project-based programs can improve research abilities, they frequently do not correspond with the program's goals, pedagogical approaches, and assessment standards and, worse, are not linked with other teaching modules. There is scarce evaluation of longitudinal research integrated programs' effects on pre-clerkship students and faculty motivation, willingness, and skills. We designed a pre-clerkship longitudinal research module integrated with the concurrent modules to enhance scores on attitudes toward research (R-ATR), cognition …


Enhancing Surgical Interest Through Pre-Clerkship Interventions: Insights For Student-Run Interest Groups, Anesu K. Murambadoro, Antoinette Burrell, Karina Zamora, Daniela Gonzalez, Theresa M. Biju, Paul Bonilla, Blake Martin, Ayesha Usman Mar 2025

Enhancing Surgical Interest Through Pre-Clerkship Interventions: Insights For Student-Run Interest Groups, Anesu K. Murambadoro, Antoinette Burrell, Karina Zamora, Daniela Gonzalez, Theresa M. Biju, Paul Bonilla, Blake Martin, Ayesha Usman

Research Symposium

Background: The Association of American Medical Colleges (AAMC) projects a shortage of 10,100 to 19,900 surgeons by 2036. Despite the need for physicians in surgical specialties, exposure to surgical education remains limited to the third and fourth year, posing a barrier to fostering early interest in surgical careers. Medical school student interest groups (SIGs) may be an avenue to increase surgical exposure pre-clerkship curriculum. We seek to establish effective interventions that can be utilized by SIGs to increase and maintain surgical interest to the point of matriculation into surgical residency.

Methods: We conducted a systematic review using electronic databases, …


Could Telemedicine Approaches Improve Inclusivity In Spinal Cord Injury Care And Research?: Insights From Epidemiological Texas Data, Anesu Karen Murambadoro, Daniel Salinas, Victoria Elizondo, Kevin Garcia Valdez, Blake Martin, Paul Bonilla, Kelsey Baker Mar 2025

Could Telemedicine Approaches Improve Inclusivity In Spinal Cord Injury Care And Research?: Insights From Epidemiological Texas Data, Anesu Karen Murambadoro, Daniel Salinas, Victoria Elizondo, Kevin Garcia Valdez, Blake Martin, Paul Bonilla, Kelsey Baker

Research Symposium

Background: Spinal cord injury (SCI) affects hundreds of Texans, with annual healthcare costs exceeding $43,800 per individual, with the bulk of these costs coming from frequent rehabilitation visits. In a geographically vast state with only two major SCI rehabilitation centers, Texans with SCI may face substantial barriers to accessing specialized care, particularly in rural and underserved areas. Telemedicine, which encompasses remote delivery of healthcare services and rehabilitation, has offered promising solutions in easing travel burden and improving physician reach. For example, nationally, in 2021, 37.0% of individuals utilized telemedicine. Furthermore, telemedicine usage was greatest among individuals living in West and …


The Use Of Hyperbaric Oxygen Therapy In The Setting Of Acute Limb Ischemia, Josue Fonseca, Andrew B. Callan Mar 2025

The Use Of Hyperbaric Oxygen Therapy In The Setting Of Acute Limb Ischemia, Josue Fonseca, Andrew B. Callan

Research Symposium

Background: Hyperbaric oxygen therapy is a long-used yet understudied intervention for a wide array of conditions. In the case of our patient with acute limb ischemia secondary to cholesterol emboli, the use of hyperbaric oxygen therapy after attempted thrombectomy and thrombolysis was utilized to promote tissue oxygenation and wound healing with the goal of preserving the patient’s limb. What makes this case novel is that an understudied treatment method was used to preserve the patient’s limb after the recommended treatment options been exhausted. This case highlights the need for more studies on the effectiveness of hyperbaric oxygen therapy in the …


Trauma In Pregnancy: A Statistical Retrospective Analysis Of Leading Causes And Demographic Insights, Andrea Argenal, Sonya Bhatia, Sowmya Duddu, Julia Paz, Sriya Gullapalli, Kelsey Baker, Bharathi Gadad Mar 2025

Trauma In Pregnancy: A Statistical Retrospective Analysis Of Leading Causes And Demographic Insights, Andrea Argenal, Sonya Bhatia, Sowmya Duddu, Julia Paz, Sriya Gullapalli, Kelsey Baker, Bharathi Gadad

Research Symposium

Background: Trauma during pregnancy is a significant contributor to maternal and fetal morbidity and mortality. Understanding the leading causes of trauma can guide interventions to improve outcomes of injuries for pregnant women. This study aimed to analyze the distribution of trauma causes in a cohort of pregnant women treated in Texas Emergency Department over the year 2021.

Methods: A retrospective statistical analysis was conducted on a sample of 96 pregnant women who experienced trauma. Data was collected from the Texas Emergency Department for patients admitted to the hospital during 2021 and categorized by the cause of injury; some of these …


First-In-Class Peptide Molecules Targeting The Mien1 Cancer Signaling Pathway, For Which No Inhibitors Have Been Identified To Date., Amit Tripathi, Jamboor K. Vishwanatha Mar 2025

First-In-Class Peptide Molecules Targeting The Mien1 Cancer Signaling Pathway, For Which No Inhibitors Have Been Identified To Date., Amit Tripathi, Jamboor K. Vishwanatha

Research Symposium

Background: Migration and Invasion Enhancer 1 (MIEN1) is a critical oncogene that drives cancer cell migration, invasion, and epithelial-to-mesenchymal transition (EMT) in various cancers. MIEN1 overexpression is linked to aggressive tumor progression and poor prognosis. Despite its established role in cancer biology, targeted therapeutic options remain unexplored. This study aimed to identify and characterize first-in-class therapeutic molecules targeting the MIEN1 signaling pathway to inhibit cancer progression.

Methods: To develop novel bio-active peptides, we leveraged conserved immunoreceptor tyrosine-based activation motif (ITAM) and prenylation motifs within the MIEN1 protein sequence. Using rational peptide design, we identified and synthesized bioactive peptides, namely LA3IK …


Memoria Sin Fronteras: A Culturally Informed Expressive Arts Program For Brain Health In The Rio Grande Valley, Andrea Ramirez, Rosa V. Pirela, Kim Finn, Gladys E. Maestre Mar 2025

Memoria Sin Fronteras: A Culturally Informed Expressive Arts Program For Brain Health In The Rio Grande Valley, Andrea Ramirez, Rosa V. Pirela, Kim Finn, Gladys E. Maestre

Research Symposium

Purpose: The Memoria Sin Fronteras program addresses the rising prevalence of Alzheimer’s Disease (AD) in rural communities by promoting health equity and targeting underserved older adults in Brownsville, Texas, in particular in the Southmost neighborhood. The program aims to reduce health disparities by providing free, accessible interventions for cognitive health, social engagement, and community support. By creating opportunities for multi-generational interaction and education, the initiative aims to mitigate the impact of AD and improve the overall quality of life for seniors who lack resources.

Description: The program centers on the future establishment of a geriatric center offering art therapy, social …


Community Health Assessment: Chronic Disease And Demographics Among Patients At The Utrgv Som Student-Run Clinic, Fernando Cisneros, Andrea Argenal, Naya Williams, Sowmya Duddu, Yolanda Gutierrez, Kassandra Pulido, Alyssa Sepulveda, Ronald Shaju, Nathaniel Alvarez, Jessica Flores, Lucinda Hinojosa, Beatriz Tapia Mar 2025

Community Health Assessment: Chronic Disease And Demographics Among Patients At The Utrgv Som Student-Run Clinic, Fernando Cisneros, Andrea Argenal, Naya Williams, Sowmya Duddu, Yolanda Gutierrez, Kassandra Pulido, Alyssa Sepulveda, Ronald Shaju, Nathaniel Alvarez, Jessica Flores, Lucinda Hinojosa, Beatriz Tapia

Research Symposium

Background: The University of Texas Rio Grande Valley School of Medicine Student-Run Clinic (UTRGV SOM SRC) is a free clinic that provides primary care to the underserved population of Hidalgo County. The Pueblo de Palmas colonias in Peñitas, Texas is a community in this medically underserved region. Understanding the unique healthcare needs of this population is essential for guiding the delivery of care and improving access to healthcare services in the area. This study aims to identify and describe the demographics of patients receiving care at the UTRGV SOM SRC in order to tailor health initiatives and provide more targeted, …