Medicine and Health Sciences Commons^™

Supplement Product Quality Woes: A Call To Action, Andrew Shao

Oxford ICSB

No abstract provided.

Digitization Of Hptlc Chromatograms For Chemometric Analysis, Menglian Zhang, Jianghao Sun

Oxford ICSB

HPTLC has been a major analytical tool for the botanical industry for many years. Its strength has been the ability to provide multiple chromatograms for parallel visual comparison of standards and samples. It’s weakness has been the lack of digitization to allow objective chemometric analysis of the data. Two studies are presented: analysis of 3 species of Echinacea (E. angustifolia, E. palida, and E. purpurea) and analysis of cranberry supplements, fruits, and juices (35 supplements, 8 dried fruits, and 4 juices). Accurate comparison of the patterns of the chromatograms required pre-processing: removing initial and final peaks, derivatization, alignment of samples …

Moving From Conundrum To Solution. Understanding The Riddle Of Data, Supply Chains And Botanical Complexity, Cris Amarillas

Oxford ICSB

No abstract provided.

Simultaneous Botanical Identification And Marker Compound Assay By High Performance Thin Layer Chromatography, James Kababick, Stacy Wise, Christine Goularte

Oxford ICSB

21 CFR part 111 (the Dietary Supplement cGMPs) require identity testing on all dietary ingredients. In many cases, botanicals are also standardized to selected marker compounds and require potency testing to ensure products meet label claim. We present a novel approach to combining the identification and assay testing into one analytical run utilizing High Performance Thin Layer Chromatography. The method eliminates the need for subsequent assay testing and greatly reduces chemical waste in the laboratory saving both time and money. Case studies will be presented.

Foraging For Methods: The Right Hptlc Method For The Right Spec, Khanh Tran, Sidney Sudberg, Anthony Fontana

Oxford ICSB

High Performance Thin Layer Chromatography (HPTLC) is a well-established analytical technique widely utilized for botanical and fungal identification. Mushrooms are known for their bioactive compounds (beta-glucans, sterols, and triterpenoids) that can have a wide range of human health benefits, such as boosting the immune system, antioxidant, and anti-inflammatory among others. The method selection for mushrooms is dependent on the species of mushroom, the compound(s) of interest, form of material, as well as standardization of extracts. Over 15 different mushroom species were analyzed by various methods by HPTLC, for both mycelia and fruiting body.

Rooted In Quality: Elevating Standards In Botanical Supplements, Katie Banaszewski

Oxford ICSB

The botanical supplement industry is currently navigating a landscape that demands an unwavering commitment to high standards of quality, transparency, and sustainability. This sector faces a host of challenges alongside new opportunities, particularly emphasizing the vital role of quality assurance in preserving the integrity of botanical products. To ensure the authenticity of botanical ingredients and safeguard consumer health, advanced scientific testing techniques have become indispensable. Methods such as DNA barcoding, mass spectrometry, and NMR spectroscopy play crucial roles in verifying the purity and identity of these natural products. Furthermore, as the market increasingly prioritizes ethical consumption, there is a growing …

Innovative Integration Of Hptlc And Ai For Detecting Adulteration And Ensuring Quality In European Elder Berry Products, Maria Monagas, Wilmer Perera, Roy Upton, Eike Reich, Tiên Do

Oxford ICSB

European Elder berry, Sambucus nigra L. has a long history of traditional use as a cold and flu remedy. Since COVID-19 pandemic, the increased demand and limited supply have increased adulteration risk. Major concerns related to adulteration are substitution of Elder berry with black rice extract, addition of synthetic dyes and species mislabeling. HPTLC analysis of a total of 167 samples from different types of ingredients marketed as containing S. nigra was conducted, including whole fruits, juice concentrates, dry juices, fruit powders, liquid extracts, aqueous extracts and Dietary Supplements (DS) products (capsules and syrups). Related species (S. cerulea, S. canadensis, …

Herbs In Commerce: Sales Trends And Consumer Attitudes In The $13 Billion U.S. Herbal Supplement Market, Bill Giebler

Oxford ICSB

No abstract provided.

The Cruciality Of Early Recognition Of Postpartum Depression In Neonatal Intensive Care Unit (Nicu) Mothers, Shelby Clark

Scholars Week

Postpartum depression is a serious complication of childbirth that is largely dismissed by society for a variety of reasons. Unfortunately, the condition is intensified for NICU mothers. If left untreated, postpartum depression can have detrimental effects. This quality-improvement project focused on early recognition of postpartum depression symptoms in mothers of infants admitted to a neonatal intensive care unit in Western Kentucky. The goal of the project was education for and recognition of postpartum depression in NICU mothers. Methodology for the project included utilizing the Edinburgh Postnatal Depression Scale to determine the severity of symptoms of postpartum depression for NICU mothers. …

Effects Of Treatment With Af38469 On Localization Of Lysosomal Proteins In Batten Disease In Vitro Models, Ainslie Robinson, Mitchell Rechtzigel, Hannah Leppert, Joelle Anderson, Jon Brudvig, Jill Weimer

Celebration of Research

Batten disease is a rare, pediatric, neurological disorder that is the result of a mutation in one of 13 CLN genes. Batten disease has an incidence rate of 1 out of 100,000 births worldwide with CLN3 being the most common form. Being a genetic disorder, gene therapy is an ideal treatment approach for Batten disease. Diagnosis of disease, however, typically does not occur until disease has progressed, when the ideal therapeutic window for gene therapy has already passed. Additionally, the durability of viral-delivered gene therapy over time is poorly understood. AF38469, a small molecule inhibitor of sortilin, was developed for …

The Most Current And Effective Pharmaceutical Treatment Options For Chronic Migraines, Sophia Riley, Sierra Wright, Hannah Hall, Jill Van Otterloo

Celebration of Research

Chronic migraine (CM) is a debilitating condition that affects a significant portion of the population. Treatment for CM is a current area of research with new medications being developed. One of the latest mechanisms of action for treatment is targeting the calcitonin gene-related peptides. Two classes of drugs block that pathway, Anti-CGRP monoclonal antibodies and CGRP receptor antagonists. Another therapy that has been utilized recently for the preventative treatment of CM Onatabotulliniumtoxin A (Botox).

Continued Care In Female Patients With Tetralogy Of Fallot Into Adulthood And Pregnancy, Taylar Boerema, Mayle Owen, Anna Topp, Jolene Harris

Celebration of Research

Tetralogy of Fallot (TOF) is a congenital heart disease with four distinct characteristics: pulmonary valve stenosis, overriding aorta, right ventricular hypertrophy (RVH), and ventral septal defect (VSD). Surgical correction is now an option with 98% survival rate. Patients with repaired TOF (rTOF) often reach adulthood and can transition out of pediatric care. Unfortunately, providers trained to care for adults with congenital heart defects are not readily available. This has caused a lapse in care for many individuals with TOF. Additionally, providers trained to care for patients with congenital heart defects are needed to monitor patients with pre-pregnancy counseling and throughout …

Cardiovascular Effects Of Glp-1ra In Patients With Type 2 Diabetes, Courtney Legner, Gabriel Legner, Sandra Muyskens

Celebration of Research

The rising prevalence of type 2 diabetes mellitus (T2DM) in the US has led to an increased risk of cardiovascular disease (CVD) among affected individuals. GLP-1RA have been used since 2005 to help manage diabetic patients by controlling glucose levels, weight loss, and in further research, reducing cardiovascular disease. This review examines the cardiovascular effects of GLP-1RA highlighting key clinical trials including the LEADER, SUSTAIN, PIONEER 6, REWIND, and AMPLITUDE-O trials looking at liraglutide, semaglutide oral and subcutaneous, dulaglutide, and efpeglenatide. These studies found a significant decrease in major adverse cardiac events (MACE) in the drug groups when compared to …

Evaluation Of Aerobic Exercise And Neck-Targeted Exercise In Reducing Migraine Frequency And Symptoms, Carissa Cunningham, Carly Christensen, Rick Loutsch

Celebration of Research

Migraine is a prevalent headache disorder that significantly impacts quality of life for sufferers, yet there continues to be no clear treatment to reduce the burden for many. Exercise is one proposed intervention that has been shown to reduce the frequency and symptoms of migraine. Both aerobic exercise and specific muscle-focused exercises have been evaluated in improving the quality of life for migraine sufferers with supporting evidence for efficacy. While more research is needed, exercise can be a beneficial method for patients wanting to avoid pharmaceutical intervention and reduce their migraine symptoms in a more holistic manner.

Implementation Of Virtual Nursing, Kennedy Van Beek, Lydia Zink, Gabrielle Johnson, Brieannah Brands, Madison Naig, Pam Hulstein

Celebration of Research

A literature review was conducted between the months of August 2024 and November 2024 to explore how virtual nursing can improve quality of care. Ten articles focusing on the implementation of virtual nursing were reviewed and analyzed. The purpose of this review is to assist Spencer Hospital in their goals of decreasing the number of staff onsite and offloading the tasks of medication checks, admissions, and documentation to virtual nurses. In the literature review below, we compile resources to explore how virtual nursing influences workflow, patient safety, finances, and satisfaction of both patients and providers. Although many benefits regarding the …

Evaluating The Efficacy Of Focused Ultrasound In Neurological Disorders And Malignancy, Kennedi Henke, Ryan Takens, Heidi Smith, Andrea Crew

Celebration of Research

Focused Ultrasound (FUS) is an emerging therapeutic strategy for neurological diseases, including Parkinson’s disease, Alzheimer’s disease, and brain tumors. Despite advancements in conventional treatments, challenges such as invasive procedures, limited drug delivery across the blood-brain barrier (BBB), and declining long-term efficacy necessitate novel approaches. FUS offers non-invasive neuroablation, BBB modulation, and enhanced drug delivery, positioning it as a promising alternative to traditional therapies. This review examines the clinical evidence on FUS’s role in tumor reduction, tremor management, and amyloid plaque reduction, highlighting its benefits, challenges, and future potential in neurological disease treatment.

Continuous Glucose Monitoring Vs Fingerstick Monitoring In Pediatric Type I Diabetes, Lucia Latawiec, Hannah Schubrych, Carmen Almendarez, Leslee Graff

Celebration of Research

Type 1 diabetes is rising in the adolescent population, and with that is a rise in technological advances, including continuous glucose monitoring (CGM). CGM and finger-stick testing provide accurate measurements of blood glucose levels, aiding in control of both hyperglycemic and hypoglycemic events. CGM provides multiple benefits over finger-stick testing, including reduced number of skin pricks, easier access sites, and various others. CGM also presents with several complications, including high costs and skin irritation. The goal of increased CGM use and awareness is to decrease long-term complications of type I diabetes in the adolescent population, including cognitive function decline, retinopathy, …

Angiotensin Converting Enzyme Inhibitor Induced Angioedema (Acei-Ae): Emergency Department Treatments, Logan Held, Marcus Blankenspoor, Kristine Her, Jolene Harris

Celebration of Research

Angiotensin Converting Enzyme Inhibitor Induced Angioedema (ACEI-AE) is the acute swelling of the upper airway in patients who are currently or were formerly taking Angiotensin Converting Enzyme Inhibitors (ACEIs) for control of primary hypertension. Though emergency department presenting signs and symptoms have overlap with angioedema associated with anaphylaxis, there are key differences, including the absence of urticaria or hypotension and history of ACEI use, that can guide clinicians in identifying the underlying cause of the angioedema and initiate appropriate treatment. Due to its differing pathophysiology, ACEI-AE must be treated uniquely with Tranexamic Acid (TXA) and Fresh Frozen Plasma (FFP) to …

Screening Resources And Interventions For Postpartum Depression, Gianna Escalera, Emma Haley, Nicholas Helderop, Stella Umphreys, Samantha Vermeer, Pam Hulstein

Celebration of Research

A literature review was conducted between the months of August 2024-November 2024 to explore screening, diagnosis and intervention for patients experiencing PPD. 10 articles focusing on these three topics were reviewed. The purpose of this project was to examine current research regarding PPD screening, diagnosis, and intervention and to suggest evidence-based modifications to the current practice at Sioux Center Health. The following literature review provides several alterations to current practice regarding time of screening, education of providers, and interventions offered, to produce best outcomes for PPD patients.

Keywords: Postpartum Depression, Postpartum, Perinatal, Prenatal, Edinburgh Postnatal Depression Scale

The Efficacy And Safety Profile Of Adalimumab And Secukinumab In Treating Hidradenitis Suppurativa, Abby Witte, Ella Eibensteiner, Madelyn Wilkinson, Andrea Crew

Celebration of Research

Hidradenitis suppurativa is a chronic inflammatory disorder of the follicular epithelium in the axilla, groin, peritoneum, and intertriginous areas that presents with painful nodules and abscesses. Due to the poorly understood etiology of the disorder, there are various different treatment options targeting proposed mechanisms of actions which results in a lot of trial and error to find the appropriate treatment plan. Clinicians must consider the whole patient while understanding the efficacy of the medication, possible adverse reactions, and patient compliance when creating a treatment plan, especially with the use of systematic biologics. This review aims to compare two currently FDA-approved …

Delaying The Newborn Bath For Twenty-Four Hours, Ashley Hellewell, Grace Radcliffe, Kendyl Ruschy, Breelle Van Zee, Pam Hulstein

Celebration of Research

Delaying newborn bathing beyond 24 hours aligns with the WHO guidelines on newborn care, and is beneficial to neonatal outcomes:

• Potential to improve several key outcomes of extrauterine stabilization and breastfeeding.
• Reduces neonatal hypothermia and hypoglycemia.
• Increases prevalence of breastfeeding rates.

Studies reported mixed results regarding the significance of these outcomes; however, data favors the practice of delayed infant bathing. Further research is warranted to address limitations and gaps in research.

By implementing delayed newborn bathing, healthcare providers have the potential to improve the overall health outcomes of the infant and support wellbeing.

Hypoglycemic Predictive Modeling Tool, Zoe Bruflat, Pam Hulstein

Celebration of Research

Introduction: This evidence-based practice (EBP) project aims to improve patient safety and outcomes through the implementation of a predictive modeling tool (XGBoost) to predict and prevent hypoglycemic events in hospitalized adults at Sanford Health. Hypoglycemia continues to be a major safety concern, and early prediction can prevent complications

Methods: The project involved a literature review of articles to identify and recommend a hypoglycemic predictive modeling tool for Sanford Health. Included articles were published between 2019 and 2024 and selected through keywords like inpatients, hypoglycemia, glucose prediction, and predictive modeling. Searches across databases, including PubMed, JAMA, JIML, …

Preseason Mileage Influences The In-Season Training Effect In Female Cross Country Runners, Abby Ervin, Dean Calsbeek

Celebration of Research

Purpose: The purpose of this study was to analyze how preseason mileage influences the in-season training effect on maximal oxygen uptake (VO_2max) and lactate threshold (LT) in trained NAIA runners. Methods: Eight female distance runners (age 21.2 0.5 y) ran preseason mileage prior to the start of the cross country season. Subjects completed a graded treadmill test to determine VO_2max and VO₂ at OBLA (VO₂ OBLA) at the beginning and end of a 9 week competitive season. Results: Postseason testing revealed VO_2max significantly improved (p=0.009), while no significant improvement occurred in VO₂ OBLA …

Point Of Care Ultrasound To Manage Fluid Resuscitation In Septic Shock​, Micah Vander Wiel, Ian Wiersma, Jaclyn Freese

Celebration of Research

Sepsis is a health complication causing immune dysregulation and ultimately end-organ damage, with millions of cases and deaths reported annually.1,2 The financial burden of sepsis is substantial and results in hospitalization costs in the United States exceeding $52 billion per year.3 Early diagnosis and effective management strategies are necessary to reduce morbidity and mortality following sepsis and septic shock.

This paper examines the use of Point-of-Care Ultrasound (POCUS), specifically Inferior Vena Cava (IVC) collapsibility and how it may be able to guide fluid resuscitation management for patients with sepsis.4 While POCUS has not consistently demonstrated a significant decrease in rates …

Assessing The Gaps Between Ethnic Populations: A Comparison Of Lipid-Lowering Interventions ​, Chasen Hershman, Gavin Lamott, Chester Dejong Md

Celebration of Research

Pharmacological and lifestyle interventions have been a proven strategy for lowering the cardiovascular risk in all populations. Despite this, certain ethnic populations have a greater ASCVD risk due to either high LDL levels or other factors. The goal of this review is to analyze variables (specifically LDL) that contribute to certain ethnic populations demonstrating a greater risk of CVD as well as interventions that can improve outcomes. Treatment of hyperlipidemia requires a multifactorial approach which is tailored to the individual patients’ needs. Statins continue to be first-line pharmacological therapy for the treatment of lowering LDL. When combining a healthy diet …

Mobile Health Interventions In Diabetic Care In Times Of Environmental Crisis, Sarah Weisbrod, Makenzie Snyder, Maren Nerem, Katrina Hopkins, Pam Hulstein

Celebration of Research

A literature review was conducted between the months of August 2024 - November 2024 to explore the impact that the environmental effects of flooding have on those with diabetes mellitus (DM) and how the implementation of multiple forms of mobile health (mHealth) can aid in recovery and preparedness. Ten articles focusing on the various impacts that flooding and other natural disasters have on diabetic individuals, as well as the positive health outcomes tied to mobile applications and SMS messaging systems were reviewed. The purpose of this review was to examine current research regarding the treatment, education, and preparedness of diabetic …

Utilizing Buprenorphine In Patients With Opioid Use Disorder, Emma Roush, Dani Prusha, Emily Smith, Jaclyn Freese

Celebration of Research

Buprenorphine, a partial mu-opioid agonist, is a critical medication in treating opioid use disorder (OUD) and chronic pain. It was initially developed in the 1960s, then approved for pain management in the 1980s. However, over the past two decades, buprenorphine’s use has expanded to OUD treatment, demonstrating improved patient outcomes, enhanced treatment retention, and reduced opioid use. Its longer half-life allows for less frequent dosing and greater adherence compared to full agonists. Buprenorphine also has a more favorable safety profile compared to methadone, which results in lower risks of respiratory depression and overdose.

Despite its efficacy, buprenorphine remains underused due …

Subcutaneous Infusions For Hydration And Nutrition, Bryn Hoekman, Kelsie Dulmes, Laci Van Hauen, Megan Vankalsbeek, Mikayla Johnson, Pam Hulstein

Celebration of Research

Subcutaneous (SC) infusions deliver fluids or medications into the body's fatty tissue using small needles. They are cost-effective, easy to use, comfortable, and carry a low risk of serious complications like infections. In hospital settings, IV access can be challenging, and oral fluid intake may be insufficient for proper hydration. Spencer Hospital was interested in the potential benefits of SC infusions and what population would benefit most. The purpose of this project was to examine SC infusions as an alternative for hydration when IV access is unavailable, focusing on pediatric, geriatric, and palliative population. It compared Hydration, nutrition status, and …

2024-2025 Tower Health Research Day Award Recipients, Tower Health

Tower Health Research Day

No abstract provided.

The Impact Of Cyber Victimization On Adolescent Mental Health, Sherri Ann Walker, Folashade Odedina

Mental Health Summit

Cyber victimization is a growing risk factor for mental health disorders among adolescents. This session explores its prevalence and impact on adolescent well-being, as well as evidence-based interventions to mitigate harm. Attendees will learn strategies for screening, risk assessment, and promoting protective factors with an integrated Christian perspective on supporting affected youth.