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Full-Text Articles in Medicine and Health Sciences

A Model Description For The Transition From Multiprofessional To Interprofessional Courses, John E. Vitale, Reed Brooks, Ms, Pa (Ascp) May 2012

A Model Description For The Transition From Multiprofessional To Interprofessional Courses, John E. Vitale, Reed Brooks, Ms, Pa (Ascp)

JCIPE 2012

Transitioning from multiprofessional to interprofessional courses requires a commitment on behalf of the faculty of the programs represented within these courses. Through the development of advisory committees, creation and implementation of curricula, obtainment of pre- and post-test data and course evaluations this transition can be achieved.

The Pathologists’ Assistant Department at Rosalind Franklin University of Medicine and Science is currently involved in a transition of many of its students’ courses from multiprofessional to interprofessional; one such example is the Neuroscience course which combines Pathologists’ Assistant, Physical Therapy, and Podiatry students. This transition includes the formation of an advisory group, review …


The Job Opportunity Investment Network Education On Diabetes In Urban Populations (Joined-Up) Project, Rickie Brawer, James D. Plumb, Neva White, David Madison, Pamela Harrod-Smith May 2012

The Job Opportunity Investment Network Education On Diabetes In Urban Populations (Joined-Up) Project, Rickie Brawer, James D. Plumb, Neva White, David Madison, Pamela Harrod-Smith

JCIPE 2012

Diabetes and obesity are inter-related health issues that impact many aspects of daily living, including workplace productivity and efficiency. Obese individuals are less likely to be employed and more often absent from work. Nearly one billion dollars per year is attributed to lost productivity for reasons relating to diabetes including early retirement, increased sick days, disability and premature mortality.

Utilizing an interdisciplinary team of a physician, public health staff, nursing and health educators, the Job Opportunity Investment Network Education on Diabetes in Urban Populations (JOINED-UP) is a diabetes and obesity healthy lifestyle education program that is embedded in a Green …


Partnerships For Health - Jeff Health And The Rwanda Village Concept Project – A Model Of Interdisciplinary Health Professions Student Global Education, James D. Plumb, Ellen Plumb, Breanne Ward, Ashlyn Sakona, Morgan Greenfield, Elisabeth Collins May 2012

Partnerships For Health - Jeff Health And The Rwanda Village Concept Project – A Model Of Interdisciplinary Health Professions Student Global Education, James D. Plumb, Ellen Plumb, Breanne Ward, Ashlyn Sakona, Morgan Greenfield, Elisabeth Collins

JCIPE 2012

A partnership between the Rwanda Village Concept Project (RVCP), a medical student program in Butare, and Jeff HEALTH (Helping East Africans Link to Health), a multidisciplinary student organization at ThomasJeffersonUniversity, has been working in two Rwandan villages for the past five years. Initially, The Rwanda Health and Healing Project consisted of two programs, a Genocide Survivors Village Transformation and creation of a GenocideMemorial Park. These programs lead to a comprehensive community health assessment, which: 1) documented the needs through key informant interviews and focus groups; 2) identified health resources currently available; and 3) reviewed needs in context of the social …


Career Support Network, Rickie Brawer, Mph, Phd, James D. Plumb Md, Mph, Stephen Kern, Phd, Otr/L, Faota May 2012

Career Support Network, Rickie Brawer, Mph, Phd, James D. Plumb Md, Mph, Stephen Kern, Phd, Otr/L, Faota

JCIPE 2012

Seminar (44 PowerPoint Slides)

Project Overview: This project is funded under the Robert Wood Johnson Foundation’s Local Funding Partnerships Annual Program in support of innovative, community-based projects that improve the health and health care for underserved and vulnerable populations.Philadelphia currently confronts an unprecedented employment crisis. InSouth Philadelphia, the unemployment rate is 35%. Those who are unemployed present with multiple health problems that are barriers to retaining jobs and achieving economic stability.

The Career Support Network was conceived to help underserved, newly-employed adults to overcome these barriers and succeed in long-term careers. It will accomplish this mission by creating an integrated, …


Partnerships For Health - Jeff Health And The Rwanda Village Concept Project – A Model Of Interdisciplinary Health Professions Student Global Education, Ellen Plumb, Md, James D. Plumb Md, Mph, Francis Barchi, Mbe, Phd, Breanne Ward, Ashlyn Sakona, Morgan Greenfield, Elisabeth Collins, Cameron Bass, Md, Kaitlan Elston, Md, Rwanda Squad May 2012

Partnerships For Health - Jeff Health And The Rwanda Village Concept Project – A Model Of Interdisciplinary Health Professions Student Global Education, Ellen Plumb, Md, James D. Plumb Md, Mph, Francis Barchi, Mbe, Phd, Breanne Ward, Ashlyn Sakona, Morgan Greenfield, Elisabeth Collins, Cameron Bass, Md, Kaitlan Elston, Md, Rwanda Squad

JCIPE 2012

Seminar (23 PowerPoint Slides)

A partnership between the Rwanda Village Concept Project (RVCP), a medical student program in Butare, and Jeff HEALTH (Helping East Africans Link to Health), a multidisciplinary student organization at ThomasJeffersonUniversity, has been working in two Rwandan villages for the past five years. Initially, The Rwanda Health and Healing Project consisted of two programs, a Genocide Survivors Village Transformation and creation of a GenocideMemorial Park. These programs lead to a comprehensive community health assessment, which: 1) documented the needs through key informant interviews and focus groups; 2) identified health resources currently available; and 3) reviewed needs in …


Career Support Network, Rickie Brawer, James D. Plumb, Stephen Kern May 2012

Career Support Network, Rickie Brawer, James D. Plumb, Stephen Kern

JCIPE 2012

Project Overview: This project is funded under the Robert Wood Johnson Foundation’s Local Funding Partnerships Annual Program in support of innovative, community-based projects that improve the health and health care for underserved and vulnerable populations.Philadelphia currently confronts an unprecedented employment crisis. InSouth Philadelphia, the unemployment rate is 35%. Those who are unemployed present with multiple health problems that are barriers to retaining jobs and achieving economic stability.

The Career Support Network was conceived to help underserved, newly-employed adults to overcome these barriers and succeed in long-term careers. It will accomplish this mission by creating an integrated, one-stop center that weaves …


The Teaching Leader Series: Interprofessional Faculty Development Update, Amy B. Smith, Phd, Cynthia A. Cappel, Msn, Rn-Bc, Ne-Bc, Jaan Naktin, Tanya Ensminger, Alexander J. Lemheney, William Boyer, Tricia Shimkus May 2012

The Teaching Leader Series: Interprofessional Faculty Development Update, Amy B. Smith, Phd, Cynthia A. Cappel, Msn, Rn-Bc, Ne-Bc, Jaan Naktin, Tanya Ensminger, Alexander J. Lemheney, William Boyer, Tricia Shimkus

JCIPE 2012

Seminar (24 PowerPoint slides)

Purpose: The mission of the Teaching Leader Series is to strengthen teaching, learning and assessment skills by providing opportunities and support for faculty to achieve educational excellence, promote interdisciplinary collaboration and encourage instructional innovation.

Background: The Series is based on the assumption that an inclusive strategy would help ensure sustainability and that unique learning experiences occur when two or more professions together learned with, from, and about each other’s teaching practice.

Since the Series began in 2008 over 20 different topics have been presented including Adult Learning, Curriculum Development, Narrative Medicine, and Teaching with Simulation and …


The Professional Curricula Time Crunch: Options For Changing Student Understanding And Perceptions Of Interprofessional Learning And Collaboration, Robert Wellmon, Pt, Phd, Ncs, Linda Knauss, Phd, Abpp, Barbara Gilin, Msw, Lcsw, Tracey Rush, Edd May 2012

The Professional Curricula Time Crunch: Options For Changing Student Understanding And Perceptions Of Interprofessional Learning And Collaboration, Robert Wellmon, Pt, Phd, Ncs, Linda Knauss, Phd, Abpp, Barbara Gilin, Msw, Lcsw, Tracey Rush, Edd

JCIPE 2012

Seminar (56 PowerPoint slides)

Purpose: The purpose of this seminar is to describe and discuss the effectiveness of an educational module designed to incorporate opportunities for interprofessional learning (IPL) and collaboration into the professional curricula of 4 disciplines. The seminar will invite participants to share their experiences with redefining education to include opportunities for IPL when limited time and resources are available.

Background: Working effectively on interprofessional healthcare teams requires prior preparation. Academic institutions can play a key role in this process by creating opportunities for IPL and collaboration prior to graduation. An increasing number of schools are looking for …


The Professional Curricula Time Crunch: Options For Changing Student Understanding And Perceptions Of Interprofessional Learning And Collaboration, Robert Wellmon, Linda Knauss, Barbara Gilin, Tracey Rush May 2012

The Professional Curricula Time Crunch: Options For Changing Student Understanding And Perceptions Of Interprofessional Learning And Collaboration, Robert Wellmon, Linda Knauss, Barbara Gilin, Tracey Rush

JCIPE 2012

Purpose: The purpose of this seminar is to describe and discuss the effectiveness of an educational module designed to incorporate opportunities for interprofessional learning (IPL) and collaboration into the professional curricula of 4 disciplines. The seminar will invite participants to share their experiences with redefining education to include opportunities for IPL when limited time and resources are available.

Background: Working effectively on interprofessional healthcare teams requires prior preparation. Academic institutions can play a key role in this process by creating opportunities for IPL and collaboration prior to graduation. An increasing number of schools are looking for ways to incorporate IPL …


College Within A College (Cwic) – Population Health, James D. Plumb Md, Mph, Rickie Brawer, Mph, Phd, Rob Simmons, Drph, Mph, Mches, Cph, Abbie Santana, Msph, Nancy L. Chernett, Ma, Mph May 2012

College Within A College (Cwic) – Population Health, James D. Plumb Md, Mph, Rickie Brawer, Mph, Phd, Rob Simmons, Drph, Mph, Mches, Cph, Abbie Santana, Msph, Nancy L. Chernett, Ma, Mph

JCIPE 2012

Seminar presentation (55 PowerPoint Slides)

The development of programmatic tracks providing students with academic opportunities outside of the traditional medical curriculum represents a national trend in medical education. With HRSA Interdisciplinary and Interprofessional Joint Graduate Degree five-year funding, the Department of Family and Community Medicine at ThomasJeffersonUniversitycreated an Inter-professional Primary Care Dual Degree Program (IPCDDP), which builds on JeffersonMedicalCollege’s College within a College (CwiC) Scholarly Concentrations Program in Population Health. The mission of the IPCDDP is to provide outstanding training in primary care and innovative education in chronic care management and population and public health in order to prepare primary …


College Within A College (Cwic) – Population Health, James D. Plumb, Rickie Brawer, Rob Simmons, Abbie Santana, Nancy L. Chernett May 2012

College Within A College (Cwic) – Population Health, James D. Plumb, Rickie Brawer, Rob Simmons, Abbie Santana, Nancy L. Chernett

JCIPE 2012

The development of programmatic tracks providing students with academic opportunities outside of the traditional medical curriculum represents a national trend in medical education. With HRSA Interdisciplinary and Interprofessional Joint Graduate Degree five-year funding, the Department of Family and Community Medicine at ThomasJeffersonUniversitycreated an Inter-professional Primary Care Dual Degree Program (IPCDDP), which builds on JeffersonMedicalCollege’s College within a College (CwiC) Scholarly Concentrations Program in Population Health. The mission of the IPCDDP is to provide outstanding training in primary care and innovative education in chronic care management and population and public health in order to prepare primary care leaders to serve as …


Computer Supported Interprofessional Education For Improving Health Profession Students’ Attitudes Toward Teamwork And Team Performance, Kellie Smith, Rn, Msn, Carolyn Carolyn Giordano, Phd May 2012

Computer Supported Interprofessional Education For Improving Health Profession Students’ Attitudes Toward Teamwork And Team Performance, Kellie Smith, Rn, Msn, Carolyn Carolyn Giordano, Phd

JCIPE 2012

15 minute research paper (19 PowerPoint Slides)

This presentation will present results from a study that investigated the effect computer supported interprofessional education (CSIE) had on healthcare profession students’ attitudes toward healthcare teamwork and to what extent computer supported group processing impacted student perceptions of team performance. A hybrid approach to interprofessional education, CSIE, was used to provide students with an educational experience that combined the benefits of traditional face-to-face communication with a computer-mediated platform.

JeffersonCenterfor InterProfessional Education has successfully been providing IPE to healthcare students for over 5 years. A long term strategic goal was identified to “create innovative …


Computer Supported Interprofessional Education For Improving Health Profession Students’ Attitudes Toward Teamwork And Team Performance, Kellie Smith, Carolyn Giordano May 2012

Computer Supported Interprofessional Education For Improving Health Profession Students’ Attitudes Toward Teamwork And Team Performance, Kellie Smith, Carolyn Giordano

JCIPE 2012

This presentation will present results from a study that investigated the effect computer supported interprofessional education (CSIE) had on healthcare profession students’ attitudes toward healthcare teamwork and to what extent computer supported group processing impacted student perceptions of team performance. A hybrid approach to interprofessional education, CSIE, was used to provide students with an educational experience that combined the benefits of traditional face-to-face communication with a computer-mediated platform.

JeffersonCenterfor InterProfessional Education has successfully been providing IPE to healthcare students for over 5 years. A long term strategic goal was identified to “create innovative learning environments that support interprofessional education including …


A Collaborative Care Summit: A Regional Model Of Interprofessional Education, Karen E. Arscott, D.O., M.Sc., Aobnmm, Diane Haleem, Phd, Edward Foote, Pharmd, Fccp, Bcps, Maria Olenick, Crnp, Phd(C) May 2012

A Collaborative Care Summit: A Regional Model Of Interprofessional Education, Karen E. Arscott, D.O., M.Sc., Aobnmm, Diane Haleem, Phd, Edward Foote, Pharmd, Fccp, Bcps, Maria Olenick, Crnp, Phd(C)

JCIPE 2012

15 minute Research Paper (31 PowerPoint slides)

Purpose: To describe an interprofessional summit

Background: Northeastern/North Central Pennsylvania is home to several excellent healthcare education programs. Unfortunately these programs are somewhat smaller and isolated with most universities/colleges housing just a few disciplines. Interprofessional education requires collaboration across institutions, professions, and county lines. The Northeast/central

Interprofessional Education Coalition, comprised of a group of educators from 12 colleges and universities, was created in 2008 with a mission to promote IPE in our region.

Description of Intervention: An Interprofessional Care Summit was held on March 30, 2011 at five different sites …


A Collaborative Care Summit: A Regional Model Of Interprofessional Education, Karen Arscott, Diane Haleem, Edward Foote, Maria Olenick May 2012

A Collaborative Care Summit: A Regional Model Of Interprofessional Education, Karen Arscott, Diane Haleem, Edward Foote, Maria Olenick

JCIPE 2012

Purpose: To describe an interprofessional summit

Background: Northeastern/North CentralPennsylvania is home to several excellent healthcare education programs. Unfortunately these programs are somewhat smaller and isolated with most universities/colleges housing just a few disciplines. Interprofessional education requires collaboration across institutions, professions, and county lines. The Northeast/central Interprofessional Education Coalition, comprised of a group of educators from 12 colleges and universities, was created in 2008 with a mission to promote IPE in our region.

Description of Intervention: An Interprofessional Care Summit was held on March 30, 2011 at five different sites inScranton,Wilkes-Barre andWilliamsport. The collaborative team designed a case …


Infection With Chlamydia Pneumoniae Alters Calcium-Associated Gene Regulation And Processes In Neuronal Cells And Monocytes: Implications For Alzheimer’S Disease, Keith G. Williams, Juliana Zoga, Susan T. Hingley, Brian J. Balin, Denah M. Appelt, Marcus G. Bell May 2012

Infection With Chlamydia Pneumoniae Alters Calcium-Associated Gene Regulation And Processes In Neuronal Cells And Monocytes: Implications For Alzheimer’S Disease, Keith G. Williams, Juliana Zoga, Susan T. Hingley, Brian J. Balin, Denah M. Appelt, Marcus G. Bell

Research Day

Background: First proposed by Khachaturian in 1994, the calcium hypothesis postulates that sustained disturbance of intracellular calcium is the leading cause of neurodegenerative disorders. Studies showing alteration in calcium signaling in both sporadic and familial Alzheimer’s disease (AD) support this hypothesis. Intracellular calcium signaling is tightly regulated in time, intensity, and space, and is responsible for a variety of neuronal functions. Calcium influx from the extracellular environment modulates calcium levels, as do intracellular stores in the endoplasmic reticulum. The focus of this study was to test various calcium related genes in both monocytes and neuronal cells. Previous studies have shown …


The Effect Of Progressive Non-Aerobic High-Intensity Maximal Effort Exercise (Mee) On The Health-Related Quality Of Life In Patients With Multiple Sclerosis, Olufolake Odutola, Michael L. Kuchera, R T. Dombroski, T Vardy, F Thomas, S O’Brien, P Yagnik, K Wenzel, S Stoll, Bruce C. Stouch, M T. W, I Vargas, Hilda Lai May 2012

The Effect Of Progressive Non-Aerobic High-Intensity Maximal Effort Exercise (Mee) On The Health-Related Quality Of Life In Patients With Multiple Sclerosis, Olufolake Odutola, Michael L. Kuchera, R T. Dombroski, T Vardy, F Thomas, S O’Brien, P Yagnik, K Wenzel, S Stoll, Bruce C. Stouch, M T. W, I Vargas, Hilda Lai

Research Day

Background: Studies indicate that Multiple Sclerosis (MS) patients are less satisfied with the quality of their lives than healthy individuals in similar circumstances. Common symptoms experienced include fatigue, cognitive dysfunction, pain, spasticity, depression, bladder/bowel dysfunction and sexual dysfunction. Several pharmacological and non-pharmacological methods have been employed for such symptoms to try to increase quality of life and reduce the mortality rate. Non-pharmacological methods recommended for MS patients include lifestyle modifications, exercise programs and physical therapy. MS patients easily fatigue during aerobic exercise but a non-aerobic progressive maximal effort exercise (MEE) protocol consisting of a few short, duration isometric and eccentric …


Imp2 Expression In The Mouse Nervous System, Sarah E. Chmielewski, Paige E. Black, Tiffany M. Holmes, Kelly S. Lau, Gary J. Bassell May 2012

Imp2 Expression In The Mouse Nervous System, Sarah E. Chmielewski, Paige E. Black, Tiffany M. Holmes, Kelly S. Lau, Gary J. Bassell

Research Day

Background: Insulin-like growth factor-II (IGF-II) mRNA-binding protein-2 (IMP2) is one of the three homologs (IMP1-3) that play important roles in the posttranscriptional regulation of gene expression in several tissues. IMP1/ZBP1 (zipcode binding protein) has been shown to play important roles in axon guidance and regeneration by regulating the localization and translation of specific mRNAs. However, the function of IMP2 is least understood, largely because an isoform-specific antibody is not available, which makes the conventional techniques to locate protein expression not feasible.


Predicting Acute Urinary Retention In Patients With Elevated Post Void Residuals, David B. Cahn Mbs, Curtis P. Ross Do, Michelle L. Persun Md, Philip C. Ginsberg Jd, Do May 2012

Predicting Acute Urinary Retention In Patients With Elevated Post Void Residuals, David B. Cahn Mbs, Curtis P. Ross Do, Michelle L. Persun Md, Philip C. Ginsberg Jd, Do

Research Day

Objectives: To perform a retrospective analysis in order to evaluate factors that may help predict which men with elevated PVRs that were at increased risk to develop AUR.


Effects Of Non-Aerobic Maximal Effort Exercise On Fatigue In Deconditioned Men And Women With Multiple Sclerosis, Jessica U. Korsh, Michael L. Kuchera, R T. Dombroski, T Vardy, F Thomas, S O’Brien, P Yagnik, K Wenzel, S Stoll, Bruce C. Stouch, M T. Wallin, Jeffrey A. Nelson May 2012

Effects Of Non-Aerobic Maximal Effort Exercise On Fatigue In Deconditioned Men And Women With Multiple Sclerosis, Jessica U. Korsh, Michael L. Kuchera, R T. Dombroski, T Vardy, F Thomas, S O’Brien, P Yagnik, K Wenzel, S Stoll, Bruce C. Stouch, M T. Wallin, Jeffrey A. Nelson

Research Day

Multiple Sclerosis (MS) is a neurodegenerative disease of unknown etiology affecting women more frequently than men. Mental and physical fatigue complaints are often the most disabling symptoms for an MS patient. Both are multifactorial, potentially exacerbated by aerobic exercise, may prevent sustained physical functioning, and significantly interfere with activities of daily living1. A multi-center study was designed to investigate the effects of non-aerobic maximal effort exercise (MEE) for deconditioned persons with MS, with the expectation of minimizing fatigue. The IsoPUMP (Neuromuscular Engineering; Nashville, TN), is a specialized exercise and strength-sensing machine, designed to allow individuals to safely perform and record …


Documenting Pressures Used For Manual Diagnosis And Treatment Of Cervical Spine Somatic Dysfunction, Joseph Yoha, Michael L. Kuchera, Precious Barnes, Frank Casella, Jeffrey A. Nelson May 2012

Documenting Pressures Used For Manual Diagnosis And Treatment Of Cervical Spine Somatic Dysfunction, Joseph Yoha, Michael L. Kuchera, Precious Barnes, Frank Casella, Jeffrey A. Nelson

Research Day

Background: Palpatory assessment of free or restricted motion patterns is part of the diagnosis of spinal somatic dysfunction (SD). Diagnostically, local soft tissues are compressed (pre-loaded) over the structure of interest followed by one or more test impulses to assess the quality of the “end-feel” motion in several planes. These barrier sensations are often described qualitatively but have not been objectively quantified. Noninvasive, tactile pressure sensors built into a digital palpation monitoring system (IsoTOUCH®; Neuromuscular Engineering; Nashville TN, USA) were used to document loading and impulse pressures for palpatory segmental diagnosis and to first engage and then quickly move …


An Analysis Of Functional Status In Multiple Sclerosis Patients After Progressive Non-Aerobic High-Intensity Maximal Effort Exercise (Mee), Hilda Lai, Michael L. Kuchera, R T. Dombroski, T Vardy, F Thomas, S O’Brien, P Yagnik, K Wenzel, S Stoll, Bruce C. Stouch, M. T. Wallin, I. Vargas,, Olufolake Odutola May 2012

An Analysis Of Functional Status In Multiple Sclerosis Patients After Progressive Non-Aerobic High-Intensity Maximal Effort Exercise (Mee), Hilda Lai, Michael L. Kuchera, R T. Dombroski, T Vardy, F Thomas, S O’Brien, P Yagnik, K Wenzel, S Stoll, Bruce C. Stouch, M. T. Wallin, I. Vargas,, Olufolake Odutola

Research Day

Background: Multiple Sclerosis (MS) is a disease with a wide-ranging impact on functional status. MS patient function has been assessed using Multiple Sclerosis Functional Composite Score (MSFCS). The MSFCS includes the standardized scores (Z-score) of three functional tests: the Paced Auditory Serial Addition Test (PASAT-3”) for cognitive function, 9-Hole Peg Test (9-HPT) for upper extremity function, and timed 25-foot walk (25-TW) for lower extremity function. One of the most common symptoms experienced by MS patients is severe fatigue, often brought on suddenly by aerobic exercise. Non-aerobic maximal effort exercise (MEE) is thought to increase strength without increasing fatigue. The …


Mechanisms Of Mouse Hepatitis Virus Entry Into Cells, Philip J. Koehler, Kristina Cade, Fiora D. Zoga, Susan T. Hingley May 2012

Mechanisms Of Mouse Hepatitis Virus Entry Into Cells, Philip J. Koehler, Kristina Cade, Fiora D. Zoga, Susan T. Hingley

Research Day

Background: Viruses can enter cells through several mechanisms, two common ones being clathrin-mediated and caveolin-mediated endocytosis. The clathrin pathway delivers viral particles to endosomes, with subsequent acidification of the endosome and endosome/lysosome fusion often a prerequisite for release of the viral genome into the cytoplasm. The caveolin-mediated pathway delivers virus initially into vesicles called caveosomes, which have a neutral pH, before viral uncoating occurs. Viral entry pathways can be examined by using various drugs to inhibit the different endocytosis pathways, as well as by siRNA technology to down-regulate expression of clathrin or caveolin proteins on the surface of host …


Characterization Of A Small Iron Protein, Pyrococcus Furiosus Rubredoxin, As A Potential Cancer Drug Delivery System, Siri L. Chirumamilla, David L. Blum, Ray L. Mernaugh, Francis E. Jenney May 2012

Characterization Of A Small Iron Protein, Pyrococcus Furiosus Rubredoxin, As A Potential Cancer Drug Delivery System, Siri L. Chirumamilla, David L. Blum, Ray L. Mernaugh, Francis E. Jenney

Research Day

Background: Cancer is an elusive neoplastic disease that claims the lives of many people around the world every year. Though treatments have become more specific to the different types of cancer, the need for antineoplastic drugs that target cancer cells and leave normal cells unharmed, with little to no systemic toxicity remains, and rubredoxin might be such a tool. Rubredoxin is a small (53 amino acids), water soluble, non-heme iron electron transfer protein that contains an iron atom cofactor, which can be substituted with various cytotoxic transition metals such as nickel and cobalt with little or no effect on …


Changes In Expression Of Genes Associated With Autophagy And Apoptosis In Neuronal Cells Infected With Hsv-1may Suggest Infection-Induced Mechanisms Of Neurodegeneration, Alexis Mark, Fiora D. Zoga, Brian J. Balin Phd, Denah M. Appelt Phd, Susan T. Hingley May 2012

Changes In Expression Of Genes Associated With Autophagy And Apoptosis In Neuronal Cells Infected With Hsv-1may Suggest Infection-Induced Mechanisms Of Neurodegeneration, Alexis Mark, Fiora D. Zoga, Brian J. Balin Phd, Denah M. Appelt Phd, Susan T. Hingley

Research Day

Background:This study investigates the potential role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of neurodegenerative disorders, such as Alzheimer’s disease (AD), by exploring changes in gene expression related to antiviral immunity and the autophagic pathway. Autophagy is a process that recycles organelles and proteins to create more energy for the cell. This pathway has been linked to neurodegeneration, as malfunctions in the completion of this process lead to a decline in overall cellular health and function. Interestingly, HSV-1 has been shown to block the completion of autophagy, which would potentially contribute to the cytopathic changes observed …


The Effects Of Dihydrobiopterin And Tetrahydrobiopterin On Hydrogen Peroxide And Nitric Oxide Release During Extracorporeal Shockwave Lithotripsy, Brittany L. Deiling, Edward S. Iames, Kerry-Anne Perkins, Qian Chen Phd, Lindon H. Young Phd May 2012

The Effects Of Dihydrobiopterin And Tetrahydrobiopterin On Hydrogen Peroxide And Nitric Oxide Release During Extracorporeal Shockwave Lithotripsy, Brittany L. Deiling, Edward S. Iames, Kerry-Anne Perkins, Qian Chen Phd, Lindon H. Young Phd

Research Day

Extracorporeal shockwave lithrotripsy (ESWL) is an effective, non-invasive clinical therapy utilized to break up stones in the kidney and urinary tract. A lithotripter generates high-energy acoustic pulses and propagates those shock waves through a lens on a region that focuses on the location of the stone, in turn breaking up the stone. The successive pulses generate shearing forces and cavitation bubbles. Cavitation bubbles are the formation and implosion of liquid free zones. The cavitation bubbles implode rapidly to create their own shockwaves that also put pressure on the stone. After treatment, fragmentation of the stone allows the debris to be …


The Human Pathogen Clostridium Dificle: A Look At A Putative Involved In Protection From Oxidative Stress, Tashinea Lee, Francis E. Jenney May 2012

The Human Pathogen Clostridium Dificle: A Look At A Putative Involved In Protection From Oxidative Stress, Tashinea Lee, Francis E. Jenney

Research Day

Background: Hospital acquired infections due to Clostridium difficile (C. diff) is associated with nosocomial diarrhea and pseudomembranous colitis. Using a published microarray analysis of C. diff strain 630, several open reading frames (ORFs) were noted for their upregulation under different environmental stresses. One of these genes (CD1134) is a putative glyoxalase I. The glyoxalase enzymes detoxify a side product of glycolysis, methylglyoxal, and use metals as a cofactor.


Electrical & Magnetic Stimulation And Health, Yiyan Li Apr 2012

Electrical & Magnetic Stimulation And Health, Yiyan Li

College of Engineering: Graduate Celebration Programs

1, Introduction Most of the patients with neural diseases such as Parkinson’s disease, Stroke and Depression, cannot be cured by taking pills or conducting surgery. In contrast to the conventional therapies, physical therapies such as TMS (transcranial magnetic stimulation) (Fig. 1) and tDCS (transcranial direct current stimulation) (Fig. 2) are the most popular methods in treating neural disorders with a non-invasive way. TMS employs electromagnetic (1-3 Tesla) induction generates an Electric field suitable for neural stimulation; tDCS employs a weak current (1-2 mA) to modulate neuronal excitabilities.


Comparative Study Of Various Data Collection Software Used For Seat-Belt Observation Surveys, Atul Sancheti, Puneet Lakhanpal, Sergio Contreras, Pushkin Kachroo, Masha Wilson Apr 2012

Comparative Study Of Various Data Collection Software Used For Seat-Belt Observation Surveys, Atul Sancheti, Puneet Lakhanpal, Sergio Contreras, Pushkin Kachroo, Masha Wilson

College of Engineering: Graduate Celebration Programs

Every year, Click It or Ticket (CIOT) mobilization is held in U.S. which aims at increasing seat-belt usage awareness among the people. Data collection for assessing current seat-belt usage rates and campaign design for influencing mass audience are the two most important components of the mobilization. This paper presents a comparative study of various data collections software used for seat-belt observational surveys. The comparison is based on the speed and accuracy of the data collected from different software at the same locations and at the same time of the day.


April 25, 2012, Geneva Henry Apr 2012

April 25, 2012, Geneva Henry

Lecture Series on E-Science

Geneva Henry, Executive Director of the Center for Digital Scholarship, Rice University. Data rights and ownership of digital research data can impact how you use data, how others use data you've collected, and how rights are determined in collaborative research. Copyright rules governing data vary from one country to the next, making data ownership in international collaborations particularly murky. Licensing the use of data sets from the start is one way to address these issues early and provide a means for easily sharing datasets that can be cited and properly attributed. This talk with introduce issues associated with digital research …