Medicine and Health Sciences Commons^™

A Comparison Of Traditional Care And Cognitive Behavioral Therapy For Treating Depression Following Open Heart Surgery, Derryk Allen

Physician Assistant Scholarly Project Posters

Depression occurs shortly after open heart surgery in many patients. When depression is identified, traditional treatment consists of antidepressant medications along with cardiac rehabilitation and follow up care but these visits may not address depression. The purpose of this study compares traditional care with cognitive behavioral therapy. Does cognitive behavioral therapy more effectively manage depression than traditional care among male and female patients that have undergone open-heart surgery and acquired depressive symptoms? An article search of the following databases was conducted: PubMed and The Cochran Library. The review of literature explored studies that compare treatment between traditional care and CBT …

Safety And Efficacy Of Electronic Cigarette Use In Smoking Cessation, Matthew R. Coy

Physician Assistant Scholarly Project Posters

• Smoking is the most prevalent cause of avoidable mortality in the world

• Smoking cessation decreases likelihood of developing CV disease, stroke, cancer, and chronic lung diseases

• The purpose of this study is to assess if E-Cig’s are effective in smoking cessation and to evaluate the safety of their use

The Effectiveness Of Antibiotic Treatment In Lyme Neuroborreliosis, Lane Lindeman

Physician Assistant Scholarly Project Posters

• Lyme disease is caused by human infection with Borrelia burgdorferi, a spirochete transmitted by the Ixodes tick which is indigenous primarily to an increasingly large area of the Northeast and Midwest United States.

• Manifestations of Lyme disease vary greatly, and can result in significant neurologic symptoms associated with complications of neuroborreliosis or neurologic Lyme disease.

• Diagnosis and treatment of Lyme disease and its complications has been a source of debate and confusion for providers and patients alike.

• The purpose of this study was to investigate the effectiveness and efficacy of antibiotic therapy in patients with symptoms …

Should The Pharmacologic Management For Chronic Hepatitis C Encompass A Response Guided Therapy Treatment Plan?, Sarah Viscarra

Physician Assistant Scholarly Project Posters

Pharmacologic advances have been made with the development of new drug therapies that essentially cure the hepatitis C virus, such as sofosbuvir. The purpose of this study is to determine whether sofosbuvir should encompass a response guided therapy treatment plan versus a standard treatment protocol, in efforts to limit the risk of adverse effects and to minimize the cost of treatment. The systematic review of literature retrieved from Pub Med and Cochrane, explored studies that compared a standard treatment protocol of 12 weeks, in male and female adults ages 18-90 years, to response guided therapy treatment plans based on each …

The Herbal Cabinet, David J. Mokler, Amber Rigdon, Samantha Schildroth

Biomedical Sciences Faculty Projects

Description of a historical Eli Lilly herb identification collection belonging to University of New England professor David Mokler, including herb scientific names, common names, ranges, and uses. Each herb bottle is pictured, its label information is reproduced, and each herb’s historical and current uses are briefly described.

Donut Hole Fall 2016, Medicare Donations & Design Committee

Donut Hole Newsletter

No abstract provided.

Cancer Research: Current Trends And Future Directions, Elsevier

Public Reports

This report was developed with Elsevier’s Research Intelligence products and services; research performance data comes from the Scopus database, which is approaching 1 million peer-reviewed publications and scientific proceedings on cancer research produced in the past decade. It assesses the extent of cancer related research.

2016 Annual Report, Center For Applied Research On Substance Use And Health Disparities

Center for Applied Research on Substance Use and Health Disparities Annual Reports

No abstract provided.

Center For Global Health Newsletter, Center For Global Health, Old Dominion University

Center for Global Health Newsletter

January-June 2016 issue of Old Dominion University's Center for Global Health Newsletter.

Bundle Vs. Non-Bundle: Looking At Differences In Care And Outcomes At A Skilled Nursing Facility, Georgia Tsmasiros

Capstone Projects 2015-Present

The Centers for Medicare and Medicaid Services (CMS) introduced the Bundled Payments for Care Improvement Initiative (BPCI) in 2013 in an effort for consumers to have higher quality and more coordinated care. This research compared the care and outcomes of four individuals with bundled payment insurance plans and four non-bundle insured individuals with the same diagnosis, accessing rehabilitation services at a skilled nursing facility. The results show no observable differences between the outcomes of individuals with a bundled insurance plan and individuals without a bundled insurance plan. The financial implications are negative for healthcare agencies participating in BPCI who must …

2015-2016 Pediatric Subspecialty Trainees, Children's Mercy Hospital

Residents and Fellows Portraits

Photo composite of the graduate pediatric trainees in allergy/immunology, child abuse pediatrics, child neurology, clinical child psychology, clinical cytogenetics, clinical pharmacology, developmental-behavioral pediatrics, neonatal-perinatal medicine, pediatric adolescent gynecology, pediatric & congenital cardiac perfusion, pediatric cardiology, pediatric critical care, pediatric dentistry, pediatric dermatology, pediatric emergency medicine, pediatric endocrinology, pediatric gastroenterology, pediatric hematology/oncology, pediatric hospital medicine, pediatric infectious diseases, pediatric nephrology, pediatric ophthalmology, pediatric optometry, pediatric otolaryngology, pediatric ophthalmology/optometry, pediatric otolaryngology, pediatric radiology, pediatric rehabilitation, pediatric surgery, pediatric residency and med/peds residency

Graduate Medical Education 2015-2016 Annual Report, Children's Mercy Hospital

GME Annual Reports

Annual report of the Children's Mercy Hospital Graduate Medical Education department, including pediatric residency, internal medicine/pediatrics residency, fellowship programs, medical students, continuing medical education, and library services.

Com Outlook Winter 2016, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Sequential And Dynamic Rna:Rna Base-Pairing Interactions Between U6atac And U12 Snrnas Predicted To Form Helix 1a And Helix 1b, Maitri Patel, Jagjit Singh

Undergraduate Research Posters 2016

In eukaryotes, pre-mRNA splicing is important step for gene expression. Splicing is a two-step process which is carried out by a multi-megadalton molecular weight ribonucleoprotein (RNP) machinery called spliceosome. Spliceosome converts pre- mRNA to mRNA by removing non-coding sequence (introns) and splice together coding sequence (exons). Mammalian pre-mRNA are spliced by two different class of spliceosomes which are known as U2- and U12- dependent spliceosomes. U12 dependent spliceosome is composed of five small nuclear RNAs (snRNA). As compared to U2-dependent spliceosome, there is very less known about the catalytic process of U12-dependent splicing. U6atac and U12 snRNA are central to …

Bioinformatic Analysis Of The Sodium Hydrogen Exchanger Protein In Plasmodium Yoelii, Jamira Virk, Raghavendra Yadavalli

Undergraduate Research Posters 2016

Since its discovery over 100 years ago, malaria has been the most important parasitic disease in the world. Malaria affects about 300 to 500 million people every year; killing 5 million people every year. The most virulent causative agent in humans is Plasmodium falciparum; it is an important member of the phylum Apicomplexa, which also includes Toxoplasma gondii. These organisms contain specialized, unique structures, including rhoptry organelles. In Plasmodium and Toxoplasma gondii, they assist invasion into the host cell. Analyses have been performed on proteins located in rhoptries in Toxoplasma and Plasmodium. Among the proteins that have been analyzed, the …

Synthesis And Characterization Of Lectin Mimetics (Neo-Lectins), Czharena Kay Rama, Joshua Whited

Undergraduate Research Posters 2016

The cell surface expresses a variety of carbohydrates such as glycoproteins, proteoglycans and glycolipids. They play critical roles in pathological and physiological processes, including cell signaling, immune responses, pathogen-host interactions, tumor metastasis, and other cellular events. Due to its function and uses in cell communication, it is a curious subject of observation for scientific research. The molecular mechanism of carbohydrate recognition is still undetermined, and lectins, sugar binding proteins, are used to analyze the particular structures expressed on the cell surface. Lectins are normally found in plants and animals, and the isolation process of lectins is laborious, toxic, immunogenic and …

Dialects Accents And Intelligence: A Study On Dialectal Perceptions, Taylor Moore

Undergraduate Research Posters 2016

Speech language pathologists are given the tools to help clients with a wide range of pathologies. Issues relating to speech, hearing, swallowing, etc can all benefit from a Speech language pathologist's insight. One area that can be difficult is dialect. People across America speak with many different dialects and speech language pathologists are taught to recognize these differences but not correct them. Dialect showcases culture but does not define intelligence. Dialects like African American Venacular English are rule governed systems of communication (Carter, 2012). The research done on AAVE is seemingly endless (Baugh, 1983; Pearson,2013; Robinson,2011; Carter 2010; Bronstein,1970......) and …

Elimination Of Acoustical Noise For Stm Examination Of Pentacene Crystallization On Si (001), William Myers, Mark Bowling

Undergraduate Research Posters 2016

Organic electronics are used in traditional solar cells and also in flexible electronics. Unfortunately, the conductivities of organic semiconductors are significantly lower than their inorganic counterparts. This project examines crystallization by directed selfassembly of the organic molecules via a surface reconstruction as a method to increase conductivity. The crystallization is characterized by Scanning Tunneling Microscopy (STM). In order to achieve optimal STM images, this work examined: (1) noise isolation, (2) etching sharp STM tips and (3) achieving reconstructed Si surface. The STM is housed in a glovebox to keep the surface reconstructions and organic molecules from degrading. However, acoustical noise …

Synchronization Of Cell Growth Makes Capture Of G2 Phase Cells Possible, Maryam Assar, Noopur Joshi

Undergraduate Research Posters 2016

During meiosis, homologous chromosomes, one set maternal and the other set paternal, pair with one another. Pairing is a prerequisite for crossing over, where allelic regions on homologs break and recombine with the corresponding homolog. This crossing over results in recombinant chromosomes that in turn increase genetic diversity. What causes the homologs to pair at specific sites is unknown. We are investigating whether specific DNA sequences are involved in pairing. Our first step to identify pairing sites involves mitotic cells of budding yeast in order to isolate pairing regions in sister chromatids. Mitotic cells are used instead of meiotic cells …

Identification Of Factors That Mediate Strand Exchange During Early Meiosis At Low Double Strand Break Levels, Isaac Kuragayla, Rima Sandhu

Undergraduate Research Posters 2016

Genetic recombination is essential in order to create diversity amongst all of the genetic information. Crossovers also contribute to segregation of homologous chromosomes to opposite spindle poles during the first meiotic division. Meiotic strand exchange in Saccharomyces cerevisiae, budding yeast, aims to diversify genetic information in the resulting gametes which in budding yeast are called spores. While Dmc1 and Rad51 are two proteins that are known to play a role in double strand break (DSB) repair, the exact function of Rad51 is still unclear. It is known that Rad51 is responsible for strand exchange in mitosis, but it is still …

Biostatistical Analysis On The Effects Of The Circadian Clock & Glucose Genes On Different Feeding Regimens, Rana Faraj, Nikkhil Velingkaar

Undergraduate Research Posters 2016

Circadian clocks are internal biological systems that control many physiological processes. The circadian clock is considered to be the master regulator of metabolism in mammals. The molecular metabolism is not very well known. The circadian clock regulated expression in metabolic enzymes and in turn, diet also regulates circadian clock on a molecular level. To better understand the interaction between circadian clock and metabolism, mice were subjected to different feeding regimens and metabolic tissue, such as liver and skeletal muscles, have been collected across the circadian cycle. Expression of genes have been analyzed in the liver using RT-QPCR. Large set of …

Understanding The Expression And Trafficking Of Plasmodium Falciparum Maurer’S Clefts Proteins, Sophia Degeorgia, Katharine Komisarz, Ashka Patel, Raghavendra Yadavalli

Undergraduate Research Posters 2016

Malaria is a potentially fatal disease caused by parasites in the genus Plasmodium. Of the five species that cause human malaria, P. falciparum causes an estimated 1 million deaths annually, particularly in young children in sub-Saharan Africa. Plasmodium falciparum is most commonly found in tropical and subtropical regions of the world. After invasion into human red blood cells, parasite induced transport structures known as Maurer's clefts, are formed within red cells. In previous studies, two Maurer's clefts proteins were identified; an approximately 130 kDa peripheral membrane protein and a 20-kDa integral membrane protein. Immunofluorescence and confocal microscopy identified both proteins …

Effect Of Calorie Restriction On Circadian Rhythms Of Glycolytic Enzymes In Mice, Enas A. Muhammad, Artem Astafev, Kuldeep Makwana

Undergraduate Research Posters 2016

Multicellular and unicellular organisms have all proven to exhibit circadian rhythms which persist over approximately 24 hours. This internal time keeping system is responsible for regulating the body's biological functions. It has been known that calorie restriction effects circadian rhythms by causing a response in clock gene expression. These clock genes react to food intake and become either upregulated or downregulated accordingly. With glycolysis being a biological pathway that occurs in most organisms, measuring glycolytic gene expression in the liver tissue of young male mice becomes of interest. More specifically, hexokinase, PFK-1, and pyruvate kinase are the enzymes of interest. …

Expression Of Recombinant Proteins In Bacteria For Antibody Production, John Sabljic, Anton Denisyuk, Hallie Schmolz, Olivera Prica

Undergraduate Research Posters 2016

The protozoan parasite Trypanosoma brucei causes fatal African trypanosomiasis in humans and nagana in cattle. Transmitted by the tsetse fly, T. brucei proliferates in the bloodstream of its mammalian host and evades the host's immune response by regularly switching its major surface antigen, VSG, which forms a thick coat on its cell membrane. VSGs are exclusively expressed from sub-telomeric regions of the T. brucei genome in a strictly monoallelic fashion. Telomeres, DNA-protein complexes located at chromosome ends, help maintain chromosome stability and integrity. We have also found that telomere proteins are important for regulating VSG expression and switching. We are …

The Identification Of Anti-Cancer Molecular Targets Of Cox-2 Inhibitor Nimesulide, Yuridia Olivera Ortiz, Nethrie D. Idippily

Undergraduate Research Posters 2016

Non-steroidal anti inflammatory drugs which were primarily used for the treatment inflammation and pain have also shown anti-cancer activity in many studies. The mechanism of action of NSAIDs in cancer may involve cyclooxygenase (COX) dependent or independent pathways. According to studies, COX-2 is overexpressed in several cancers such as prostate, breast, nonsmall-cell lung, colon, and pancreas. Nimesulide is an NSAID with COX-2 inhibitory activity and investigations show that it could induce apoptosis in cancer. Previously, a library of compounds was synthesized using Nimesulide as a lead compound. However, they displayed different molecular targets: tubulin and heat shock protein 27 (HSP27). …

Light Scattering Characterization Of Elastin-Like Polypeptide Trimer Micelles, Ilona Tsuper, Daniel Terrano, Adam Maraschky

Undergraduate Research Posters 2016

Elastin-Like Polypeptides (ELP) can be used to form thermo-reversible vehicles for drug delivery systems. The ELP nanoparticles are composed of three-armed star polypeptides. Each of the three arms extending from the negatively charged foldon domain includes 20 repeats of the (GVGVP) amino acid sequence. The ELP polymer chains are soluble at room temperature and become insoluble at the transition temperature (close to 50 oC), forming micelles. The size and shape of the micelle is dependent on the temperature and the pH of solution, along with the concentration of the Phosphate Buffered Saline (PBS) solvent. The technique of Depolarized Dynamic Light …

Variation Of Bone Microarchitecture Within And Among Contemporaneous Species Of Fossil Horses: Feasibility, Emily A. Edwards

Undergraduate Research Posters 2016

Mesohippus, Miohippus, and Merychippus are extinct horse species that date back fifteen to thirty million years ago, which spanned over three time periods in North America. Each of the horses habituated different terrains from wet to dry. The third metacarpal became the prominent one-toe of horse evolution and is the specimen of this study. The aim is to determine if reorientation, segmentation, correcting size differences, and isolation are feasible. Horse fossils are extensive, documented, and are used as an analogous fossil lineage to humans for this study. Imaging of the third metacarpal was accomplished by micro-CT scanning with a focus …

Elimination Of Acoustic Noise In Stm Analysis Of Polymer Crystallization On Au (111), Mark Bowling, William Myers

Undergraduate Research Posters 2016

Organic molecules offer a potentially cheap and environmentally friendly alternative to traditional silicon based electronics. The main limitation is that they are not as conductive as their inorganic counter parts. By crystalizing organic molecules, it is possible to increase the conductivity so that they can be more competitive with silicon electronics. This project examines the crystallization of polymers through selfassembly on the Au(111) surface reconstruction. The success of the crystallization is characterized with scanning tunneling microscopy (STM). In order to achieve high resolution STM images, we examined acoustic isolation by enclosing the microscope within a rubber-coated box, which was not …

Which Clouds Are Important: Variation Of Cloud Size Distribution Functions In Large Eddy Simulations, Dorothy Pharis, Nicholas Barron

Undergraduate Research Posters 2016

Accurately measuring and modeling clouds is an important factor in improving weather and climate prediction. One way of measuring the most important cloud size in a cloud field is a cloud size distribution (CSD) function, or the number of clouds per cloud size within the field. The information from a cloud size distribution can then be used to determine which cloud sizes contribute the most to cloud cover. This research focuses on creating and comparing cloud size distributions for a variety of cumulus cloud fields generated by Large Eddy Simulations (LES), a high resolution computer model. Our work found that …

How Dry Is The Lower Atmosphere: Finding Relations Between Various Moments In The Atmospheric Boundary Layer, Vladimir Sworski

Undergraduate Research Posters 2016

The Atmospheric Boundary Layer (ABL), consisting of the bottom few kilometers of the troposphere, is a highly turbulent region with strong mixing of moisture and winds. This region's activity is driven by thermals, which rise to the top of the boundary layer and thicken it through entrainment of warm air from above. To better predict the behavior of the ABL, a good understanding of the distribution of heat, moisture and momentum is important. In this study, we use a high resolution computer model (LES) to determine those distributions. We were able to reproduce observations when using a temporal averaging that …