Medicine and Health Sciences Commons^™

Testing A Model Of Bacterial Vaginosis Among Black Women, Jessica Brumley

USF Tampa Graduate Theses and Dissertations

Bacterial Vaginosis is an inbalance of vaginal flora which has been associated with increased risk of numerous gynecological and obstetric morbidities including increased risk of acquisition of HIV from an infected partner and increased risk of preterm delivery. Black race has been consistently identified as a risk factor for BV. Black women also suffer from significant disparities in most of the morbidities also associated with BV when compared to women of other ethnicities and races. Traditional predictors of BV such as douching practices and sexual behaviors do not fully account for the racial disparities in BV prevalence. Researchers have begun …

A Systematic Review Of Interventions To Increase Mental Health Service Use, Jennifer Greene

USF Tampa Graduate Theses and Dissertations

Relatively few pre-treatment interventions to increase out-patient mental health (MH) service use have been created and experimentally tested. Therefore, not only is there limited availability of these interventions, it is uncertain whether existing interventions are effective. Moreover, it is unclear which components of the interventions are effective. To address these gaps in knowledge, a systematic review of pre-treatment interventions was conducted, using the Cochrane Review methodology. Three primary outcomes were evaluated: attendance at any type of out-patient MH visit; number of appointments of any type of out-patient MH visit; and/or initiation and adherence to psychotropic medication. PubMed and PsycINFO databases …

Willingness-To-Pay For Maintenance And Improvements To Existing Sanitation Infrastructure: Assessing Community-Led Total Sanitation In Mopti, Mali, Justin Vern Meeks

USF Tampa Graduate Theses and Dissertations

In recent years, much focus has been put on the sustainability of water and sanitation development projects. Experts in this field have found that many of the projects of the past have failed to achieve sustainability because of a lack of demand for water and sanitation interventions at a grassroots level. For years projects looked to create this demand through various subsidy schemes, with the "software" of behavior change and education taking a backseat to the "hardware" of infrastructure provision. Community-Led Total Sanitation (CLTS) is a fairly new way of looking at the issues of increasing basic sanitation coverage, promoting …

Evaluation Of Transfer Technologies To Preserve Shoulder Function In Sci, Karen Michelle Mann

USF Tampa Graduate Theses and Dissertations

This study investigated a series of independent unassisted and device-assisted transfers from a wheelchair to vehicle mock-up and vice versa while simultaneously capturing kinematic, kinetic and electromyographic (EMG) data of impaired volunteers. The study provides a venue for observation and evaluation of upper extremity (UE) joint stresses, muscular force and functional demands associated with transfers in persons with spinal cord injury (SCI) to ultimately prevent UE injury, minimize excessive stress, preserve functionality and limit pain. If people with SCI lose function of their UEs, due to pain and/or degeneration, they must then rely on others for everyday tasks.

Five paraplegic …

Hurricane Preparedness Of Community-Dwelling Dementia Caregivers In South Florida, Janelle J. Christensen

USF Tampa Graduate Theses and Dissertations

The aim of this dissertation is to explore how informal caregivers for people with dementia (PWD), who are community dwelling (i.e., not in nursing homes), prepare and plan for disasters. The research site is a particularly hurricane-prone region of Florida, second only to New Orleans in its vulnerability. An underlying assumption of this research is that caregivers for PWD have to plan and anticipate problems that are unique to their role. The rationale for the study described here is that disaster planning and mitigation save lives (Tengs et al. 1995), but there is little or no literature on disaster planning …

Evaluation Of Urinary Pesticide Biomarkers Among A Sample Of The Population In The United States, Alex Lance Lebeau

USF Tampa Graduate Theses and Dissertations

Pesticide use in the United States continues to attract negative public attention. In recent years, this attention has focused on the effects that chronic, low-level pesticides may have, especially on children and various sub-populations. Over the past decade, studies have attempted to correlate negative health effects with detections of pesticide biomarkers in biological media. The current research investigates biomarker of exposure levels in a sample of the United States population. Data from the 2001-2002 NHANES dataset (n=11,039) was evaluated. The detection frequency of urinary biomarkers of exposure and the geometric mean from the NHANES pesticide dataset (n=3,152) were determined. Of …

The Creation Of A Robotics Based Human Upper Body Model For Predictive Simulation Of Prostheses Performance, Derek James Lura

USF Tampa Graduate Theses and Dissertations

This work focuses on the use of 3D motion capture data to create and optimize a robotic human body model (RHBM) to predict the inverse kinematics of the upper body. The RHBM is a 25 degrees of freedom (DoFs) upper body model with subject specific kinematic parameters. The model was developed to predict the inverse kinematics of the upper body in the simulation of a virtual person, including persons with functional limitations such as a transradial or transhumeral amputation. Motion data were collected from 14 subjects: 10 non-amputees control subjects, 1 person with a transradial amputation, and 3 persons with …

The Relationship Between Death Depression And Death Anxiety Among Cancer Patients In Saudi Arabia, Doaa A. Almostadi

USF Tampa Graduate Theses and Dissertations

Abstract

Cancer is one of the main public health problems in the world. People diagnosed with cancer may become depressed and fearful of dying. This causes them to question treatments and sometimes avoid treatment altogether. Cancer may change the person's life and the lives of others around them. The current study focused on the psychosocial impact of impending death for cancer patients in Saudi Arabia. Currently, the relationship between the death anxiety and death depression in persons with cancer in Saudi Arabia is not yet clear. Added to that, little research has been conducted with Muslim cancer patients and their …

Matrix Metalloproteinase Genes Are Transcriptionally Regulated By E2f Transcription Factors: A Link Between Cell Cycle Control And Metastatic Progression, Jacqueline Lea Johnson

USF Tampa Graduate Theses and Dissertations

The RbµE2F transcriptional regulatory pathway plays a critical role in the cell cycle. Rb is inactivated through multiple waves of phosphorylation, mediated mainly by cyclin D and cyclin E associated kinases. Once Rb is inactivated, cells can enter Sµphase. Collectively, three Rb family members and ten E2F proteins coordinate every additional stage of the cell cycle, from quiescence to mitosis. However the RbµE2F pathway is frequently altered in cancer. Aside from cell proliferation, the RbµE2F pathway regulates other essential cellular processes including apoptosis, cell differentiation, angiogenesis and DNA damage repair pathways, but its role in invasion and cancer progression is …

The Effects Of Oxygen On The Electrophysiology Of Co2/H+-Chemosensitive And -Insensitive Neurons Of The Solitary Complex Of The Rat, Michael Patrick Matott

USF Tampa Graduate Theses and Dissertations

This study tested the hypothesis that decreasing the control O₂ level from 95% to 40% (5% CO₂ + 55% N₂) maintains viability in caudal solitary complex (cSC) neurons in transverse slices (~300-400ꝳ) prepared from neonatal rat (P2-22) maintained at 32-34°C. The underlying rationale is to reduce exposure to redox and nitrosative stimuli generated during several hours of exposure to 95% O₂ that produces a tissue O₂ tension throughout the slice which is in excess of 203 kPa (2.0 atmospheres absolute,ATA) oxygen. Whole cell recordings of cSC neurons maintained in 40% O₂ exhibited spontaneous …

Bereavement Outcomes Among Spousal Hospice Caregivers: The Role Of Rumination, Feelings Of Relief, And Perceived Suffering, Jessica Y. Allen

USF Tampa Graduate Theses and Dissertations

Background: The death of a spouse is among the most distressing life events faced by older adults and frequently follows long periods of providing extensive care and support. Although many spouses are resilient following loss, a number of bereaved spousal caregivers have poor psychological well-being and may benefit from clinical services. However, it can be difficult to determine who may most benefit from bereavement services and why some individuals are at greater risk for poor bereavement; thus, there is a need for greater understanding of the process of bereavement. Therefore, the purpose of this dissertation was to investigate a number …

A Comparison Of Direct And Indirect Contingencies Of Reinforcement For Teaching Advanced Receptive Skills, Catherine Czerwonka

USF Tampa Graduate Theses and Dissertations

An important variable not often examined in the literature is the relationship between target behaviors and their reinforcers. Previous research has demonstrated faster acquisition rates of simple receptive and imitative skills when the reinforcer used was part of the behavior chain that it reinforced. The current study evaluated the effectiveness of a direct reinforcement contingency to teach pairs of advanced receptive skills with three children with autism. During the indirect reinforcement condition, the therapist reinforced correct responding by handing the child an edible reinforcer. During the direct reinforcement condition, the reinforcer was located under the container displaying the correct response. …

A Smoking Cessation Program Using Vouchers With Individuals With Traumatic Brain Injury, Thomas Karl Erickson

USF Tampa Graduate Theses and Dissertations

This study examined the effects of a smoking cessation program using vouchers as reinforcers with individuals with traumatic brain injury and a history of substance abuse. The intervention was conducted at a residential facility that houses individuals with Traumatic Brain Injury (TBI). Vouchers were delivered contingent on reductions of carbon monoxide (CO) samples of 5 ppm or less across a shaping phase, and an abstinence induction phase. A standard pay phase was added at the end of the study to examine the effects of a standardized reinforcement scale with the abstinence criterion set at 8 ppm or less. Reductions in …

Ncr Vs Dro: Evaluation Of Effectiveness, Teacher Preference, And Fidelity Of Implementation, Jackie Courntey Lansdale

USF Tampa Graduate Theses and Dissertations

Abstract

Previous research has demonstrated that non-contingent reinforcement (NCR) and differential reinforcement of other behaviors (DRO) are effective procedures in reducing problem behavior of children both in and out of the classroom. However, few studies have assessed which procedure is most socially acceptable among teachers. In addition, studies have not recorded data on fidelity of implementation among teachers. A non-concurrent multiple baseline across teachers design was used to (a) demonstrate the effect of NCR and DRO on the problem behaviors of school aged children with no identified developmental disability, and (b) assess implementation fidelity of each procedure by the teacher. …

Evaluation Of Video Modeling And In Situ Training To Teach Gun Safety Skills To Individuals With Autism Spectrum Disorder, Kelsey Lynn Morgan

USF Tampa Graduate Theses and Dissertations

Currently, there is no known research on teaching gun safety skills to individuals with developmental disabilities. Research has shown that children typically engage in gunplay behaviors if they find a firearm. These behaviors can lead to unintentional firearm injuries and even death, especially for young children. Previous research has shown the success of video modeling for teaching various skills to individuals with autism. This study examined the effectiveness of video modeling for teaching gun safety skills to three children with autism spectrum disorder, and found that video modeling was effective for one participant, but in situ training was needed to …

Training Deictic Relational Responding In People With Schizophrenia, John O'Neill

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to replicate and extend recent findings in the functional contextual literature by 1) establishing complex deictic relational responding skills in 3 persons diagnosed with Schizophrenia and mild-moderate Mental Retardation and 2) assessing generalization through pre and post-instructional measures of Social Anhedonia and Theory of Mind functioning. Results suggest that increasingly complex levels of deictic relational responses were acquired and mastered by all 3 participants and that generalization extended to the Deceptive Container Task (ToM levels 4 & 5) and Hinting Task. Support is provided for the notion that perspective taking skills might be shaped …

Influence Of Stress And Cytokinic Profiles On Cognitive Performance In Older Adults, Kerri S. Rawson

USF Tampa Graduate Theses and Dissertations

ABSTRACT

With aging, changes in the immune system, makes cognitive performance, and the prevalence of stressors can lead to poorer overall functioning. Within the immune system, a balance should exist between cytokines regulating Th1 and Th2 immune responses; however, age-related declines in the endocrine and immune systems can disrupt this equilibrium. Several studies report higher levels of Th1 associated cytokines in inflammatory conditions of the brain, whereas fewer studies remark on Th2 associated cytokines and cognitive functioning. Declining cognitive abilities are a common concern that accompanies advancing age and some research has suggested the prevalence and impact of stressors lead …

An Evaluation Of Reactivity To Observer Presence While Self-Monitoring To Improve Swimming Performance, Sara Wendi Schonwetter

USF Tampa Graduate Theses and Dissertations

The current study evaluated the effects of self-monitoring by swimmers to improve their performance at practice and assessed the effects of reactivity to observer presence on their performance. Additionally, it investigated the accuracy of the swimmers' self-reports. Seven public high school swim team members used program boards to self-monitor in order to increase the number of assigned laps completed at practice. Reactivity to observer presence was assessed by having a confederate record the number of laps completed during observer absent conditions. A series of AB replications and an ABAB reversal design were used. The percentage of assigned laps completed increased …

Sugar Consumption And Cognitive Aging In The Swedish Adoption/Twin Study Of Aging, Shyam Seetharaman

USF Tampa Graduate Theses and Dissertations

Abstract

Consumption of foods high in sugar content has been linked with the development of metabolic abnormalities such as cardiovascular disease and type II diabetes, major sources of global health concerns. Although the detrimental consequences of high intake of sugar on abnormal metabolic processes are established, it is not known how this association affects (or accelerates) cognitive aging.

The current project was based on data from the Swedish Adoption/Twin Study of Aging (SATSA) to test the hypothesis that high refined sugar intake contributes to accelerated trajectories of cognitive decline assessed longitudinally. Trajectories of cognitive change were assessed as a function …

Modulating The Pharmacokinetics Of Bioflavonoids, Adam John Smith

USF Tampa Graduate Theses and Dissertations

One of the largest obstacles in drug development is to overcome solubility and bioavailability problems. Preformulation strategies such as nanoparticle formation are often employed but sometimes create new issues and are limited in their effectiveness and applications. Since the majority of drugs are marketed and sold as solid forms, drug delivery systems are not always desirable. This is where solid-state chemistry becomes important. Traditional solid-state chemistry approaches are often successful but are sometimes too restrictive and cannot be applied to certain compounds. Cocrystals have emerged as an alternative solid-state technique that can be applied to a broad range of compounds. …

Effects Of G-Csf On Monocytes And Neurons: In Vitro And In Vivo Studies In A Mouse Model Of Alzheimer's Disease, Amanda Renee Pennington

USF Tampa Graduate Theses and Dissertations

G-CSF is routinely used to treat neutropenia/leukopenia or to increase hematopoietic stem cell generation in bone marrow donors. G-CSF and its receptor, G-CSFR, are produced by various cell types both in the peripheral circulation and within brain. As a consequence, exogenous administration of G-CSF results in a broad spectrum of effects involving hematopoietic, immune and central nervous systems.

G-CSF administration in a mouse model of Alzheimer's disease (AD) has revealed both cognitive benefits and disease modifying effects: a) decreased Aβ plaque burden, b) increased microgliosis, c) increased neurogenesis and d) improved performance in radial arm water maze (RAWM). In clinical …

Behavioral And Immunological Phenotypes Of Transgenic Mice Overexpressing Human Secreted Amyloid Precursor Protein Alpha: Implications For Autism, Antoinette R. Bailey

USF Tampa Graduate Theses and Dissertations

Autism is a heterogeneous neurodevelopmental disorder that is characterized by impaired social interaction and communication as well as restricted and repetitive behaviors and focused interests. In addition to the cardinal behavioral characteristics observed for diagnosis, autistic individuals exhibit a number of comorbid conditions as well as a variety of aberrant immunological features. Recent studies report that plasma from autistic children contained elevated levels of secreted amyloid precursor protein alpha (sAPP-á), the á-secretase cleavage product of the amyloid precursor protein (APP) which is ubiquitously expressed in the brain, spleen, thymus and other organs. Interestingly, the sAPP-á fragment functions as a neurotrophic …

Aberrant Sialylation Alters Cardiac Electrical Signaling, Andrew Ednie

USF Tampa Graduate Theses and Dissertations

In the heart, electrical signaling is responsible for its rhythmicity and is necessary to initiate muscle contraction. The net electrical activity in a cardiac myocyte during a contraction cycle is observed as the action potential (AP), which describes a change in membrane potential as a function of time. In ventricular cardiac myocytes, voltage-gated sodium channels (Nav) and voltage-gated potassium channels (Kv) play antagonistic roles in shaping the AP with the former initiating membrane depolarization and the latter repolarizing it. Functional changes in the primary cardiac Nav isoform, Nav 1.5, or any one of the many Kv isoforms expressed in the …

Comparative Outcomes Assessment Of The C-Leg And X2 Knee Prosthesis, Michael Jason Highsmith

USF Tampa Graduate Theses and Dissertations

Background

There are more than 300,000 persons in the U.S. living with transfemoral amputation (TFA). Persons with TFA use a knee prosthesis for gait and mobility. Presently, the C-Leg microprocessor knee prosthesis is the standard of care. C-Leg has significantly improved safety and cost efficacy and has created modest gains in gait efficiency. Recently, a new prosthesis has introduced a new sensor array and processor that reportedly improves knee motion, stair function and standing stability. Early claims of the reported functional benefits of the new Genium knee (formerly X2) have not been validated in a rigorous clinical trial. Therefore, the …

Efficacy Of Increased Ube3a Protein Levels In The Brain In Rescuing The Phenotype Of An Angelman Syndrome Mouse, Jennifer L. Daily

USF Tampa Graduate Theses and Dissertations

Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is characterized by severe mental retardation, seizures, difficulty speaking and ataxia. The gene responsible for AS was discovered to be UBE3A and encodes an E6-AP ubiquitin ligase. A unique feature of this gene is that it undergoes maternal imprinting in a neuron-specific manner. In the majority of AS cases, there is a mutation or deletion in the maternally inherited UBE3A gene, although other cases are the result of uniparental disomy or mismethylation of the maternal gene. While most human disorders characterized by severe mental retardation involve …

Maternal Immune Dysregulation In The Pathogenesis Of Neurodevelopmental Disorders: Interleukin-6 As A Central Mechanism And Therapeutic Target Of Flavonoids, Ellisa Carla Parker-Athill

USF Tampa Graduate Theses and Dissertations

Activation of the maternal immune system and resultant maternal cytokine expression due to prenatal infection has been implicated as a significant contributor to the pathology of neuropsychiatric and neurodevelopmental disorders such as schizophrenia and Autism Spectrum Disorder (ASD). Increased maternal interleukin-6 (IL-6) expression, observed clinically and in animal models of prenatal infection, and resultant activation of key signaling pathways, has been shown to be a biological indicator of pathology, and a central component of the pathological mechanism. In animal models of prenatal infection and clinically in pregnancy disorders hallmarked by immunological irregularities and increased IL-6 expression, inhibition of IL-6 has …

Neuron To Microglia Communication; A Study Of Cx3cl1 Signaling Implications In Cognitive Function, Inflammation, And Neurodegeneration, Joshua M. Morganti

USF Tampa Graduate Theses and Dissertations

As a consequence of aging, the brain is subject to chronic neuroinflammatory conditions. The resident immune cells of the brain, microglia, act similarly to peripheral macrophages to protect the brain from insults, infection, and physical trauma. However, without proper regulation of their respective host defense mechanisms, these actions can become neurotoxic. In the healthy brain neurons have several signaling systems that directly interact with microglia in order to maintain a calming influence upon their actions, one of particular interest is the chemokine CX3CL1. This chemokine is found predominantly on neurons, while its cognate receptor CX3CR1 is found exclusively on microglia. …

Hospice Nurses- Attitudes And Knowledge About Pain Management, Amie Jacqueline Miller

USF Tampa Graduate Theses and Dissertations

It has been well established that many people will suffer with pain at the end of life, and untreated pain contributes to reduced quality of life. Many barriers contribute to this issue including a lack of knowledge in nurses who care for dying patients. Many nurses in general practice settings do not possess adequate knowledge about basic pain management principles; and the same may be true about hospice nurses despite the assumption that hospice nurses are more adept at pain management. Contributing to this problem may be the attitudes that nurses, including hospice nurses, have regarding pain and its management. …

Bayesian Inference On Mixed-Effects Models With Skewed Distributions For Hiv Longitudinal Data, Ren Chen

USF Tampa Graduate Theses and Dissertations

Statistical models have greatly improved our understanding of the pathogenesis of HIV-1 infection

and guided for the treatment of AIDS patients and evaluation of antiretroviral (ARV) therapies.

Although various statistical modeling and analysis methods have been applied for estimating the

parameters of HIV dynamics via mixed-effects models, a common assumption of distribution is

normal for random errors and random-effects. This assumption may lack the robustness against

departures from normality so may lead misleading or biased inference. Moreover, some covariates

such as CD4 cell count may be often measured with substantial errors. Bivariate clustered

(correlated) data are also commonly encountered in …

The Yellow Flag Of Quarantine: An Analysis Of The Historical And Prospective Impacts Of Socio-Legal Controls Over Contagion, Peter Oliver Okin

USF Tampa Graduate Theses and Dissertations

Under the ancient threat of morbidity and mortality from infectious diseases, human societies have responded for thousands of years by imposing social containment measures. Even before theorists and laymen recognized the existence of pathogenic organisms, or fully understood the principles of contagion, many societies and individuals did empirically infer that such diseases were transmissible from human to human (as well as sometimes between animals and humans). Having few effective technological measures to prevent or treat contagions, they did devise a variety of socio-behavioral procedures for separating overtly ill persons or suspected disease-carriers from nominally uninfected people. These methods included various …