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Full-Text Articles in Medicine and Health Sciences
Pathological And Immunohistochemical Changes In The Liver Of Monocrotaline-Treated Rats, Şevket Soylu, Aydin Çevi̇k, Necati̇ Ti̇murkaan
Pathological And Immunohistochemical Changes In The Liver Of Monocrotaline-Treated Rats, Şevket Soylu, Aydin Çevi̇k, Necati̇ Ti̇murkaan
Turkish Journal of Veterinary & Animal Sciences
Pathological and immunohistochemical changes in livers were investigated in monocrotaline-treated rats. Eighty adult-male Wistar rats were distributed in 5 groups, each containing 16 animals according to monocrotaline dose (Group I: 50 mg/kg, Group II: 100 mg/kg, Group III: 150 mg/kg, and Group IV: 200 mg/kg). The control group was administered with physiological saline. Half of the animals in each group were euthanized at the 18th hour while the remaining half at the 6th week postinoculation. At the end of the 18th hour, the most prominent lesion was hepatocytic apoptosis which was dose-dependent. Apoptotic cells were mostly located in periportal and …
Monensin Induces Apoptosis In The Liver Tissue And Primary Hepatocytes Of Chicks, Muhammet Yasi̇n Tekeli̇, Murat Kanbur
Monensin Induces Apoptosis In The Liver Tissue And Primary Hepatocytes Of Chicks, Muhammet Yasi̇n Tekeli̇, Murat Kanbur
Turkish Journal of Veterinary & Animal Sciences
In this study, monensin (MON) was investigated for its apoptotic and genotoxic effects on chick liver tissue and cytotoxic and apoptotic effects on chick primary hepatocytes isolated from perfused liver tissue. Western blotting and real-time PCR (qPCR) were used to determine the apoptotic effect on primary hepatocytes and liver tissue, and the comet assay was used to determine the genotoxic effect on liver tissue. MON decreased cell viability in primary hepatocytes with increasing concentrations. When administered at concentrations of 1 and 10 μM, MON increased the levels of apoptotic p53, caspase-3, and caspase-9, and downregulated the expression of the antiapoptotic …
Ultrasonographic Features Of Liver, Gallbladder, Spleen, Kidneys, And Urinary Bladder Ofrescued Long-Tailed Macaques, Macaca Fascicularis, Paul Cardenio, Jezie Acorda, Emilia Lastica-Ternura
Ultrasonographic Features Of Liver, Gallbladder, Spleen, Kidneys, And Urinary Bladder Ofrescued Long-Tailed Macaques, Macaca Fascicularis, Paul Cardenio, Jezie Acorda, Emilia Lastica-Ternura
Turkish Journal of Veterinary & Animal Sciences
This study was conducted to determine the ultrasonographic features of the liver, gallbladder, spleen, kidneys, and urinary bladder of 24 apparently healthy male and female long-tailed macaques (LTM) and the correlations of organ measurements with body weight and crown?rump length. The animals were grouped into 12 males and 12 females. Examination was performed in sedated LTM using an ultrasound machine with 6.0 MHz microconvex scanner. Ultrasound appearance, dimensions, and echotexture of the liver, gallbladder, kidneys, spleen, and urinary bladder were evaluated. The results showed that there were no sex-related differences in echo mean values, thickness, and length of the selected …
Cannabinoid Receptor Type 2 Agonist Jwh-133 Deteriorates The Liver Toxicity Induced By Cypermethrin*, Hi̇dayet Tutun, Emi̇ne Baydan
Cannabinoid Receptor Type 2 Agonist Jwh-133 Deteriorates The Liver Toxicity Induced By Cypermethrin*, Hi̇dayet Tutun, Emi̇ne Baydan
Turkish Journal of Veterinary & Animal Sciences
Cannabinoid receptor 2 (CB2) has a role in the pathology of some liver diseases. Cypermethrin (CYP) is a synthetic pyrethroid insecticide used commonly for the control of pests and vectors, and for protection of foodstuffs. In this study, the involvement of CB2 in CYP-induced liver damage in rats was investigated. CYP was applied to rats orally at a dose of 125 mg/kg bw per day for 14 days. CB2 agonist JWH-133 was administered by intraperitoneal injection at a dose of 3 mg/kg bw per day for the last 4 days of CYP toxicity. JWH-133 deteriorated the liver damage induced by …
Influence Of Flaxseed Combined With Thyme, Rosemary, And Sage Leaves Asfodder Additives On Antioxidant Status In The Liver Of Japanese Quail, Radoslaw Drozd, Artur Rybarczyk, Agata Wasak, Malgorzata Jakubowska, Kinga Rybak, Magdalena Skolmowska
Influence Of Flaxseed Combined With Thyme, Rosemary, And Sage Leaves Asfodder Additives On Antioxidant Status In The Liver Of Japanese Quail, Radoslaw Drozd, Artur Rybarczyk, Agata Wasak, Malgorzata Jakubowska, Kinga Rybak, Magdalena Skolmowska
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to investigate the influence of a combination of plant supplements with antioxidant properties on the total antioxidant status measured by FRAP and the activity of selected antioxidant enzymes in the livers of Japanese quails. The birds were given feed with the 4% addition of flaxseed combined with a 1% admixture of dried thyme, rosemary, or sage leaves, respectively. The results showed an increased value of the antioxidant potential in the livers of quails fed with a diet that contained the combination of flaxseed and thyme, compared to the control diet and the diet that …
Immunohistochemical Distribution Of Glutathione Peroxidase And Its Gene Expression Via Rt-Pcr In The Liver Tissue Of Melatonin-Administered Mice, Serap Koral Taşçi, Nurhayat Gülmez
Immunohistochemical Distribution Of Glutathione Peroxidase And Its Gene Expression Via Rt-Pcr In The Liver Tissue Of Melatonin-Administered Mice, Serap Koral Taşçi, Nurhayat Gülmez
Turkish Journal of Veterinary & Animal Sciences
The purpose of this study is to investigate the effect of exogenous administration of melatonin, which is a strong antioxidant agent, on the gene expression of glutathione peroxidase, which is one of the antioxidant enzymes, in the livers of mice and also to examine the immunohistochemical localization of the enzyme. The 24 male Swiss albino mice used in the study were divided into 3 groups: experimental (n = 8), sham (n = 8), and control (n = 8). A 10 mg/kg dose of melatonin was administered intraperitoneally to the experimental group for 4 weeks. Only ethanol and a serum physiological …
Immunohistochemical Localization Of Glutathione Peroxidase 1 Enzyme And Its Gene Expression By Rt-Pcr In The Liver Tissue Of Healthy And Diabetic Mice, Turgay Deprem, Nurhayat Gülmez
Immunohistochemical Localization Of Glutathione Peroxidase 1 Enzyme And Its Gene Expression By Rt-Pcr In The Liver Tissue Of Healthy And Diabetic Mice, Turgay Deprem, Nurhayat Gülmez
Turkish Journal of Veterinary & Animal Sciences
The purpose of this study is to examine the gene expression level of glutathione peroxidase 1 (GPx1) in the liver of healthy and diabetic mice, its localization in the tissue, and structural changes in the liver. In this study, 36 Swiss albino mice were divided into 3 groups: experimental (diabetic) (n = 15), sham (n = 15), and control (n = 6). Streptozotocin (100 mg/kg) was intraperitoneally administered to mice in the experimental group. While the gene expression level of GPx1 was determined using the RT-PCR method, its localization in the liver was determined using an immunohistochemical method. The GPx1 …
Evaluation Of Ultrasonography As A Diagnostic Tool For Hepatic Hydatid Cysts In Sheep, Hussein Awad Hussein, Mohammed Elrashidy
Evaluation Of Ultrasonography As A Diagnostic Tool For Hepatic Hydatid Cysts In Sheep, Hussein Awad Hussein, Mohammed Elrashidy
Turkish Journal of Veterinary & Animal Sciences
This retrospective study was designed to evaluate the use of ultrasonography for the diagnosis of hepatic hydatid cysts. This study was conducted on 22 sheep, which were classified into 2 groups according to their liver health group (healthy liver = 13 and cystic liver = 9). Biochemically, serum concentrations of gamma-glutamyl transferase, aspartate aminotransferase, total bilirubin, and globulins were significantly increased (P < 0.01) while albumin was lowered (P < 0.01) in sheep with cystic livers. Ultrasonographically, rounded, anechoic, and unilocular hydatid cysts with elliptical circumferences ranging from 6 to 10 cm were seen. The interiors of cysts contained echogenic particulate materials, septations, or fine echoes. At the 10th intercostal space (ICS), ventral margin, size, thickness, and angle of livers increased in sheep with hepatic cysts, while the diameter of portal vein decreased in sheep with liver cysts. At the 9th ICS, the circumference of the gall bladder was lowered in sheep with hepatic cysts (P < 0.01). The sensitivity, specificity, and positive and negative predictive values of ultrasonography for diagnosis of hepatic hydatid cysts were 80%, 100%, and 100% and 83%, respectively. In conclusion, ultrasonography alone or in combination with some biochemical parameters reflecting liver function could be helpful for the diagnosis of hepatic hydatid cysts in sheep.
Helical Computed Tomography Application In Rabbit Liver Anatomy: Comparison With Frozen Cross-Sectional Cuts, Kamelia Stamatova Yovcheva, Rosen Dimitrov, Yuliana Toneva, Penka Yonkova, Dimitar Kostov, Anton Rusenov, Krassimira Uzunova, Violeta Yordanova
Helical Computed Tomography Application In Rabbit Liver Anatomy: Comparison With Frozen Cross-Sectional Cuts, Kamelia Stamatova Yovcheva, Rosen Dimitrov, Yuliana Toneva, Penka Yonkova, Dimitar Kostov, Anton Rusenov, Krassimira Uzunova, Violeta Yordanova
Turkish Journal of Veterinary & Animal Sciences
Our focus has been to study and compare the anatomical helical computed tomography (CT) features of the normal rabbit liver with its native cross-sectional anatomy. Helical CT was used for scanning the cranial part of the abdominal cavity. The slice thickness was 5 mm. Frozen transversal anatomic cross-sections with a thickness of 10 mm were obtained from the cranial abdominal part of 4 animals following euthanasia. They were compared with the corresponding helical CT scans. At Th9 (thoracic vertebra), the helical CT images showed in the whole aspect a normal liver. It was a massive, heterogeneous, soft tissue, with normal …
Purification And Characterization Of Glutathione Reductase From Turkey Liver, Pinar Taşer, Mehmet Çi̇ftci̇
Purification And Characterization Of Glutathione Reductase From Turkey Liver, Pinar Taşer, Mehmet Çi̇ftci̇
Turkish Journal of Veterinary & Animal Sciences
This study aimed to purify glutathione reductase (GR) from turkey liver and investigate some of its characteristic features. The purification procedure comprised 2 steps: homogenate preparation and 2',5'-ADP Sepharose 4B affinity gel chromatography. Thanks to the 2 consecutive procedures, the enzyme, having the specific activity of 606.67 EU mg protein^{-1}, was purified with a yield of 10.75% and 2476-fold, and, in order to control enzyme purity, SDS-PAGE was done. Optimal pH, stable pH, optimal temperature, optimal ionic strength, molecular weight, turnover number of enzyme, and k_{cat}/K_M and K_M and V_{max} values for NADPH and glutathione disulfide substrates were also determined …
Seasonal Variation Of Vitamin A And Beta-Carotene Levels In Ghezel Sheep, Gholamreza Afshari, A. Hasanpour, H. Haghpanah, Bahram Amoughli-Tabrizi
Seasonal Variation Of Vitamin A And Beta-Carotene Levels In Ghezel Sheep, Gholamreza Afshari, A. Hasanpour, H. Haghpanah, Bahram Amoughli-Tabrizi
Turkish Journal of Veterinary & Animal Sciences
The present study was conducted to investigate the variations in blood serum and hepatic levels of vitamin A and b-carotene in Ghezel sheep throughout the year. From 1000 sheep aged 1-5 years, blood and liver samples were collected before and after slaughter. The levels of vitamin A and \beta-carotene in both samples were determined spectrophotometrically. The results showed significant differences between summer and winter values (P < 0.05), but no differences were found between the sexes (P > 0.05). There were significant correlations between the vitamin A levels in serum and the liver (P < 0.05). Due to low levels of vitamin A and \beta -carotene in Ghezel sheep during the winter, supplementary feeding of vitamin A is recommended during this season.
Ultrasonographic Examination Of The Goat Liver, Sarang Soroori, Afshin Raoofi, Ali Reza Vajhi, Sara Ghorbani Nezami
Ultrasonographic Examination Of The Goat Liver, Sarang Soroori, Afshin Raoofi, Ali Reza Vajhi, Sara Ghorbani Nezami
Turkish Journal of Veterinary & Animal Sciences
The purpose of this study was to obtain detailed information about the normal size and texture of the goat liver by means of ultrasonographic examination. The structure, location, and size of the liver, portal vein, and caudal vena cava were examined ultrasonographically in 6 goats. The angle of the liver and the thickness of the gallbladder wall were also determined. Examinations were performed on the right side of the abdomen, from the 6th through 12th intercostal space, using a 6-13 MHz linear transducer. In each intercostal space the dimensions of the liver, and if visible, the location and diameter of …
In Vitro Effects Of Some Antibiotics On Glutathione Reductase Obtained From Chicken Liver, Hülya Demi̇r, Mustafa Erat, Hali̇s Şaki̇roğlu
In Vitro Effects Of Some Antibiotics On Glutathione Reductase Obtained From Chicken Liver, Hülya Demi̇r, Mustafa Erat, Hali̇s Şaki̇roğlu
Turkish Journal of Veterinary & Animal Sciences
Glutathione reductase (GR) is important in maintaining high levels of reduced glutathione in cells. The enzyme is inhibited by some drugs used in antimicrobial chemotherapy. The effects of some antibiotics on GR activity were investigated in this study. At first, the enzyme, having a specific activity of 88.28 EU/mg proteins, was purified 1636-fold with a yield of 35%. Purity of the enzyme was checked by means of sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Activity of the enzyme was determined spectrophotometrically at 340 nm and in vitro effects of ofloxacin, levofloxacin, cefazolin, and cefepime were determined. The antibiotics used in …
Alterations To Lipid Parameters In Response To Fig Tree (Ficus Carica) Leaf Extract In Chicken Liver Slices, Farzad Asadi, Malihe Pourkabir, Robin Maclaren, Ali Shahriari
Alterations To Lipid Parameters In Response To Fig Tree (Ficus Carica) Leaf Extract In Chicken Liver Slices, Farzad Asadi, Malihe Pourkabir, Robin Maclaren, Ali Shahriari
Turkish Journal of Veterinary & Animal Sciences
Lipid storage, particularly in the abdominal cavity, is a major concern in poultry breeding because it affects the net meat yield. The major contributors to lipid storage in the abdominal cavity are hepatic fatty acid synthesis and VLDL secretion. These factors are strongly correlated with the body fatness in the chicken. The aim of our study was to determine if a traditional food supplement, the extract from fig tree leaves (fig tree leaf extract (FTE)), can be used to decrease hepatic triglyceride (TG) content and secretion of TG and cholesterol (TC) from the liver. Livers from 8-week-old roosters (n = …
Purification And Characterization Of Glutathione Reductase From Sheep Liver, Göktuğ Ulusu, Mustafa Erat, Mehmet Çi̇ftçi̇, Hali̇s Şaki̇roğlu, Ebubeki̇r Bakan
Purification And Characterization Of Glutathione Reductase From Sheep Liver, Göktuğ Ulusu, Mustafa Erat, Mehmet Çi̇ftçi̇, Hali̇s Şaki̇roğlu, Ebubeki̇r Bakan
Turkish Journal of Veterinary & Animal Sciences
Glutathione reductase (Glutathione: NADP^+ oxidoreductase, EC 1.8.1.7; GR) was purified from sheep liver. The purification included 4 steps: preparation of homogenate, ammonium sulfate fractionation, 2', 5'-ADP Sepharose-4B affinity chromatography, and gel filtration chromatography. GR was obtained with a yield of 14.1% having a specific activity of 47.27 EU/mg proteins. Optimal pH, stable pH, and optimal temperature were 8.0, 5.5, and 60 °C, respectively. K_M and V_max values for NADPH and GSSG substrates were 0.0258 and 0.0239 mM, and 0.266 and 0.255 EU/ml, respectively. The overall purification was about 1477-fold for liver GR. The enzyme activity was measured spectrophotometrically at 340 …
Histopathologic Changes In Liver And Renal Tissues Induced By Different Doses Of Diclofenac Sodium In Rats, Gülsen Aydin, Alparslan Gökçi̇men, Meral Öncü, Ekrem Çi̇çek, Nermi̇n Karahan, Osman Gökalp
Histopathologic Changes In Liver And Renal Tissues Induced By Different Doses Of Diclofenac Sodium In Rats, Gülsen Aydin, Alparslan Gökçi̇men, Meral Öncü, Ekrem Çi̇çek, Nermi̇n Karahan, Osman Gökalp
Turkish Journal of Veterinary & Animal Sciences
Non-steroidal anti-inflammatory drugs (NSAIDs) are in common use worldwide. These drugs may sometimes be used in high or toxic doses by mistake. In this study we investigated the effects of different doses of diclofenac sodium on liver and renal tissues. Forty albino adult male Wistar rats weighing 200 to 220 g were divided equally into four groups. The rats in the control group (n = 10) were each intramuscularly injected with 1 cc of physiologic saline. The other three groups were given diclofenac sodium doses. The rats in the first (n = 10), second (n = 10) and third (n …
The Effects Of Replacing Fish Oil With Vegetable Oils In Starter Feeds On The Liver Fat Composition Of Sea Bass (Dicentrarchus Labrax L., 1758), Mustafa Yildiz, Erdal Şener
The Effects Of Replacing Fish Oil With Vegetable Oils In Starter Feeds On The Liver Fat Composition Of Sea Bass (Dicentrarchus Labrax L., 1758), Mustafa Yildiz, Erdal Şener
Turkish Journal of Veterinary & Animal Sciences
The effects of replacing fish oil with soybean oil, sunflower oil, corn oil and olive oil in starter feeds on the vicerosomatic index, hepatosomatic index and liver fatty acid composition of the sea bass were studied. Juvenile sea bass (initial weight = 7.58 ± 0.13 g) were fed experimental diets for 75 days. The fish were then killed and liver samples were collected. The lowest total crude fat value (17.61%) was found in the fish fed the fish oil diet. The highest total crude fat value (34.30%) was found in the fish fed the olive oil diet (P < 0.05). Similarly, the fish fed the fish oil diet had the lowest hepatosomatic index value (2.08) and all the fish fed vegetable oils had similarly high hepatosomatic index values (P < 0.05). Likewise, vicerosomatic index values were lowest (9.06%) in the fish fed fish oil and highest in the fish fed soybean and other vegetable oils (P < 0.05). Fatty acid analyses showed that EPA and DHA from n-3 HUFA's in the fish fed the fish oil diet, linolenic acid (18:3n-3) and linoleic acid (18:2n-6) in the fish fed the soybean oil diet and oleic acid (18:1n-9) in the fish fed the olive oil diet were higher than in the fish fed the other diets.
Hepatorenal Syndrome And Efficiency Of Aldosterone Receptor Blockade On Hepatorenal System And Systemic Hemodynamics In Dogs With Experimentally Induced Hepatic Cirrhosis, Remzi̇ Gönül, Utku Bakirel, Abdullah Kayar, Yücel Meral, Mehmet Erman Or, Gülbi̇n Şennazli, Aydin Gürel, Emi̇ne Akdeni̇zli̇
Hepatorenal Syndrome And Efficiency Of Aldosterone Receptor Blockade On Hepatorenal System And Systemic Hemodynamics In Dogs With Experimentally Induced Hepatic Cirrhosis, Remzi̇ Gönül, Utku Bakirel, Abdullah Kayar, Yücel Meral, Mehmet Erman Or, Gülbi̇n Şennazli, Aydin Gürel, Emi̇ne Akdeni̇zli̇
Turkish Journal of Veterinary & Animal Sciences
In this study, the clinical signs of hepatorenal syndrome that occurs during hepatic cirrhosis were investigated and a variety of diagnosis and therapy methods were investigated in the experimentally ligated bile ducts of dogs. The test group with ligated bile ducts (n = 14) and the sham operated control group (n = 14) were divided into 2 sub groups and administered a derivative of spironalactone (Aldoctan® tablet), an antagonist of the aldosteron receptor, at 1.5 mg/kg daily for 5 weeks. Hepatorenal changes and the systemic effects of the drug were determined by comparing the control and test groups during the …
The Effect Of Aflatoxin B1 On The Vitamin A Storage In The Livers Of Broiler Chicks, Berri̇n Salmanoğlu
The Effect Of Aflatoxin B1 On The Vitamin A Storage In The Livers Of Broiler Chicks, Berri̇n Salmanoğlu
Turkish Journal of Veterinary & Animal Sciences
The effect of AFB1 in feed on the liver and serum vitamin A and b-carotene levels and the ability of the liver to stor vitamin A in broiler chicks were investigated. Twenty day-old Ross broiler chicks were randomly allocated into 4 groups with 5 each in the control group, group I, group II, and group III. The chicks of the control group and group I were fed ad libitum on broiler chick growing feed. The chicks of group II and group III were fed ad libitum on feed with AFB1 (4 ppm/kg) feed. On the seventh day, vitamin A palmitate …
Ultrasonographic Evaluation Of Liver Damage And Obstruction Of The Biliary Tract In Experimentally Bile Duct Ligated Dogs, Remzi̇ Gönül, Yücel Meral, Abdullah Kayar, Utku Bakirel, Mehmet Erman Or, Gülbi̇n Şennazli, Aydin Gürel, Zi̇ya Aslan
Ultrasonographic Evaluation Of Liver Damage And Obstruction Of The Biliary Tract In Experimentally Bile Duct Ligated Dogs, Remzi̇ Gönül, Yücel Meral, Abdullah Kayar, Utku Bakirel, Mehmet Erman Or, Gülbi̇n Şennazli, Aydin Gürel, Zi̇ya Aslan
Turkish Journal of Veterinary & Animal Sciences
The liver damage and obstructions of the biliary tract were evaluated ultrasonographically in experimentally bile duct ligated dogs. Seven healthy dogs of different breeds were used. The common bile duct was double ligated at the duodenal region after clinical and ultrasonographic examinations. After that, clinical examinations, biochemical analyses and examinations of the liver, gallbladder and biliary tract were done ultrasonographically over 6 weeks. All dogs were necropsied and macroscopic and histologic alterations were determined at the end of the study. It was determined that the levels of serum ALT, ALP, GGT and T. Bilirubin were (p < 0.001-0.05) statistically significantly increased after the operation in all dogs. As a result of ultrasonographic examinations, it was determined that the bile ducts and gallbladder were distended, the neck of the gallbladder was larger and more tortuous than normal, hypoechoic sludge was prominent in the gallbladder, and perivascular, multifocal hyperechoic areas appeared in the liver parenchyma toward the end of the study. These alterations were confirmed macroscopically and microscopically at the end of the autopsy in all dogs. We consider that as well as blood serum parameters, ultrasonographic examinations are useful in the early diagnosis of biliary diseases and in differentiating them from hepatic diseases.
Incidence And Pathologic Studies On Liver Telangiectasis In Beef Cattle, Ayhan Atasever, Sevi̇l Atalay Vural, Şenay Berki̇n
Incidence And Pathologic Studies On Liver Telangiectasis In Beef Cattle, Ayhan Atasever, Sevi̇l Atalay Vural, Şenay Berki̇n
Turkish Journal of Veterinary & Animal Sciences
In this study, 3470 livers of beef cattle slaughtered by the Ankara Meat and Fish Company were inspected. In these animals, 82 livers had telangiectasis, and the incidence of lesions was 2.3%. They were characterized grossly by single or multiple red-brown foci, generally 1 to 5 mm in diameter, and occasionally larger. They were located on the parietal surface of the lobus dexter or rarely scattered throughout the organ. Microscopically, dilated sinusoids filled with erythrocytes were observed in initial lesions; the distortion, atrophy and necrosis of hepatocytic cordons were seen in advanced cases. There was no correlation between liver abscesses …
The Levels Of Pyruvate Kinase Activity In Renal And Hepatic Tissues Of Rats With Diabetes Induced By Streptozotocin, Seval Yilmaz, Bi̇lal Üstündağ
The Levels Of Pyruvate Kinase Activity In Renal And Hepatic Tissues Of Rats With Diabetes Induced By Streptozotocin, Seval Yilmaz, Bi̇lal Üstündağ
Turkish Journal of Veterinary & Animal Sciences
In this study, the changes in pyruvate kinase enzyme activities in the liver and kidney tissues of rats with diabetes induced by streptozotocin were examined and the relations with the disease were investigated. Diabetes mellitus was induced in Wistar-Albino rats by the administration of a single intraperitoneal dose of streptozotocin (60 mg/kg body weight). After streptozotocin was injected, the pyruvate kinase activities in the livers and kidneys of the rats were analysed according to Beutler's method on days 3 and 12. It was determined that liver pyruvate kinase enzyme levels in rats with diabetes induced with streptozotocin were decreased on …
Reference Values For Erythrocyte And Liver Antioxidant Systems In Healthy Male Mice (Mus Musculus), Ergül Belge Kurutaş, Fi̇gen Doran, Seyhan Vari̇nli̇
Reference Values For Erythrocyte And Liver Antioxidant Systems In Healthy Male Mice (Mus Musculus), Ergül Belge Kurutaş, Fi̇gen Doran, Seyhan Vari̇nli̇
Turkish Journal of Veterinary & Animal Sciences
The aim of the present study was to define the reference values for erythrocyte and liver tissue glucose-6-phosphate dehydrogenase (G6PDH), glutathione peroxidase (GPX), glutathione reductase (GR) and superoxide dismutase (SOD) activities and also reduced glutathione (GSH) levels in order to obtain basal data for subsequent toxicological investigations. In addition, the best storage conditions were determined for liver G6PDH enzyme. Male, apparently healthy Mus musculus (38) speciemens that had normal livers (histopathological data) were included in the study. G6PDH and GPX activities and GSH levels were measured by the Beutler method, and SOD aktivity was measured by the Fridovich method in …
Effects Of Phorbol Myristate Acetate On The Liver: A Biochemical And Ultrastructural Study, Memduha Gülhal Bozkir, Ufuk Ö. Mete, Özkan Oğuz
Effects Of Phorbol Myristate Acetate On The Liver: A Biochemical And Ultrastructural Study, Memduha Gülhal Bozkir, Ufuk Ö. Mete, Özkan Oğuz
Turkish Journal of Veterinary & Animal Sciences
The effects of free radicals in the liver tissue of 20 mice were studied. The mice, separated into acute and chronic groups, were injected with phorbol myristate acetate (PMA) to trigger the release of free radicals. For evaluation of the effects of free radicals, malandialdehyde (MDA) measurement and electron microscopic examination were performed. The results showed that the level of lipid peroxide in the chronic PMA group was significantly higher than it was in the acute PMA group (P
Histopathological Examination Of Gill, Liver And Kidney Tissues Of Carp (Cyprinus Carpio L., 1758) Fish In The Upper Sakarya River Basin, Nurhayat Barlas
Histopathological Examination Of Gill, Liver And Kidney Tissues Of Carp (Cyprinus Carpio L., 1758) Fish In The Upper Sakarya River Basin, Nurhayat Barlas
Turkish Journal of Veterinary & Animal Sciences
In this study, 80 carp specimens (Cyprinus carpio) (16 fish from each station) of ages between 1-2 were caught at five stations in the upper Sakarya river basin the four seasons between October 1995 and October 1996. The structural changes of gill, liver and spleen tissue of the carp were examined. The gills of fishes which live in aquatic habitat exhibit tissue lesions caused by water pollutants, because they are in direct contact with their environment. In the results of this study, it was found at secondary lamellae fused together, and the gills are the most affected organs. Other histopathological …
The Effects Of Carbon Tetrachloride (Ccl_4 ) Induced Experimental Acute And Chronicintoxication On Hystological Structure Of Liver And Some Hematological Values Andelectrocardiogram In Rabbits, Ali̇ Çinar, Meci̇t Yörük, İsmai̇l Meral, Di̇de Kiliçalp, Ahmet Koç, Ali̇ Erteki̇n
The Effects Of Carbon Tetrachloride (Ccl_4 ) Induced Experimental Acute And Chronicintoxication On Hystological Structure Of Liver And Some Hematological Values Andelectrocardiogram In Rabbits, Ali̇ Çinar, Meci̇t Yörük, İsmai̇l Meral, Di̇de Kiliçalp, Ahmet Koç, Ali̇ Erteki̇n
Turkish Journal of Veterinary & Animal Sciences
This paper reports an investigation of the effects of acute and chronic carbon tetrachloride intoxications on the histologic structure of the liver and hematological values and electrocardiograms in rabbits. The rabbits were divided into 3 groups of 7. The first group was the control group, the second group was acutely intoxicated and the third group was chronically intoxicated. In the acutely intoxicated group, caryorexsis, along with necrosis was observed in the hepatocyte of the centrolobular area of the liver. In the chronically intoxicated group, connective tissue mass around the V. centralis increased. This increase of connective tissue caused chirrosis. Hematological …
The Effects Of Danofloxacin On Some Biochemical Parameters And Liver In Broilers, Fatma Uyanik, Bi̇lal Cem Li̇man, Nari̇n Li̇man
The Effects Of Danofloxacin On Some Biochemical Parameters And Liver In Broilers, Fatma Uyanik, Bi̇lal Cem Li̇man, Nari̇n Li̇man
Turkish Journal of Veterinary & Animal Sciences
In this study, a total of 160 one day old broiler chicks were devided into two groups consisting of 60 chicks in control group and 100 chicks in treatment group. The birds in treatment group received 50 ppm, 25 ppm, 37.5 ppm and 50 ppm danofloxacin via drinking water between the days during 0-7, 8-21, 22-35 and 36-42 respectively. Live weight, liver weight, serum total protein, albumin, globulin, copper, zinc and magnesium levels as well as \gamma-GT, GOT and GPT activities of 15 birds from control group and 25 birds from treatment group were determined on days 15, 21, 35 …