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Full-Text Articles in Medicine and Health Sciences
Metformin Promotes Apoptosis In Primary Breast Cancer Cells By Downregulation Ofcyclin D1 And Upregulation Of P53 Through An Ampk-Alpha Independent Mechanism, Güven Yenmi̇ş, Nai̇l Beşli̇, Eli̇f Yaprak Saraç, Fatma Si̇nem Hocaoğlu Emre, Kazim Şenol, Gönül Kanigür
Metformin Promotes Apoptosis In Primary Breast Cancer Cells By Downregulation Ofcyclin D1 And Upregulation Of P53 Through An Ampk-Alpha Independent Mechanism, Güven Yenmi̇ş, Nai̇l Beşli̇, Eli̇f Yaprak Saraç, Fatma Si̇nem Hocaoğlu Emre, Kazim Şenol, Gönül Kanigür
Turkish Journal of Medical Sciences
Background/aim: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs). Materials and methods: PBCCs were treated with two doses of metformin (0 mM, 25 mM). Proliferation was determined by BrdU assay. Real-time PCR was used to assess AMPK-alpha, cyclin D1, and Tp53 gene expressions; apoptotic indexes of PBCCs were analyzed using flow-cytometry. Results: Twenty-four-hour incubation with 25 mM metformin reduced the proliferation of PBCCs. AMPK-alpha gene expression in PBCCs was not affected by 25 mM metformin treatment compared with …
Retrospective Analysis Of The Effect Of Breast Surgery On Body Posture In Patients Withearly-Stage Breast Cancer After Cancer Treatment (Venus Study)(Breast Cancer And Body Posture), Özgür Tanriverdi̇, Ahmet Ozan Çeti̇n, Ali̇ Alkan
Retrospective Analysis Of The Effect Of Breast Surgery On Body Posture In Patients Withearly-Stage Breast Cancer After Cancer Treatment (Venus Study)(Breast Cancer And Body Posture), Özgür Tanriverdi̇, Ahmet Ozan Çeti̇n, Ali̇ Alkan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine whether breast surgery changes body posture in patients with early-stage breast cancer. Materials and methods: Study variables include age, side and localization of the tumor in the breast, applied breast surgery, axillary interference, pathological tumor size, axillary lymph node metastasis, body mass index, bone density, adjuvant therapies, and histological type. Thoracic kyphosis angle due to the anatomically affected primary region to detect changes in body posture and Cobb's method were used to measure this. Results: There was a statistically significant difference in the mean Cobb's angle between the follow-up times of …
The Association Between Mrna Expression Of Resistin, Tnf- Α, Il-6, Il-8, And Er-Α Inperipheral Blood Mononuclear Cells And Breast Cancer, Masome Zare-Moayedi, Fatame Ahmmadpour, Mojtaba Rashidi, Ahmad Ahmadzadeh, Amirahmad Salmasi, Ghorban Mohammadzadeh
The Association Between Mrna Expression Of Resistin, Tnf- Α, Il-6, Il-8, And Er-Α Inperipheral Blood Mononuclear Cells And Breast Cancer, Masome Zare-Moayedi, Fatame Ahmmadpour, Mojtaba Rashidi, Ahmad Ahmadzadeh, Amirahmad Salmasi, Ghorban Mohammadzadeh
Turkish Journal of Medical Sciences
Background/aim: Adipocytokines, adipose tissue-derived proteins, were demonstrated to be involved in the pathogenesis of breast cancer. We assessed the mRNA expression of resistin, tumor necrosis factor-alpha (TNF-α), interleukins 6 and 8 (IL-6, and IL-8), and estrogen receptor alpha (ER-α) in peripheral blood mononuclear cells (PBMCs) of women with and without breast cancer. Materials and methods: The PBMCs were isolated from the whole blood of 32 women with breast cancer and 18 women without breast cancer using density gradient centrifugation. The mRNA expression of the target genes was measured by reverse-transcription polymerase chain reaction (RT-PCR). Body mass index was calculated, additionally, …
The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç
The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç
Turkish Journal of Medical Sciences
Background/aim: Targeting the new and unique proteins is an important medical strategy for treating breast cancer. It is quite important to find out proteins that have a role in the development of cancer. Sirtuins (SIRT) are well related in different physiological activities and connected with cancer. We aimed to determine the effect of radiotherapy on SIRT1 and SIRT2, which have not been yet been clarified as a tumor suppressor or promoter. Materials and methods: Twenty-two women with nonmetastatic breast cancer enrolled in the study. Blood samples were taken before and after radiotherapy, soluble SIRT1 and SIRT2 levels were determined with …
The Evaluation Of Breast Findings Detected Through Different Visualisation Techniques Inacromegaly Patients ? A Retrospective Study, Pinar Akhanli, Sema Hepşen, Beki̇r Uçan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Muhammed Erkam Sencar, Erman Çakal
The Evaluation Of Breast Findings Detected Through Different Visualisation Techniques Inacromegaly Patients ? A Retrospective Study, Pinar Akhanli, Sema Hepşen, Beki̇r Uçan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Muhammed Erkam Sencar, Erman Çakal
Turkish Journal of Medical Sciences
Background/aim: It is known that the increased growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have mitogenic and antiapoptotic properties in breast cells in acromegaly. Our study aims to evaluate breast findings in patients with acromegaly by comparing them to the control group. Materials and methods: Sixty-one patients followed with acromegaly diagnosis and 180 healthy controls were included in our study. Demographic data, laboratory results, Breast Imaging-Reporting and Data System (BI-RADS) scores, and breast density evaluated via mammography, malign and benign breast lesions evaluated via mammography, breast ultrasonography (USG), and breast magnetic resonance imaging (MRI) of patients were compared to …