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Articles 211 - 219 of 219
Full-Text Articles in Medicine and Health Sciences
Histopathological Findings Obtained From Reduction Mammoplasty Specimens, Aynur Albayrak, Çi̇ğdem Güler Mesci̇, Gülnur Güler
Histopathological Findings Obtained From Reduction Mammoplasty Specimens, Aynur Albayrak, Çi̇ğdem Güler Mesci̇, Gülnur Güler
Turkish Journal of Medical Sciences
Background/aim: Reduction mammoplasty is a common surgical procedure. We report the incidence of nonproliferative and proliferative breast lesions in breast reduction specimens from a single institution over a 6-year period. Materials and methods: The histopathology reports of all patients were analyzed. The clinical and histopathological findings of the patients were recorded. Results: Between 2004 and 2010, 106 patients underwent breast reduction. Fifty-six patients (52.8%) had proliferative breast lesions, 84 patients (79.2%) had nonproliferative lesions, 8 patients (7.5%) had columnar cell lesions without atypia, 61 patients (57.5%) had columnar cell lesions with atypia, 5 patients (4.7%) had atypical ductal hyperplasia, and …
Spontaneous Withdrawal In Intermittent Morphine Administration In Rats And Mice: Effect Of Clonidine Coadministration And Sex-Related Differences, Oruc Allahverdi̇yev, Asli Zengi̇n Türkmen, Asi̇ye Nurten, İclal Şehi̇rli̇, Nurhan Engi̇nar
Spontaneous Withdrawal In Intermittent Morphine Administration In Rats And Mice: Effect Of Clonidine Coadministration And Sex-Related Differences, Oruc Allahverdi̇yev, Asli Zengi̇n Türkmen, Asi̇ye Nurten, İclal Şehi̇rli̇, Nurhan Engi̇nar
Turkish Journal of Medical Sciences
Background/aim: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and assess sex-related differences in withdrawal signs and their suppression by clonidine. Materials and methods: Male and female rats and mice were administered with increasing doses of morphine twice daily at different dosing intervals. Rats were given clonidine in drinking water (5 μg/mL). Spontaneous and naloxone-precipitated withdrawal signs and novelty-induced grooming were evaluated. Results: Male rats and male and female rats displayed manifestations of morphine withdrawal at …
Investigation Of The Protective Effect Of Erdosteine Against Cyclosporine-Inducedinjury In Rat Liver With Histological And Biochemical Methods, Ahmet Nacar, İhsan Karaboğa, Hamza Mali̇k Okuyan, Nebi̇hat Kaplan Sefi̇l, Emel Nacar, Sedat Motor, Seçki̇n Akküçük, Orhan Veli̇ Özkan
Investigation Of The Protective Effect Of Erdosteine Against Cyclosporine-Inducedinjury In Rat Liver With Histological And Biochemical Methods, Ahmet Nacar, İhsan Karaboğa, Hamza Mali̇k Okuyan, Nebi̇hat Kaplan Sefi̇l, Emel Nacar, Sedat Motor, Seçki̇n Akküçük, Orhan Veli̇ Özkan
Turkish Journal of Medical Sciences
Background/aim: In the present study, the protective effect of erdosteine against cyclosporine-induced injury in rat liver was investigated with histological and biochemical methods. Materials and methods: Thirty-two Wistar albino male rats were randomly divided into 4 groups: control (n = 8), cyclosporine (n = 8, 20 mg kg-1 day-1 i.p.), cyclosporine + erdosteine (n = 8, erdosteine 12 mg kg-1 day-1 orally), and erdosteine (n = 8). At the end of day 12, liver tissues were removed for histological and biochemical analysis. After liver tissues were fixed in 10% buffered neutral formalin, routine histological processes were applied and tissue sections …
Effects Of Contemporary Orthodontic Composites On Tooth Color Following Short-Term Fixed Orthodontic Treatment: A Controlled Clinical Study, Bayram Çörekçi̇, Ebubeki̇r Toy, Firat Öztürk, Siddik Malkoç, Bora Öztürk
Effects Of Contemporary Orthodontic Composites On Tooth Color Following Short-Term Fixed Orthodontic Treatment: A Controlled Clinical Study, Bayram Çörekçi̇, Ebubeki̇r Toy, Firat Öztürk, Siddik Malkoç, Bora Öztürk
Turkish Journal of Medical Sciences
Background/aim: To determine the color alterations of natural teeth associated with different orthodontic composites used in comprehensive short-term treatment. Materials and methods: Twenty-two patients were treated with ?xed appliances and 22 untreated subjects were also evaluated. Lower incisors were bonded with different orthodontic composites: 42 with Grengloo, 41 with Light Bond, 31 with Kurasper F, and 32 with Transbond XT. The color parameters of the Commission Internationale de l'Eclairage (CIE) were measured for each tooth with a spectrophotometer. Color assessment in relation to time, adhesive material, and their interaction was made with 2-way mixed analysis of variance (ANOVA) and 1-way …
Plasma 8-Isopgf2? And Serum Melatonin Levels In Patients With Minimal Cognitive Impairment And Alzheimer Disease, Fevzi̇ye Burcu Şi̇ri̇n, Duygu Kumbul Doğuç, Hüseyi̇n Vural, İbrahi̇m Eren, İkbal İnanli, Recep Sütcü, Namik Deli̇baş
Plasma 8-Isopgf2? And Serum Melatonin Levels In Patients With Minimal Cognitive Impairment And Alzheimer Disease, Fevzi̇ye Burcu Şi̇ri̇n, Duygu Kumbul Doğuç, Hüseyi̇n Vural, İbrahi̇m Eren, İkbal İnanli, Recep Sütcü, Namik Deli̇baş
Turkish Journal of Medical Sciences
Background/aim: F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not. Materials and methods: Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method. Results: Significant differences were observed in …
Malnutrition Is Associated With Dementia Severity And Geriatricsyndromes In Patients With Alzheimer Disease, Demet Yildiz, Ni̇lüfer Büyükkoyuncu Pekel, Ahmet Kasim Kiliç, Eli̇f Nalan Tolgay, Fati̇h Tufan
Malnutrition Is Associated With Dementia Severity And Geriatricsyndromes In Patients With Alzheimer Disease, Demet Yildiz, Ni̇lüfer Büyükkoyuncu Pekel, Ahmet Kasim Kiliç, Eli̇f Nalan Tolgay, Fati̇h Tufan
Turkish Journal of Medical Sciences
Background/aim: Malnutrition is associated with increased morbidity and mortality in patients with Alzheimer disease (AD). In this study, we aimed to screen for malnutrition and geriatric syndromes and seek their associations in patients with AD. Materials and methods: The Mini Mental State Examination (MMSE), Mini Nutritional Assessment (MNA), Katz Activities of Daily Living (ADL), and Lawton Instrumental Activities of Daily Living (IADL) tests were applied. Mean daily oral fluid intake was assessed according to patients' and relatives' declarations. Results: Seventy-six patients with a mean age of 79 ± 7.4 years were included. Most of the patients had mild or moderate …
The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz
The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease (AD) is characterized by the accumulation of senile plaques composed of amyloid β-peptide, which is derived from β-amyloid precursor protein through degradation by β-secretase and γ-secretase complexes. One of the major components of γ-secretase complex, anterior pharynx-defective-1 (APH-1), is responsible for the activity of the γ-secretase complex. In this study, we searched for not only the most known common genetic risk factor, APOE, but also the APH-1a gene polymorphism in AD patients in a Turkish population. Materials and methods: In this study, 49 AD patients and 45 healthy controls were included. The genetic polymorphisms and allele frequencies …
Evaluation Of Retinal Nerve Fiber Layer Thickness In Alzheimer Disease Usingspectral-Domain Optical Coherence Tomography, Ali̇me Güneş, Seden Demi̇rci̇, Levent Tök, Özlem Tök, Serpi̇l Demi̇rci̇
Evaluation Of Retinal Nerve Fiber Layer Thickness In Alzheimer Disease Usingspectral-Domain Optical Coherence Tomography, Ali̇me Güneş, Seden Demi̇rci̇, Levent Tök, Özlem Tök, Serpi̇l Demi̇rci̇
Turkish Journal of Medical Sciences
Background/aim: To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) and to compare the results with those of healthy controls. Materials and methods: Forty patients (mean age: 75.02 ± 6.34 years; 23 women) with untreated AD and 40 age-, sex-, and education-matched healthy patients were examined in this case-control prospective study. All patients underwent detailed ophthalmic and neurological examination. The Mini Mental State Examination (MMSE) was performed and RNFL thickness was measured using spectral-domain optical coherence tomography. The association between RNFL and MMSE score was also assessed. Results: The average RNFL thickness was 84 …
Neurodegeneration In Ocular And Central Nervous Systems: Optical Coherence Tomography Study In Normal-Tension Glaucoma And Alzheimer Disease*, Muhsi̇n Eraslan, Eren Çerman, Osman Çeki̇ç, Sevcan Balci, Volkan Deri̇ci̇oğlu, Özlem Şahi̇n, Devran Süer, Biman Chabou, Emi̇ne Neşe Tuncer Elmaci
Neurodegeneration In Ocular And Central Nervous Systems: Optical Coherence Tomography Study In Normal-Tension Glaucoma And Alzheimer Disease*, Muhsi̇n Eraslan, Eren Çerman, Osman Çeki̇ç, Sevcan Balci, Volkan Deri̇ci̇oğlu, Özlem Şahi̇n, Devran Süer, Biman Chabou, Emi̇ne Neşe Tuncer Elmaci
Turkish Journal of Medical Sciences
Background/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects. Materials and methods: This cross-sectional study included 18 patients with NTG, 20 with AD, and 20 control subjects. An ophthalmologic examination and OCT scans of both eyes were performed in all patients. Results: There was a significant reduction in peripapillary RNFL thickness and macular GCC thickness and a significant increase in the global loss volume (GLV) rate in both the NTG …