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Full-Text Articles in Medicine and Health Sciences
The Effect Of Vitamin E And L-Carnitine Against Methotrexate-Induced Injury In Rat Testis, Mehmet Yüncü, Nezahat Bükücü, Nuray Bayat, Leman Sencar, Mehmet Tarakçioğlu
The Effect Of Vitamin E And L-Carnitine Against Methotrexate-Induced Injury In Rat Testis, Mehmet Yüncü, Nezahat Bükücü, Nuray Bayat, Leman Sencar, Mehmet Tarakçioğlu
Turkish Journal of Medical Sciences
Background/aim: Methotrexate (MTX), used commonly as an antimetabolite drug in cancer therapy, leads to acute toxic side effects in tissues or organs containing rapidly dividing cells, such as bone marrow, gastrointestinal mucosa, and seminiferous tubules. In this study, we investigated the protective effects of vitamin E and L-carnitine against MTX-induced injury in rat testis. Materials and methods: Rats were divided into 4 groups, including the control group. The study took 17 days and the animals received daily doses of 0.5 mL/kg saline, 250 mg/kg vitamin E, or 500 mg/kg L-carnitine intraperitoneally. The experimental groups received 20 mg/kg methotrexate intraperitoneally on …
Beneficial Effects Of Melatonin And Bq-123 On The Rat Testis Damage Caused By Cigarette Smoke, Hüseyi̇n Aslan, Hakan Kesi̇ci̇, Zafer İsmai̇l Karaca, Bi̇rsen Özyurt, Ufuk Taş, Fati̇h Eki̇ci̇, Hasan Erdoğan, Fi̇kret Gevrek, Sevi̇l Çayli
Beneficial Effects Of Melatonin And Bq-123 On The Rat Testis Damage Caused By Cigarette Smoke, Hüseyi̇n Aslan, Hakan Kesi̇ci̇, Zafer İsmai̇l Karaca, Bi̇rsen Özyurt, Ufuk Taş, Fati̇h Eki̇ci̇, Hasan Erdoğan, Fi̇kret Gevrek, Sevi̇l Çayli
Turkish Journal of Medical Sciences
Several studies have demonstrated that cigarette smoke has detrimental effects on testicular function. However, it is unknown whether melatonin or BQ-123 has beneficial effects on the rat testis damage caused by cigarette smoke. The aim of the present study was to investigate the beneficial effects of melatonin or BQ-123 on the testicular damage caused by cigarette smoke. Materials and methods: Twenty Wistar rats were randomly divided into 4 equal groups: control group (n = 5), cigarette smoke group (n = 5), melatonin group (n = 5), and BQ-123 group (n = 5). At the end of 4 weeks, all the …
Efficacy Of Diffusion-Weighted Magnetic Resonance Imaging In The Evaluation Of Extrahepatic Cholestasis-Related Hepatic Fibrosis, Süleyman Ayvaz, Sedat Alpaslan Tuncel, Güray Can, Beki̇r Çağli, Turan Karaca, Seli̇m Demi̇rtaş, Muhammed Elmaoğlu, Mehmet Ercüment Ünlü, Mehmet Pul
Efficacy Of Diffusion-Weighted Magnetic Resonance Imaging In The Evaluation Of Extrahepatic Cholestasis-Related Hepatic Fibrosis, Süleyman Ayvaz, Sedat Alpaslan Tuncel, Güray Can, Beki̇r Çağli, Turan Karaca, Seli̇m Demi̇rtaş, Muhammed Elmaoğlu, Mehmet Ercüment Ünlü, Mehmet Pul
Turkish Journal of Medical Sciences
Background/aim: To investigate the efficacy of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis and staging of fibrosis induced by experimental bile duct ligation (BDL). Materials and methods: Twenty-four rats were divided randomly into four groups: control, BDL - 3 days, BDL - 2 weeks, and BDL - 4 weeks. DWI was performed with b-values of 100 and 500 on the rats from control group at day zero, on the rats from the BDL - 3 days group at the end of day 3, on the rats from the BDL - 2 weeks group at the end of day 14, …
Comparison Of Thiopental And Ketamine+Xylazine Anesthesia Inischemia/Reperfusion-Induced Arrhythmias In Rats, Ersöz Gonca
Comparison Of Thiopental And Ketamine+Xylazine Anesthesia Inischemia/Reperfusion-Induced Arrhythmias In Rats, Ersöz Gonca
Turkish Journal of Medical Sciences
Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia score and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the …
Effects Of Prenatally Exposed Diclofenac Sodium On Rat Heart Tissue:A Stereological And Histological Study, Fi̇kret Gevrek, Mi̇kai̇l Kara, Murat Çeti̇n Rağbetli̇, Hüseyi̇n Aslan
Effects Of Prenatally Exposed Diclofenac Sodium On Rat Heart Tissue:A Stereological And Histological Study, Fi̇kret Gevrek, Mi̇kai̇l Kara, Murat Çeti̇n Rağbetli̇, Hüseyi̇n Aslan
Turkish Journal of Medical Sciences
Background/aim: Diclofenac sodium (DS) can cross the placental barrier and affect the fetus, and its consumption during pregnancy may cause developmental malformation of embryos. This study investigates the effect of prenatally applied DS on the quantitative morphology of the adult rat heart. Materials and methods: Pregnant rats were divided into three groups (control, sham, and test). The rats in the test group were injected with DS; the control group received physiological saline (1 mL; 1 mg/kg, i.m.) from the 5th to the 20th day of pregnancy; and the rats in the sham group were not injected at all. At the …
Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini
Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini
Turkish Journal of Medical Sciences
Background/aim: The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. Materials and methods: The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVX-PTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Mel/Thea-PTZ. Groups 1-4 received saline, while groups 5 and 6 received a combination of Mel/Thea for 6 weeks. All animals except for those in groups 1 and 2 received a single injection of PTZ. Results: The OVX-PTZ group had higher generalized tonic-clonic seizure (GTCS) latency compared to the sham-PTZ …