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Articles 31 - 60 of 105
Full-Text Articles in Medicine and Health Sciences
Unexpected Complication Due To Shigella Flexneri In A Child: Acute Appendicitis, Cüneyt Tayman, Alparslan Tonbul, Emi̇n Mete, Ferhat Çatal, Burhan Köseoğlu
Unexpected Complication Due To Shigella Flexneri In A Child: Acute Appendicitis, Cüneyt Tayman, Alparslan Tonbul, Emi̇n Mete, Ferhat Çatal, Burhan Köseoğlu
Turkish Journal of Medical Sciences
Acute bacillary dysentery (shigellosis) occurs due to infections with shigella sp. The spectrum of acute shigellosis ranges from mild watery diarrhea to severe dysentery. Surgical complications of shigellosis described in children have included appendicitis with or without perforation, colonic perforation, intestinal obstruction, and intraabdominal abscess. Acute appendicitis and infective diarrheal illness can be difficult to differentiate, particularly in children. Thus, patients must be followed up closely until the differentiation between bacterial gastroenteritis and acute appendicitis can be made. We report herein a 10-year-old boy who had acute appendicitis due to Shigella flexneri.
Scie, Impact Factor, Journal Volume And Quality, M. Mahi̇r Özmen
Scie, Impact Factor, Journal Volume And Quality, M. Mahi̇r Özmen
Turkish Journal of Medical Sciences
No abstract provided.
Attenuation Of Vasospasm By Dexmedetomidine After Experimental Subarachnoidal Haemorrhage In Rabbits, Olcay Eser, Hüseyi̇n Fi̇dan, Ömer Çoşkun, Yüksel Ela, Ahmet Songur, Murat Coşar
Attenuation Of Vasospasm By Dexmedetomidine After Experimental Subarachnoidal Haemorrhage In Rabbits, Olcay Eser, Hüseyi̇n Fi̇dan, Ömer Çoşkun, Yüksel Ela, Ahmet Songur, Murat Coşar
Turkish Journal of Medical Sciences
Aim: Vasospasm is one of the most important factors that influence the successful treatment of ruptured intracranial aneurysm. We studied if vasospasm following subarachnoidal haemorrhage (SAH) can be alleviated by dexmedetomidine in an animal model. Materials and Methods: Experimental SAH was induced in 12 of 18 New Zealand rabbits by intracisternal injection of autologous blood. Control animals (sham SAH, n = 6) received intracisternal injection of the respective volume of physiological saline solution. Forty eight hours after the operation, rabbits in sham SAH and SAH-alone (n = 6) groups were infused intravenously with 0.9% sodium chloride for 2 h, whereas …
The Effect Of Alcohol On Total Antioxidant Activity And Nitric Oxide Levels In The Sera And Brains Of Rats, Sevi̇l Kurban, İdri̇s Mehmetoğlu
The Effect Of Alcohol On Total Antioxidant Activity And Nitric Oxide Levels In The Sera And Brains Of Rats, Sevi̇l Kurban, İdri̇s Mehmetoğlu
Turkish Journal of Medical Sciences
Background: The present study investigated the effect of alcohol consumption on total antioxidant activity (AOA) and nitric oxide (NO) levels in the sera and brains of rats. Materials and methods: The study included 24 rats that were divided into 2 groups: the control group (n = 12) and the alcohol group (n = 12). Both groups were fed regular laboratory chow and tap water for a period of 2 months; however, the alcohol group received 15% (v/v) ethanol in their drinking water. Then, the rats were decapitated, and serum and brain AOA and NO levels were measured. Results: Both serum …
The Association Of D-Dimer Levels With Other Prognostic Factors In Patients With Lung Cancer, Satilmiş İnal, Cantürk Taşçi, Nuri̇ Karadurmuş, Okan Kuzhan, Arzu Balkan, Meti̇n Özkan, Hayati̇ Bi̇lgi̇ç, Ahmet Özet, Kudret Eki̇z
The Association Of D-Dimer Levels With Other Prognostic Factors In Patients With Lung Cancer, Satilmiş İnal, Cantürk Taşçi, Nuri̇ Karadurmuş, Okan Kuzhan, Arzu Balkan, Meti̇n Özkan, Hayati̇ Bi̇lgi̇ç, Ahmet Özet, Kudret Eki̇z
Turkish Journal of Medical Sciences
Aim: To determine the factors related with coagulation disorders, deep venous thrombosis and thromboembolic events that are significant causes of morbidity and mortality in patients with lung cancer. Materials and Methods: D-dimer (DD) levels at the time of diagnosis were determined in patients diagnosed with lung cancer and these cases were monitored prospectively for thromboembolic events and survival. Results: DD levels significantly increased and were associated with length of survival in lung cancer patients. Age, histopathological type, extent of the disease (stage), DD, performance status (ECOG), and thromboembolism were found to effect survival. DD, thromboembolism, ECOG, and histopathological type were …
Structural Changes Of Placenta In Preeclamptic Patients: Light And Electron Microscopic Study, Reda Awadallah Saleh, Mohamed Abdel Monem Dkhil
Structural Changes Of Placenta In Preeclamptic Patients: Light And Electron Microscopic Study, Reda Awadallah Saleh, Mohamed Abdel Monem Dkhil
Turkish Journal of Medical Sciences
Background: Preeclampsia is a disorder that occurs only during pregnancy and the postpartum period and affects both the mother and the unborn baby. It is a rapidly progressive condition characterized by high blood pressure and the presence of protein in the urine. The study was designed to investigate the histological and ultrastructural changes in placentas from pregnancies complicated by preeclampsia. Methods: Paraffin sections from placenta biopsies were prepared for light microscopic examination. For ultrastructural examination, biopsies were prepared and examined by digital scanning electron microscope. Results: Light microscopic examinations showed that the nuclei of syncytiotrophoblast layer were aggregated into clusters …
Elective Treatment Of Detorsioned Sigmoid Volvulus, S. Selçuk Atamanalp, Durkaya Ören, Bülent Aydinli, Gürkan Öztürk, K. Yalçin Polat, Mahmut Başoğlu, M. İlhan Yildirgan, Abdul Meci̇t Kantarci, Ahmet A. Balik
Elective Treatment Of Detorsioned Sigmoid Volvulus, S. Selçuk Atamanalp, Durkaya Ören, Bülent Aydinli, Gürkan Öztürk, K. Yalçin Polat, Mahmut Başoğlu, M. İlhan Yildirgan, Abdul Meci̇t Kantarci, Ahmet A. Balik
Turkish Journal of Medical Sciences
Aim: Recurrence after a successful nonoperative detorsion or a nondefinitive operation is an important problem in the treatment of sigmoid volvulus (SV). This study was designed to review the outcomes of elective treatment of successfully detorsioned SV and to discuss the treatment algorithm. Materials and Methods: The records of 873 patients were reviewed retrospectively. Results: Nonoperative treatment was applied in 614 patients. The success, mortality, complication and recurrence rates were 77.5%, 0.8%, 2.8%, and 4%, respectively. Emergency surgical treatment was performed in 416 patients with 15.6% mortality, 36.5% complication, 0.7% early recurrence and 6.5% late recurrence rates. Elective surgical treatment …
Upper Extremity Musculoskeletal Disorders Among Computer Users, Ali̇ Aydeni̇z, Savaş Gürsoy
Upper Extremity Musculoskeletal Disorders Among Computer Users, Ali̇ Aydeni̇z, Savaş Gürsoy
Turkish Journal of Medical Sciences
Aim: The aim of this study was to determine whether upper extremity musculoskeletal disorders are more prevalent in intense computer users and the relation between cumulative hours of computer use and symptoms. Materials and Methods: The study group included 100 bank workers, who worked more than 6 h per day for at least 2 years on a video display unit and were recruited through convenience sampling. Sixty-five age and sex matched healthy subjects who worked not more than 2 h on computer keyboards for office work constituted the control group. Results: There were no significant differences between groups when the …
Genetic Variability Of The Serine-Rich Gene Of Entamoeba Histolytica In Clinical Isolates From Turkey, Mehmet Tanyüksel, Mustafa Ulukanligi̇l, Hasan Yilmaz, Zeynep Güçlü, Engi̇n Araz, Gürkan Mert, Özgür Koru, William A. Petri
Genetic Variability Of The Serine-Rich Gene Of Entamoeba Histolytica In Clinical Isolates From Turkey, Mehmet Tanyüksel, Mustafa Ulukanligi̇l, Hasan Yilmaz, Zeynep Güçlü, Engi̇n Araz, Gürkan Mert, Özgür Koru, William A. Petri
Turkish Journal of Medical Sciences
Aim: The spectrum of clinical intestinal disease due to Entamoeba histolytica infection ranges from an asymptomatic carrier state to fulminant colitis with an array of manifestations. The extent of strain diversity for E. histolytica and the extent to which strains differ in virulence are not clearly known. In this study, we aimed to investigate the genetic diversity of E. histolytica isolates from Turkey. Materials and Methods: In order to study genetic diversity, the serine-rich gene of E. histolytica (SREHP) was investigated in 26 clinical isolates from Turkey by nested PCR amplification and restriction enzyme fragment length polymorphism (RFLP) analysis. Results: …
Is Mefvgene Arg202gln (605 G>A) A Disease-Causing Mutation?, Ayşenur Öztürk, Bi̇rsi̇n Özçakar, Mesi̇ha Eki̇m, Nejat Akar
Is Mefvgene Arg202gln (605 G>A) A Disease-Causing Mutation?, Ayşenur Öztürk, Bi̇rsi̇n Özçakar, Mesi̇ha Eki̇m, Nejat Akar
Turkish Journal of Medical Sciences
Aim: Familial Mediterranean fever (FMF) is an autosomal recessive disease. Arg202Gln was reported as a frequent polymorphism, and G allele of the mutation was in linkage disequilibrium with M694V. Thus, the aim of this study was to determine the distribution of the R202Q (605G>A) mutation in exon 2 of the MEFVgene in Turkish FMF patients and controls. Materials and Methods: The study included 160 FMF and 41 FMF/amyloid patients and 121 controls. Sequencing of exon 10 and exon 5 and PCR/RFLP analysis of E148Q and R202Q mutations of exon 2 of the MEFVgene were performed for all patients according …
Second-Line Drug Susceptibilities Of Multidrug-Resistant Mycobacterium Tuberculosis Isolates In Aegean Region - Turkey, Nuri̇ Özkütük, Süheyla Sürücüoğlu, Hörü Gazi̇, Meral Coşkun, Aydan Özkütük, Beri̇l Özbakkaloğlu
Second-Line Drug Susceptibilities Of Multidrug-Resistant Mycobacterium Tuberculosis Isolates In Aegean Region - Turkey, Nuri̇ Özkütük, Süheyla Sürücüoğlu, Hörü Gazi̇, Meral Coşkun, Aydan Özkütük, Beri̇l Özbakkaloğlu
Turkish Journal of Medical Sciences
Aim: The emergence of multidrug-resistant tuberculosis (MDR-TB) is increasing, and the standard short-course regimen used for the treatment of TB is likely to be ineffective against MDR-TB, leading to the need for second-line drugs. In such situations, drug susceptibility testing is necessary to select an appropriate treatment regimen. Unfortunately, there are few studies showing the pattern of the second-line drug resistance in Turkey. We aimed to analyze the resistance to second-line anti-tuberculosis drugs of MDR strains of Mycobacterium tuberculosis isolated from the Aegean region of Turkey. Materials and Methods: In this study, drug susceptibility testing of 40 MDR-TB strains isolated …
Partial Purification Of Topoisomerase I From Mycobacterium Phlei, Asli Pinar, N. Leyla Açan, Nazmi̇ Özer
Partial Purification Of Topoisomerase I From Mycobacterium Phlei, Asli Pinar, N. Leyla Açan, Nazmi̇ Özer
Turkish Journal of Medical Sciences
Aim: DNA topoisomerases control several cellular activities by catalyzing the relaxation of superhelices, which are produced during the replication of DNA. Investigation of the inhibitory action of the candidate substances on topoisomerase activity is widely used in drug development. The purpose of this study was to purify topoisomerase I from Mycobacterium phlei, which is closely related to Mycobacterium tuberculosis, and investigate some of its properties. Materials and Methods: Topoisomerase I from Mycobacterium phlei was partially purified with the method including homogenization followed by DNase treatment, Sephadex G50 and Heparin Sepharose column chromatography steps. Results: The enzyme was purified 31.8-fold with …
Antimicrobial Susceptibility Of Brucella Melitensis Isolates From Blood Samples, Ergi̇n Ayaşlioğlu, Selçuk Kiliç, Kemaletti̇n Aydin, Di̇lek Kiliç, Sedat Kaygusuz, Canan Ağalar
Antimicrobial Susceptibility Of Brucella Melitensis Isolates From Blood Samples, Ergi̇n Ayaşlioğlu, Selçuk Kiliç, Kemaletti̇n Aydin, Di̇lek Kiliç, Sedat Kaygusuz, Canan Ağalar
Turkish Journal of Medical Sciences
Aim: Brucellosis is a worldwide zoonotic disease that remains an important public health problem in rural Turkey. The aim of the present study was to identify Brucella species and biotypes, and to assess the antimicrobial susceptibility of isolates from blood samples. Materials and Methods: The study included 46 Brucella isolates from the Kırıkkale region of central Anatolia. The identification and biotyping of the isolates were based on conventional methods. The minimal inhibitory concentration (MIC) values of tetracycline, rifampin, streptomycin, ciprofloxacin, and azithromycin were determined using the E test method. Results: All isolates were identified as B. melitensis (45 isolates, biotype-3) …
Descriptive Epidemiology Of Secondary Transport From The Emergency Unit Of A State Hospital, Mücahi̇t Emet, Nazim Ercüment Beyhun, Mustafa Uzkeser, Şahi̇n Aslan
Descriptive Epidemiology Of Secondary Transport From The Emergency Unit Of A State Hospital, Mücahi̇t Emet, Nazim Ercüment Beyhun, Mustafa Uzkeser, Şahi̇n Aslan
Turkish Journal of Medical Sciences
Aims: To determine the decision time (DT) in the Emergency Department (ED) to establish the factors that prolong DT. Methods: This was a prospective study performed between November 17 and December 18, 2005, involving patients who had been admitted to the ED and whose transfer to other hospitals was decided. We used ´´The Patient Transfer Questionnaire´´, which included the date of transfer, demographics of the patient, and the physician´s decision of the time of transfer. The statistical variables were assessed using SPSS. Results: A total of 507 patients were included, of whom 53.4% were male. The most frequent diagnoses in …
Surgical Management Of Anterior Lenticonus In A Patient With Alport´S Syndrome, Çi̇ğdem Ülkü Can, Bayazit İlhan, Si̇bel Polat, Kuddusi̇ Teberi̇k, Orhan Zi̇leli̇oğlu
Surgical Management Of Anterior Lenticonus In A Patient With Alport´S Syndrome, Çi̇ğdem Ülkü Can, Bayazit İlhan, Si̇bel Polat, Kuddusi̇ Teberi̇k, Orhan Zi̇leli̇oğlu
Turkish Journal of Medical Sciences
Background: To discuss ophthalmic features and management of a patient with Alport´s syndrome and anterior lenticonus. Materials and Methods: A 22-year-old female patient with Alport´s syndrome who, in another center, had undergone laser in situ keratomileusis (LASIK) because of high myopia was determined to have bilateral anterior lenticonus. We treated the other eye by phacoemulsification and intraocular lens (IOL) implantation. Results: Lens extraction and IOL implantation gave satisfactory results. The eye undergone LASIK was rehabilitated by a contact lens. Conclusion: As anterior and/or posterior lenticonus is easily overlooked, careful evaluation of patients with high refractive errors is essential before any …
Gastrointestinal Stromal Tumor With Pulmonary Metastasis, Ahmet Gürer, Selma Göğkuş, Bülent Demi̇rbaş, Eren Ersoy, Raci̇ Aydin
Gastrointestinal Stromal Tumor With Pulmonary Metastasis, Ahmet Gürer, Selma Göğkuş, Bülent Demi̇rbaş, Eren Ersoy, Raci̇ Aydin
Turkish Journal of Medical Sciences
Gastrointestinal stromal tumor (GIST) is rare but is the most common mesenchymal tumor of the gastrointestinal tract. It is usually arises from the stomach and small intestine. We present a case of GIST treated with surgery and adjuvant imatinib mesylate for pulmonary metastasis.
A Rare Cause Of Intestinal Obstruction: Meckel´S Diverticulitis, Oskay Kaya, Münevver Moran, Fati̇h Özdemi̇r, Süleyman Çeti̇nkunar
A Rare Cause Of Intestinal Obstruction: Meckel´S Diverticulitis, Oskay Kaya, Münevver Moran, Fati̇h Özdemi̇r, Süleyman Çeti̇nkunar
Turkish Journal of Medical Sciences
Small bowel obstruction is a rare complication of Meckel´s diverticulitis. Our purpose is to present a case of a 16-year-old boy with a 3 days history of abdominal pain, recurrent vomiting, and absence of stool discharge. He had appendectomy 3 years ago. Upon laparotomy, we observed small bowel obstruction due to an adhesion between the tip of the inflamed Meckel´s diverticulum and anterior abdominal wall. Although postoperative abdominal adhesions account for the most frequent cause of intestinal obstruction, Meckel´s diverticulitis should also be kept in mind.
Neuroblastoma In Adulthood, Turgut Yapanoğlu, İsa Özbey, Yilmaz Aksoy, Nesri̇n Gürsan, Özkan Polat
Neuroblastoma In Adulthood, Turgut Yapanoğlu, İsa Özbey, Yilmaz Aksoy, Nesri̇n Gürsan, Özkan Polat
Turkish Journal of Medical Sciences
Neuroblastoma is a common malignancy in children, but rarely occurs in adults. Neuroblastoma occurring in adolescents, compared to those occurring in children, are more frequently diagnosed in advanced stages and have common sites of metastases. Currently there are no standard treatment guidelines for patients with neuroblastoma in adulthood. If treated with standard protocols as those used for children, their survival is poor, particularly patients with localized disease seem to have a more aggressive course compared to children.
Transient Fetal And Neonatal Ascites: A New Finding Of Down Syndrome?, Nurdan Uras, Semra Kara, Alparslan Tonbul, Meli̇ke Meti̇n, Tuğba Halici, Mustafa Mansur Tatli, Ahmet Karadağ
Transient Fetal And Neonatal Ascites: A New Finding Of Down Syndrome?, Nurdan Uras, Semra Kara, Alparslan Tonbul, Meli̇ke Meti̇n, Tuğba Halici, Mustafa Mansur Tatli, Ahmet Karadağ
Turkish Journal of Medical Sciences
No abstract provided.
Abnormal Uterine Bleeding In Adolescents: Treatment With Combined Oral Contraceptive Pills Is Effective Even In Hospitalized Patients With Bleeding Disorders, M. Meti̇n Altay, Ali̇ Haberal
Abnormal Uterine Bleeding In Adolescents: Treatment With Combined Oral Contraceptive Pills Is Effective Even In Hospitalized Patients With Bleeding Disorders, M. Meti̇n Altay, Ali̇ Haberal
Turkish Journal of Medical Sciences
Aims: To show the efficacy of oral contraceptive (OC) treatment for hospitalized adolescent patients with abnormal uterine bleeding (AUB). Materials and Methods: Thirty-one girls with AUB and anemia hospitalized within the last two years were included. The patients´ medical records were evaluated retrospectively. All patients were given combined OC containing 0.03 mg ethinyl estradiol plus 0.15 mg desogestrel according to a defined protocol. Results: Among 31 patients, 8 (25.8%) had bleeding disorders: 3 (9.7%) had factor VII deficiency, 3 (9.7%) thrombocytopenia, 1 (3.2%) factor VIII deficiency and 1 (3.2%) von Willebrand disease. Vaginal bleeding stopped in all patients within a …
Assessment Of Mental Health Of University Students With Ghq-12, Sarp Üner, Hi̇lal Özcebe, T. Gökhan Telatar, Sabahat Tezcan
Assessment Of Mental Health Of University Students With Ghq-12, Sarp Üner, Hi̇lal Özcebe, T. Gökhan Telatar, Sabahat Tezcan
Turkish Journal of Medical Sciences
Aims: The aim of this study was to assess the mental health status of university students and the factors affecting their mental health. Materials and Methods: The universe of the study consisted of a total of 8407 students enrolled as first- or third-year students of a university. The study sample was determined by using the ``sampling size where the population in universe is known´´ formula. The study questionnaire was designed to include questions regarding some sociodemographic characteristics and the General Health Questionnaire (GHQ)-12. Data were analyzed by SPSS 15.0, and binary logistic regression forward selection method was used to determine …
What Influences Herbal Medicine Use? - Prevalence And Related Factors, Serpi̇l Aydin, Ayfer O. Bozkaya, Mümtaz M. Mazicioğlu, Ayfer Gemalmaz, Ali̇s Özçakir, Ahmet Öztürk
What Influences Herbal Medicine Use? - Prevalence And Related Factors, Serpi̇l Aydin, Ayfer O. Bozkaya, Mümtaz M. Mazicioğlu, Ayfer Gemalmaz, Ali̇s Özçakir, Ahmet Öztürk
Turkish Journal of Medical Sciences
Aims: The use and cost of complementary/alternative medicine (CAM) has been gaining in importance worldwide. Herbal medicine is one of the most commonly used methods. To understand the effectiveness, reliability, and quality of CAM and provide standardization in its analysis, its prevalence and the factors influencing its use must be identified. This study was conducted to identify the prevalence of CAM use and the effective factors in our population. Materials and Methods: A stratified multistage probability sampling design was used in this cross-sectional, population-based study, which was conducted in Aydin. Participants were interviewed face to face by trained interviewers with …
Ear Lobule Flap For Reconstruction Of A Near Total Auricle Defect, Bi̇rol Ci̇velek, Ercan Demi̇rbağ, Uğur Çakmak, Tayyar Selçuk, Seli̇m Çelebi̇oğlu
Ear Lobule Flap For Reconstruction Of A Near Total Auricle Defect, Bi̇rol Ci̇velek, Ercan Demi̇rbağ, Uğur Çakmak, Tayyar Selçuk, Seli̇m Çelebi̇oğlu
Turkish Journal of Medical Sciences
A number of surgical procedures can be performed for partial auricular defects occurring due to various causes. The most appropriate reconstruction method should be employed with regard to the defect dimensions and the status of local adjacent tissues. We present a case of near total excision of external ear due to recurrent basal cell carcinoma and the reconstruction of the defect with ear lobule flap.
Is Cd117 Expression Related With Plasma Cell Differentiation, Irf4/Mum1 And Cd38 Expressions In Lymphoid Neoplasms?, Gülşah Kaygusuz, Işinsu Kuzu, Saba Ki̇remi̇tçi̇, Duygu Kankaya, Zeynep Biyikli
Is Cd117 Expression Related With Plasma Cell Differentiation, Irf4/Mum1 And Cd38 Expressions In Lymphoid Neoplasms?, Gülşah Kaygusuz, Işinsu Kuzu, Saba Ki̇remi̇tçi̇, Duygu Kankaya, Zeynep Biyikli
Turkish Journal of Medical Sciences
Aim: In this study, we aimed to assess the expression of CD117 in a large series of both Hodgkin´s and non-Hodgkin´s lymphoma, and to investigate the association between the expression patterns of CD117, IRF4/MUM1, and CD38. Materials and Methods: A total of 237 lymphoma cases were selected and examined within six tissue microarray paraffin blocks. Immunohistochemistry was performed using antibodies against CD117, IRF4/MUM1 and CD38. Results: CD117 and IRF4/MUM1 immunoreactivity were seen in a subset of high-grade and low-grade B-cell lymphomas, as well as T-cell lymphomas and classical type Hodgkin´s lymphomas. CD38 positivity was only detected in 1% of diffuse …
The Effect Of Erythropoietin On Neurotrophic Factors In N9 Murine Microglial Cells, Fi̇li̇z Kuralay, Başak Bi̇ngöl Çakirli, Şermi̇n Genç
The Effect Of Erythropoietin On Neurotrophic Factors In N9 Murine Microglial Cells, Fi̇li̇z Kuralay, Başak Bi̇ngöl Çakirli, Şermi̇n Genç
Turkish Journal of Medical Sciences
Aim: In this study, we investigated whether interferon gamma (IFN\gamma), lipopolysaccharides (LPS) and amyloid beta (AMY\beta), as toxic stimulator agents, and erythropoietin (EPO), as a neurotrophic agent, have an effect on the production of the following neurotrophic factors in the N9 murine microglia cell line: neurotrophin 3 (NT3), neurotrophin 4 (NT4), and brain-derived neurotrophic factor (BDNF). Materials and Methods: Microglial cells were incubated with 50 μg/ml AMY\beta, or 1 μg/ml of LPS plus 100 U/ml recombinant murine IFN\gamma, and/or one of three different concentrations (0.1, 1.0, and 5.0 U/ml) of recombinant mouse EPO for 24 h. Results: EPO 0.1 U/ml …
The Effect Of Caffeic Acid Phenethyl Ester (Cape) Treatment On Levels Of Mda, No And Antioxidant Enzyme Activities In Retinas Of Streptozotocin-Induced Diabetic Rats, Mustafa Durmuş, H. Ramazan Yilmaz, Efkan Uz, Nurten Özçeli̇k
The Effect Of Caffeic Acid Phenethyl Ester (Cape) Treatment On Levels Of Mda, No And Antioxidant Enzyme Activities In Retinas Of Streptozotocin-Induced Diabetic Rats, Mustafa Durmuş, H. Ramazan Yilmaz, Efkan Uz, Nurten Özçeli̇k
Turkish Journal of Medical Sciences
Aim: This study was performed to determine the effect of caffeic acid phenethyl ester (CAPE) treatment on levels of malondialdehyde (MDA) and nitric oxide (NO) and activities of antioxidant enzymes in retinas of streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Twenty-seven rats were enrolled and divided into three groups: group 1: non-diabetic rats as control (n = 9); group 2: STZ-induced, untreated diabetic rats (n = 8); and group 3: STZ-induced, CAPE-treated diabetic rats (n = 10). Levels of MDA and NO and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in retinal tissues were analyzed. Results: In …
Peripheral Blood Lymphocyte Activation And Rantes Levels In Asthma, Gaye Erten, Benan Müselli̇m, Bülent Tutluoğlu, Bi̇lun Gemi̇ci̇oğlu, Günnur Deni̇z
Peripheral Blood Lymphocyte Activation And Rantes Levels In Asthma, Gaye Erten, Benan Müselli̇m, Bülent Tutluoğlu, Bi̇lun Gemi̇ci̇oğlu, Günnur Deni̇z
Turkish Journal of Medical Sciences
Aim: Bronchial mucosal inflammation is one of the major characteristics of atopic asthma. Th2 activation and the related cytokine profile, eosinophil activation and infiltration play the main role in the pathogenesis of atopic asthma. The aim of this study was to demonstrate the activation and RANTES (regulated on activation, normal T-cell expressed and presumably secreted) expression of peripheral blood lymphocytes of non-atopic and atopic asthmatic patients. Materials and Methods: CD3, CD4, CD8, CD16, CD23, CD25, CD45RA and CD45RO expressions were determined in 22 asthma patients and 20 healthy control subjects by flow cytometry, and RANTES levels were measured by ELISA. …
Current Trends And Future Implications In Sepsis Treatment, Bariş Doğu Yildiz, Kaya Yorganci
Current Trends And Future Implications In Sepsis Treatment, Bariş Doğu Yildiz, Kaya Yorganci
Turkish Journal of Medical Sciences
Sepsis is a systemic illness caused by invasion of tissues by pathogens. It is highly lethal, causing circulatory failure and death. There has been extensive research trying to identify possible therapies for sepsis. Apart from source control, and antibiotic and supportive therapy, glucocorticoids, anticoagulant agents, and immunoglobulins have been tried in both the experimental setting and in septic patients. Newer strategies include novel anticoagulant agents like ethyl pyruvate, statins, insulin receptor modulators and Toll-like receptor modulators. This review article summarizes both the current therapies and endeavors for future treatment in sepsis.
Total Antioxidant Capacity And C-Reactive Protein Levels In Patients With Community-Acquired Pneumonia, Ahmet Bi̇rcan, Recep Sütçü, Müni̇re Gökirmak, Hi̇cran Hi̇çyilmaz, Ahmet Akkaya, Önder Öztürk
Total Antioxidant Capacity And C-Reactive Protein Levels In Patients With Community-Acquired Pneumonia, Ahmet Bi̇rcan, Recep Sütçü, Müni̇re Gökirmak, Hi̇cran Hi̇çyilmaz, Ahmet Akkaya, Önder Öztürk
Turkish Journal of Medical Sciences
Aims: The aim of this study was to evaluate the oxidative stress measured by serum total antioxidant capacity (TAC) and malondialdehyde (MDA) in patients with community-acquired pneumonia (CAP), and to evaluate their possible correlation with the serum C-reactive protein (CRP) and pneumonia severity index (PSI). Materials and Methods: The PSI, chest X-ray (CXR) scores, and the serum TAC, MDA, and CRP levels were determined in 67 CAP patients on admission and compared to 45 healthy controls. Results: In the whole study population, the TAC level was inversely correlated with CRP levels and WBC counts (r=-0.648, P=0.0001; r=-0.626, P=0.0001, respectively). Lower …
Effect Of Metformin Or Gliclazide On Lipid Peroxidation And Antioxidant Levels In Patients With Diabetes Mellitus, Ramazan Memi̇şoğullari, Mehmet Türkeli̇, Ebubeki̇r Bakan, Fati̇h Akçay
Effect Of Metformin Or Gliclazide On Lipid Peroxidation And Antioxidant Levels In Patients With Diabetes Mellitus, Ramazan Memi̇şoğullari, Mehmet Türkeli̇, Ebubeki̇r Bakan, Fati̇h Akçay
Turkish Journal of Medical Sciences
Aim: The association between oxidative stress and diabetic complications is well known. The main goal of antidiabetic therapy is to prevent the complications of diabetes. Gliclazide (sulfonylurea) and metformin (biguanide) are two oral antidiabetic drugs that have been proven to prevent diabetic complications. In this study, we aimed to investigate the antioxidant effects of gliclazide or metformin. Materials and Methods: In this study, we evaluated 46 patients with type 2 diabetes mellitus. The patients were divided into three groups according to their treatment modality of gliclazide, metformin, or diet. Erythrocyte glutathione peroxidase (Gpx), glutathione S-transferase (GST), and catalase (CAT) activities …