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The Effect Of Caffeic Acid Phenethyl Ester (Cape) Treatment On Levels Of Mda, No And Antioxidant Enzyme Activities In Retinas Of Streptozotocin-Induced Diabetic Rats, Mustafa Durmuş, H. Ramazan Yilmaz, Efkan Uz, Nurten Özçeli̇k
The Effect Of Caffeic Acid Phenethyl Ester (Cape) Treatment On Levels Of Mda, No And Antioxidant Enzyme Activities In Retinas Of Streptozotocin-Induced Diabetic Rats, Mustafa Durmuş, H. Ramazan Yilmaz, Efkan Uz, Nurten Özçeli̇k
Turkish Journal of Medical Sciences
Aim: This study was performed to determine the effect of caffeic acid phenethyl ester (CAPE) treatment on levels of malondialdehyde (MDA) and nitric oxide (NO) and activities of antioxidant enzymes in retinas of streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Twenty-seven rats were enrolled and divided into three groups: group 1: non-diabetic rats as control (n = 9); group 2: STZ-induced, untreated diabetic rats (n = 8); and group 3: STZ-induced, CAPE-treated diabetic rats (n = 10). Levels of MDA and NO and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in retinal tissues were analyzed. Results: In …
Effect Of Metformin Or Gliclazide On Lipid Peroxidation And Antioxidant Levels In Patients With Diabetes Mellitus, Ramazan Memi̇şoğullari, Mehmet Türkeli̇, Ebubeki̇r Bakan, Fati̇h Akçay
Effect Of Metformin Or Gliclazide On Lipid Peroxidation And Antioxidant Levels In Patients With Diabetes Mellitus, Ramazan Memi̇şoğullari, Mehmet Türkeli̇, Ebubeki̇r Bakan, Fati̇h Akçay
Turkish Journal of Medical Sciences
Aim: The association between oxidative stress and diabetic complications is well known. The main goal of antidiabetic therapy is to prevent the complications of diabetes. Gliclazide (sulfonylurea) and metformin (biguanide) are two oral antidiabetic drugs that have been proven to prevent diabetic complications. In this study, we aimed to investigate the antioxidant effects of gliclazide or metformin. Materials and Methods: In this study, we evaluated 46 patients with type 2 diabetes mellitus. The patients were divided into three groups according to their treatment modality of gliclazide, metformin, or diet. Erythrocyte glutathione peroxidase (Gpx), glutathione S-transferase (GST), and catalase (CAT) activities …